P. Holt

P. Sly, P. Holt, B. Björkstén, 1997, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Breast feeding and respiratory morbidity in infancy: a birth cohort study

P. Sly, F. Stanley, P. Holt, 2003, Archives of disease in childhood.

Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

P. Holt, L. Beilin, P. Jacoby, 2014, British Journal of Nutrition.

Functional studies on dendritic cells in the respiratory tract and related mucosal tissues

P. Holt, A. McWilliam, P. Stumbles, 1999, Journal of leukocyte biology.

Functional characteristics of the veiled cells in afferent lymph from the rat intestine.

G. Mayrhofer, P. Holt, J. Papadimitriou, 1986, Immunology.

Staphylococcal Enterotoxin-B-Mediated Stimulation of Interleukin-13 Production as a Potential Aetiologic Factor in Eczema in Infants

P. Holt, T. Heaton, H. S. Lehmann, 2004, International Archives of Allergy and Immunology.

Low serum 25‐hydroxyvitamin D concentrations associate with non‐alcoholic fatty liver disease in adolescents independent of adiposity

P. Holt, L. Beilin, P. Jacoby, 2014, Journal of gastroenterology and hepatology.

The developing immune system and allergy

P. Holt, E. Hollams, 2010 .

CHAPTER 6 – The Developing Immune System and Allergy

P. Holt, E. Hollams, J. Rowe, 2010 .

Alveolar macrophages. I. A simple technique for the preparation of high numbers of viable alveolar macrophages from small laboratory animals.

P. Holt, 1979, Journal of immunological methods.

Fish Oil Supplementation in Pregnancy Modifies Neonatal Progenitors at Birth in Infants at Risk of Atopy

J. Denburg, P. Holt, R. Sehmi, 2005, Pediatric Research.

Mucosal immunity in relation to the development of oral tolerance/sensitization

P. Holt, P. Holt, 1998, Allergy.

The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage.

P. Holt, 2015, The Journal of allergy and clinical immunology.

Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period.

P. Holt, C. Macaubas, Patrick G. Holt, 1997, Current opinion in immunology.

Allergen recognition in the origin of asthma.

P. Sly, P. Holt, B. Björkstén, 1997, Ciba Foundation symposium.

T‐cell “priming” against environmental allergens in human neonates: sequential deletion of food antigen reactivity during infancy with concomitant expansion of responses to ubiquitous inhalant allergens

W. Thomas, P. Holt, B. Holt, 1995, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Primary sensitisation to inhalant allergens during infancy

P. Holt, D. Nelson, C. Mcmenamin, 1990 .

The airway epithelium as immune modulator: the LARC ascending.

P. Holt, S. Stick, 2003, American journal of respiratory cell and molecular biology.

Selective Enhancement of Systemic Th1 Immunity in Immunologically Immature Rats with an Orally Administered Bacterial Extract

P. Holt, L. M. Bowman, 2001, Infection and Immunity.

Acute Laryngitis in the Rat Induced by Moraxella catarrhalis and Bordetella pertussis: Number of Neutrophils, Dendritic Cells, and T and B Lymphocytes Accumulating during Infection in the Laryngeal Mucosa Strongly Differs in Adjacent Locations

P. Holt, M. Westhofen, P. Jecker, 1999, Pediatric Research.

Major histocompatibility complex (MHC) class II--positive dendritic cells in the rat iris. In situ development from MHC class II-negative precursors.

P. Holt, P. McMenamin, R. Steptoe, 1997, Investigative ophthalmology & visual science.

Regulation of T‐cell activation in the lung: isolated lung T cells exhibit surface phenotypic characteristics of recent activation including down‐modulated T‐cell receptors, but are locked into the G0/G1 phase of the cell cycle

P. Holt, D. Strickland, D. Strickland, 1996, Immunology.

Regulation of T‐cell activation in the lung: alveolar macrophages induce reversible T‐cell anergy in vitro associated with inhibition of interleukin‐2 receptor signal transduction

P. Holt, D. Strickland, U. Kees, 1996, Immunology.

Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T‐cells from infants at low versus high genetic risk for atopy

P. Sly, P. Holt, B. Holt, 1995, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Suppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, IL-2R expression, and proliferation.

P. Holt, U. Kees, D. Strickland, 1994, The European respiratory journal.

Phenotypic and functional analysis of mucosal T cells isolated from tissue explants of rat upper respiratory tract.

P. Holt, C. Mcmenamin, B. Chilna, 1993, Journal of immunological methods.

Development of allergen-specific T-cell memory in atopic and normal children

P. Sly, P. Holt, B. Holt, 1999, The Lancet.

Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk

M. Inouye, K. Holt, C. Khor, 2019, bioRxiv.

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

M. Inouye, K. Holt, C. Khor, 2020, Nature Communications.

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

P. Holt, P. Jacoby, P. Hart, 2014, Archives of Women's Mental Health.

Whole-cell pertussis vaccine in early infancy for the prevention of allergy

P. Holt, M. Estcourt, C. Brennan-Jones, 2020 .

Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study

P. Holt, Jing Guo, G. Zhang, 2019, Allergy, Asthma & Clinical Immunology.

Airways inflammation, atopy, and (1--> 3)-beta-D-glucan exposures in two schools.

R. Rylander, P. Holt, A. Tunsäter, 1998, American journal of respiratory and critical care medicine.

Airways Inflammation, Atopy, and (1 → 3)- β -d-Glucan Exposures in Two Schools

R. Rylander, P. Holt, A. Tunsäter, 1998 .

Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children.

Martin J Firth, P. Sly, P. Holt, 2004, American journal of respiratory and critical care medicine.

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition

P. Calder, P. Holt, T. Mori, 2004, European Journal of Clinical Nutrition.

Atopy, eczema and breast milk fatty acids in a high‐risk cohort of children followed from birth to 5 yr

P. Burton, P. Sly, F. Stanley, 2006, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Rewiring of mite allergen-specific Th-memory-associated gene networks during immunotherapy

P. Holt, Denise Anderson, M. Serralha, 2019 .

in T Memory Responses to Allergens Identification of Novel Th2-Associated Genes

Martin J Firth, P. Sly, P. Holt, 2013 .

for the Pathogenesis of Infectious and Differentiating Dendritic Cells: Implications Functional Phenotype of Locally Airway Epithelial Cells Regulate the

P. Holt, J. Upham, A. Bosco, 2013 .

Identification of Novel Th2-Associated Genes

Martin J Firth, P. Sly, P. Holt, 2006 .

Identification of Novel Th2-Associated Genes in T Memory Responses to Allergens1

Martin J Firth, P. Sly, P. Holt, 2006, The Journal of Immunology.

Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity

P. Holt, T. Thepen, C. Mcmenamin, 1991, European journal of immunology.

In utero and neonatal concerns in allergy

P. Holt, S. Prescott, C. Macaubas, 2001 .

Ontogeny of the immune response

P. Holt, J. Rowe, 2005 .

Neonatal interleukin‐12 capacity is associated with variations in allergen‐specific immune responses in the neonatal and postnatal periods

P. Holt, S. Prescott, C. Thornton, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Function of Inducing Stimulus Use of Alternative Chemokine Receptors as a Resting and Inflamed Airway Epithelium : Regulation of Dendritic Cell Recruitment into

P. Holt, Timothy, A. Proudfoot, 2001 .

Human Bronchial Epithelium Controls TH2 Responses by TH1-Induced, Nitric Oxide-Mediated STAT5 Dephosphorylation: Implications for the Pathogenesis of Asthma 1

U. Eriksson, P. Holt, M. Bihl, 2005, The Journal of Immunology.

Implications for the Pathogenesis of Asthma Oxide-Mediated STAT5 Dephosphorylation: Responses by TH1-Induced, Nitric Human Bronchial Epithelium Controls TH2

U. Eriksson, P. Holt, M. Bihl, 2005 .

Suppression of IgE responses by antigen inhalation: studies on the role of genetic and environmental factors.

P. Holt, J. Sedgwick, D. Britten, 1987, Immunology.

Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses.

P. Sly, P. Holt, G. Baynam, 2008, Vaccine.

Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults

L. Straker, P. Holt, C. Pennell, 2019, Journal of the Endocrine Society.

Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes

P. Holt, J. Upham, A. Bosco, 2012, PloS one.

Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children1

P. Sly, W. Thomas, P. Holt, 2009, The Journal of Immunology.

Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming

P. Holt, A. Bosco, P. Stumbles, 2020, Frontiers in Immunology.

Transplacental innate immune training via maternal microbial exposure: the XBP1-ERN1 axis in programming dendritic cell precursors

P. Holt, A. Bosco, P. Stumbles, 2019 .

Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development

R. Rabin, P. Sly, P. Holt, 2019, The Journal of allergy and clinical immunology.

Meta-analysis identifies seven susceptibility loci involved in the atopic march

Manuel A. R. Ferreira, C. Gieger, D. Postma, 2015, Nature Communications.

Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma.

C. Witt, P. Sly, P. Holt, 2013, Tissue antigens.

Febrile respiratory illnesses in infancy & atopy are risk factors for persistent asthma & wheeze. Authors List

S. Johnston, P. Sly, P. Holt, 2011 .

Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens.

P. Holt, J. Sedgwick, J. Sedgwick, 1987, Immunology today.

Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile.

P. Sly, P. Holt, B. Holt, 1998, Journal of immunology.

Environment and development of atopy

P. Holt, J. Upham, 2005, Current opinion in allergy and clinical immunology.

Potential role of environmental factors in the etiology and pathogenesis of atopy: a working model.

P. Holt, Patrick G. Holt, 1999, Environmental health perspectives.

A modified histochemical technique for sarcoplasmic reticular ATPase

P. Holt, B. Kakulas, J. Papadimitriou, 2004, Histochemie.

Cell-mediated immune responses to transplanted tumors in mice chronically exposed to cigarette smoke.

P. Holt, D. Keast, J. Chalmer, 1975, Journal of the National Cancer Institute.

META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES IDENTIFIES THREE NEW RISK LOCI FOR ATOPIC DERMATITIS

Christian Gieger, Nicholas J Timpson, Manuel A. R. Ferreira, 2011, Nature Genetics.

Early immunological influences.

C. Naspitz, P. Holt, J. Warner, 2004, Chemical immunology and allergy.

Extraction of immune and inflammatory cells from human lung parenchyma: evaluation of an enzymatic digestion procedure.

P. Holt, U. Kees, J. Papadimitriou, 1986, Clinical and experimental immunology.

Maternal smoking in pregnancy alters neonatal cytokine responses

P. Holt, S. Prescott, P. Holt, 2003, Allergy.

Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine.

P. Holt, J. Bienenstock, I. Maric, 1996, Journal of immunology.

Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

R. Lucas, P. Holt, L. Beilin, 2016, British Journal of Nutrition.

Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.

P. Holt, E. Hollams, P. L. Le Souëf, 2018, The Journal of allergy and clinical immunology.

Expression of the T–Cell Markers CD3, CD4 and CD8 in Healthy and Atopic Children during the First 18 Months of Life

P. Holt, J. Ernerudh, B. Björkstén, 1999, International Archives of Allergy and Immunology.

Infections and the development of allergy.

P. Holt, 1996, Toxicology letters.

Ontogeny of Toll-Like and NOD-Like Receptor-Mediated Innate Immune Responses in Papua New Guinean Infants

W. Pomat, P. Siba, P. Holt, 2012, PloS one.

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Neonatal immune function and vaccine responses in children born in low‐income versus high‐income countries

P. Holt, P. Holt, A. H. van den Biggelaar, 2010, Clinical and experimental immunology.

Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5 years of life

R. Ware, P. Sly, P. Holt, 2021, Pediatric pulmonology.

Predicting steroid responsiveness in asthmatic children: Are we there yet?

P. Sly, P. Holt, 2019, The Journal of allergy and clinical immunology.

Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes

P. Holt, J. Goldblatt, Guicheng Zhang, 2011, ISRN allergy.

Dendritic cells and macrophages in lung allografts: A role in chronic rejection?

G. Rosen, G. Berry, P. Holt, 2000, American journal of respiratory and critical care medicine.

Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages.

P. Holt, 1986, Clinical and experimental immunology.

Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations.

P. Holt, D. Strickland, 2010, The Journal of allergy and clinical immunology.

Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells

P. Holt, J. Thomas, 1997, Immunology.

Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood

P. Holt, Patrick G. Holt, 1996, The Journal of experimental medicine.

Immunomodulating mechanisms in the lower respiratory tract: nitric oxide mediated interactions between alveolar macrophages, epithelial cells, and T-cells.

P. Holt, R. Bingisser, Roland Bingisser, 2001, Swiss medical weekly.

Do early-life viral infections cause asthma?

P. Sly, P. Holt, M. Kusel, 2010, The Journal of allergy and clinical immunology.

TH2‐polarized immunological memory to inhalant allergens in atopies is established during infaney and early childhood

P. Sly, P. Holt, B. Holt, 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthma

C. Bachert, P. Sly, W. Thomas, 2010 .

Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling.

P. Sly, P. Holt, M. Deverell, 2009, The Journal of allergy and clinical immunology.

The concept of airway inflammation.

P. Holt, G. Larsen, 2000, American journal of respiratory and critical care medicine.

Cord blood hemopoietic progenitor profiles predict acute respiratory symptoms in infancy

J. Denburg, S. Johnston, K. Holt, 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect

P. Sly, P. Holt, M. Tang, 2017, The Journal of allergy and clinical immunology.

Serum total IgE levels and CD14 on chromosome 5q31

P. Holt, C. Adra, T. Shirakawa, 1999, Clinical genetics.

Non‐atopic intrinsic asthma and the ‘family tree’ of chronic respiratory disease syndromes

P. Sly, P. Holt, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The increase in allergic disease: environment and susceptibility. Proceedings of a Symposium held at the Royal Society of Edinburgh, 4th June 2002

D. Strachan, A. Woodcock, P. Burney, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children.

P. Sly, P. Holt, A. Rudin, 2000, The Journal of allergy and clinical immunology.

Developing patterns of T cell memory to environmental allergens in the first two years of life.

P. Sly, P. Holt, B. Holt, 1997, International archives of allergy and immunology.

Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system.

P. Sly, P. Holt, A. Charles, 2009, The American journal of pathology.

Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children

G. Morahan, P. Sly, P. Holt, 2002, The Lancet.

CpG methylation patterns in the IFNγ promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non‐atopics

P. Sly, P. Holt, M. Kusel, 2006, Pediatric Allergy and Immunology.

Effect of influenza virus infection on allergic sensitization to inhaled antigen in mice.

P. Holt, J. Vines, N. Bilyk, 1988, International archives of allergy and applied immunology.

Regulation of antigen-presenting cell function(s) in lung and airway tissues.

P. Holt, PG Holt, 1993, The European respiratory journal.

Immunoprophylaxis of atopy: light at the end of the tunnel?

P. Holt, 1994, Immunology today.

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production

P. Holt, C. Mcmenamin, 1993, The Journal of experimental medicine.

Early identification of children likely to develop persistent asthma : atopy is an integral component of the high risk phenotype

A. Boner, A. Custovic, U. Wahn, 2015 .

Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents.

P. Sly, P. Holt, N. de Klerk, 2014, American journal of respiratory and critical care medicine.

Toll-like receptor 7 function is reduced in adolescents with asthma

P. Sly, P. Holt, J. Upham, 2009, European Respiratory Journal.

Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells

P. Sly, P. Holt, G. Zosky, 2006, The Journal of experimental medicine.

Th2-Associated Local Reactions to the Acellular Diphtheria-Tetanus-Pertussis Vaccine in 4- to 6-Year-Old Children

P. Sly, P. Holt, P. Richmond, 2005, Infection and Immunity.

Immunoregulation of asthma: control of T-lymphocyte activation in the respiratory tract.

P. Holt, P. McMenamin, B. Holt, 1991, The European respiratory journal. Supplement.

T cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macrophages.

P. Holt, C. O'Leary, A. Degebrodt, 1985, Clinical and experimental immunology.

Down-regulation of immune responses to inhaled antigen: studies on the mechanism of induced suppression.

P. Holt, J. Sedgwick, 1985, Immunology.

Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

P. Sly, P. Holt, A. Larcombe, 2011, Mucosal Immunology.

Prenatal versus postnatal priming of allergen specific immunologic memory: the debate continues.

P. Holt, 2008, The Journal of allergy and clinical immunology.

Microbial exposure, interferon gamma gene demethylation in naïve T‐cells, and the risk of allergic disease

A. Ponsonby, P. Sly, P. Holt, 2009, Allergy.

Targeting maternal immune function during pregnancy for asthma prevention in offspring: harnessing the "farm effect"?

A. Custovic, P. Holt, D. Strickland, 2020, The Journal of allergy and clinical immunology.

Reciprocal patterns of allergen‐induced GATA‐3 expression in peripheral blood mononuclear cells from atopics vs. non‐atopics

P. Sly, P. Holt, B. Holt, 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort.

P. Sly, P. Holt, S. Ahlstedt, 2007, The Journal of allergy and clinical immunology.

Tolerance induction via antigen inhalation: isotype specificity, stability, and involvement of suppressor T cells.

P. Holt, S. Leivers, 1982, International archives of allergy and applied immunology.

Key factors in the development of asthma: atopy.

P. Holt, 2000, American journal of respiratory and critical care medicine.

Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs

P. Sly, P. Holt, P. Holt, 2000, Thorax.

Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10.

P. Sly, P. Holt, D. Knight, 2001, American journal of respiratory cell and molecular biology.

Current trends in research on the etiology and pathogenesis of byssinosis.

P. Holt, 1987, American journal of industrial medicine.

Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial

M. Alpers, W. Pomat, P. Siba, 2013, PloS one.

Paediatric origins of adult lung diseases

P. Sly, P. Holt, 2000 .

Early Immunological Influences on Asthma Development: Opportunities for Early Intervention

P. Holt, 2009 .

Original article: Predictors of response to bronchial allergen challenge in 5‐ to 6‐year‐old atopic children

P. Sly, P. Holt, M. Kusel, 2007, Allergy.

The role of airway dendritic cell populations in regulation of T-cell responses to inhaled antigens: atopic asthma as a paradigm.

P. Holt, 2002, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Dendritic cells as sentinel cells in asthma

P. Holt, 2001 .

Regulation of Antigen Presentation in the Lung and Airways: The Central Role of Class II MHC-Bearing Dendritic Cells

S. McWilliam, P. Holt, D. Nelson, 1997 .

Macrophage and Dendritic Cell Populations in the Respiratory Tract

P. Holt, 1995 .

Macrophage: dendritic cell interaction in regulation of the IgE response in asthma

P. Holt, P. Holt, 1993, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Ozone hazard in UV isolation units.

P. Holt, A. Nulsen, 1975, Journal of occupational medicine. : official publication of the Industrial Medical Association.

Developmental factors as determinants of risk for infections and atopy in childhood

P. Holt, 2005, European Respiratory Review.

The role of genetic and environmental factors in the development of T-cell mediated allergic disease in early life.

P. Holt, 2004, Paediatric respiratory reviews.

Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood.

P. Sly, P. Holt, J. Rowe, 2003, Vaccine.

Interactions between RSV Infection, Asthma, and Atopy

P. Sly, P. Holt, P. Holt, 2002, The Journal of experimental medicine.

Parasites, atopy, and the hygiene hypothesis: resolution of a paradox?

P. Holt, 2000, The Lancet.

Primary sensitization to inhalant allergens.

P. Sly, P. Holt, B. Holt, 2000, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: the respiratory tract as a paradigm.

P. Holt, P. Stumbles, Patrick G. Holt, 2000, The Journal of allergy and clinical immunology.

Functional differences in airway dendritic cells determine susceptibility to IgE‐sensitization

P. Holt, F. Blank, D. Mok, 2018, Immunology and cell biology.

Title Functional differences in airway dendritic cells determine susceptibility to IgE-sensitisation Running head Inhaled allergen uptake and IgE-sensitisation

P. Holt, F. Blank, D. Mok, 2017 .

Identification and isolation of rodent respiratory tract dendritic cells.

P. Holt, C. von Garnier, P. Stumbles, 2010, Methods in molecular biology.

Influence of Mucosal Adjuvants on Antigen Passage and CD4+ T Cell Activation during the Primary Response to Airborne Allergen1

P. Holt, C. von Garnier, P. Stumbles, 2006, The Journal of Immunology.

the Primary Response to Airborne Allergen T Cell Activation during + Passage and CD4 Influence of Mucosal Adjuvants on Antigen

P. Holt, P. Stumbles, E. Batanero, 2006 .

and Other APCs in the Respiratory Tract Distribution and Function of Dendritic Cells Anatomical Location Determines the

P. Holt, L. Filgueira, P. Stumbles, 2005 .

The role of dendritic cells in asthma

P. Holt, J. Upham, 2004, Current opinion in allergy and clinical immunology.

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract

P. Holt, D. Nelson, A. McWilliam, 1994, The Journal of experimental medicine.

Regulation of IgE production in pre‐sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen *

P. Holt, T. Thepen, C. Mcmenamin, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age.

P. Sly, P. Holt, P. Hart, 2014, Annals of the American Thoracic Society.

Functionally mature virus-specific CD8(+) T memory cells in congenitally infected newborns: proof of principle for neonatal vaccination?

P. Holt, 2003, The Journal of clinical investigation.

Environmental Factors in Children's Asthma and Respiratory Effects

P. Sly, P. Holt, P. Franklin, 2011 .

Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing.

P. Sly, P. Holt, J. Upham, 2009, The Journal of allergy and clinical immunology.

THE SEVERITY OF BOTH ATOPIC AND NONATOPIC ASTHMA IN CHILDREN IS ASSOCIATED WITH IL12B POLYMORPHISM

G. Morahan, P. Sly, P. Holt, 2002 .

Early childhood asthma: What are the questions?

W. Busse, P. Holt, R. Martin, 1995 .

Discussion session II: Inflammation

P. Thompson, S. Dahlén, S. Holgate, 2001 .

Restricted Aeroallergen Access to Airway Mucosal Dendritic Cells In Vivo Limits Allergen-Specific CD4+ T Cell Proliferation during the Induction of Inhalation Tolerance

P. Sly, P. Holt, F. Blank, 2011, The Journal of Immunology.

during the Induction of Inhalation Tolerance T Cell Proliferation + Allergen-Specific CD4 Mucosal Dendritic Cells In Vivo Limits Restricted Aeroallergen Access to Airway

P. Sly, P. Holt, F. Blank, 2011 .

“Bystander” amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children

P. Holt, A. Rudin, B. Holt, 2001, Allergy.

Allergen‐induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses

P. Holt, M. Jenmalm, B. Björkstén, 1999, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations.

W. Pomat, P. Siba, D. Lehmann, 2009, The Journal of allergy and clinical immunology.

OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule

P. Holt, D. Campbell, M. Gold, 2020, BMJ Open.

Th 2-Associated Local Reactions to the Acellular Diphtheria-Tetanus-Pertussis Vaccine in 4to 6-Year-Old Children

P. Sly, P. Holt, P. Richmond, 2005 .

Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea

W. Pomat, P. Siba, D. Lehmann, 2009, Vaccine.

Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: reappraisal of the role of infections and air pollution.

P. Holt, 1995, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Early life ovalbumin sensitization and aerosol challenge for the induction ofallergic airway inflammation in a BALB/c murine model.

P. Holt, P. Stumbles, D. Strickland, 2019, Bio-protocol.

Specific patterns of responsiveness to microbial antigens staphylococcal enterotoxin B and purified protein derivative by cord blood mononuclear cells are predictive of risk for development of atopic dermatitis

P. Sly, P. Holt, M. Kusel, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The Effect of Tobacco Smoke on Protein Synthesis in Macrophages 1

P. Holt, D. Keast, 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Allergic respiratory disease: strategic targets for primary prevention during childhood.

P. Sly, P. Holt, 1997, Thorax.

Atopic allergy and other hypersensitivities: The aetiology and pathogenesis of allergic disease: new insights and new challenges

P. Holt, 1998 .

Strategic targets for primary prevention of allergic disease in childhood

P. Sly, P. Holt, C. Macaubas, 1998, Allergy.

Th2 cytokines in the asthma late-phase response

P. Sly, P. Holt, 2007, The Lancet.

Modification of Acute and Late-Phase Allergic Responses to Ovalbumin with Lipopolysaccharide

P. Sly, P. Holt, M. Tulic, 2002, International Archives of Allergy and Immunology.

Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection.

P. Gergen, W. Busse, C. Ober, 2020, American journal of respiratory and critical care medicine.

Functional analysis of human bronchial mucosal T cells extracted with interleukin-2.

P. Holt, J. Upham, B. Robinson, 1994, American journal of respiratory and critical care medicine.

Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response.

P. Sly, P. Holt, J. Upham, 2009, The Journal of allergy and clinical immunology.

Immunosuppression in the mouse induced by long-term exposure to cigarette smoke.

P. Holt, D. Keast, J. Mackenzie, 1978, The American journal of pathology.

Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM85.

P. Sly, P. Holt, N. Troy, 2019, The Journal of allergy and clinical immunology.

Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles.

P. Sly, P. Holt, Denise Anderson, 2019, The Journal of allergy and clinical immunology.

Sublingual allergen administration. I. Selective suppression of IgE production in rats by high allergen doses

P. Holt, D. Britten, J. Vines, 1988, Clinical allergy.

Lung homing T‐cell generation is dependent on strength and timing of antigen delivery to lymph nodes

P. Holt, P. Stumbles, P. G. Holt, 2010, Immunology and cell biology.

(1-->3)-beta-D-glucan and endotoxin modulate immune response to inhaled allergen.

R. Rylander, P. Holt, 1998, Mediators of inflammation.

Breast is best for preventing asthma and allergies—or is it?

P. Sly, P. Holt, 2002, The Lancet.

Breaking the nexus between asthma and atopy

P. Sly, P. Holt, 1998, The Medical journal of Australia.

Production of a histamine-releasing lymphokine by antigen- or mitogen-stimulated human peripheral T cells.

P. Holt, J. Sedgwick, K. Turner, 1981, Clinical and experimental immunology.

Prevention of allergy and asthma: interim report.

A. Chuchalin, A. Custovic, C. Naspitz, 2000 .

Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages.

P. Holt, U. Kees, T. Thepen, 1993, Immunology.

Relationship between cytokine expression patterns and clinical outcomes: two population‐based birth cohorts

A. Custovic, P. Sly, A. Simpson, 2015, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Alveolar macrophages: functional heterogeneity within macrophage populations from rat lung.

P. Holt, J. Papadimitriou, L. A. Warner, 1982, The Australian journal of experimental biology and medical science.

Alveolar macrophages. IV. Interspecies differences in activity in proliferating lymphocyte cultures.

P. Holt, 1980, Cellular immunology.

Selective inhibition of T cell proliferation but not expression of effector function by human alveolar macrophages.

P. Holt, J. Upham, B. Robinson, 1997, Thorax.

Ontogeny of rat pulmonary alveolar macrophage function: evidence for a selective deficiency in il-10 and nitric oxide production by newborn alveolar macrophages.

P. Holt, A. McWilliam, P. Lee, 2001, Cytokine.

Expression of and responses to CD2 and CD3 in 18‐month‐old children with and without atopic dermatitis

P. Holt, M. Jenmalm, B. Björkstén, 2000, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Developmental Immunology and Host Defense: Kinetics of Postnatal Maturation of Immune Competence as a Potential Etiologic Factor in Early Childhood Asthma

P. Holt, 1995 .

Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school‐aged children

P. Sly, P. Holt, N. de Klerk, 2019, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Infection and the development of allergic disease

P. Holt, 2011, Allergy.

No day-care visits during the first year of life for infants with atopic parents? Reply

P. Sly, P. Holt, M. Kusel, 2008 .

Support for 2 variants of eczema.

P. Sly, P. Holt, N. de Klerk, 2005, The Journal of allergy and clinical immunology.

Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells.

P. Holt, B. Holt, G. P. White, 2002, Journal of immunology.

Original articles Support for 2 variants of eczema

P. Sly, P. Holt, N. Klerk, 2005 .

Maternal influence on IgG subclass antibodies to Bet v 1 during the first 18 months of life as detected with a sensitive ELISA.

P. Holt, M. Jenmalm, B. Björkstén, 1997, International archives of allergy and immunology.

Mechanisms of ozone‐induced inhibitory effect of bronchoalveolar lavage fluid on alveolar macrophage‐mediated immunosuppressive activity in rats

P. Holt, E. Koike, T. Kobayashi, 1999, Journal of leukocyte biology.

γδ T cells provide a breath of fresh air for asthma research

P. Sly, P. Holt, 1999, Nature Medicine.

Role of microbial burden in aetiology of allergy and asthma

P. Holt, F. Martínez, 1999, The Lancet.

Staphylococcal enterotoxin induced IL‐5 stimulation as a cofactor in the pathogenesis of atopic disease: the hygiene hypothesis in reverse?

P. Holt, T. Heaton, T. Venaille, 2003, Allergy.

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

Manuel A. R. Ferreira, David M. Evans, N. Eriksson, 2014, The Journal of allergy and clinical immunology.

Innate Immune Training for Prevention of Recurrent Wheeze in Early Childhood

P. Holt, D. Strickland, 2021, American journal of respiratory and critical care medicine.

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children

P. Sly, P. Holt, P. Young, 2017, Respirology.

Environmental Microbial Exposure and Protection against Asthma.

P. Sly, P. Holt, 2015, The New England journal of medicine.

Interstitial and free lung cells in acute inflammation in the guinea-pig

R. Rylander, P. Holt, M. Snella, 1987, Agents and Actions.

Improved method for the isolation of purified mouse peritoneal macrophages.

P. Holt, M. Schon-Hegrad, 1981, Journal of immunological methods.

Soothing signals: transplacental transmission of resistance to asthma and allergy

P. Holt, D. Strickland, 2009, The Journal of experimental medicine.

Low‐level exposure to house dust mites stimulates T‐cell responses during early childhood independent of atopy

P. Holt, B. Björkstén, B. Holt, 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Primary sensitization to inhalant allergens

P. Sly, P. Holt, B. Holt, 2000, American journal of respiratory and critical care medicine.

Th-1/Th-2 switch regulation in immune responses to inhaled antigens. Role of dendritic cells in the aetiology of allergic respiratory disease.

P. Holt, D. Nelson, A. McWilliam, 1997, Advances in experimental medicine and biology.

What are the prospects for immunization?

P. Holt, 1996, American journal of respiratory and critical care medicine.

A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals.

N. Mavaddat, P. Holt, R. Bowman, 1992, Immunology.

Dendritic Cell Immaturity during Infancy Restricts the Capacity To Express Vaccine-Specific T-Cell Memory

P. Sly, P. Holt, J. Upham, 2006, Infection and Immunity.

DNA Vaccines for Allergic Diseases

P. Holt, K. Chua, B. Wolfowicz, 2003 .

High IFN-γ production by CD8+ T cells and early sensitization among infants at high risk of atopy

P. Sly, P. Holt, N. Klerk, 2004 .

TLR4 Polymorphisms Mediate Impaired Responses to Respiratory Syncytial Virus and Lipopolysaccharide1

P. Sly, P. Holt, J. Upham, 2007, The Journal of Immunology.

Vaccine in 4to 6-Year-Old Children Acellular Diphtheria-Tetanus-Pertussis Th 2-Associated Local Reactions to the

P. Sly, P. Holt, P. Richmond, 2005 .

Th2-polarisation of cellular immune memory to neonatal pertussis vaccination.

P. Holt, H. Marshall, N. Wood, 2010, Vaccine.

Inhibitory activity of unstimulated alveolar macrophages on T-lymphocyte blastogenic response.

P. Holt, 2015, The American review of respiratory disease.

Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions.

W. Pomat, P. Siba, P. Holt, 2012, The Journal of allergy and clinical immunology.

Early life origins of allergy and asthma

P. Sly, P. Holt, G. Devereux, 2006 .

The Hygiene Hypothesis: Modulation of the Atopic Phenotype by Environmental Microbial Exposure

P. Holt, 2004 .

Origin and steady-state turnover of major histocompatibility complex Class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye

P. Holt, P. McMenamin, R. Steptoe, 1996, Journal of Neuroimmunology.

Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion.

P. Holt, J. Upham, B. Robinson, 1995, Immunology.

Role of alveolar macrophages in innate immunity in neonates: evidence for selective lipopolysaccharide binding protein production by rat neonatal alveolar macrophages.

P. Holt, A. McWilliam, P. Lee, 2000, American journal of respiratory cell and molecular biology.

Immunopathology of allergy and asthma in childhood.

P. Holt, C. Jones, 2000, American journal of respiratory and critical care medicine.

Dendritic cells as sentinels of immune surveillance in the airways

P. Holt, P. Gehr, A. McWilliam, 2000 .

Suppression of IgE responses by antigen inhalation: failure of tolerance mechanism(s) in newborn rats.

P. Holt, D. Britten, J. Vines, 1988, Immunology.

Centrality of the XBP1-ERN1 axis in transplacental innate immune training via a microbial- derived immunomodulator Authors:

P. Holt, A. Bosco, P. Stumbles, 2020 .

Limiting-dilution analysis of T cells extracted from solid human lung tissue: comparison of precursor frequencies for proliferative responses and lymphokine production between lung and blood T cells from individual donors.

P. Holt, U. Kees, R. Bowman, 1988, Immunology.

Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye.

P. Holt, J. Crewe, P. McMenamin, 1994, Investigative ophthalmology & visual science.

Studies on the mechanism of induction of tyrosine aminotransferase in neonatal rat liver.

P. Holt, I. T. Oliver, 1969, Biochemistry.

Alveolar macrophages. II. Inhibition of lymphocyte proliferation by purified macrophages from rat lung.

P. Holt, 1979, Immunology.

The value of perinatal immune responses in predicting allergic disease at 6 years of age

P. Holt, S. Prescott, P. Holt, 2003, Allergy.

Environmental pollutants as co-factors in IgE production.

P. Holt, 1989, Current opinion in immunology.

Tracking of vitamin D status from childhood to early adulthood and its association with peak bone mass.

P. Holt, C. Pennell, K. Zhu, 2017, The American journal of clinical nutrition.

A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment

P. Holt, Yuchun Li, B. Hales, 2018, Allergy.

reduces exposure in children non-allergic subjectsSmoke-free legislation bacterial antigen between allergic and Differences in the antibody response to a mucosal

P. Sly, W. Thomas, P. Holt, 2008 .

Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjectsSmoke-free legislation reduces exposure in children

P. Sly, W. Thomas, P. Holt, 2007, Thorax.

Effects of maternal allergen‐specific IgG in cord blood on early postnatal development of allergen‐specific T‐cell immunity

P. Holt, M. Jenmalm, B. Björkstén, 2000, Allergy.

Skewing of Initial T Cell Responses Toward the System to Environmental Allergens: Universal Transplacental Priming of the Human Immune

P. Sly, P. Holt, B. Holt, 1998 .

Environmental antigens and atopic disease: underlying mechanisms and prospects for therapy and prophylaxis.

P. Holt, 1995, Molecular medicine today.

Immune tolerance and protection against allergic sensitization

P. Holt, P. Holt, 1995, Allergy.

HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses.

P. Holt, J. Upham, S. Prescott, 2004, The Journal of allergy and clinical immunology.

Basic and clinical immunology HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses

P. Holt, J. Upham, S. Prescott, 2004 .

Quantification of serum ovalbumin-specific immunoglobulin E titrevia in vivo passive cutaneous anaphylaxis assay.

P. Holt, P. Stumbles, D. Strickland, 2019, Bio-protocol.

Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor

P. Holt, N. Bilyk, P. G. Holt, 1993, The Journal of experimental medicine.

Role of dendritic cells, macrophages, and gamma delta T cells in antigen processing and presentation in the respiratory mucosa

P. Holt, J. Upham, D. Nelson, 1996 .

Functional studies on macrophage populations in the airways and the lung wall of SPF mice in the steady-state and during respiratory virus infection.

P. Holt, J. Papadimitriou, N. Bilyk, 1988, Immunology.

Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study.

P. Sly, P. Holt, H. Sampson, 2013, The Journal of allergy and clinical immunology.

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment

P. Sly, P. Holt, 2012, Nature Medicine.

Transiently increased IgE responses in infants and pre-schoolers receiving only acellular Diphtheria-Pertussis-Tetanus (DTaP) vaccines compared to those initially receiving at least one dose of cellular vaccine (DTwP) - Immunological curiosity or canary in the mine?

P. Sly, J. Carapetis, P. Holt, 2016, Vaccine.

Enumeration of antibody-secreting cells by immunoprinting: sequential readout of different antibody isotypes on individual cell monolayers employing the ELISA plaque assay.

P. Holt, T. Plozza, 1986, Journal of immunological methods.

Enumeration of human immunoglobulin-secreting cells by the ELISA-plaque method: IgE and IgG isotypes.

P. Holt, J. Sedgwick, G. Stewart, 1984, Clinical immunology and immunopathology.

Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

P. Sly, P. Holt, K. Ling, 2018, Scientific Reports.

Dendritic cells in the respiratory tract.

P. Holt, P. McMenamin, M. Schon-Hegrad, 1990, International reviews of immunology.

Relationship of asthma, atopy, and bronchial responsiveness to serum eosinophil cationic proteins in early childhood.

P. Sly, P. Holt, N. de Klerk, 2004, The Journal of allergy and clinical immunology.

Long-lived IgE- and IgG-secreting cells in rodents manifesting persistent antibody responses.

P. Holt, J. Sedgwick, C. O'Leary, 1984, Cellular immunology.

4th Pediatric Allergy and Asthma Meeting (PAAM)

Manuel A. R. Ferreira, C. Gieger, D. Postma, 2016, Clinical and Translational Allergy.

High IFN-gamma production by CD8+ T cells and early sensitization among infants at high risk of atopy.

P. Sly, P. Holt, N. de Klerk, 2004, The Journal of allergy and clinical immunology.

Suppression of IgE responses by passive antigen inhalation: dissociation of local (mucosal) and systemic immunity.

P. Holt, H. Bazin, J. Sedgwick, 1987, Cellular immunology.

Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation.

P. Holt, J. Sedgwick, J. Sedgwick, 1985, Cellular immunology.

Induction of adjuvant-independent IgE responses in inbred mice: primary, secondary, and persistent IgE responses to ovalbumin and ovomucoid.

P. Holt, K. Turner, A. Rose, 1981, International archives of allergy and applied immunology.

The significance of the "dilution effect" in the determination of serum creatine kinase.

P. Holt, B. Kakulas, J. Knight, 1971, Clinica chimica acta; international journal of clinical chemistry.

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.

Rosalind J Wright, P. Gergen, M. Cabana, 2014, The Journal of allergy and clinical immunology.

Incubation film technique for the histochemical localization of creatine kinase

P. Holt, B. Kakulas, M. A. Khan, 2004, Histochemie.

Preparation of interstitial lung cells by enzymatic digestion of tissue slices: preliminary characterization by morphology and performance in functional assays.

P. Holt, H. Farrell, G. Shellam, 1985, Immunology.

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

P. Holt, P. McMenamin, R. Steptoe, 2000 .

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells.

P. Holt, P. McMenamin, R. Steptoe, 2000, Ocular immunology and inflammation.

IgE and mucosal immunity: Studies on the role of intraepithelial Ia+ Dendritic Cells and γ/δ T‐Lymphocytes in regulation of T‐cell activation in the lung

P. Holt, C. Mcmenamin, 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa.

P. Holt, J. Sedgwick, 1983, Immunology.

Suppression of IgE responses in inbred rats by repeated respiratory tract exposure to antigen: Responder phenotype influences isotype specificity of induced tolerance

P. Holt, J. Sedgwick, Jon D. Sedgwick, 1984, European journal of immunology.

Alveolar macrophages. III. Studies on the mechanisms of inhibition of T-cell proliferation.

P. Holt, 1979, Immunology.

Identification and isolation of rodent lung dendritic cells.

P. Holt, P. Stumbles, J. Thomas, 2001, Methods in molecular medicine.

Isoforms of the Major Peanut Allergen Ara h 2: IgE Binding in Children with Peanut Allergy

W. Thomas, P. Holt, B. Hales, 2004, International Archives of Allergy and Immunology.

Regulation of Cytokine Production in T-Cell Responses to Inhalant Allergen:GATA-3 Expression Distinguishesbetween Th1- and Th2-Polarized Immunity

P. Holt, C. Macaubas, 2001, International Archives of Allergy and Immunology.

Dendritic Cell Influx Differs between the Subglottic and Glottic Mucosae during Acute Laryngotracheitis Induced by a Broad Spectrum of Stimuli

P. Holt, W. Mann, P. Jecker, 2002, The Annals of otology, rhinology, and laryngology.

Acute Laryngotracheitis in the Rat Induced by Sendai Virus: The Influx of Six Different Types of Immunocompetent Cells Into the Laryngeal Mucosa Differs Strongly Between the Subglottic and the Glottic Compartment

P. Holt, W. Mann, P. Jecker, 2001, The Laryngoscope.

Sublingual immunotherapy for allergic respiratory disease

P. Sly, P. Holt, WilliamI. Smith, 1998, The Lancet.

Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model.

P. Sly, P. Holt, M. Tulic, 2000, The European respiratory journal.

Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants

W. Pomat, P. Siba, D. Lehmann, 2009, Clinical and Vaccine Immunology.

Pulmonary dendritic cell populations.

P. Holt, 1993, Advances in experimental medicine and biology.

Childhood atopy and mental health: a prospective, longitudinal investigation

P. Sly, P. Holt, R. Goodwin, 2016, Psychological Medicine.

Rat models of respiratory inflammation.

P. Holt, A. McWilliam, 2000, Methods in molecular biology.

Immunobiology of dendritic cells in the respiratory tract: steady-state and inflammatory sentinels?

P. Holt, A. McWilliam, 1998, Toxicology letters.

Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children1

Anthony Bosco, Peter D Sly, Jack Goldblatt, 2009, The Journal of Immunology.

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis.

R. Ware, P. Sly, P. Holt, 2017, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Lung interstitial natural killer cells in patients with lung cancer: presence, activity and response to interleukin-2

P. Holt, U. Kees, B. Robinson, 1989 .

Development of sensitization versus tolerance to inhalant allergens during early life

P. Holt, P. Holt, 1997, Pediatric pulmonology. Supplement.

A neonatal pneumococcal conjugate vaccine trial in Papua New guinea: study population, methods and operational challenges.

W. Pomat, P. Siba, D. Lehmann, 2010, Papua and New Guinea medical journal.

The biology of airway dendritic cells

P. Holt, D. Nelson, A. McWilliam, 1995, Immunology and cell biology.

Vitamin C and immunity: an assessment of the evidence.

W. Thomas, P. Holt, 1978, Clinical and experimental immunology.

In vitro synthesis of IgE by human peripheral blood leucocytes. III. Release of pre-formed antibody.

P. Holt, B. Holt, K. Turner, 1983, Clinical and experimental immunology.

Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.

P. Holt, T. Hünig, C. Mcmenamin, 1995, Journal of immunology.

Functional heterogeneity within the human peripheral blood B cell pool engaged in IgE synthesis.

P. Holt, B. Holt, K. Turner, 1987, International archives of allergy and applied immunology.

In vitro synthesis of IgE by human peripheral blood leucocytes: relationship to serum titre of leucocyte donor.

P. Holt, B. Holt, K. Turner, 1981, Clinical and experimental immunology.

Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations.

P. Holt, N. Bilyk, 1995, Immunology.

Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

W. Pomat, P. Siba, P. Holt, 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age

A. Ponsonby, M. Wake, A. Lowe, 2016, Allergy.

Genome-wide association study identiﬁes peanut allergy-speciﬁc loci and evidence of epigenetic mediation in US children

Kari Christine Nadeau, Xin Xu, Terri H Beaty, 2022 .

Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants.

P. Sly, S. Wesselingh, P. Holt, 2007, Vaccine.

Class II major histocompatibility complex (Ia) antigen-bearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia.

P. Holt, P. McMenamin, I. Holthouse, 1992, Immunology.

Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

M. Inouye, A. Custovic, S. Johnston, 2018, eLife.

Myogenesis in vitro. Enhancement by dibutyryl cAMP.

P. Holt, P. Simons, E. Aw, 1974, Experimental cell research.

Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages

P. Holt, T. Thepen, P. McMenamin, 1993, The Journal of experimental medicine.

Factors affecting the premature induction of tyrosine aminotransferase in foetal rat liver.

P. Holt, I. T. Oliver, 1968, The Biochemical journal.

Modification by soluble antigen of the immune response to mycobacterial infection

P. Holt, D. Keast, P. J. Fimmel, 1977, Infection and immunity.

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces

P. Holt, D. Nelson, A. McWilliam, 1994, The Journal of experimental medicine.

The role of the thymus in the maintenance of natural killer cells in vivo.

G. Mayrhofer, P. Holt, G. Shellam, 1985, Cellular immunology.

Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery.

Peter D Sly, P. Sly, W. Thomas, 2006, The Journal of allergy and clinical immunology.

Immune and inflammatory function in cigarette smokers.

P. Holt, 1987, Thorax.

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

Stephen C. Watts, M. Inouye, S. Johnston, 2018, Cell Host & Microbe.

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

Stephen C. Watts, M. Inouye, S. Johnston, 2017, bioRxiv.

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

Kari Christine Nadeau, Xin Xu, Terri H Beaty, 2015 .

Cell cycle-dependent fluctuations in IgE secretion in a human myeloma line.

P. Holt, K. Turner, T. Plozza, 1985, Clinical immunology and immunopathology.

Serum blocking factor as an index of metastatic spread following primary tumour excision.

P. Holt, A. E. Bray, 1975, European journal of cancer.

The L.A.I. microtest: a rapid and sensitive precedure for the demonstration of cell-mediated immunity in vitro.

P. Holt, D. Keast, P. J. Fimmel, 1975, Journal of immunological methods.

11 – Comparison of Microplate LAI with Other in Vitro Assays of Cell-Mediated Immunity: Assessment of Responses to Bacterial, Viral, and Tumor Antigens in Man and Experimental Animals

P. Holt, 1982 .

Evaluation of the microplate leukocyte adherence inhibition test and its reproducibility, sensitivity, and relationship to other tests of cellular immunity.

P. Holt, R. Flower, P. J. Fimmel, 1979, Cancer research.

Development of two manifestations of T-lymphocyte reactivity during tumor growth: altered kinetics associated with elevated growth rates.

P. Holt, D. Keast, J. Chalmer, 1975, Journal of the National Cancer Institute.

Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway.

P. Holt, U. Kees, P. A. Tilbrook, 1998, Journal of immunology.

Immune function during early adolescence positively predicts adult facial sexual dimorphism in both men and women

D. Perrett, G. Rhodes, L. Simmons, 2020, Evolution and Human Behavior.

DNA synthesis in cell cultures following repeated exposure to fresh cigarette smoke

P. Holt, D. Keast, L. M. Roberts, 1975, Experientia.

Prevention of allergic respiratory disease in infants: current aspects and future perspectives

Peter D Sly, P. Sly, P. Holt, 2007, Current opinion in allergy and clinical immunology.

IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

P. Holt, C. Christophersen, A. Larcombe, 2021, Frontiers in Immunology.

The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges.

M. Inouye, P. Sly, P. Holt, 2021, The Journal of allergy and clinical immunology.

A genomics-based approach to assessment of vaccine safety and immunogenicity in children.

Anthony Bosco, P. Holt, A. Bosco, 2012, Vaccine.

Airway Epithelial Cells Regulate the Functional Phenotype of Locally Differentiating Dendritic Cells: Implications for the Pathogenesis of Infectious and Allergic Airway Disease1

P. Holt, J. Upham, A. Bosco, 2009, The Journal of Immunology.

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

P. Holt, P. Stumbles, Peter T. Lee, 1998, The Journal of experimental medicine.

Brief Definitive Report Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli

P. Holt, D. Nelson, A. McWilliam, 2022 .

Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings.

R. Rylander, P. Holt, M. Dentener, 2003, The Journal of allergy and clinical immunology.

Multi-ancestry association study identifies new asthma risk loci that co-localize with 1 immune cell enhancer marks 2

Sina A. Gharib, Cameron D. Palmer, L. Liang, 2017 .

Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period.

P. Holt, Patrick G. Holt, 1998, Environmental health perspectives.

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Kari Stefansson, Melanie Waldenberger, Dirkje S Postma, 2013, Nature Genetics.

Low-tar and high-tar cigarettes.

W. Thomas, P. Holt, D. Keast, 1976, Archives of environmental health.

Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial.

P. Holt, L. Beilin, Trevor A. Mori, 2003, The Journal of allergy and clinical immunology.

Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery

Patrick Holt, D. Lehmann, P. Holt, 2011, Archives of Disease in Childhood.

IgE responses of malnourished mice: immunogenic and tolerogenic effects of low-grade antigenic stimulation.

P. Holt, K. Turner, A. Rose, 1983, Clinical immunology and immunopathology.

Suppression of allergic reactions in helminth-parasitized rats of low-IgE-responder phenotype.

P. Holt, K. Turner, E. H. Fisher, 1982, Clinical immunology and immunopathology.

The effect of a low protein diet on the immunogenic activity of murine peritoneal macrophages.

P. Holt, K. Turner, A. Rose, 1982, International archives of allergy and applied immunology.

Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen.

P. Holt, K. Turner, J. Batty, 1981, Immunology.

Adoptive transfer of "persistent' IgE responses in mice in the absence of secondary antigenic stimulation.

P. Holt, S. Leivers, J. Batty, 1981, International archives of allergy and applied immunology.

Plasma corticosterone concentrations in the perinatal rat.

P. Holt, I. T. Oliver, Patrick G. Holt, 1968, The Biochemical journal.

Cord blood Streptococcus pneumoniae‐specific cellular immune responses predict early pneumococcal carriage in high‐risk infants in Papua New Guinea

W. Pomat, D. Lehmann, P. Holt, 2016, Clinical and experimental immunology.

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood.

A. Custovic, P. Sly, A. Simpson, 2011, The Journal of allergy and clinical immunology.

Local and systemic immune response of mice after intratracheal and intravenous inoculations of sheep erythrocytes.

W. Thomas, P. Holt, D. Keast, 1974, International archives of allergy and applied immunology.

In vitro antibody‐mediated macrophage activity on Breinlia macropi microfilariae. II. Ultrastructural and video recording investigations of adherence and cytotoxicity

P. Holt, T. Robertson, P. K. Yen, 1986, Parasite immunology.

In vitro antibody‐mediated macrophage activity on Breinlia macropi microfilariae. I. Adherence and cytotoxicity

P. Holt, K. Turner, P. K. Yen, 1986, Parasite immunology.

ELISA plaque assay for the detection of antibody secreting cells: observations on the nature of the solid phase and on variations in plaque diameter.

P. Holt, J. Sedgwick, G. Stewart, 1984, Journal of immunological methods.

Kinetics and distribution of antigen-specific IgE-secreting cells during the primary antibody response in the rat

P. Holt, J. Sedgwick, 1983, The Journal of experimental medicine.

A Network Modeling Approach to Analysis of the Th2 Memory Responses Underlying Human Atopic Disease1

Martin J Firth, P. Sly, P. Holt, 2009, The Journal of Immunology.

Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)- bearing dendritic cells (DC) in the conducting airways

P. Holt, P. McMenamin, J. Oliver, 1991, The Journal of experimental medicine.

Role of Respiratory Viruses in Acute Upper and Lower Respiratory Tract Illness in the First Year of Life: A Birth Cohort Study

S. Johnston, P. Sly, P. Holt, 2006, The Pediatric infectious disease journal.

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

P. Holt, D. Nelson, J. Sedgwick, 1994, Journal of immunology.

Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

P. Holt, P. Hart, A. Whitehouse, 2012, Pediatrics.

Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide.

P. Sly, P. Holt, M. Tulic, 2000, American journal of respiratory cell and molecular biology.

Emerging Concepts of T-Cell Regulation in Asthma and allergy

P. Sly, P. Holt, 2003 .

Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study

J. Blackwell, P. Holt, C. Pennell, 2014, Genes and Immunity.

Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

Anthony Bosco, P. Holt, N. Troy, 2016, BMC Medical Genomics.

Systems biology and big data in asthma and allergy: recent discoveries and emerging challenges

M. Inouye, K. Holt, P. Sly, 2019, European Respiratory Journal.

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

P. Sly, P. Holt, J. Logan, 2015, American journal of respiratory cell and molecular biology.

The role of allergy in the development of asthma

P. Sly, P. Holt, C. Macaubas, 1999, Nature.

Adjuvant Costimulation during Secondary Antigen Challenge Directs Qualitative Aspects of Oral Tolerance Induction, Particularly during the Neonatal Period

W. Thomas, P. Holt, Iriani T. Tobagus, 2004, The Journal of Immunology.

Neonatal Period Aspects of Oral Tolerance Induction , Antigen Challenge Directs Qualitative Adjuvant Costimulation during Secondary

W. Thomas, P. Holt, Iriani T. Tobagus, 2004 .

Environmentally induced changes in immunological function: acute and chronic effects of inhalation of tobacco smoke and other atmospheric contaminants in man and experimental animals.

P. Holt, D. Keast, 1977, Bacteriological reviews.

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma

P. Sly, P. Holt, F. Jahnsen, 2003, Journal of Experimental Medicine.

Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells.

P. Holt, C. Mcmenamin, C. Pimm, 1994, Science.

Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

P. Sly, P. Holt, K. Ling, 2018, Scientific Reports.

Persistent activation of interlinked Th2-airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic atopic asthmatics

P. Sly, P. Holt, K. Ling, 2016, bioRxiv.

Failure of MHC class II expression in neonatal alveolar macrophages: potential role of class II transactivator

P. Holt, A. McWilliam, P. Lee, 2001, European journal of immunology.

T regulatory cells in childhood asthma.

P. Holt, D. Strickland, 2011, Trends in immunology.

Localization of T cells, macrophages and dendritic cells in rat respiratory tract tissue: implications for immune function studies.

P. Holt, M. Schon-Hegrad, 1987, Immunology.

Differential Patterns of Methylation of the IFN-γ Promoter at CpG and Non-CpG Sites Underlie Differences in IFN-γ Gene Expression Between Human Neonatal and Adult CD45RO− T Cells1

P. Holt, B. Holt, G. P. White, 2002, The Journal of Immunology.

Lung dendritic cells

P. Holt, A. McWilliam, P. Stumbles, 1998 .

Studies on the surface phenotype and functions of dendritic cells in parenchymal lung tissue of the rat.

P. Holt, C. Mcmenamin, J. Oliver, 1992, Immunology.

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations

P. Holt, J. Oliver, M. Schon-Hegrad, 1988, The Journal of experimental medicine.

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring

P. Holt, P. Hart, A. Whitehouse, 2013, Journal of autism and developmental disorders.

Anatomical Location Determines the Distribution and Function of Dendritic Cells and Other APCs in the Respiratory Tract1

P. Holt, C. von Garnier, L. Filgueira, 2005, The Journal of Immunology.

Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris.

P. Holt, P. McMenamin, R. Steptoe, 1995, Immunology.

Recovery of immune system after cigarette smoking

P. Holt, D. Keast, W. R. Thomas, 1974, Nature.

Smoking and immunity.

W. Thomas, P. Holt, D. Keast, 1973, Lancet.

Effect of Cigarette Smoking on Primary and Secondary Humoral Responses of Mice

W. Thomas, P. Holt, D. Keast, 1973, Nature.

Occurrence and management of acute respiratory illnesses in early childhood

P. Sly, P. Holt, N. de Klerk, 2007, Journal of paediatrics and child health.

Cellular immunity in mice chronically exposed to fresh cigarette smoke.

W. Thomas, P. Holt, D. Keast, 1973, Archives of environmental health.

Acute effects of cigarette smoke on murine macrophages.

P. Holt, D. Keast, 1973, Archives of environmental health.

Cigarette smoke inhalation: Effects on cells of the immune series in the murine lung

P. Holt, D. Keast, 1973 .

Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis

H. Zar, D. Savitz, W. Dupont, 2020, The Lancet. Respiratory medicine.

Distinguishing benign from pathologic TH2 immunity in atopic children.

Adnan Custovic, Angela Simpson, Danielle Belgrave, 2016, The Journal of allergy and clinical immunology.

Allergic Airways Disease Develops after an Increase in Allergen Capture and Processing in the Airway Mucosa1

P. Sly, P. Holt, G. Zosky, 2007, The Journal of Immunology.

Drug development strategies for asthma: in search of a new paradigm

Scott T Weiss, Peter D Sly, U. Wahn, 2004, Nature Immunology.

After asthma: redefining airways diseases

Richard Beasley, Paul Cullinan, Urs Frey, 2017, The Lancet.

Inhalant allergen‐specific T‐cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum‐free medium

L. Palmer, P. Sly, W. Thomas, 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Selective attrition of non-recirculating T cells during normal passage through the lung vascular bed.

P. Holt, D. Nelson, D. Strickland, 1990, Immunology.

Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk

M. Inouye, K. Holt, Kristine E. Lee, 2020, Journal of Allergy and Clinical Immunology.

Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation

P. Holt, A. Larcombe, C. Pasquali, 2018, The Journal of clinical investigation.

Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection

P. Holt, G. Zosky, C. von Garnier, 2014, PloS one.

THE EARLY-LIFE NASOPHARYNGEAL MICROBIOME INTERACTS WITH ALLERGIC AND NON-ALLERGIC MECHANISMS OF CHILDHOOD WHEEZE

M. Inouye, K. Holt, P. Sly, 2019 .

Dissociation of correlates of cellular immunity in man: functional heterogeneity within the antigen-reactive cell population?

P. Holt, D. Keast, M. Tandon, 1976, International archives of allergy and applied immunology.

The effect of cigarette smoking on susceptibility to epidemic influenza and on serological responses to live attenuated and killed subunit influenza vaccines

P. Holt, J. Mackenzie, I. Mackenzie, 1976, Journal of Hygiene.

Role of innate immunity in the development of allergy and asthma

Peter D Sly, P. Sly, P. Holt, 2011, Current opinion in allergy and clinical immunology.

Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy

M. Inouye, A. Custovic, S. Johnston, 2017, bioRxiv.

Bronchus-associated lymphoid tissue and immune-mediated respiratory diseases

P. Holt, D. T. Umetsu, 2013 .

Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood.

K. Hao, H. Bauchner, P. Holt, 2011, The Journal of allergy and clinical immunology.

Sensitization to airborne environmental allergens: unresolved issues

W. Thomas, P. Holt, 2005, Nature Immunology.

Dendritic cell ontogeny as an aetiological factor in respiratory tract diseases in early life

P. Holt, 2001, Thorax.

Immunogenicity and tolerogenicity of a major house dust mite allergen, Der p I from Dermatophagoides pteronyssinus, in mice and rats.

P. Holt, G. Stewart, 1987, International archives of allergy and applied immunology.

Clinical outcome with enalapril in symptomatic chronic heart failure; a dose comparison. The NETWORK Investigators.

S. Ball, M. Buchalter, J. Hampton, 1998, European heart journal.

Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study

P. Burton, P. Sly, F. Stanley, 1999, BMJ.

Jak 3 / STAT 5 Signaling Pathway Cell Activation via Reversible Disruption of the Macrophage-Derived Nitric Oxide Regulates

P. Holt, P. A. Tilbrook, R. Bingisser, 1998 .

Disease Mechanisms and Cell Biology

P. Sly, P. Holt, R. Stein, 2008 .

Early identification of atopy in the prediction of persistent asthma in children

Adnan Custovic, Peter D Sly, Harald Renz, 2008, The Lancet.

birth cohort study in 6 year old children: findings of a prospective Association between breast feeding and asthma

P. Burton, F. Stanley, P. Holt, 2005 .

The Growth of Transplanted Tumours in Mice after Chronic Inhalation of Fresh Cigarette Smoke

W. Thomas, P. Holt, D. Keast, 1974, British Journal of Cancer.

Inflammation in organic dust-induced lung disease: new approaches for research into underlying mechanisms.

P. Holt, 1990, American journal of industrial medicine.

Cell recruitment into lung wall and airways of conventional and pathogen-free guinea pigs after inhalation of endotoxin.

R. Rylander, P. Holt, M. Snella, 1989, The American review of respiratory disease.

Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM‐85

P. Holt, P. Stumbles, D. Strickland, 2021, Clinical & translational immunology.

Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition.

L. Schmidt, P. Sly, P. Arck, 2014, The Journal of allergy and clinical immunology.

The infant airway microbiome in health and disease impacts later asthma development

M. Inouye, S. Johnston, K. Holt, 2014, bioRxiv.

Oestrogen amplifies pre‐existing atopy‐associated Th2 bias in an experimental asthma model

P. Holt, D. Strickland, Kyle T. Mincham, 2019, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Davos declaration: Allergy as a global problem (Allergy: European Journal of Allergy and Clinical Immunology (2012) 67, (141-143))

J. Drazen, B. Menne, R. Lockey, 2012 .

Regulation of natural killer cell activity and interferon production in the rat lung following aerosol challenge.

P. Holt, H. Farrell, G. Shellam, 1985, International archives of allergy and applied immunology.

Transplacentally mediated immune training to accelerate fetal immune competence

P. Holt, A. Bosco, P. Stumbles, 2019, bioRxiv.

The Hygiene Hypothesis Revisited: Role of Materno-Fetal Interactions

P. Holt, C. Thornton, T. Macfarlane, 2010, Current allergy and asthma reports.

Antigen presentation in the lung.

P. Holt, 2000, American journal of respiratory and critical care medicine.

Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

T. Ahluwalia, K. Bønnelykke, H. Bisgaard, 2019, Allergy.

Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction.

P. Holt, H. Savelkoul, G. Kraal, 1997, Journal of immunology.

A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium.

P. Holt, P. McMenamin, B. Holt, 1990, International archives of allergy and applied immunology.

692 693 694 695 696 697 698 699 700 701 702 703 704 705 706

A. Custovic, D. Belgrave, P. Sly, 2015 .

Effect of Early Carriage of Streptococcus pneumoniae on the Development of Pneumococcal Protein-specific Cellular Immune Responses in Infancy

W. Pomat, P. Siba, D. Lehmann, 2012, The Pediatric infectious disease journal.

Accelerated Antigen Sampling and Transport by Airway Mucosal Dendritic Cells following Inhalation of a Bacterial Stimulus1

P. Sly, P. Holt, G. Zosky, 2006, The Journal of Immunology.

Characterization of dendritic cell populations in the respiratory tract.

P. Holt, P. Stumbles, 2000, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Rewiring of gene networks underlying mite allergen‐induced CD4 + Th‐cell responses during immunotherapy

P. Holt, Denise Anderson, M. Serralha, 2020, Allergy.

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

P. Holt, Denise Anderson, M. Serralha, 2018, bioRxiv.

Title 1 Persistent activation of interlinked Th 2-airway epithelial gene networks in sputum-derived 2 cells from aeroallergen-sensitized symptomatic atopic asthmatics 3

P. Sly, P. Holt, K. Ling, 2016 .

The distribution of IgE plasma cells in lymphoid and non-lymphoid tissues of high-IgE responder rats: differential localization of antigen-specific and 'bystander' components of the IgE response to inhaled antigen.

P. Holt, C. Mcmenamin, B. Girn, 1992, Immunology.

Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes.

Alke Fink, Barbara Rothen-Rutishauser, Fabian Blank, 2013, American journal of respiratory cell and molecular biology.

Identification and Characterization of a Dendritic Cell Precursor in Parenchymal Lung Tissue

P. Holt, B. Rothen‐Rutishauser, F. Blank, 2017, American journal of respiratory cell and molecular biology.

Transplacental protection against asthma by maternal treatment with a bacterial-derived immunomodulatory agent

P. Holt, A. Larcombe, C. Pasquali, 2017, bioRxiv.

Serum modulation ofin vitro cellular immune reactivity to Epstein-Barr virus-associated antigen

P. Holt, D. Keast, P. J. Fimmel, 1976, Medical Microbiology and Immmunology.

Auditory stress and the immune system

P. Holt, 1978 .

Macrophages as effectors of T suppression: T-lymphocyte-dependent macrophage-mediated suppression of mitogen-induced blastogenesis in the rat.

G. Mayrhofer, P. Holt, L. A. Warner, 1981, Cellular immunology.

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

M. Jarvelin, C. Gieger, D. Strachan, 2018, Nature Genetics.

Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

W. Thomas, P. Holt, G. Zosky, 2012, International Archives of Allergy and Immunology.

Whole cell pertussis vaccination and decreased risk of IgE-mediated food allergy: a nested case-control study.

P. Holt, D. Campbell, M. Gold, 2019, The journal of allergy and clinical immunology. In practice.

Interleukin-10/interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history.

P. Sly, P. Holt, N. de Klerk, 2009, American journal of respiratory and critical care medicine.

IL-10:IL-5 Responses at Birth Predict Risk for Respiratory Infections in Atopic Family History Positive Children

P. Sly, P. Holt, N. Klerk, 2008 .

Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell tolerance

W. Pomat, P. Siba, D. Lehmann, 2011, Vaccine.

Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection: Mechanistic Insight Using Mouse Models

P. Holt, P. Stumbles, D. Strickland, 2019, The Journal of infectious diseases.

Virus infection and allergy in the development of asthma: what is the connection?

P. Sly, P. Holt, D. Strickland, 2012, Current opinion in allergy and clinical immunology.

Parental smoking impairs vaccine responses in children with atopic genotypes.

P. Sly, P. Holt, G. Baynam, 2007, The Journal of allergy and clinical immunology.

Postnatal maturation of mast cell subpopulations in the rat respiratory tract.

P. Holt, C. Mcmenamin, L. Wilkes, 1992, Immunology.

World Allergy Organization guidelines for prevention of allergy and allergic asthma.

A. Boner, C. Baena-Cagnani, G. Canonica, 2004, International archives of allergy and immunology.

A histochemical analysis of mammalian oxidative skeletal muscle fibres using the enzymes of energetic metabolism

P. Holt, B. Kakulas, J. Papadimitriou, 2004, Histochemie.

Allergen presentation in the airways

P. Holt, D. Nelson, A. McWilliam, 1995 .

Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE.

H. Bauchner, P. Holt, H. Tsai, 2010, The Journal of allergy and clinical immunology.

A calcium-citro-phosphate technique for the histochemical localization of myosin ATPase.

P. Holt, B. Kakulas, J. Papadimitriou, 1972, Stain technology.

Time spent outdoors through childhood and adolescence – assessed by 25‐hydroxyvitamin D concentration – and risk of myopia at 20 years

D. Mackey, R. Lucas, P. Holt, 2021, Acta ophthalmologica.

Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies.

P. Sly, P. Holt, M. Serralha, 2022, The Journal of allergy and clinical immunology.

Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

P. Holt, N. Troy, E. Hollams, 2016, BMC Medical Genomics.

a birth cohort study Breast feeding and respiratory morbidity in infancy

P. Sly, F. Stanley, P. Holt, 2005 .

Prevention of Allergy and Asthma Interim Report

A. Chuchalin, A. Custovic, C. Naspitz, 2000, Allergy.

Regulatory role of IL10 genetic variations in determining allergen-induced T(H)2 cytokine responses in children.

P. Holt, J. Goldblatt, Guicheng Zhang, 2011, The Journal of allergy and clinical immunology.

Further histochemical properties of rabbit skeletal muscle fibres

P. Holt, B. Kakulas, J. Papadimitriou, 2004, Histochemie.

Resource The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development Graphical

M. Inouye, S. Johnston, K. Holt, 2015 .

Immunological consequences of intestinal helminth infections: antigen presentation and immunosuppression by peritoneal cells.

P. Holt, P. Price, 1986, Australian Journal of Experimental Biology and Medical Science.

Early-life respiratory viral infection results in impairment of adult lung function

D. Martino, P. Holt, A. Larcombe, 2021, bioRxiv.

ESR spectroscopy in the study of antigen processing--uptake of spin-labelled antigens by macrophages.

P. Holt, C. Curtain, F. D. Looney, 1987, Journal of Biochemical and Biophysical Methods.

Genome-wide expression profiling of T-cells in childhood wheeze

P. Holt, A. Bosco, 2008, European Respiratory Journal.

The impact of the indoor environment on the development of allergic sensitization and asthma in children

P. Sly, P. Holt, S. Stick, 2001 .

Atopy-Dependent and Independent Immune Responses in the Heightened Severity of Atopics to Respiratory Viral Infections: Rat Model Studies

P. Holt, L. A. Rosenthal, A. Bosco, 2018, Front. Immunol..

Immunological function in mice chronically exposed to nitrogen oxides (NOx).

P. Holt, D. Keast, L. Finlay-Jones, 1979, Environmental research.

LPS binding protein and activation signatures are upregulated during asthma exacerbations in children

P. Sly, P. Holt, P. Lesouef, 2023, Respiratory Research.

Submicronic airborne allergens

P. Holt, G. Stewart, 1985, The Medical journal of Australia.

The development of the immune system during pregnancy and early life

P. Holt, P. Holt, C. Jones, 2000, Allergy.

Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways.

P. Sly, P. Holt, G. Zosky, 2009, American journal of physiology. Lung cellular and molecular physiology.

The surface phenotypic characterization of lung macrophages in C3H/HeJ mice.

P. Holt, N. Bilyk, 1991, Immunology.

A novel role for interleukin‐1 receptor signaling in the developmental regulation of immune responses to endotoxin

P. Holt, S. Prescott, D. Martino, 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Cellular immune responses to ovalbumin and house dust mite in egg‐allergic children

P. Holt, S. Prescott, P. Holt, 2002, Allergy.

Creatine kinase, a histochemical study by the gelatin film-lead precipitation technique

P. Holt, B. Kakulas, J. Papadimitriou, 2004, Histochemie.

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years

M. Iqbal, P. Holt, M. Serralha, 2023, bioRxiv.

The use of collagen polypeptides in the histochemical demonstration of creatine kinase

P. Holt, B. Kakulas, J. Papadimitriou, 1972, Histochemie.

Mucosal dendritic cells and macrophages

P. Holt, A. McWilliam, P. Stumbles, 1998 .

Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function

Lorna M. Lopez, Sina A. Gharib, Bonnie R. Joubert, 2011, Nature Genetics.

Professional antigen-presenting cells

W. B. Smith, P. Holt, 2000 .

Ovalbumin‐sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation

Z. Hantos, P. Sly, P. Holt, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Maternal fish oil supplementation in pregnancy reduces interleukin‐13 levels in cord blood of infants at high risk of atopy

L. Beilin, P. Holt, T. Mori, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Mucosal regulatory T cells in airway hyperresponsiveness.

P. Holt, D. Strickland, D. Turner, 2008, Chemical immunology and allergy.

Abstracts of ICI 2016 International Congress of Immunology, 21-26 August 2016, Melbourne, Australia.

P. Holt, N. Troy, S. Prescott, 2016, European journal of immunology.

Regulation of IgE responses to inhaled antigens: cellular mechanisms underlying allergic sensitization versus tolerance induction.

P. Holt, C. Mcmenamin, J. Oliver, 1991, International archives of allergy and applied immunology.

The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose

P. Sly, P. Holt, G. Zosky, 2004, Respiratory research.

Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

P. Holt, P. Hart, A. Whitehouse, 2012, Pediatrics.

Pathogenic mechanisms of allergic inflammation: atopic asthma as a paradigm.

P. Holt, F. Jahnsen, A. Bosco, 2009, Advances in immunology.

Early identification of atopy in the prediction of persistent asthma in children

A. Boner, A. Custovic, U. Wahn, 2008, The Lancet.

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

P. Holt, P. Stumbles, Peter T. Lee, 1998, The Journal of experimental medicine.

Exacerbations in Children Precipitate and Sustain Asthma Atopic Immunoinflammatory Pathways Interactions between Innate Antiviral And

P. Sly, W. Thomas, P. Holt, 2022 .

Platelet serotonin release by human polymorphonuclear leucocytes stimulated by cotton dust bacteria.

R. Rylander, P. Holt, B. Holt, 1983, Clinical and experimental immunology.

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.

Rosalind J Wright, P. Gergen, M. Cabana, 2014, The Journal of allergy and clinical immunology.

P. Holt, C. Mcmenamin, 1993, The Journal of experimental medicine.

Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses.

P. Sly, P. Holt, G. Baynam, 2008, Vaccine.

Ia‐positive dendritic cells form a tightly meshed network within the human airway epithelium

P. Holt, P. McMenamin, M. Phillips, 1989, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Restricted Aeroallergen Access to Airway Mucosal Dendritic Cells In Vivo Limits Allergen-Specific CD4+ T Cell Proliferation during the Induction of Inhalation Tolerance

P. Sly, P. Holt, F. Blank, 2011, The Journal of Immunology.

Size-dependent uptake of particles by pulmonary antigen-presenting cell populations and trafficking to regional lymph nodes.

P. Holt, B. Rothen‐Rutishauser, A. Fink, 2013, American Journal of Respiratory Cell and Molecular Biology.

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Christian Gieger, David Torrents, Kari Stefansson, 2018, Nature Genetics.

Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3+ Tcr alpha-/beta- lymphocytes (putative gamma/delta T cells).

W. Thomas, P. Holt, U. Kees, 1991, Immunology.

Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations.

P. Holt, D. Strickland, 2010, The Journal of allergy and clinical immunology.

Kinetics and distribution of antigen-specific IgE-secreting cells during the primary antibody response in the rat

Zhongheng Zhang, P. Holt, C. Tsao, 1983, The Journal of experimental medicine.

Cigarette smoke and phagocyte function: effect of chronic exposure in vivo and acute exposure in vitro

W. Thomas, P. Holt, D. Keast, 1978, Infection and immunity.

Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function

Lorna M. Lopez, Sina A. Gharib, Bonnie R. Joubert, 2011, Nature Genetics.

Prenatal versus postnatal priming of allergen specific immunologic memory: the debate continues.

P. Holt, 2008, The Journal of allergy and clinical immunology.

a birth cohort study Breast feeding and respiratory morbidity in infancy

P. Sly, F. Stanley, P. Holt, 2005 .