I. Ben-Sahra

发表

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

J. Asara, G. Hoxhaj, J. Hughes-Hallett, 2017, Cell reports.

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2010, Molecular Cancer Therapeutics.

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

D. Sinclair, J. Haefliger, L. Brace, 2018, Cell.

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

J. Asara, M. Yuan, I. Ben-Sahra, 2019, Nature Protocols.

A spoonful of DHAP keeps mTORC1 running on sugars

J. Locasale, G. Hoxhaj, I. Ben-Sahra, 2020, Nature Metabolism.

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

I. Ben-Sahra, J. Tanti, F. Bost, 2012, Cell Death and Differentiation.

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

Atique U. Ahmed, R. Stupp, I. Ben-Sahra, 2020, bioRxiv.

Obésité et cancers du côlon et de la prostate: implication des adipokines

I. Ben-Sahra, Y. Marchand Brustel, J. Tanti, 2008 .

Mark S. Schmidt, S. Quake, C. Brenner, 2019, bioRxiv.

Apoptosis in Prostate Cancer Cells Metformin and 2-Deoxyglucose Induces p 53-Dependent Targeting Cancer Cell Metabolism : The Combination of

C. Bertolotto, I. Ben-Sahra, J. Tanti, 2010 .

The TSC-mTOR pathway regulates macrophage polarization

Dudley Lamming, D. Sabatini, I. Ben-Sahra, 2013, Nature Communications.

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

J. Asara, G. Hoxhaj, Rebecca C. Timson, 2019, Science.

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

L. Scorrano, I. Ben-Sahra, N. Mazure, 2017, Scientific Reports.

Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia

K. Stegmaier, M. Hemann, G. Alexe, 2016 .

Mark S. Schmidt, C. Brenner, I. Ben-Sahra, 2019 .

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

J. Asara, G. Hoxhaj, I. Ben-Sahra, 2016, Science.

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

J. Asara, G. Hoxhaj, I. Ben-Sahra, 2022, Nature Communications.

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

J. Asara, I. Ben-Sahra, B. Manning, 2013, Science.

ASS1igning purine dependency to cancer

I. Ben-Sahra, E. Villa, 2020, Nature Cancer.

PGC1 α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness

I. Ben-Sahra, N. Mazure, J. Tanti, 2020 .

mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms

J. Asara, I. Ben-Sahra, B. Manning, 2014, Cancer & Metabolism.

Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response

Shashank Srivastava, Young Ah Goo, Neil L. Kelleher, 2019, bioRxiv.

Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia.

I. Ben-Sahra, F. Bost, J. Peyron, 2014, Cancer letters.

Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

I. Ben-Sahra, F. Bost, G. Robert, 2009, PloS one.

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

D. Stumpo, P. Blackshear, I. Ben-Sahra, 2018, Proceedings of the National Academy of Sciences.

mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.

J. Asara, I. Ben-Sahra, B. Singer, 2021, Molecular cell.

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

I. Ben-Sahra, U. Sahu, E. Villa, 2019, Cancers.

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

I. Ben-Sahra, B. Manning, J. Yecies, 2015, Oncogene.

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2011, Cancer research.

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

I. Ben-Sahra, J. Tanti, F. Bost, 2008, Oncogene.

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2009, Diabetes.

MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation

Tong Xu, J. Little, J. Asara, 2014, Cell Death and Differentiation.

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.

C. Bertolotto, I. Ben-Sahra, Y. Le Marchand-Brustel, 2010, Cancer research.

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.

Thijs J. Hagenbeek, I. Ben-Sahra, F. Bost, 2013, Cancer letters.

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

K. Stegmaier, M. Hemann, G. Alexe, 2017, Nature Medicine.

Metformin and cancer therapy

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2012, Current opinion in oncology.

EVIDENCES FOR A BENEFICIAL EFFECT OF METFORMIN IN PREVENTING CANCER IN DIABETIC PATIENTS

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2011 .

The hexokinase “HKDC1” interaction with the mitochondria is essential for hepatocellular carcinoma progression

B. Wicksteed, I. Ben-Sahra, M. Priyadarshini, 2021, bioRxiv.

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells

D. Kwiatkowski, J. Asara, E. Henske, 2017, Oncotarget.

mTORC1 signaling and the metabolic control of cell growth.

I. Ben-Sahra, B. Manning, 2017, Current opinion in cell biology.

Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.

I. Ben-Sahra, G. Robert, P. Auberger, 2012, Journal of molecular cell biology.

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

I. Ben-Sahra, S. Weinberg, N. Chandel, 2019, Cell metabolism.

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Dudley Lamming, I. Ben-Sahra, B. Manning, 2016, eLife.

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

J. Asara, I. Ben-Sahra, U. Sahu, 2020, Molecular cell.

Regulation of nucleotide metabolism in cancers and immune disorders.

I. Ben-Sahra, Eunus S. Ali, 2023, Trends in cell biology.

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

J. Asara, I. Ben-Sahra, B. Manning, 2019, Nature Protocols.

PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness.

I. Ben-Sahra, N. Mazure, J. Tanti, 2019, Cancer research.

Hexokinase 1 cellular localization regulates the metabolic fate of glucose.

I. Ben-Sahra, S. Weinberg, N. Chandel, 2022, Molecular cell.

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

I. Ben-Sahra, J. Tanti, F. Bost, 2010, Autophagy.

The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells.

I. Ben-Sahra, J. Tanti, F. Bost, 2010, Autophagy.

Prevention of Mutagenesis: New Potential Mechanisms of Metformin Action in Neoplastic Cells

I. Ben-Sahra, J. Tanti, F. Bost, 2012, Cancer Prevention Research.

A growing role for mTOR in promoting anabolic metabolism.

I. Ben-Sahra, B. Manning, S. Ricoult, 2013, Biochemical Society transactions.

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis

John M. Asara, Zhi-Min Yuan, Issam Ben-Sahra, 2014, Genes & development.

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth.

I. Ben-Sahra, A. Puissant, 2018, Cell metabolism.

Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.

I. Ben-Sahra, G. Robert, P. Auberger, 2012, Journal of Molecular Cell Biology.

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2011, Cancer research.

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

I. Ben-Sahra, Y. Le Marchand-Brustel, J. Tanti, 2010, Molecular Cancer Therapeutics.

repression of glycolysis ZBTB 7 A acts as a tumor suppressor through the transcriptional Material Supplemental

Zhi-Min Yuan, J. Asara, I. Ben-Sahra, 2014 .

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.

Thijs J. Hagenbeek, I. Ben-Sahra, F. Bost, 2013, Cancer letters.

Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis

J. Asara, I. Ben-Sahra, N. Chandel, 2024, Science.

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia

I. Ben-Sahra, K. Sathyan, Natalia Khalatyan, 2021, Science Advances.