D. Drasdo

I. Vignon-Clementel, D. Drasdo, J. Olesch, 2016, 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD).

Simulating tissue mechanics with Agent Based Models: concepts and perspectives

Margriet M. Palm, P. V. Liedekerke, D. Drasdo, 2020 .

Guided interactive image segmentation using machine learning and color-based image set clustering

S. Hoehme, D. Drasdo, A. Friebel, 2020, Bioinform..

Quantitative analysis of hepatic macro‐ and microvascular alterations during cirrhogenesis in the rat

W. D. De Vos, P. Segers, S. Hoehme, 2018, Journal of anatomy.

Classifying the expansion kinetics and critical surface dynamics of growing cell populations.

E. Schöll, D. Drasdo, M. Block, 2006, Physical review letters.

On the Mechanisms of Biliary Flux

J. Hengstler, D. Drasdo, M. Trauner, 2021, Hepatology.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

U. Hofmann, S. Dooley, C. Trautwein, 2018, Hepatology.

The virtual liver: state of the art and future perspectives

S. Dooley, J. Timmer, H. Holzhütter, 2014, Archives of Toxicology.

A multilevel framework to reconstruct anatomical 3D models of the hepatic vasculature in rat livers (vol 230, pg 471, 2017) (corrigendum)

Jan R. Detrez, P. Segers, S. Hoehme, 2017 .

Composite waves for a cell population system modeling tumor growth and invasion

B. Perthame, I. Vignon-Clementel, D. Drasdo, 2013, Chinese Annals of Mathematics, Series B.

Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results

Nick Jagiella, Dirk Drasdo, Margriet Palm, 2015 .

In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin

J. Hengstler, A. Ghallab, D. Drasdo, 2022, Frontiers in Bioengineering and Biotechnology.

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

Jan Böttger, Jan G. Hengstler, Raymond Reif, 2014, Archives of Toxicology.

Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data

Nick Jagiella, Irene E. Vignon-Clementel, Dirk Drasdo, 2016, PLoS Comput. Biol..

Model Prediction and Validation of an Order Mechanism Controlling the Spatiotemporal Phenotype of Early Hepatocellular Carcinoma

Jan G. Hengstler, Stefan Hoehme, Dirk Drasdo, 2018, Bulletin of Mathematical Biology.

Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation

D. Drasdo, J. Galle, A. Krinner, 2009, Cell proliferation.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

A Statistical Theory of Sequence Alignment with Gaps

Terence Hwa, Michael Lässig, Dirk Drasdo, 1998, ISMB.

Comparing the growth kinetics of cell populations in two and three dimensions.

E Schöll, E. Schöll, J. Hengstler, 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

Tumor Cell Load and Heterogeneity Estimation From Diffusion-Weighted MRI Calibrated With Histological Data: an Example From Lung Cancer

Irene E. Vignon-Clementel, Dirk Drasdo, Yi Yin, 2018, IEEE Transactions on Medical Imaging.

A Monte-Carlo Approach to Growing Solid Non-Vascular Tumors

D. Drasdo, D. Drasdo, 1998 .

Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines

Dirk Drasdo, Pierre Nassoy, Paul Van Liedekerke, 2019, PLoS Comput. Biol..

Quantitative agent-based modeling reveals mechanical stress response of growing tumor spheroids is predictable over various growth conditions and cell lines

Dirk Drasdo, Pierre Nassoy, Paul Van Liedekerke, 2017, bioRxiv.

Enabling multiscale modeling in systems medicine

Olaf Wolkenhauer, Luigi Preziosi, Charles Auffray, 2014, Genome Medicine.

A cell-based simulation software for multi-cellular systems

Stefan Hoehme, Dirk Drasdo, S. Hoehme, 2010, Bioinform..

Gene network inference from incomplete expression data: transcriptional control of hematopoietic commitment

Dirk Drasdo, Kristin Missal, Michael A. Cross, 2006, Bioinform..

Estimating Dose Painting Effects in Radiotherapy: A Mathematical Model

Nick Jagiella, Dirk Drasdo, Miguel A. Herrero, 2014, PloS one.

Influence of Liver Fibrosis on Lobular Zonation

C. Trautwein, J. Saez-Rodriguez, R. Gebhardt, 2019, Cells.

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling

C. Trautwein, T. Karlsen, J. Hengstler, 2021, Nature Metabolism.

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

Matthias Hermes, Michael Schwarz, Stefan Hoehme, 2010, Proceedings of the National Academy of Sciences.

Modeling Dynamics of Cell-to-Cell Variability in TRAIL-Induced Apoptosis Explains Fractional Killing and Predicts Reversible Resistance

Dirk Drasdo, Grégory Batt, Szymon Stoma, 2014, PLoS Comput. Biol..

Scaling Laws and Similarity Detection in Sequence Alignment with Gaps

Terence Hwa, Michael Lässig, Dirk Drasdo, 1998, J. Comput. Biol..

Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux

I. Vignon-Clementel, J. Hengstler, S. Hoehme, 2020, Hepatology.

Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non‐small cell lung cancer (NSCLC) cells

F. Matthäus, A. Warth, P. Schirmacher, 2015, The Journal of pathology.

On the Role of Physics in the Growth and Pattern Formation of Multi-Cellular Systems: What can we Learn from Individual-Cell Based Models?

S. Hoehme, D. Drasdo, M. Block, 2007 .

Diffusion-weighted MRI-guided needle biopsies permit quantitative tumor heterogeneity assessment and cell load estimation

Irene E. Vignon-Clementel, Dirk Drasdo, Hans-Ulrich Kauczor, 2021, 2103.00714.

Modulating Portal Hemodynamics With Vascular Ring Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model

I. Vignon-Clementel, J. Hengstler, D. Drasdo, 2017, Annals of surgery.

Emergence of Regulatory Networks in Simulated Evolutionary Processes

Dirk Drasdo, Matthias Kruspe, D. Drasdo, 2005, Adv. Complex Syst..

Individual fates of mesenchymal stem cells in vitro

Martin Hoffmann, Axel Krinner, Markus Löffler, 2010, BMC Systems Biology.

Unraveling liver complexity from molecular to organ level: challenges and perspectives.

A. Henney, A. Henney, U. Klingmüller, 2015, Progress in biophysics and molecular biology.

Simulation of a detoxifying organ function: Focus on hemodynamics modeling and convection‐reaction numerical simulation in microcirculatory networks

I. Vignon-Clementel, D. Drasdo, Noémie Boissier, 2020, International journal for numerical methods in biomedical engineering.

The virtual liver: state of the art and future perspectives

Ursula Klingmüller, Jens Timmer, Jan G. Hengstler, 2014, Archives of Toxicology.

Mathematical modelling of liver regeneration after intoxication with CCl(4).

Marc Brulport, Alexander Bauer, Rolf Gebhardt, 2007, Chemico-biological interactions.

Modeling the impact of granular embedding media, and pulling versus pushing cells on growing cell clones

Stefan Hoehme, Dirk Drasdo, S. Hoehme, 2012 .

Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy

J. Hengstler, S. Hoehme, D. Drasdo, 2022, iScience.

Digital twin demonstrates regeneration after partial liver hepatectomy to require biomechanical growth control

J. Hengstler, S. Hoehme, D. Drasdo, 2022, iScience.

A proof-of-concept pipeline to guide evaluation of tumor tissue perfusion by dynamic contrast-agent imaging: Direct simulation and inverse tracer-kinetic procedures

I. Vignon-Clementel, F. Kiessling, D. Drasdo, 2023, Frontiers in Bioinformatics.

Modeling Steps from a Begnin Tumor to an Invasive Cancer: Examples of Instrinsically Multiscale Problems

I. Vignon-Clementel, D. Drasdo, Ignacio Ramis-Conde, 2010 .

How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis.

Stefan Hoehme, Jan G Hengstler, Dirk Drasdo, 2014, Journal of hepatology.

Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation

P. V. Liedekerke, D. Drasdo, F. Lemaigre, 2022, PLoS Comput. Biol..

Intravital multi-modal flux analysis reveals the transport mechanism of bile acids through hepatic microconduits

I. Vignon-Clementel, J. Hengstler, S. Hoehme, 2019, bioRxiv.

Center-based Single-cell Models: An Approach to Multi-cellular Organization Based on a Conceptual Analogy to Colloidal Particles

D. Drasdo, 2007 .

Off-Lattice Agent-Based Models for Cell and Tumor Growth: Numerical Methods, Implementation, and Applications

Dirk Drasdo, P. Van Liedekerke, A. Buttenschön, 2018 .

TiQuant: Software for tissue analysis, quantification and surface reconstruction

Jan G. Hengstler, Stefan Hoehme, Dirk Drasdo, 2014, Bioinform..

Quantifying the mechanics and growth of cells and tissues in 3D using high resolution computational models

Dirk Drasdo, Paul Van Liedekerke, Johannes Neitsch, 2018, bioRxiv.

Coarse Graining in Simulated Cell Populations

Dirk Drasdo, D. Drasdo, 2005, Adv. Complex Syst..

On Selected Individual-based Approaches to the Dynamics in Multicellular Systems

Dirk Drasdo, D. Drasdo, 2003 .

Modeling Steps from Benign Tumor to Invasive Cancer

Nick Jagiella, Ignacio Ramis-Conde, Irene E. Vignon-Clementel, 2010 .

Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice

J. Hengstler, S. Hoehme, D. Drasdo, 2010, Histochemistry and Cell Biology.

Agent-Based Lattice Models of Multicellular Systems

Dirk Drasdo, A. Buttenschön, Paul Van Liedekerke, 2018 .

Modeling Steps from Benign Tumor to Invasive Cancer: Examples of Intrinsically Multiscale Problems

Nick Jagiella, Ignacio Ramis-Conde, Dirk Drasdo, 2010 .

From genotypes to phenotypes: classification of the tumour profiles for different variants of the cadherin adhesion pathway

Ignacio Ramis-Conde, Dirk Drasdo, D. Drasdo, 2012, Physical biology.

Buckling instabilities of one-layered growing tissues.

D. Drasdo, D Drasdo, Dirk Drasdo, 2000, Physical review letters.

Modeling the impact of granular embedding media, and pulling versus pushing cells on growing cell clones

S. Hoehme, D. Drasdo, 2012 .

Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations

Stefan Hoehme, Dirk Drasdo, S. Hoehme, 2010 .

Systems Biology, Bioinformatics and Medicine Approaches to Cancer Progression Outcomes

Marcus Schmidt, J. Hengstler, M. Gehrmann, 2011 .

Composite waves for a cell population system modeling tumor growth and invasion

B. Perthame, I. Vignon-Clementel, D. Drasdo, 2013, Chinese Annals of Mathematics, Series B.

Automated Quantification of Amyloid Fibrils Morphological Features by Image Processing Techniques

Marie Doumic, Dirk Drasdo, Yi Yin, 2019, 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019).

Monte Carlo approach to tissue-cell populations.

J. McCaskill, R. Kree, D. Drasdo, 1995, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration

R. Guthke, R. Gebhardt, J. Hengstler, 2014, Hepatology.

Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis

M. Chaplain, D. Drasdo, Ignacio Ramis-Conde, 2009, Physical biology.

An integrative experimental and computational twin modeling approach to understand the clonal dynamics in normal liver.

Jieling Zhao, D. Drasdo, 2023, Journal of hepatology.

J. Hengstler, D. Drasdo, S. V. D. van de Graaf, 2022, Hepatology.

BIOINFORMATICS APPLICATIONS NOTE

S. Hoehme, D. Drasdo, Dirk Drasdo, 2001 .

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.

D. Fell, C. Auffray, J. Tyson, 2010, Cancer research.

DNA sequence alignment and critical phenomena

Terence Hwa, Michael Lässig, Dirk Drasdo, 1996 .

A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage

J. Hengstler, A. Ghallab, D. Drasdo, 2023, iScience.

Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux

I. Vignon-Clementel, J. Hengstler, S. Hoehme, 2020, Hepatology.