P. Crouch

发表

A domain level interaction network of amyloid precursor protein and Aβ of Alzheimer's disease

N. Faux, C. Masters, H. Hermjakob, 2010, Proteomics.

The role of metals in modulating metalloprotease activity in the AD brain

Peter J. Crouch, P. Crouch, Anthony R White, 2008, European Biophysics Journal.

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND

R. Cappai, G. Ciccotosto, P. Crouch, 2021, Cellular and molecular life sciences : CMLS.

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

A. Bush, P. Adlard, R. Cappai, 2017, Molecular Psychiatry.

The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1

P. Crouch, Anthony R White, J. B. Hilton, 2018, Experimental Neurology.

Therapeutic treatments for Alzheimer's disease based on metal bioavailability.

A. Bush, P. Crouch, Anthony R White, 2006, Drug news & perspectives.

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)

A. Bush, P. Crouch, D. Hare, 2017, Journal of visualized experiments : JoVE.

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder.

James L. Hickey, M. D. Jonge, P. Crouch, 2014, Chemical science.

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation.

C. Masters, R. Cappai, G. Ciccotosto, 2008, Free radical biology & medicine.

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

P. Crouch, J. B. Hilton, Anthony R. White, 2016, Metallomics : integrated biometal science.

Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Blaine R. Roberts, James L. Hickey, C. Masters, 2014, The Journal of Neuroscience.

Oral Treatment with Cu [ superscript II ] ( atsm ) Increases Mutant SOD 1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

James L. Hickey, C. Masters, A. Bush, 2014 .

TDP‐43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA‐binding protein hnRNP K and affect the Nrf2 antioxidant pathway

L. Petrucelli, P. Crouch, Anthony R White, 2017, Human molecular genetics.

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Grace E. Lidgerwood, P. Crouch, M. Hasegawa, 2013, PloS one.

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

C. Masters, P. Crouch, Qiao-Xin Li, 2011, Molecular Neurodegeneration.

CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

A. Bush, P. Crouch, A. Belaidi, 2020, British journal of pharmacology.

The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells

James L. Hickey, P. Crouch, S. James, 2012 .

Copper‐dependent inhibition of cytochrome c oxidase by Aβ1−42 requires reduced methionine at residue 35 of the Aβ peptide

C. Masters, P. Crouch, J. Duce, 2006 .

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Christopher J. Tonkin, K. Rogers, Michael J. Mlodzianoski, 2020, Cell.

SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia

J. Vadolas, P. Crouch, S. Dames, 2021, British journal of haematology.

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

P. Crouch, Anthony R White, J. Dilworth, 2010, JBIC Journal of Biological Inorganic Chemistry.

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity.

C. Masters, P. Crouch, Anthony R White, 2008, The international journal of biochemistry & cell biology.

Investigating copper‐regulated protein expression in Menkes fibroblasts using antibody microarrays

C. Masters, A. Bush, R. Cherny, 2008, Proteomics.

Clioquinol Promotes Cancer Cell Toxicity through Tumor Necrosis Factor α Release from Macrophages

P. Crouch, Anthony R White, G. Filiz, 2008, Journal of Pharmacology and Experimental Therapeutics.

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model*

James L. Hickey, C. Masters, P. Crouch, 2011, The Journal of Biological Chemistry.

Microglial ferroptotic stress causes non-cell autonomous neuronal death

Blaine R. Roberts, K. Double, A. Bush, 2022, bioRxiv.

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

L. Barbeito, P. Crouch, Nathan I. Lopez, 2016, Neurobiology of Disease.

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

C. Masters, P. Crouch, Qiao-Xin Li, 2010, Neuromuscular Disorders.

mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

P. Crouch, Qiao-Xin Li, Anthony R White, 2014 .

Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

P. Crouch, Qiao-Xin Li, Anthony R White, 2014, Front. Aging Neurosci..

Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes

P. Crouch, M. Hasegawa, Anthony R White, 2012, PloS one.

The modulation of metal bio‐availability as a therapeutic strategy for the treatment of Alzheimer's disease

Ashley I Bush, A. Bush, P. Crouch, 2007, The FEBS journal.

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Grace E. Lidgerwood, R. Cappai, P. Crouch, 2013, Metallomics : integrated biometal science.

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

M. Horne, P. Crouch, R. Wallace, 2013, PloS one.

Gene Knockout of tau Expression Does Not Contribute to the Pathogenesis of Prion Disease

C. Masters, R. Cappai, G. Ciccotosto, 2011, Journal of neuropathology and experimental neurology.

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

P. Crouch, J. B. Hilton, S. Nikseresht, 2020, Life.

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

David E. James, A. Lusis, P. Crouch, 2022, bioRxiv.

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide.

C. Masters, A. Hill, P. Crouch, 2008, The international journal of biochemistry & cell biology.

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

James L. Hickey, P. Crouch, Qiao-Xin Li, 2013, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Zinc induces depletion and aggregation of endogenous TDP-43.

C. Masters, P. Crouch, Qiao-Xin Li, 2010, Free radical biology & medicine.

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

P. Crouch, K. Kanninen, Anthony R. White, 2012, Neurochemistry International.

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND

R. Cappai, G. Ciccotosto, P. Crouch, 2021, Cellular and Molecular Life Sciences.

Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord

Melanie Y. White, D. Paterson, R. Ortega, 2022, Brain : a journal of neurology.

Prion protein “gamma-cleavage”: characterizing a novel endoproteolytic processing event

N. Hooper, P. Crouch, G. Klug, 2016, Cellular and Molecular Life Sciences.

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes.

P. Crouch, H. Tochon-Danguy, G. O'Keefe, 2015, Inorganic chemistry.

ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

Blaine R. Roberts, James L. Hickey, P. Crouch, 2015, Neurobiology of Disease.

Intracellular distribution of fluorescent copper and zinc bis(thiosemicarbazonato) complexes measured with fluorescence lifetime spectroscopy.

James L. Hickey, C. Henderson, P. Crouch, 2015, Inorganic chemistry.

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper.

P. Crouch, J. White, A. Caragounis, 2011, Dalton transactions.

II inhibits ferroptosis: implications for treatment of neurodegenerative disease

P. Crouch, A. Belaidi, I. Volitakis, 2019 .

Construction of 3D native elemental maps for large biological specimens using LA-ICP-MS coupled with X-ray tomography

P. Crouch, D. Hare, J. Black, 2020 .

Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β1-42

C. Masters, R. Cherny, R. Cappai, 2005, The Journal of Neuroscience.

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

Paul S. Francis, A. Hannan, P. Crouch, 2016, Human molecular genetics.

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

P. Crouch, J. Cooper, J. Koistinaho, 2014, Metallomics : integrated biometal science.

Restored degradation of the Alzheimer’s amyloid‐β peptide by targeting amyloid formation

C. Masters, R. Cherny, P. Crouch, 2009, Journal of neurochemistry.

Transdermal Application of Soluble CuII(atsm) Increases Brain and Spinal Cord Uptake Compared to Gavage with an Insoluble Suspension

A. Bush, P. Crouch, H. Koay, 2022, Neuroscience.

Disrupted copper availability in sporadic ALS: Implications for CuII(atsm) as a treatment option

Blaine R. Roberts, A. Bush, P. Crouch, 2020, bioRxiv.

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis

P. Crouch, 2015, Neurology.

Metal-deficient SOD1 in amyotrophic lateral sclerosis

P. Crouch, Anthony R. White, James Hilton, 2015, Journal of Molecular Medicine.

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

A. Bush, P. Adlard, R. Cappai, 2011, PloS one.

Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation

R. Cappai, P. Crouch, J. Camakaris, 2014, PloS one.

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

P. Crouch, K. Price, Anthony R. White, 2011, Metallomics : integrated biometal science.

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

P. Crouch, I. Volitakis, K. Price, 2011, Inorganic chemistry.

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

P. Crouch, A. Caragounis, Tai Du, 2011, BioMetals.

Membrane-targeted strategies for modulating APP and Aβ-mediated toxicity

C. Masters, P. Crouch, K. Price, 2008, Journal of cellular and molecular medicine.

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

G. Ciccotosto, P. Crouch, G. Evin, 2013, PloS one.

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

P. Crouch, I. Trounce, Anthony R. White, 2011, Proceedings of the National Academy of Sciences.

Water-soluble Bis(thiosemicarbazonato)copper(II) Complexes

P. Crouch, J. White, C. Schieber, 2011 .

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups.

D. Binns, P. Crouch, R. Hicks, 2019, Inorganic chemistry.

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease.

P. Crouch, S. S. Mok, D. Obando, 2013, Free radical biology & medicine.

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5.

V. Perreau, P. Crouch, K. Kanninen, 2011, Free radical biology & medicine.

Linker histone H1 binds to disease associated amyloid-like fibrils.

Colin L Masters, C. Masters, P. Crouch, 2006, Journal of molecular biology.

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

Peter J. Crouch, Imke Tammen, James L. Hickey, 2013, PloS one.

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.

M. Horne, P. Crouch, B. J. Turner, 2016, Human molecular genetics.

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Grace E. Lidgerwood, P. Crouch, K. Kanninen, 2013, Biology Open.

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

Blaine R. Roberts, David M. Shackleford, C. Masters, 2012, The Journal of experimental medicine.

Biometals and Alzheimer’s Disease

P. Crouch, Alexandra I. Mot, 2017 .

The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity

C. Masters, A. Bush, R. Cherny, 2011, Journal of neurochemistry.

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage

A. Bush, P. Crouch, G. Lynch, 2021, Journal of cachexia, sarcopenia and muscle.

Therapeutic redistribution of metal ions to treat Alzheimer's disease.

P. Crouch, K. Barnham, 2012, Accounts of chemical research.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Grace E. Lidgerwood, T. Boeckers, P. Crouch, 2015, Human molecular genetics.

A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples

P. Crouch, D. Hare, J. B. Hilton, 2018, Analytical and Bioanalytical Chemistry.

Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

C. Masters, A. Bush, R. Cherny, 2009, Proceedings of the National Academy of Sciences.

Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

C. Masters, A. Bush, R. Cherny, 2009 .

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

M. Atalay, P. Crouch, Veronika Górová, 2021, International journal of molecular sciences.

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease.

R. Cappai, P. Crouch, Anthony R. White, 2009, Molecular bioSystems.

Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease

C. Masters, A. Bush, P. Crouch, 2008 .

Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide.

C. Masters, P. Crouch, J. Duce, 2006, Journal of neurochemistry.

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

P. Crouch, K. Price, A. White, 2007, Recent patents on CNS drug discovery.

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

James L. Hickey, Grace E. Lidgerwood, P. Crouch, 2014, Acta neuropathologica communications.

Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic

K. Double, P. Crouch, D. Hare, 2020, Angewandte Chemie.

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

A. Bush, P. Crouch, D. Hare, 2022, Journal of cachexia, sarcopenia and muscle.

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

P. Crouch, Anthony R. White, J. R. Liddell, 2016, The international journal of biochemistry & cell biology.

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

A. Hannan, P. Crouch, Qiao-Xin Li, 2014, Human molecular genetics.

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

C. Masters, P. Crouch, I. Volitakis, 2009, Journal of medicinal chemistry.

Metals and Neurodegeneration: Restoring the Balance

P. Crouch, K. Kanninen, A. White, 2016 .

Editorial: Metals and neurodegeneration: restoring the balance

P. Crouch, K. Kanninen, Anthony R. White, 2015, Front. Aging Neurosci..

A potential role for Zinc in Restless Legs Syndrome.

A. Walters, J. Connor, M. Aschner, 2020, Sleep.

Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain

P. Crouch, N. Saunders, M. Habgood, 2020, Fluids and barriers of the CNS.

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

C. Masters, A. Hill, R. Cherny, 2007, The Biochemical journal.

Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques.

P. Crouch, J. White, C. Cullinane, 2019, Inorganic chemistry.

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

Erika P. Raven, Colin L. Masters, Dominic J. Hare, 2016, NeuroImage.

An integrated mass spectrometry imaging and digital pathology workflow for objective detection of colorectal tumours by unique atomic signatures

A. Bush, P. Crouch, C. Rosty, 2021, Chemical science.

Mitochondria in aging and Alzheimer's disease.

A. Bush, P. Crouch, J. Duce, 2007, Rejuvenation research.

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background

P. Crouch, K. Vine, Jeremy S. Lum, 2021, Scientific Reports.

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1.

P. Crouch, D. Hare, J. B. Hilton, 2019, Metallomics : integrated biometal science.

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Blaine R. Roberts, N. Faux, P. Crouch, 2017, Scientific Reports.

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain

P. Crouch, N. Saunders, M. Habgood, 2020, F1000Research.

Glycogen Synthase Kinase-3

P. Crouch, Ana Martínez, A. Cole, 2011, International journal of Alzheimer's disease.

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model

J. Hodges, P. Schofield, K. Double, 2013, Disease Models & Mechanisms.

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells.

P. Crouch, I. Trounce, M. McKenzie, 2013, Biochimica et biophysica acta.

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease.

C. Masters, A. Bush, P. Crouch, 2008, The international journal of biochemistry & cell biology.

Correction: Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

G. Ciccotosto, P. Crouch, G. Evin, 2013, PLoS ONE.

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.