W. V. Van Nostrand

发表

The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.

C. Colton, D. Wilcock, D. Wink, 2008, Journal of Alzheimer's disease : JAD.

Charge Alterations of E22 Enhance the Pathogenic Properties of the Amyloid β‐Protein

W. V. Van Nostrand, J. Melchor, L. Mcvoy, 2000 .

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

Andrew Brooks, R. Deane, W. V. Van Nostrand, 2007, Proceedings of the National Academy of Sciences.

Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

Joanna Wardlaw, Saad Nadeem, Maiken Nedergaard, 2020, Scientific Reports.

Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy

H. Benveniste, D. Rothman, J. Wardlaw, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport

A. Tannenbaum, H. Benveniste, M. Nedergaard, 2019, bioRxiv.

Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid β-protein precursor abolishes its anti-thrombotic properties in vivo.

Judianne Davis, W. V. Van Nostrand, Feng Xu, 2017, Thrombosis research.

Protease nexin-2/Amyloid beta-protein precursor regulates factor VIIa and the factor VIIa-tissue factor complex.

A. Schmaier, A. Rehemtulla, W. V. Van Nostrand, 2000, Thrombosis research.

Protease Nexin-2/Amyloid β-Protein Precursor Inhibits Factor Xa in the Prothrombinase Complex (*)

A. Schmaier, W. V. Van Nostrand, F. Mahdi, 1995, The Journal of Biological Chemistry.

Enhanced Plasmin Inhibition by a Reactive Center Lysine Mutant of the Kunitz-type Protease Inhibitor Domain of the Amyloid β-Protein Precursor (*)

A. Schmaier, S. Wagner, W. V. Van Nostrand, 1995, The Journal of Biological Chemistry.

Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2.

A. Schmaier, S. Wagner, W. V. Van Nostrand, 1994, Biochimica et biophysica acta.

Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats

H. Benveniste, W. V. Van Nostrand, Hedok Lee, 2020, International journal of molecular sciences.

Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques.

W. V. Van Nostrand, L. Miller, Feng Xu, 2020, Metallomics : integrated biometal science.

Fibrillar Amyloid β-Protein Mediates the Pathologic Accumulation of Its Secreted Precursor in Human Cerebrovascular Smooth Muscle Cells*

W. V. Van Nostrand, J. Melchor, 2000, The Journal of Biological Chemistry.

Pathologic Amyloid β‐Protein Cell Surface Fibril Assembly on Cultured Human Cerebrovascular Smooth Muscle Cells

W. V. Van Nostrand, J. Melchor, L. Ruffini, 1998 .

Amyloid β-Protein Aggregation Nullifies Its Pathologic Properties in Cultured Cerebrovascular Smooth Muscle Cells (*)

W. V. Van Nostrand, J. Davis-Salinas, Judianne Davis-Salinas, 1995, The Journal of Biological Chemistry.

Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy

B. J. Anderson, W. V. Van Nostrand, L. Robison, 2019, Journal of Neuroinflammation.

Animal models of cerebral amyloid angiopathy.

D. Werring, M. Verbeek, W. V. Van Nostrand, 2017, Clinical science.

The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2.

C. Cotman, S. Wagner, W. V. Van Nostrand, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor.

S. Wagner, W. V. Van Nostrand, D. Cunningham, 1990, The Journal of biological chemistry.

Monoclonal antibodies to protease nexin 1 that differentially block its inhibition of target proteases.

S. Wagner, W. V. Van Nostrand, A. Lau, 1988, Biochemistry.

Purification of a form of protease nexin 1 that binds heparin with a low affinity.

S. Wagner, W. V. Van Nostrand, D. Cunningham, 1988, Biochemistry.

Brain and Circulating Levels of A&bgr;1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain

C. Iadecola, G. Carlson, W. V. Van Nostrand, 2013, Stroke.

Distinct brain regional proteome changes in the rTg‐DI rat model of cerebral amyloid angiopathy

W. V. Van Nostrand, Feng Xu, Joseph Schrader, 2021, Journal of neurochemistry.

Emergent White Matter Degeneration in the rTg-DI Rat Model of Cerebral Amyloid Angiopathy Exhibits Unique Proteomic Changes.

H. Benveniste, W. V. Van Nostrand, Hedok Lee, 2021, The American journal of pathology.

Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy

W. V. Van Nostrand, Feng Xu, Xiaoyue Zhu, 2020, Journal of Neuroinflammation.

Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells.

C. Cotman, W. V. Van Nostrand, D. Cribbs, 1999, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Localization of a Fibrillar Amyloid β-Protein Binding Domain on Its Precursor*

Judianne Davis, W. V. Van Nostrand, J. Melchor, 2002, The Journal of Biological Chemistry.

beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin.

R. Neve, H. Kleinman, W. V. Van Nostrand, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Rapid degeneration of cultured human brain pericytes by amyloid beta protein.

M. Verbeek, W. V. Van Nostrand, R. D. de Waal, 1997, Journal of neurochemistry.

rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2

Judianne Davis, W. V. Van Nostrand, Feng Xu, 2022, Cerebral circulation - cognition and behavior.

Abeta does not induce oxidative stress in human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, Sonia S. Jung, 2002, Neuroreport.

A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.

H. Benveniste, Judianne Davis, W. V. Van Nostrand, 2018, The American journal of pathology.

Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double A beta in human A betaPP transgenic mice.

Judianne Davis, W. V. Van Nostrand, M. L. Previti, 2006, Neurobiology of aging.

Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1

W. V. Van Nostrand, John K. Robinson, Dominique L Popescu, 2020, International journal of molecular sciences.

The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.

W. V. Van Nostrand, 2016, Biochimica et biophysica acta.

Experimental Investigation of Antibody-Mediated Clearance Mechanisms of Amyloid-β in CNS of Tg-SwDI Transgenic Mice

W. V. Van Nostrand, V. Vasilevko, D. Cribbs, 2007, The Journal of Neuroscience.

Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.

L. Lue, T. Beach, D. Walker, 2008, The American journal of pathology.

Pathogenic Aβ induces the expression and activation of matrix metalloproteinase‐2 in human cerebrovascular smooth muscle cells

W. V. Van Nostrand, Sonia S. Jung, Weibing Zhang, 2003 .

Distinct Brain Proteomic Signatures in Cerebral Small Vessel Disease Rat Models of Hypertension and Cerebral Amyloid Angiopathy.

W. V. Van Nostrand, Feng Xu, Aleksandra Stanisavljevic, 2022, Journal of neuropathology and experimental neurology.

Pathogenic effects of D23N Iowa mutant amyloid beta -protein.

S. Greenberg, W. V. Van Nostrand, H. Cho, 2001, The Journal of biological chemistry.

Coagulation Factor XIa Cleaves the RHDS Sequence and Abolishes the Cell Adhesive Properties of the Amyloid β-Protein (*)

W. V. Van Nostrand, S. Saporito-irwin, 1995, The Journal of Biological Chemistry.

Elevated expression of urokinase plasminogen activator in rodent models and patients with cerebral amyloid angiopathy

W. F. Abdo, S. Greenberg, M. Verbeek, 2021, Neuropathology and applied neurobiology.

The Kunitz Protease Inhibitor Form of the Amyloid Precursor Protein (KPI/APP) Inhibits the Proneuropeptide Processing Enzyme Prohormone Thiol Protease (PTP)

N. Robakis, W. V. Van Nostrand, S. Yasothornsrikul, 1999, The Journal of Biological Chemistry.

Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity

W. V. Van Nostrand, Sonia S. Jung, 2003, Journal of neurochemistry.

Platelet Protease Nexin‐2/Amyloid β‐Protein Precursor

A. Schmaier, W. V. Van Nostrand, D. Cunningham, 1991 .

Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein.

A. Schmaier, W. V. Van Nostrand, D. Cines, 1991, Biochemical and biophysical research communications.

Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions.

A. Schmaier, W. V. Van Nostrand, D. Cunningham, 1991, Annals of the New York Academy of Sciences.

Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa

W. V. Van Nostrand, Steven O. Smith, Z. Fu, 2021, International journal of molecular sciences.

Enhanced Capillary Amyloid Angiopathy-Associated Pathology in Tg-SwDI Mice With Deleted Nitric Oxide Synthase 2

C. Colton, W. V. Van Nostrand, A. Rozemuller, 2010, Stroke.

Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro.

W. V. Van Nostrand, Steven O. Smith, Mahiuddin Ahmed, 2009, Biochemistry.

Induction of complement proteins in a mouse model for cerebral microvascular Aβ deposition

W. V. Van Nostrand, Rong Fan, Kelly DeFilippis, 2007, Journal of Neuroinflammation.

Further evidence of local ganglioside-dependent amyloid &bgr;-protein assembly in brain

W. V. Van Nostrand, Naoki Yamamoto, K. Yanagisawa, 2006, Neuroreport.

Assembly of hereditary amyloid β‐protein variants in the presence of favorable gangliosides

W. V. Van Nostrand, M. Amari, H. Yamaguchi, 2005, FEBS letters.

Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells.

Judianne Davis, W. V. Van Nostrand, Feng Xu, 2003, The Journal of biological chemistry.

Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging

H. Benveniste, J. Wardlaw, W. V. Van Nostrand, 2022, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.

M. Lefranc, W. V. Van Nostrand, D. Cribbs, 2010, Molecular immunology.

Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells

C. Cotman, W. V. Van Nostrand, J. Davis-Salinas, 1995 .

A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein.

P. Tempst, W. V. Van Nostrand, H. Potter, 1991, Biochemical and biophysical research communications.

Identification of a novel serine protease-like molecule in human brain.

W. V. Van Nostrand, C. Abraham, M. Pietropaolo, 1998, Brain research. Molecular brain research.

A simple two-step purification of protease nexin.

W. V. Van Nostrand, D. Farrell, D. Cunningham, 1986, The Biochemical journal.

Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease.

W. Kamphorst, W. V. Van Nostrand, P. Eikelenboom, 1993, The American journal of pathology.

Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis–dutch type share a decrease in cerebrospinal fluid levels of amyloid β‐protein precursor

R. Roos, S. Wagner, W. V. Van Nostrand, 1992 .

Expression of protease nexin-II in human dorsal root ganglia. A correlative immunocytochemical and in situ hybridization study.

S. Wagner, W. V. Van Nostrand, B. H. Choi, 1992, Molecular and chemical neuropathology.

Expression of active secreted forms of human amyloid beta-protein precursor by recombinant baculovirus-infected insect cells.

W. V. Van Nostrand, D. Goldgaber, W. Quitschke, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Insights into Cerebral Amyloid Angiopathy Type 1 and Type 2 from Comparisons of the Fibrillar Assembly and Stability of the Aβ40-Iowa and Aβ40-Dutch Peptides

W. V. Van Nostrand, Steven O. Smith, Elliot J Crooks, 2022, Biochemistry.

Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, J. Melchor, 2000, The Journal of biological chemistry.

Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia

W. V. Van Nostrand, Steven O. Smith, Xiaoyue Zhu, 2022, Biomedicines.

Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity.

W. V. Van Nostrand, M. Porter, Margaret Porter, 1999, Biochemistry.

An electrostatic cluster guides Aβ40 fibril formation in cerebral amyloid angiopathy

W. V. Van Nostrand, Steven O. Smith, Z. Fu, 2022, bioRxiv.

Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, J. Melchor, L. Ruffini, 1998, Journal of neurochemistry.

Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor.

W. V. Van Nostrand, D. Cunningham, J. Davis-Salinas, 1994, The Journal of biological chemistry.

Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant

W. V. Van Nostrand, C. Simmerling, T. Kawakami, 2020, The Journal of Biological Chemistry.

Evaluation of Copper Chelation Therapy in a Transgenic Rat Model of Cerebral Amyloid Angiopathy.

Judianne Davis, W. V. Van Nostrand, Aleksandra Stanisavljevic, 2023, ACS chemical neuroscience.

The Mechanism by Which Heparin Promotes the Inhibition of Coagulation Factor XIa by Protease Nexin-2*

W. V. Van Nostrand, P. Walsh, J. Scandura, 1997, The Journal of Biological Chemistry.

Amyloid β-Protein Stimulates the Expression of Urokinase-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Human Cerebrovascular Smooth Muscle Cells*

Judianne Davis, W. V. Van Nostrand, Feng Xu, 2003, Journal of Biological Chemistry.

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Linda J. C. van Waalwijk van Doorn, K. Jellinger, A. Fagan, 2017, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Amyloid Reduction by Amyloid-β Vaccination Also Reduces Mouse Tau Pathology and Protects from Neuron Loss in Two Mouse Models of Alzheimer's Disease

Nastaran Gharkholonarehe, Michael P Vitek, Carol A Colton, 2009, The Journal of Neuroscience.

Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Judianne Davis, W. V. Van Nostrand, Steven O. Smith, 2016, Nature Communications.

Mechanism of Nucleated Conformational Conversion of Aβ42.

Judianne Davis, W. V. Van Nostrand, Steven O. Smith, 2015, Biochemistry.

Capping of Aβ42 Oligomers by Small Molecule Inhibitors

W. V. Van Nostrand, Steven O. Smith, M. Ziliox, 2014, Biochemistry.

Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils

Judianne Davis, W. V. Van Nostrand, J. Elliott, 2010, Nature Structural &Molecular Biology.

Human Apolipoprotein E Redistributes Fibrillar Amyloid Deposition in Tg-SwDI Mice

C. Colton, Judianne Davis, W. V. Van Nostrand, 2008, The Journal of Neuroscience.

Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer's disease that exhibit neurodegeneration.

C. Colton, W. V. Van Nostrand, R. Tappero, 2013, Biomedical spectroscopy and imaging.

Degradation of Amyloid β Protein by Purified Myelin Basic Protein*

W. V. Van Nostrand, Steven O. Smith, Mahiuddin Ahmed, 2009, The Journal of Biological Chemistry.

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β

C. Iadecola, S. Younkin, L. Younkin, 2011, Proceedings of the National Academy of Sciences.

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

W. V. Van Nostrand, Ming-Hsuan Ou-Yang, 2013, Journal of Neuroinflammation.

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity*

R. Kane, Judianne Davis, W. V. Van Nostrand, 2012, The Journal of Biological Chemistry.

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

R. Deane, Judianne Davis, W. V. Van Nostrand, 2004, Neuron.

Review: Sporadic cerebral amyloid angiopathy

K. Jellinger, J. Attems, W. V. Van Nostrand, 2011, Neuropathology and applied neurobiology.

Functional and structural similarities between protease nexin I and C1 inhibitor.

W. V. Van Nostrand, J. Baker, D. Cunningham, 1988, The Journal of biological chemistry.

Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils

Judianne Davis, W. V. Van Nostrand, A. Rozemuller, 2021, The Journal of biological chemistry.

Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries

A. Tannenbaum, H. Benveniste, J. Kipnis, 2022, Nature Aging.

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

C. Cotman, M. Dick, E. Wolters, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2.

W. V. Van Nostrand, P. Walsh, J. Scandura, 1997, Biochemistry.

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

C. Colton, W. V. Van Nostrand, M. Vitek, 2006, Journal of Neuroinflammation.

Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2

Nastaran Gharkholonarehe, Michael P Vitek, Carol A Colton, 2008, The Journal of Neuroscience.

Early-onset Formation of Parenchymal Plaque Amyloid Abrogates Cerebral Microvascular Amyloid Accumulation in Transgenic Mice*

Judianne Davis, W. V. Van Nostrand, Steven O. Smith, 2014, The Journal of Biological Chemistry.

Absence of Nitric Oxide Synthase 3 Increases Amyloid β-Protein Pathology in Tg-5xFAD Mice.

W. V. Van Nostrand, Z. Hu, Annmarie E Kotarba, 2013, Neuroscience and medicine.

Fine mapping of the amyloid β-protein binding site on myelin basic protein.

W. V. Van Nostrand, Steven O. Smith, Michael D. Hoos, 2013, Biochemistry.

N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly*

Judianne Davis, W. V. Van Nostrand, Steven O. Smith, 2010, The Journal of Biological Chemistry.

Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling.

W. V. Van Nostrand, W. Xia, C. Abraham, 2019, Journal of Alzheimer's disease : JAD.

Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein*

S. Greenberg, W. V. Van Nostrand, J. Melchor, 2001, The Journal of Biological Chemistry.

Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β Protein

M. Verbeek, W. V. Van Nostrand, R. D. de Waal, 1997 .

Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro(*)

W. V. Van Nostrand, D. Goldgaber, M. Figueiredo-Pereira, 1995, The Journal of Biological Chemistry.

Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein.

A. Schmaier, W. V. Van Nostrand, D. Cunningham, 1990, Science.

Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice.

C. Colton, Judianne Davis, W. V. Van Nostrand, 2012, Journal of Alzheimer's disease : JAD.

NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

C. Colton, D. Wink, W. V. Van Nostrand, 2006, Proceedings of the National Academy of Sciences.

Interactions of serine proteases with cultured fibroblasts

W. V. Van Nostrand, D. Farrell, Dennis Cunningham, 1986, Journal of cellular biochemistry.

Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro.

W. V. Van Nostrand, Mei-Chen Liao, 2010, Biochemistry.

Cerebral microvascular rather than parenchymal amyloid-β protein pathology promotes early cognitive impairment in transgenic mice.

Judianne Davis, W. V. Van Nostrand, John K. Robinson, 2013, Journal of Alzheimer's disease : JAD.

Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.

Irene Otte-Höller, Feng Xu, M. Verbeek, 2005, The American journal of pathology.

Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor*

R. Deane, Judianne Davis, W. V. Van Nostrand, 2004, Journal of Biological Chemistry.

Increased Severity of Hemorrhage in Transgenic Mice Expressing Cerebral Protease Nexin-2/Amyloid &bgr;-Protein Precursor

W. V. Van Nostrand, M. L. Previti, Feng Xu, 2007, Stroke.

Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, Sonia S. Jung, Weibing Zhang, 2003, Journal of neurochemistry.

Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model

W. V. Van Nostrand, L. Robison, John K. Robinson, 2020, International journal of molecular sciences.

Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models.

Mathias Jucker, W. V. Van Nostrand, M. Jucker, 2006, Brain pathology.

Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid

Judianne Davis, W. V. Van Nostrand, John K. Robinson, 2007, The Journal of Neuroscience.

Impact of Non-pharmacological Chronic Hypertension on a Transgenic Rat Model of Cerebral Amyloid Angiopathy

W. V. Van Nostrand, Feng Xu, John K. Robinson, 2022, Frontiers in Neuroscience.

The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease

F. Bouwman, A. Jonker, W. V. Van Nostrand, 2020, Acta Neuropathologica.

Voluntary Wheel Running Reduces Amyloid-β42 and Rescues Behavior in Aged Tg2576 Mouse Model of Alzheimer's Disease.

Judianne Davis, W. V. Van Nostrand, L. Robison, 2019, Journal of Alzheimer's disease : JAD.

Reducing Cerebral Microvascular Amyloid-β Protein Deposition Diminishes Regional Neuroinflammation in Vasculotropic Mutant Amyloid Precursor Protein Transgenic Mice

Judianne Davis, W. V. Van Nostrand, M. Vitek, 2005, The Journal of Neuroscience.

The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease*

M. Hayden, J. Poirier, W. V. Van Nostrand, 2005, Journal of Biological Chemistry.

Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells

W. V. Van Nostrand, M. L. Previti, Weibing Zhang, 2006, Journal of Neuroinflammation.

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer’s Disease Transgenics

C. Colton, D. Wilcock, Judianne Davis, 2012, Neurodegenerative Diseases.

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

Ping Zhou, C. Iadecola, G. Carlson, 2014, Stroke.

Intensive 'Brain Training' Intervention Fails to Reduce Amyloid Pathologies or Cognitive Deficits in Transgenic Mouse Models of Alzheimer's Disease.

Judianne Davis, W. V. Van Nostrand, John K. Robinson, 2016, Journal of Alzheimer's disease : JAD.

Normal cerebrospinal fluid concentrations of PDGFRβ in patients with cerebral amyloid angiopathy and Alzheimer's disease

S. Greenberg, M. Verbeek, J. Claassen, 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

AβPP/APLP2 Family of Kunitz Serine Proteinase Inhibitors Regulate Cerebral Thrombosis

A. Schmaier, Judianne Davis, W. V. Van Nostrand, 2009, The Journal of Neuroscience.

Apolipoprotein E Genotype Regulates Amyloid-β Cytotoxicity

M. Verbeek, Judianne Davis, W. V. Van Nostrand, 2005, The Journal of Neuroscience.

Amyloid‐β‐induced Degeneration of Human Brain Pericytes Is Dependent on the Apolipoprotein E Genotype

P. Wesseling, M. Verbeek, W. V. Van Nostrand, 2000, Annals of the New York Academy of Sciences.

Inhibition of Familial Cerebral Amyloid Angiopathy Mutant Amyloid β-Protein Fibril Assembly by Myelin Basic Protein*

W. V. Van Nostrand, Steven O. Smith, Mahiuddin Ahmed, 2007, Journal of Biological Chemistry.

Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

A. Tannenbaum, H. Benveniste, M. Nedergaard, 2020, Scientific Reports.

Clearance of Amyloid-β Protein Deposits in Transgenic Mice following Focal Cerebral Ischemia

W. V. Van Nostrand, M. L. Previti, F. Xu, 2012, Neurodegenerative Diseases.

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

W. V. Van Nostrand, Ming-Hsuan Ou-Yang, 2013, Journal of Neuroinflammation.

An electrostatic cluster guides Aβ40 fibril formation in cerebral amyloid angiopathy

W. V. Van Nostrand, Saikat D Chowdhury, Steven O. Smith, 2023, bioRxiv.

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.

C. Cotman, J. Geddes, S. Wagner, 1989, Nature.

Purification of protease nexin II from human fibroblasts.

W. V. Van Nostrand, W. E. Nostrand, D. Cunningham, 1987, The Journal of biological chemistry.

Factor IXa inhibition by protease nexin-2/amyloid beta-protein precursor on phospholipid vesicles and cell membranes.

A. Schmaier, W. V. Van Nostrand, D. Cines, 1995, Biochemistry.

Cerebrovascular Smooth Muscle Cell Surface Fibrillar Aβ: Alteration of the Proteolytic Environment in the Cerebral Vessel Wall

Judianne Davis, W. V. Van Nostrand, J. Melchor, 2000, Annals of the New York Academy of Sciences.

Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy

W. V. Van Nostrand, Feng Xu, Xiaoyue Zhu, 2020, Journal of Neuroinflammation.

Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy

W. V. Van Nostrand, L. Robison, John K. Robinson, 2019, Journal of Neuroinflammation.

Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein.

W. V. Van Nostrand, J. Davis, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells.

C. Cotman, W. V. Van Nostrand, J. Davis-Salinas, 1995, Journal of neurochemistry.

Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa.

Raymond, A. Schmaier, R. Roos, 1993, The Journal of clinical investigation.

Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells.

W. V. Van Nostrand, J. Melchor, 2001, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis.

Judianne Davis, W. V. Van Nostrand, M. L. Previti, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID)

H. Benveniste, W. V. Van Nostrand, Hedok Lee, 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Judianne Davis, W. V. Van Nostrand, Steven O. Smith, 2016, Nature Communications.

Localization of a fibrillar amyloid beta-protein binding domain on its precursor.

Judianne Davis, W. V. Van Nostrand, J. Melchor, 2002, The Journal of biological chemistry.

Brain and Circulating Levels of A&bgr;1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain

C. Iadecola, G. Carlson, W. V. Van Nostrand, 2013, Stroke.

Mechanism of Nucleated Conformational Conversion of Aβ42.

Judianne Davis, W. V. Van Nostrand, Steven O. Smith, 2015, Biochemistry.

Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques.

W. V. Van Nostrand, L. Miller, Feng Xu, 2020, Metallomics : integrated biometal science.

The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.

W. V. Van Nostrand, W. E. Nostrand, 2016, Biochimica et biophysica acta.

Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share a decrease in cerebrospinal fluid levels of amyloid beta-protein precursor.

R. Roos, S. Wagner, W. V. Van Nostrand, 1992, Annals of neurology.

Purification of a proteinase inhibitor from bovine serum with C1-inhibitor activity.

W. V. Van Nostrand, D. Cunningham, 1987, Biochimica et biophysica acta.

Fibrillar amyloid beta-protein binds protease nexin-2/amyloid beta-protein precursor: stimulation of its inhibition of coagulation factor XIa.

W. V. Van Nostrand, J. Melchor, D. Keane, 2000, Biochemistry.

A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.

H. Benveniste, Judianne Davis, W. V. Van Nostrand, 2018, The American journal of pathology.

Potential role of protease nexin-2/amyloid beta-protein precursor as a cerebral anticoagulant.

A. Schmaier, S. Wagner, W. V. Van Nostrand, 1992, Annals of the New York Academy of Sciences.

Functional and structural similarities between protease nexin I and C1 inhibitor.

W. V. Van Nostrand, J. Baker, L. McKay, 1988, The Journal of biological chemistry.