C. Link

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Amyloid-β-Induced Pathological Behaviors Are Suppressed by Ginkgo biloba Extract EGb 761 and Ginkgolides in Transgenic Caenorhabditis elegans

Y. Christen, W. Klein, Yanjue Wu, 2006, The Journal of Neuroscience.

Reporter transgenes for study of oxidant stress in Caenorhabditis elegans.

C. Link, C. J. Johnson, Carolyn J. Johnson, 2002, Methods in enzymology.

Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods.

G. Stormo, Stuart K. Kim, D. Guhathakurta, 2002, Genome research.

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34

David H. Hall, William E. Klunk, Chester A. Mathis, 2001, Neurobiology of Aging.

A global analysis of Caenorhabditis elegans operons

Jean Thierry-Mieg, Alessandro Guffanti, Thomas Blumenthal, 2002, Nature.

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

Alfred L. Fisher, C. Link, S. Rea, 2016, PLoS genetics.

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

C. Link, R. Vázquez-Manrique, C. Néri, 2018, Cell Death & Differentiation.

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

C. Link, R. Vázquez-Manrique, C. Néri, 2018, bioRxiv.

The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2

L. Petrucelli, C. Link, T. Saldi, 2018, Molecular and Cellular Biology.

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

L. Petrucelli, D. Dickson, C. Link, 2009, Proceedings of the National Academy of Sciences.

Invertebrate models of Alzheimer's disease

C. Link, 2005, Genes, brain, and behavior.

Interaction of intracellular beta amyloid peptide with chaperone proteins.

C. Link, V. Fonte, A. Taft, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Neurodegeneration, Heterochromatin, and Double-Stranded RNA

C. Link, T. Saldi, P. Gonzales, 2019, Journal of experimental neuroscience.

In Vivo Aggregation of β‐Amyloid Peptide Variants

C. Link, D. Fay, C. J. Johnson, 1998 .

Biochemical Analysis of Caenorhabditis elegans Surface Mutants.

M. Blaxter, C. Link, M. Silverman, 1997, Journal of nematology.

A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons

C. Link, S. Murakami, K. Machino, 2014, Front. Genet..

Is There a Brain Microbiome?

C. Link, 2021, Neuroscience insights.

In vitro and in vivo oxidative stress associated with Alzheimer ’ s amyloid b-peptide ( 1 – 42 )

D. Butterfield, C. Link, S. Varadarajan, 1999 .

Amyloid beta acts synergistically as a pro-inflammatory cytokine

C. Link, C. Roberts, Alyssa N. Cavalier, 2020, Neurobiology of Disease.

Progranulin regulates neuronal outgrowth independent of Sortilin

L. Petrucelli, C. Link, J. Gass, 2012, Molecular Neurodegeneration.

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

L. Petrucelli, M. Murray, D. Dickson, 2016, Nature Neuroscience.

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

D. Butterfield, C. Link, S. Varadarajan, 1999, Neurobiology of aging.

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

Christian A. Ross, Kevin F. Bieniek, Hu Li, 2015, Nature Neuroscience.

Direct observation of stress response in Caenorhabditis elegans using a reporter transgene.

C. Link, J. Cypser, T. Johnson, 1999, Cell stress & chaperones.

Identifying Optimal Neuroinflammation Treatment Using Nanoligomer™ Discovery Engine

C. Link, P. Nagpal, A. Chatterjee, 2022, bioRxiv.

Feedback inhibition controls spike transfer in hybrid thalamic circuits

Stuart K. Kim, T. Blumenthal, J. Thierry-Mieg, 2022 .

Inverted repeats surround the ribitol–arabitol genes of E. coli C

C. Link, A. Reiner, 1982, Nature.

Genotypic exclusion: A novel relationship between the ribitol-arabitol and galactitol genes of E. coli

C. Link, A. Reiner, 2004, Molecular and General Genetics MGG.

Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood

L. Petrucelli, M. Benatar, J. Wuu, 2021, bioRxiv.

The C. elegans ortholog of TDP-43 regulates the chromatin localization of the heterochromatin protein 1 homolog, HPL-2

L. Petrucelli, C. Link, T. Saldi, 2018 .

Caenorhabditis elegans Model for Initial Screening and Mechanistic Evaluation of Potential New Drugs for Aging and Alzheimer’s Disease

Yanjue Wu, C. Link, Yuan Luo, 2009 .

Erratum to: Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans. Autophagy 2007; 3:569-80

C. Link, M. Florez-McClure, 2009 .

Oxidative stress and glomerular filtration barrier injury : role of the renin-angiotensin system in the Ren 2 transgenic rat

C. Link, J. Sowers, A. Whaley-connell, 2006 .

Cloning a gene for life-extension in Caenorhabditis elegans

E. W. Hutchinson, C. Link, T. Johnson, 1990 .

Cell Death by Glutamine Repeats?

C. Link, T. Saldi, Tassa K. Saldi, 2012, Science.

Identifying Optimal Neuroinflammation Treatment Using Nanoligomer™ Discovery Engine

C. Link, P. Nagpal, A. Chatterjee, 2022, bioRxiv.

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

C. Link, C D Link, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Progranulin regulates neuronal outgrowth independent of Sortilin

L. Petrucelli, C. Link, J. Gass, 2012, Molecular Neurodegeneration.

Oxidative stress precedes fibrillar deposition of Alzheimer’s disease amyloid β-peptide (1–42) in a transgenic Caenorhabditis elegans model

D. Butterfield, C. Link, J. Drake, 2003, Neurobiology of Aging.

Expression of the small heat‐shock protein Hsp‐16‐2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761

Y. Christen, Zhixin Wu, C. Link, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients

L. Petrucelli, D. Dickson, C. Link, 2017, Human molecular genetics.

Heat Shock in C. elegans Induces Downstream of Gene Transcription andAccumulation of Double-Stranded RNA

C. Link, R. Dowell, Joseph M Cabral, 2018, bioRxiv.

Neurotoxic effects of TDP-43 overexpression in C. elegans.

H. Hutter, L. Petrucelli, C. Link, 2010, Human molecular genetics.

Lysosomal and pseudocoelom routing protects Caenorhabditis elegans from ricin toxicity

C. Link, A. Coomans, G. Borgonie, 2003 .

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA

L. Stein, L. Petrucelli, T. Blumenthal, 2014, The EMBO journal.

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

C. Link, Vishantie Dostal, 2010, Journal of visualized experiments : JoVE.

Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.

C. Link, K. Caldwell, G. Caldwell, 2014, Antioxidants & redox signaling.

Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21

C. Link, G. Stein, V. Fonte, 2017, bioRxiv.

TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes

L. Watkins, C. Link, A. Mariani, 2019, Neurobiology of Disease.

The β amyloid peptide can act as a modular aggregation domain

C. Link, G. Stein, V. Fonte, 2008, Neurobiology of Disease.

Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans.

C. Link, T. Johnson, L. Klotz, 2003, Journal of molecular biology.

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

C. Link, D. Seals, Vienna E. Brunt, 2020, GeroScience.

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease

B. Gibson, D. Bredesen, C. Link, 2005, Annals of neurology.

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

Roy Parker, R. Parker, C. Link, 2018, Proceedings of the National Academy of Sciences.

AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

C. Link, V. Fonte, Wail M. Hassan, 2009, Human molecular genetics.

Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin

M. Aschner, C. Link, T. Schwerdtle, 2016, Scientific Reports.

Compensatory regulation among ER chaperones in C. elegans

C. Link, Brian G. Hiester, Vadim Kapulkin, 2005, FEBS letters.

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts

Stanley N Cohen, L. Petrucelli, R. Petersen, 2016, Science.

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

L. Petrucelli, D. Dickson, Connor H. Ludwig, 2019, Science.

Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA

C. Link, R. Dowell, Joseph M Cabral, 2018, bioRxiv.

Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.

A. Hubbard, P. Kapahi, S. Melov, 2010, Cell metabolism.

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

Blaine R. Roberts, C. Masters, A. Bush, 2012, Molecular Neurodegeneration.

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegansfor drug screening for Alzheimer’s disease

C. Masters, A. Bush, R. Cherny, 2012, Molecular Neurodegeneration.

What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

C. Link, Dawn Teschendorf, 2009, Molecular Neurodegeneration.

In vivo aggregation of beta-amyloid peptide variants.

C. Link, D. Fay, A. Fluet, 1998, Journal of neurochemistry.

Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat.

C. Link, J. Sowers, A. Whaley-connell, 2006, American journal of physiology. Renal physiology.

Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans.

Nicole R. Cunningham, N. M. Jones, R. Fairman, 2017, Biochemistry.

Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Aβ(1–42): Implications for Alzheimer's disease

D. Butterfield, D. Boyd-Kimball, H. Poon, 2006, Neurobiology of Aging.

The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity.

P. Navas, C. Link, J. C. Fierro-González, 2012, Antioxidants & redox signaling.

C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer’s disease

C. Link, 2006, Experimental Gerontology.

Transgenic invertebrate models of age-associated neurodegenerative diseases

C. Link, Christopher D Link, 2001, Mechanisms of Ageing and Development.

A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans.

C. Link, C. Grevelding, T. Johnson, 2003, Free radical biology & medicine.

Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling.

C. Link, J. Sowers, A. Whaley-connell, 2007, Endocrinology.

Toxic Role of K+ Channel Oxidation in Mammalian Brain

C. Link, F. Sesti, S. Oddo, 2012, The Journal of Neuroscience.

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo

C. Link, G. Stein, V. Fonte, 2011, Molecular Neurodegeneration.

Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein*

C. Link, V. Fonte, C. Roberts, 2008, Journal of Biological Chemistry.

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

G. Varani, V. Daggett, C. Link, 2019, Proceedings of the National Academy of Sciences.

Rapid communication Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid -peptide (1-42) in a transgenic Caenorhabditis elegansmodel

D. Butterfield, C. Link, J. Drake, 2003 .

Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of β-Amyloid Peptide Toxicity

C. Link, Vishantie Dostal, C. Roberts, 2010, Genetics.

Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans

Yanjue Wu, Zhixin Wu, C. Link, 2005, BMC Neuroscience.

Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer’s disease model

Stuart K. Kim, K. Duke, C. Link, 2003, Neurobiology of Aging.

Characterization of Caenorhabditis elegans lectin-binding mutants.

C. Link, S. Dames, M. Breen, 1992, Genetics.

Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection

Nicole R. Cunningham, R. Fairman, C. Link, 2016, Protein science : a publication of the Protein Society.

Genetic dissection of late-life fertility in Caenorhabditis elegans.

P. Phillips, C. Link, J. Cypser, 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease

C. Link, J. Cypser, T. Johnson, 2002, Journal of Inherited Metabolic Disease.

Mutant expression of male copulatory bursa surface markers in Caenorhabditis elegans.

W. Wood, C. Link, C. Ehrenfels, 1988, Development.

Interaction of intracellular β amyloid peptide with chaperone proteins

C. Link, V. Fonte, A. Taft, 2002, Proceedings of the National Academy of Sciences of the United States of America.

In vivo induction of membrane damage by β-amyloid peptide oligomers

C. Link, G. Stein, Colson Tomberlin, 2018, Acta Neuropathologica Communications.

Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity.

C. Link, A. Lublin, 2013, Drug discovery today. Technologies.

Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide*

C. Link, G. Stein, V. Fonte, 2006, Journal of Biological Chemistry.

The reverse transcriptase inhibitor 3TC protects against age‐related cognitive dysfunction

C. Link, Shelby C. Osburn, Devin Wahl, 2023, Aging cell.

Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of β-Amyloid Peptide in C. elegans

C. Link, M. Florez-McClure, M. T. Bealor, 2007, Autophagy.

Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors

C. Link, J. Cypser, T. Johnson, 2000, Experimental Gerontology.

Identifying Aβ-specific pathogenic mechanisms using a nematode model of Alzheimer's disease

C. Link, Vishantie Dostal, Wail M. Hassan, 2015, Neurobiology of Aging.

TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord.

C. Link, Zuoshang Xu, C. Hoeffer, 2022, Cerebral cortex.

Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta.

C. Link, Yuan Luo, Marishka Brown, 2010, Journal of Alzheimer's disease : JAD.

Life‐span extension by dietary restriction is mediated by NLP‐7 signaling and coelomocyte endocytosis in C. elegans

C. Link, T. Johnson, Sang-Kyu Park, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

In Vitro and in vivo Protein Oxidation Induced by Alzheimer's Disease Amyloid β‐Peptide (1–42)

D. Butterfield, C. Link, S. Yatin, 1999, Annals of the New York Academy of Sciences.

Isolation and characterization of a nematode transposable element from Panagrellus redivivus.

W. Wood, C. Link, J. Graf-Whitsel, 1987, Proceedings of the National Academy of Sciences of the United States of America.

increases long-term anoxia survival in a Reduction in ovulation or male sex phenotype

P. Phillips, C. Link, V. Shulaev, 2015 .

Exercise training prevents development of cardiac contractile dysfunction in hypertensive TG (mREN-2)27 rats.

F. Booth, C. Link, J. Sowers, 2007, Journal of the American Society of Hypertension : JASH.

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

C. Link, D. Seals, Vienna E. Brunt, 2020, GeroScience.

Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods.

G. Stormo, Stuart K. Kim, C. Link, 2002, Genome research.

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

L. Petrucelli, D. Dickson, C. Link, 2009, Proceedings of the National Academy of Sciences.

C. Link, J. Sowers, M. Hayden, 2007, Endocrinology.