H. Akiyama

发表

C. Plata-salamán, C. Finch, H. Hampel, 2000, Neurobiology of Aging.

Inflammatory response in Alzheimer's disease.

H. Akiyama, H Akiyama, Haruhiko Akiyama, 1994, The Tohoku journal of experimental medicine.

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide

P. Mcgeer, E. Mcgeer, H. Akiyama, 2001, Neuroscience Letters.

Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders

H. Akiyama, K. Kosaka, Takayuki Yamamoto, 1995, Neuroscience Letters.

Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease

T. Iwatsubo, H. Akiyama, K. Kosaka, 1998, Neuroscience Letters.

Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using α-synuclein-immunohistochemistry

H. Akiyama, K. Kosaka, E. Iseki, 2000, Neuroscience Letters.

INFLAMMATION AND ALZHEIMERS DISEASE

Scott R. Barnum, Haruhiko Akiyama, S. Barnum, 2000 .

Reticulons RTN3 and RTN4‐B/C interact with BACE1 and inhibit its ability to produce amyloid β‐protein

Hideaki Kume, Haruhiko Akiyama, H. Akiyama, 2006, The European journal of neuroscience.

Distinct pathways leading to TDP-43-induced cellular dysfunctions.

H. Akiyama, M. Hasegawa, M. Yamashita, 2014, Human molecular genetics.

Thalamic hypoperfusion in early stage of progressive supranuclear palsy(Richardson's syndrome): Report of an autopsy-confirmed case

H. Akiyama, S. Ishihara, S. Shintani, 2013, Journal of the Neurological Sciences.

A pathological study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease

H. Akiyama, Kyoko Suzuki, K. Kosaka, 1995 .

A high incidence of apolipoprotein E ε4 allele in middle-aged non-demented subjects with cerebral amyloid β protein deposits

H. Akiyama, N. Sahara, H. Mori, 1999, Acta Neuropathologica.

Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses

G. Brewer, H. Akiyama, J. Fenton, 1997, Brain Research.

Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects

H. Shill, C. Adler, M. Sabbagh, 2014, Neuroscience Letters.

Abnormal phosphorylation of Ser409/410 of TDP‐43 in FTLD‐U and ALS

T. Beach, H. Akiyama, M. Hasegawa, 2008, FEBS letters.

Microglia in degenerative neurological disease

D. Walker, I. Tooyama, P. Mcgeer, 1993, Glia.

Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain

Y. Hirayasu, H. Akiyama, M. Hosokawa, 2012, Acta Neuropathologica.

Morel's laminar sclerosis showing apraxia of speech: Distribution of cortical lesions in an autopsy case

H. Akiyama, H. Mizusawa, O. Yokota, 2010, Neuropathology : official journal of the Japanese Society of Neuropathology.

Familial British dementia: colocalization of furin and ABri amyloid

P. Mcgeer, H. Akiyama, M. Hosokawa, 2003, Acta Neuropathologica.

The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas

F. Turkheimer, H. Fukuyama, H. Akiyama, 2007, Journal of Neuro-Oncology.

Columnar arrangement of beta-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease.

I. Tooyama, P. Mcgeer, H. Akiyama, 1993, Acta neuropathologica.

Identification of amino‐terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

H. Akiyama, M. Hasegawa, A. Mochizuki, 2004, Annals of neurology.

Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene

Masanori Kato, H. Akiyama, M. Okochi, 1997, Neuroscience Letters.

Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review

N. Kuroki, H. Akiyama, K. Kosaka, 1996, Acta Neuropathologica.

Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy

Masanori Kato, H. Akiyama, K. Kosaka, 1995, Neuroscience Letters.

Rate of cell death in parkinsonism indicates active neuropathological process

Haruhiko Akiyama, P. Mcgeer, E. Mcgeer, 1988, Annals of neurology.

Microglial response to 6-hydroxydopamine-induced substantia nigra lesions

P. Mcgeer, H. Akiyama, 1989, Brain Research.

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

P. Mcgeer, H. Akiyama, S. Itagaki, 1988, Neuroscience Letters.

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

H. Kimura, I. Tooyama, P. Mcgeer, 1990, Brain Research.

Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease.

P. Mcgeer, H. Akiyama, H. Mori, 1999, Glia.

Occurrence of the diffuse amyloid β‐protein (Aβ) deposits with numerous Aβ‐containing glial cells in the cerebral cortex of patients with Alzheimer's disease

P. Mcgeer, H. Akiyama, H. Mori, 1999 .

Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein

Kenji Ikeda, Tetsuaki Arai, Hiromi Kondo, 1999, Neuroscience Letters.

TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan.

M. Itokawa, S. Tsuji, H. Akiyama, 2010, Internal medicine.

Phosphorylated and cleaved TDP‐43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP‐43 proteinopathy

H. Akiyama, F. Kametani, M. Hasegawa, 2010, Neuropathology : official journal of the Japanese Society of Neuropathology.

Familial ALS with G298S mutation in TARDBP: a comparison of CSF tau protein levels with those in sporadic ALS.

M. Itokawa, H. Akiyama, Kazuya Takahashi, 2010, Internal medicine.

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43

H. Akiyama, F. Kametani, M. Hasegawa, 2009, Alzheimer's & Dementia.

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

H. Akiyama, I. Mackenzie, M. Hasegawa, 2009, Acta Neuropathologica.

Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

D. Mann, T. Beach, H. Akiyama, 2017, Scientific Reports.

Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease

I. Tooyama, P. Mcgeer, H. Akiyama, 1993, Brain Research.

Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive astrocytes in adrenoleukodystrophy brain

Masanori Kato, H. Akiyama, K. Kosaka, 1996, Neuroscience Letters.

Fas antigen expression in brains of patients with Alzheimer-type dementia

Masanori Kato, H. Akiyama, S. Yonehara, 1995, Brain Research.

Further observations on Tau-positive glia in the brains with progressive supranuclear palsy

P. Mcgeer, E. Mcgeer, H. Akiyama, 2004, Acta Neuropathologica.

Amino‐truncated amyloid β‐peptide (Aβ5‐40/42) produced from caspase‐cleaved amyloid precursor protein is deposited in Alzheimer’s disease brain

T. Tabira, H. Akiyama, W. Araki, 2004 .

Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy

T. Beach, J. Rogers, P. Mcgeer, 2001, Acta Neuropathologica.

Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

D. Mann, H. Akiyama, F. Kametani, 2012, Biochemical and biophysical research communications.

[Molecular dissection of TDP-43 in ALS and FTLD].

H. Akiyama, F. Kametani, M. Hasegawa, 2010, Rinsho shinkeigaku = Clinical neurology.

Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice

H. Akiyama, M. Hasegawa, T. Arai, 2017, Experimental animals.

Long‐term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice

T. Tabira, H. Akiyama, F. Kametani, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Progressive nonfluent aphasia: A rare clinical subtype of FTLD‐TDP in Japan

Y. Hirayasu, H. Akiyama, T. Arai, 2012, Neuropathology : official journal of the Japanese Society of Neuropathology.

Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies

H. Akiyama, K. Kosaka, E. Iseki, 2001, Journal of the Neurological Sciences.

Phosphorylated TDP-43 in frontotemporal lobar degeneration and ALS

M. Morita, T. Beach, H. Akiyama, 2009 .

Frontotemporal lobar degeneration with ubiquitin pathology: an autopsy case presenting with semantic dementia and upper motor neuron signs with a clinical course of 19 years

H. Akiyama, E. Otomo, M. Ikeda, 2006, Acta Neuropathologica.

White matter amyloid in Alzheimer's disease brain

H. Akiyama, T. Uchihara, K. Ikeda, 2004, Acta Neuropathologica.

Gray matter lesions in Nasu‐Hakola disease: A report on three autopsy cases

Y. Hirayasu, H. Akiyama, Kyoko Suzuki, 2011, Neuropathology : official journal of the Japanese Society of Neuropathology.

Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia

P. Mcgeer, E. Mcgeer, H. Akiyama, 2004, Acta Neuropathologica.

Corticobasal degeneration as cause of progressive non‐fluent aphasia: Clinical, radiological and pathological study of an autopsy case

M. Mimura, H. Akiyama, N. Suzuki, 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.

Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain.

H. Akiyama, T. Uchihara, K. Ikeda, 1997, Stroke.

[Thrombin deposition in brains of patients with Alzheimer's disease--activation of the coagulation system in the central nervous system].

H. Akiyama, 1997, Rinsho byori. The Japanese journal of clinical pathology.

[An autopsy case of corticobasal degeneration clinically misdiagnosed as Pick's disease].

H. Akiyama, K. Ikeda, K. Hori, 1995, Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.

Astrocytic pathology in progressive supranuclear palsy: significance for neuropathological diagnosis

H. Akiyama, K. Ikeda, S. Yagishita, 1998, Acta Neuropathologica.

4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy

Masanori Kato, A. Lees, R. Silva, 2003, Acta Neuropathologica.

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Virginia M. Y. Lee, J. Trojanowski, M. Shigeta, 2020, Neuron.

FUS/TLS-Immunoreactive Neuronal and Glial Cell Inclusions Increase With Disease Duration in Familial Amyotrophic Lateral Sclerosis With an R521C FUS/TLS Mutation

H. Akiyama, H. Konno, Masako Kato, 2012, Journal of neuropathology and experimental neurology.

Early response of brain resident microglia to kainic acid-induced hippocampal lesions

H. Kimura, I. Tooyama, P. Mcgeer, 1994, Brain Research.

An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys

H. Akiyama, Y. Mizuno, H. Mochizuki, 1996, Brain Research.

Methylene blue and dimebon inhibit aggregation of TDP‐43 in cellular models

M. Goedert, H. Akiyama, F. Kametani, 2009, FEBS letters.

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

P. Mcgeer, H. Akiyama, T. Kawamata, 1992, The American journal of pathology.

Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62

H. Akiyama, M. Hasegawa, T. Nonaka, 2003, Neuroscience Letters.

Progranulin Reduction Is Associated With Increased Tau Phosphorylation in P301L Tau Transgenic Mice

H. Akiyama, M. Hasegawa, M. Nishihara, 2015, Journal of neuropathology and experimental neurology.

Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

H. Akiyama, M. Hasegawa, T. Nonaka, 2016, Acta Neuropathologica Communications.

Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43*

H. Akiyama, F. Kametani, M. Hasegawa, 2016, The Journal of Biological Chemistry.

Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions

P. Mcgeer, H. Akiyama, S. Itagaki, 1988, Journal of neuroscience research.

TAU-IMMUNOHISTOCHEMICAL AND -IMMUNOELECTRON MICROSCOPICAL INVESTIGATION OF ASTROCYTIC PLAQUES IN PROGRESSIVE SUPRANUCLEAR PALSY

Masanori Kato, H. Akiyama, K. Kosaka, 1997 .

Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy

H. Akiyama, K. Ikeda, S. Yagishita, 2001, Neuroreport.

Progressive supranuclear palsy with fronto-temporal atrophy and various tau-positive abnormal structures.

H. Akiyama, K. Kosaka, E. Iseki, 1996, Clinical neuropathology.

Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling.

T. Tabira, H. Akiyama, F. Checler, 2001, Journal of Alzheimer's disease : JAD.

Frontotemporal dementia with trans‐activation response DNA‐binding protein 43 presenting with catatonic syndrome

H. Akiyama, M. Hasegawa, M. Onaya, 2018, Neuropathology : official journal of the Japanese Society of Neuropathology.

Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues

Masanori Kato, H. Akiyama, K. Kosaka, 2001, Neuroscience Letters.

Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease

Masanori Kato, P. Mcgeer, H. Akiyama, 1993, Neuroscience Letters.

Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes

H. Akiyama, H. Mizusawa, T. Arai, 2010, Journal of the Neurological Sciences.

Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss

H. Akiyama, H. Mizusawa, M. Onaya, 2010, Journal of the Neurological Sciences.

SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

H. Budka, H. Akiyama, M. Pallàs, 2017, Neuropathology : official journal of the Japanese Society of Neuropathology.

[TDP-43 proteinopathies, toward understanding of the molecular pathogenesis].

H. Akiyama, F. Kametani, M. Hasegawa, 2009, Rinsho shinkeigaku = Clinical neurology.

An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia

H. Akiyama, M. Hasegawa, S. Murayama, 2021, eNeurologicalSci.

Association of amyloid P component with complement proteins in neurologically diseased brain tissue

P. Mcgeer, H. Akiyama, Tatsuo Yamada, 1991, Brain Research.

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

D. Mann, H. Akiyama, F. Kametani, 2013, Acta Neuropathologica Communications.

Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases

H. Akiyama, M. Hasegawa, S. Terada, 2013, Journal of the Neurological Sciences.

TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.

H. Akiyama, M. Hasegawa, K. Oyanagi, 2007, Brain : a journal of neurology.

Expression of MRP14, 27E10, interferon-α and leukocyte common antigen by reactive microglia in postmortem human brain tissue

P. Mcgeer, E. Mcgeer, H. Akiyama, 1994, Journal of Neuroimmunology.

Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease.

T. Kodama, S. Gordon, D. Greaves, 1998, Biochemical and biophysical research communications.

Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 1

A. Kakita, H. Akiyama, Hitoshi Takahashi, 2008, Acta Neuropathologica.

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

I. Tooyama, P. Mcgeer, H. Akiyama, 2004, Acta Neuropathologica.

Argyrophilic grains are not always argyrophilic—Distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods

H. Akiyama, T. Uchihara, A. Nakamura, 2005, Acta Neuropathologica.

Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions

A. Lees, R. Silva, H. Akiyama, 2004, Acta Neuropathologica.

Evidence that neurofibrillary tangles undergo glial modification

H. Akiyama, K. Ikeda, S. Haga, 2004, Acta Neuropathologica.

Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain

D. Walker, P. Mcgeer, E. Mcgeer, 1991, Brain Research.

Immunohistochemical localization of beta‐amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy

D. Walker, P. Mcgeer, H. Akiyama, 1992, Journal of neuroscience research.

Reactions of the Immune System in Chronic Degenerative Neurological Diseases

P. Mcgeer, E. Mcgeer, H. Akiyama, 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Phosphorylated and ubiquitinated TDP‐43 pathological inclusions in ALS and FTLD‐U are recapitulated in SH‐SY5Y cells

H. Akiyama, M. Hasegawa, E. Buratti, 2009, FEBS letters.

TDP-43 pathology in familial British dementia

P. Mcgeer, H. Akiyama, M. Hasegawa, 2009, Acta Neuropathologica.

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

H. Akiyama, M. Hasegawa, T. Nonaka, 2020, Acta neuropathologica communications.

An autopsy case of familial amyotrophic lateral sclerosis with FUS R521G mutation

H. Akiyama, T. Mizutani, K. Oyanagi, 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Novel FUS mutation in patients with sporadic amyotrophic lateral sclerosis and corticobasal degeneration

H. Akiyama, Keiko Tanaka, M. Arai, 2012, Journal of Clinical Neuroscience.

Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis

H. Akiyama, M. Hasegawa, H. Mizusawa, 2010, Journal of the Neurological Sciences.

Pick’s disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke’s column, and lower motor neuron

A. Lees, H. Akiyama, R. de Silva, 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

Distinct distribution of apolipoprotein E and β-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam

P. Mcgeer, H. Akiyama, J. Steele, 1996, Acta Neuropathologica.

Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease

P. Mcgeer, E. Mcgeer, H. Akiyama, 1989, Neurology.

Cortical Glutaminase , ( 3-Glucuronidase and Glucose Utilization in Alzheimer ' s Disease

P. Mcgeer, E. Mcgeer, H. Akiyama, 2014 .

Cortical Glutaminase, β-Glucuronidase and Glucose Utilization in Alzheimer's Disease

P. Mcgeer, E. Mcgeer, H. Akiyama, 1989, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists: Additional autopsy case with a clinical course of 19 years

H. Akiyama, I. Nakano, K. Ikeda, 2004, Neuropathology : official journal of the Japanese Society of Neuropathology.

Bunina body in frontal lobe dementia without clinical manifestations of motor neuron disease

H. Akiyama, T. Uchihara, K. Ikeda, 2001, Acta Neuropathologica.

Differential diagnosis of amyotrophic lateral sclerosis from Guillain–Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid

H. Akiyama, M. Hasegawa, M. Yamashita, 2014, The International journal of neuroscience.

H. Akiyama, K. Kosaka, K. Ikeda, 1996, Journal of the Neurological Sciences.

Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies

Masanori Kato, H. Akiyama, Kyoko Suzuki, 1998, Journal of the Neurological Sciences.

Pseudopolyneuritic form of ALS revisited: Clinical and pathological heterogeneity

H. Akiyama, H. Mizusawa, O. Yokota, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM)

H. Kimura, H. Fukuyama, H. Akiyama, 2004, Acta Neuropathologica.

[Loss of dendritic spines in hippocampal CA1 pyramidal cells in senescence accelerated mouse (SAM)--a quantitative Golgi study].

H. Akiyama, I. Akiguchi, M. Kameyama, 1987, Rinsho shinkeigaku = Clinical neurology.

A study of dementia with argyrophilic grains Possible cytoskeletal abnormality in dendrospinal portion of neurons and oligodendroglia

H. Akiyama, K. Ikeda, C. Haga, 2004, Acta Neuropathologica.

Clinical aspects of argyrophilic grain disease.

H. Akiyama, K. Ikeda, T. Arai, 2000, Clinical neuropathology.

Immunohistochemical localization of amyloid β-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease

H. Akiyama, H. Mori, K. Ikeda, 1999, Brain Research.

Two Types of Spheroid Bodies in the Nigral Neurons in Parkinson's Disease

P. Mcgeer, H. Akiyama, T. Yamada, 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Clinical features of the behavioural variant of frontotemporal dementia that are useful for predicting underlying pathological subtypes of frontotemporal lobar degeneration

H. Akiyama, H. Mizusawa, A. Shiraishi, 2018, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

T-cell infiltration and expression of MHC class II antigen by macrophages and microglia in a heterogeneous group in leukoencephalopathy.

H. Akiyama, J. Kimura, I. Akiguchi, 1993, The American journal of pathology.

An autopsy case of chronic active Epstein–Barr virus infection (CAEBV): Distribution of central nervous system (CNS) lesions

H. Akiyama, H. Mizusawa, O. Yokota, 2008, Journal of the Neurological Sciences.

Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease: Lesion staging and dynamic changes of axons and microglial subsets

J. Satoh, H. Akiyama, S. Terada, 2017, Journal of the Neurological Sciences.

Immune System Reaction to Model Lesions of Rat Brain

P. Mcgeer, E. Mcgeer, H. Akiyama, 1990 .

A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele.

H. Akiyama, T. Mizutani, N. Sahara, 1997, Annals of neurology.

Kobe University Repository : Kernel タイトル Tit le Accumulat ion of tumor-suppressor PTEN in Alzheimer neurofibrillary

H. Akiyama, Y. Ono, K. Matsuo, 2018 .

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

H. Akiyama, Y. Ono, K. Matsuo, 2010, Neuroscience Letters.

Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein

P. Mcgeer, H. Akiyama, F. Kametani, 1996, Neuroscience Letters.

Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases

K. Arima, A. Kakita, H. Akiyama, 2006, Acta Neuropathologica.

Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy: A report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions

H. Akiyama, I. Nakano, K. Ikeda, 2002, Neuropathology : official journal of the Japanese Society of Neuropathology.

Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia

H. Akiyama, K. Kosaka, K. Ikeda, 2002, Acta Neuropathologica.

Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice

H. Akiyama, M. Hasegawa, M. Yamashita, 2012, PloS one.

Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction

H. Kimura, I. Tooyama, P. Mcgeer, 1994, Brain Research.

Prion-like spreading of pathological α-synuclein in brain

Masato Hasegawa, Tetsuaki Arai, Masato Hosokawa, 2013, Brain : a journal of neurology.

Loss of glutaminase-positive cortical neurons in Alzheimer's disease

T. Kaneko, P. Mcgeer, E. Mcgeer, 1989, Neurochemical Research.

Characteristics of Reactive Microglia in Alzheimer’s and Parkinson’s Disease Brain Tissue

P. Mcgeer, E. Mcgeer, H. Akiyama, 1990 .

A case of adult‐onset dementia with argyrophilic grains

B. L. Beattie, G. Moore, D. Walker, 1989, Annals of neurology.

Herpes simplex virus type I infection of the CNS induces major histocompatibility complex antigen expression on rat microglia

D. Walker, P. Mcgeer, H. Akiyama, 1990, Journal of neuroscience research.

[Frontotemporal dementia (FTD) and genetic mutations including progranulin gene].

M. Morita, T. Beach, H. Akiyama, 2008, Rinsho shinkeigaku = Clinical neurology.

Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

H. Akiyama, K. Ishiguro, K. Ikeda, 2003, Acta Neuropathologica.

Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains

H. Akiyama, K. Ikeda, T. Arai, 1998, Neuroscience Letters.

Degeneration of the inferior olive in spinocerebellar ataxia 6 may depend on disease duration: Report of two autopsy cases and statistical analysis of autopsy cases reported to date

H. Akiyama, Mari Yoshida, H. Sasaki, 2005, Neuropathology : official journal of the Japanese Society of Neuropathology.

Distribution of cerebello‐olivary degeneration in idiopathic late cortical cerebellar atrophy: Clinicopathological study of four autopsy cases

H. Akiyama, K. Tsuchiya, K. Niizato, 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

Coexistence of paired helical filaments and glial filaments in astrocytic processes within ghost tangles

H. Akiyama, K. Ikeda, C. Haga, 1992, Neuroscience Letters.

A Histochemical Study of Iron and Ferritin in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Hemiparkinsonian Monkeys

H. Akiyama, Y. Mizuno, H. Mochizuki, 1996 .

Possible association of limbic tau pathology with psychosis or behavioral disturbances: Studies of two autopsied psychiatric patients

H. Akiyama, K. Ikeda, T. Arai, 2022, Neuropathology : official journal of the Japanese Society of Neuropathology.

Numerous glial fibrillary tangles in oligodendroglia in cases of subacute sclerosing panencephalitis with neurofibrillary tangles

H. Akiyama, S. Yagishita, T. Arai, 1995, Neuroscience Letters.

Expression of CD40 in the brain of Alzheimer’s disease and other neurological diseases

Masanori Kato, H. Akiyama, K. Kosaka, 2000, Brain Research.

Amyloid β–protein granules in glial cells in Alzheimer’s disease brain

H. Akiyama, K. Ikeda, H. Kondo, 2001 .

Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Campbell-Switzer methods

H. Akiyama, T. Uchihara, A. Nakamura, 2005, Acta Neuropathologica.

Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain

Masanori Kato, P. Mcgeer, H. Akiyama, 2003, Acta Neuropathologica.

FALS with Gly72Ser mutation in SOD1 gene: Report of a family including the first autopsy case

H. Akiyama, N. Shibata, H. Mizusawa, 2011, Journal of Neurological Sciences.

Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue

S. Dedhar, P. Mcgeer, H. Akiyama, 1991, Journal of Neuroimmunology.

A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele

H. Akiyama, T. Mizutani, Hitoshi Takahashi, 1997 .

Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease

P. Mcgeer, H. Akiyama, S. Itagaki, 2004, Acta Neuropathologica.

Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory

H. Akiyama, M. Ueno, I. Akiguchi, 1997, Experimental Gerontology.

Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain

H. Akiyama, M. Ueno, I. Akiguchi, 1990 .

Distribution of choline acetyltransferase immunopositive structures in the rat brainstem

L. Hersh, P. Mcgeer, E. Mcgeer, 1989, Brain Research.

Vascular and parenchymal Aβ deposition in the aging dog: correlation with behavior

J. Hauw, H. Akiyama, F. Checler, 2000, Neurobiology of Aging.

Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement

H. Akiyama, T. Arai, M. Matsushita, 2005, Acta Neuropathologica.

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Virginia M. Y. Lee, J. Trojanowski, M. Shigeta, 2020, Neuron.

Immunohistochemical demonstration of glutaminase in catecholaminergic and serotoninergic neurons of rat brain

T. Kaneko, N. Mizuno, H. Akiyama, 1990, Brain Research.

Immunohistochemical demonstration of glutamate dehydrogenase in astrocytes

T. Kaneko, N. Mizuno, H. Akiyama, 1987, Neuroscience Letters.

Distribution of phosphate‐activated glutaminase in the human cerebral cortex

T. Kaneko, N. Mizuno, P. Mcgeer, 1990, The Journal of comparative neurology.

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

H. Akiyama, M. Hasegawa, H. Mori, 2006, Biochemical and biophysical research communications.

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

D. Selkoe, P. Mcgeer, H. Akiyama, 1989, Journal of Neuroimmunology.

Prion-like properties of pathological TDP-43 aggregates from diseased brains.

D. Mann, H. Akiyama, M. Hasegawa, 2013, Cell reports.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

Ryuji Kaji, Keiko Imamura, Shinya Yamanaka, 2017, Science Translational Medicine.

A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

C. Duyckaerts, D. Campion, V. Deramecourt, 2022, Acta neuropathologica communications.

Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

H. Akiyama, M. Hasegawa, T. Nonaka, 2016, Acta neuropathologica communications.

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

John Q. Trojanowski, Bernardino Ghetti, Paul G. Ince, 2009, Acta Neuropathologica.

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

M. Goedert, H. Akiyama, M. Jucker, 2010, Proceedings of the National Academy of Sciences.

Identification of casein kinase-1 phosphorylation sites on TDP-43.

H. Akiyama, F. Kametani, M. Hasegawa, 2009, Biochemical and biophysical research communications.

Autopsy case of concurrent Huntington's disease and neurofibromatosis type 1

Y. Hirayasu, H. Akiyama, Kyoko Suzuki, 2014, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Masanori Kato, H. Akiyama, K. Kosaka, 2002, Journal of Neuroimmunology.

Activation of vascular endothelial cells and perivascular cells by systemic inflammation—an immunohistochemical study of postmortem human brain tissues

Masanori Kato, H. Akiyama, K. Kosaka, 2004, Acta Neuropathologica.

Open peer commentary Inflammation and Alzheimer's disease

C. Finch, H. Hampel, G. Cole, 2000 .

Brain microglia constitutively express β-2 integrins

P. Mcgeer, H. Akiyama, 1990, Journal of Neuroimmunology.

Brain microglia constitutively express beta-2 integrins.

P. Mcgeer, H. Akiyama, 1990, Journal of neuroimmunology.

Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease

P. Mcgeer, H. Akiyama, S. Itagaki, 1994, Brain Research.

Immune System Response in Alzheimer's Disease

P. Mcgeer, E. Mcgeer, H. Akiyama, 1989, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

H. Shill, C. Adler, D. Connor, 2009, Acta Neuropathologica.

Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

D. Mann, T. Beach, H. Akiyama, 2017, Scientific Reports.

Submandibular gland needle biopsy for the diagnosis of Parkinson disease

H. Shill, C. Adler, Erika Driver-dunckley, 2014, Neurology.

Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies

D. Mann, J. Thompson, H. Akiyama, 2012, Neurobiology of Disease.

Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain.

S. Moestrup, I. Tooyama, P. Mcgeer, 1993, Molecular and chemical neuropathology.

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

H. Shill, C. Adler, M. Sabbagh, 2013, Experimental Neurology.

Activation of the classical complement pathway in brain tissue of Alzheimer patients

P. Mcgeer, E. Mcgeer, H. Akiyama, 1989, Neuroscience Letters.

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

D. Mann, K. Arima, T. Iwatsubo, 2015, Acta Neuropathologica.

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

D. Mann, H. Akiyama, F. Kametani, 2013, Acta neuropathologica communications.

Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

M. Morita, H. Akiyama, F. Kametani, 2008, Annals of neurology.

Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid β-protein (Aβ) deposition

Masanori Kato, P. Mcgeer, H. Akiyama, 2001, Brain Research.

Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy

H. Akiyama, T. Arai, K. Tsuchiya, 2009, Neurology.

Subcellular localization of the low density lipoprotein receptor-related protein (α 2-macroglobulin receptor) in human brain

H. Kimura, S. Moestrup, I. Tooyama, 1995, Brain Research.

Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in alzheimer's disease

R Harrop, P. Mcgeer, E. Mcgeer, 1990, Journal of neuroscience research.

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau

H. Akiyama, F. Kametani, M. Hasegawa, 2015, Acta Neuropathologica.

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

J. Trojanowski, D. Dickson, N. Cairns, 2008, Acta Neuropathologica.

Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders

H. Shill, C. Adler, D. Connor, 2008, Acta Neuropathologica.

[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques].

H. Akiyama, K. Tsuchiya, R. Nakamura, 2007, Brain and nerve = Shinkei kenkyu no shinpo.

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

H. Shill, C. Adler, M. Sabbagh, 2010, Acta Neuropathologica.

Tau progression in single severe frontal traumatic brain injury in human brains

H. Akiyama, M. Hasegawa, K. Ikeda, 2019, Journal of the Neurological Sciences.

The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system

T. Kudo, H. Kazui, T. Tokuda, 2009, EMBO molecular medicine.

Clinical Aspects of ‘Senile Dementia of the Tangle Type’ – A Subset of Dementia in the Senium Separable from Late-Onset Alzheimer’s Disease

Masanori Kato, H. Akiyama, Hitoshi Takahashi, 1998, Dementia and Geriatric Cognitive Disorders.

Changes in density of calcium‐binding‐protein‐immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder

H. Akiyama, I. Ida, M. Mikuni, 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pathological alpha-synuclein propagates through neural networks

H. Akiyama, M. Hasegawa, T. Nonaka, 2014, Acta neuropathologica communications.

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation*

H. Akiyama, M. Hasegawa, T. Nonaka, 2016, The Journal of Biological Chemistry.

Identification of septins in neurofibrillary tangles in Alzheimer's disease.

H. Akiyama, M. Kinoshita, J. Kimura, 1998, The American journal of pathology.

Glial Tau Pathology in Neurodegenerative Diseases: Their Nature and Comparison with Neuronal Tangles

H. Akiyama, K. Ikeda, K. Ikeda, 1998, Neurobiology of Aging.

A study of dementia with argyrophilic grains

H. Akiyama, K. Ikeda, C. Haga, 1995 .

Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy

Kenji Ikeda, Hiromi Kondo, Kunimasa Arima, 1994, Neuroscience Letters.

Prion-like properties of alpha-synuclein fibrils 1 Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation

H. Akiyama, M. Hasegawa, T. Nonaka, 2016 .

The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.

H. Akiyama, M. Hasegawa, S. Murayama, 2016, The American journal of pathology.

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

S. Shimohama, H. Akiyama, R. Takahashi, 2015, Molecular Brain.

Molecular analysis and biochemical classification of TDP-43 proteinopathy.

D. Mann, H. Akiyama, F. Kametani, 2012, Brain : a journal of neurology.

Cell mediators of inflammation in the Alzheimer disease brain.

H. Akiyama, K. Ikeda, T. Arai, 2000, Alzheimer disease and associated disorders.

Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis

P. Mcgeer, H. Akiyama, K. Ikeda, 1994, Brain Research.

Thrombin accumulation in brains of patients with Alzheimer's disease

P. Mcgeer, H. Akiyama, K. Ikeda, 1992, Neuroscience Letters.

Clinicopathological study of early progressive multifocal leukoencephalopathy incidentally found in a schizophrenia patient

H. Akiyama, K. Nagashima, T. Arai, 2009, Neuropathology : official journal of the Japanese Society of Neuropathology.

Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease

H. Akiyama, K. Ikeda, T. Arai, 2002, Acta Neuropathologica.

Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140

V. Tarabykin, M. Hoshino, H. Akiyama, 2018, Neuron.

Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia

H. Akiyama, H. Arai, K. Kosaka, 2006, Neuroscience Letters.

Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

E. Bigio, D. Mann, H. Akiyama, 2010, Acta Neuropathologica.

Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease

Y. Hirayasu, H. Akiyama, M. Hasegawa, 2009, Acta Neuropathologica.

Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles

T. Tokuda, H. Akiyama, S. Ikeda, 2004, Acta Neuropathologica.

Positive florbetapir PET amyloid imaging in a subject with frequent cortical neuritic plaques and frontotemporal lobar degeneration with TDP43-positive inclusions.

M. Mintun, M. Sabbagh, A. Joshi, 2014, Journal of Alzheimer's disease : JAD.

Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies

T. Iwatsubo, H. Akiyama, M. Hasegawa, 2008, Experimental Neurology.

Metastatic CNS lymphoma presenting with periventricular dissemination — MRI and neuropathological findings in an autopsy case

H. Akiyama, H. Mizusawa, J. Goto, 2009, Journal of the Neurological Sciences.

An atypical autopsy case of Lewy Body disease with clinically diagnosed major depression: A clinical, radiological and pathological study

H. Akiyama, K. Ikeda, T. Arai, 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

Choline acetyltransferase immunopositive neurons in the lateral septum

L. Hersh, H. Kimura, I. Tooyama, 1990, Brain Research.

Clinicopathological study of diffuse neurofibrillary tangles with calcification With special reference to TDP-43 proteinopathy and alpha-synucleinopathy

H. Akiyama, M. Hasegawa, Hirotaka Sekiguchi, 2011, Journal of the Neurological Sciences.

Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases

M. Mimura, K. Arima, H. Akiyama, 2005, Acta Neuropathologica.

Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions

H. Akiyama, S. Terada, Hidetoshi Yoshida, 2009, Acta Neuropathologica.

Relative paucity of tau accumulation in the small areas with abundant Aβ42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology

Masanori Kato, H. Akiyama, H. Arai, 2006, Acta Neuropathologica.

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

E. Bigio, S. Weintraub, D. Mann, 2009, Acta Neuropathologica.

Molecular Dissection of TDP-43 Proteinopathies

H. Akiyama, F. Kametani, M. Hasegawa, 2011, Journal of Molecular Neuroscience.

[Significance of the TDP-43 deposition in FTLD-U and ALS].

M. Morita, T. Beach, H. Akiyama, 2008, Rinsho shinkeigaku = Clinical neurology.

Intractable hiccup caused by medulla oblongata lesions: A study of an autopsy patient with possible neuromyelitis optica

H. Akiyama, T. Uchihara, A. Nakamura, 2009, Journal of the Neurological Sciences.

Corticobasal degeneration initially developing motor versus non‐motor symptoms: a comparative clinicopathological study

H. Akiyama, S. Terada, Y. Uchitomi, 2014, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain?

H. Akiyama, S. Murayama, K. Ikeda, 2000, Neuroscience Letters.

Argyrophilic grain disease with delusions and hallucinations: a pathological study.

H. Akiyama, M. Hasegawa, M. Onaya, 2010, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

Alcoholic cerebellar degeneration: A clinicopathological study of six Japanese autopsy cases and proposed potential progression pattern in the cerebellar lesion

H. Akiyama, S. Terada, O. Yokota, 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

Frequency and clinicopathological characteristics of alcoholic cerebellar degeneration in Japan: a cross-sectional study of 1,509 postmortems

H. Akiyama, S. Terada, O. Yokota, 2006, Acta Neuropathologica.

[An autopsied case of schizophrenic patient who died from heat stroke].

H. Akiyama, K. Tsuchiya, K. Oshima, 2006, No to shinkei = Brain and nerve.

18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans

B. L. Beattie, R Harrop, D B Calne, 1990, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

T. Tabira, H. Akiyama, W. Araki, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Complement-activated oligodendroglia: A new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d

P. Mcgeer, H. Akiyama, T. Yamada, 1990, Neuroscience Letters.

Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: A non‐demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala

H. Akiyama, O. Yokota, K. Tsuchiya, 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

Effect of topographical distribution of α-synuclein pathology on TDP-43 accumulation in Lewy body disease

D. Mann, H. Akiyama, M. Hasegawa, 2010, Acta Neuropathologica.

Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: a comparative clinicopathological study

H. Akiyama, S. Terada, K. Oyanagi, 2008, Acta Neuropathologica.

Immunohistochemical detection of coagulation factor XIIIa in postmortem human brain tissue

Masanori Kato, H. Akiyama, K. Ikeda, 1995, Neuroscience Letters.

Submandibular gland biopsy for the diagnosis of Parkinson disease.

H. Shill, C. Adler, M. Sabbagh, 2013, Journal of neuropathology and experimental neurology.

Columnar arragement of β-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease

I. Tooyama, P. Mcgeer, H. Akiyama, 2004, Acta Neuropathologica.

3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease

D. Mann, H. Akiyama, M. Hasegawa, 2013, Acta Neuropathologica.

Specificity of mechanisms for plaque removal after Aβ immunotherapy for Alzheimer disease

P. Mcgeer, H. Akiyama, 2004, Nature Medicine.

TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing

D. Neary, D. Mann, A. Lees, 2009, Acta Neuropathologica.

Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study

H. Akiyama, Hirotaka Sekiguchi, N. Ozaki, 2012, Schizophrenia Research.

Detection of Neurofibrillary Tangles by the Methenamine‐Silver Method: Comparison with Other Silver Stains and with Immunostaining Methods

H. Akiyama, K. Kosaka, K. Ikeda, 1993 .

Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings.

H. Akiyama, H. Mizusawa, O. Yokota, 2011, Internal medicine.

Methenamine-silver staining: a simple and sensitive staining method for senile plaques and neurofibrillary tangles.

H. Akiyama, K. Kosaka, K. Ikeda, 1994, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Complement Activation in Capillary Cerebral Amyloid Angiopathy

N. Sawamoto, H. Akiyama, R. Takahashi, 2018, Dementia and Geriatric Cognitive Disorders.

Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease

K. Mori, Y. Yoshihara, H. Akiyama, 1997, Brain Research.

Feasibility Study: Comparison of Frontal Cortex Needle Core Versus Open Biopsy for Detection of Characteristic Proteinopathies of Neurodegenerative Diseases

C. Adler, M. Sabbagh, T. Beach, 2015, Journal of neuropathology and experimental neurology.

Tau accumulation in the nucleus accumbens in tangle-predominant dementia

Y. Hirayasu, H. Akiyama, M. Hasegawa, 2014, Acta neuropathologica communications.

Involvement of microglia in Alzheimer's disease.

D. Walker, P. Mcgeer, E. Mcgeer, 1994, Neuropathology and applied neurobiology.

The amino-terminally truncated forms of amyloid β-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients

Masanori Kato, P. Mcgeer, H. Akiyama, 1996, Neuroscience Letters.

[An autopsy case of "progressive supranuclear palsy" without psychiatric or neurological signs].

H. Akiyama, H. Arai, K. Ikeda, 2004, No to shinkei = Brain and nerve.

Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type

H. Akiyama, K. Ikeda, K. Ikeda, 1993, Neuroscience Letters.

Amyotrophic lateral sclerosis with dementia: an autopsy case showing many Bunina bodies, tau-positive neuronal and astrocytic plaque-like pathologies, and pallido-nigral degeneration

A. Lees, R. Silva, H. Akiyama, 2006, Acta Neuropathologica.

[Argyrophilic grain disease clinically mimicking Parkinson's disease with dementia: report of an autopsy case].

Y. Hirayasu, H. Akiyama, K. Ikeda, 2004, No to shinkei = Brain and nerve.

Atypical FTLD‐FUS associated with ALS‐TDP: A case report

H. Akiyama, H. Mizusawa, O. Yokota, 2013, Neuropathology : official journal of the Japanese Society of Neuropathology.

Immunohistochemical localization of hyaluronic acid in rat and human brain

P. Mcgeer, E. Mcgeer, H. Akiyama, 1994, Brain Research.

[CERAD (The Consortium to Establish a Registry for Alzheimer's Disease) criteria].

H. Akiyama, 2011, Nihon rinsho. Japanese journal of clinical medicine.

Biochemical Increase in Phosphorylated Alpha‐Synuclein Precedes Histopathology of Lewy‐Type Synucleinopathies

H. Shill, C. Adler, M. Sabbagh, 2012, Brain pathology.

Lewy body variant of Alzheimer’s disease or cerebral type Lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem

H. Akiyama, S. Terada, T. Uchihara, 2007, Neuropathology (Kyoto. 1993).

Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient

Y. Sakurai, H. Akiyama, M. Iwata, 2006, Journal of the Neurological Sciences.

“Forme fruste” of amyotrophic lateral sclerosis with dementia: A report of five autopsy cases without dementia and with ubiquitinated intraneuronal inclusions

H. Akiyama, K. Tsuchiya, S. Ota, 2005, Neuropathology : official journal of the Japanese Society of Neuropathology.

605 Senile dementia with abundant neurofibrillary tangles without accompanying senile plaques. A new disease entity separable from SDAT?

H. Akiyama, T. Mizutani, N. Sahara, 1996, Neurobiology of Aging.

Vascular changes in white matter lesions of Alzheimer’s disease

H. Budka, H. Akiyama, I. Akiguchi, 1999, Acta Neuropathologica.

Title The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer ' s disease

S. Shimohama, H. Akiyama, R. Takahashi, 2016 .

[An autopsy case of dementia lacking distinctive histology showing semantic dementia].

H. Akiyama, K. Tsuchiya, S. Ota, 2005, No to shinkei = Brain and nerve.

Single-laser three-color immunolabeling of a histological section by laser scanning microscopy: application to senile plaque-related structures in post-mortem human brain tissue.

H. Akiyama, T. Uchihara, K. Ikeda, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles

Kazuhiko Matsuo, Hisato Sugata, Haruhiko Akiyama, 2009, Neuroscience Letters.

Gain of function by phosphorylation in Presenilin 1‐mediated regulation of insulin signaling

S. Shimohama, H. Akiyama, R. Takahashi, 2012, Journal of neurochemistry.

S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease

I. Tooyama, H. Akiyama, H. Mukai, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

[Abeta, tau and alpha-synuclein and glial cells].

H. Akiyama, 2006, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

S. Shimohama, H. Akiyama, R. Takahashi, 2015, Molecular Brain.

Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients

H. Kimura, I. Tooyama, P. Mcgeer, 1991, Neuroscience Letters.

Both N‐terminal and C‐terminal fragments of Presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease

T. Tabira, H. Akiyama, D. Chui, 1998, Journal of neuroscience research.

Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease.

H. Akiyama, H. Mori, K. Ikeda, 1999, Brain research.

Prion-like properties of pathological TDP-43 aggregates from diseased brains.

D. Mann, H. Akiyama, M. Hasegawa, 2013, Cell reports.

Molecular analysis and biochemical classification of TDP-43 proteinopathy.

D. Mann, H. Akiyama, F. Kametani, 2012, Brain : a journal of neurology.

Early diagnosis of Alzheimer's type dementia with special reference to the clinicopathology of mild cognitive impairment

H. Akiyama, K. Ikeda, M. Matsushita, 2004 .

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

H. Shill, C. Adler, M. Sabbagh, 2010, Acta Neuropathologica.

The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system

T. Kudo, H. Kazui, T. Tokuda, 2009, EMBO molecular medicine.

Reactive Astrocytes Express Acidic Fibroblast Growth Factor in Alzheimer's Disease Brain

H. Kimura, I. Tooyama, P. Mcgeer, 1991 .

A family with hereditary diffuse leukoencephalopathy with spheroids caused by a novel c.2442+2T>C mutation in the CSF1R gene

N. Hattori, H. Akiyama, H. Arai, 2016, Journal of the Neurological Sciences.