I. Mackenzie

发表

C. Plata-salamán, C. Finch, H. Hampel, 2000, Neurobiology of Aging.

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

K. Jellinger, J. Morris, J. Schneider, 2012, Journal of neuropathology and experimental neurology.

Janna H. Neltner, K. Jellinger, J. Schneider, 2014, Acta Neuropathologica.

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

D. Geschwind, B. Miller, M. Mesulam, 2010, Neurology.

NONLINEAR N-SCORE ESTIMATION FOR ESTABLISHING COGNITIVE NORMS FROM THE NATIONAL ALZHEIMER’S COORDINATING CENTER (NACC) DATASET

David T. Jones, B. Miller, A. Toga, 2018, Alzheimer's & Dementia.

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

J. Schneider, J. Trojanowski, C. Duyckaerts, 2007, Acta Neuropathologica.

Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex.

B. Miller, M. Gorno-Tempini, W. Seeley, 2008, Brain : a journal of neurology.

The heritability and genetics of frontotemporal lobar degeneration

Nick C Fox, J. Hardy, M. Rossor, 2009, Neurology.

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

Bruce L. Miller, William W. Seeley, Adam L. Boxer, 2011, Neuron.

Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.

S. Melquist, M. Mesulam, B. Boeve, 2006, Human molecular genetics.

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Bruce L. Miller, Murray Grossman, John Q. Trojanowski, 2006, Science.

Review: Neuropathology of non‐tau frontotemporal lobar degeneration

I. Mackenzie, M. Neumann, 2019, Neuropathology and applied neurobiology.

Angiotropism in Primary Cutaneous Melanoma With Brain Metastasis: A Study of 20 Cases

I. Mackenzie, C. Lugassy, R. Barnhill, 2013, The American Journal of dermatopathology.

Superficial Siderosis: A Potential Diagnostic Marker of Cerebral Amyloid Angiopathy in Alzheimer Disease

H. Feldman, B. Forster, I. Mackenzie, 2008, Stroke.

Ataxin-2 repeat-length variation and neurodegeneration.

B. Miller, R. Petersen, B. Boeve, 2011, Human molecular genetics.

Clinical phenotypes of Cerebral Amyloid Angiopathy

H. Feldman, I. Mackenzie, L. Maia, 2007, Journal of the Neurological Sciences.

Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.

H. Feldman, G. Hsiung, I. Mackenzie, 2012, Brain : a journal of neurology.

Clinical and pathological features of familial frontotemporal dementia caused by C 9 ORF 72 mutation on chromosome 9 p

H. Feldman, G. Hsiung, I. Mackenzie, 2012 .

Arginine methylation next to the PY‐NLS modulates Transportin binding and nuclear import of FUS

E. Kremmer, I. Mackenzie, T. Madl, 2012, The EMBO journal.

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS

E. Kremmer, T. Arzberger, I. Mackenzie, 2016, Acta Neuropathologica.

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

A. Hill, I. Mackenzie, S. Plotkin, 2014, Proceedings of the National Academy of Sciences.

Sex differences in the prevalence of genetic mutations in FTD and ALS

E. Rogaeva, G. Hsiung, M. Tierney, 2017, Neurology.

Frontotemporal lobar degeneration: current perspectives

Hans Förstl, A. Kurz, J. Diehl-Schmid, 2014, Neuropsychiatric disease and treatment.

Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.

I. Mackenzie, J. Woulfe, D. Foti, 2008, Brain : a journal of neurology.

A Reassessment of the Neuropathology of Frontotemporal Dementia Linked to Chromosome 3

P. Johannsen, E. Englund, I. Mackenzie, 2007, Journal of neuropathology and experimental neurology.

The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments

I. Mackenzie, R. Rademakers, R. Rademakers, 2007, Neurogenetics.

Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative

D. Geschwind, G. Schellenberg, B. Miller, 2007, The Lancet Neurology.

Dementia lacking distinctive histology (DLDH) revisited

D. Neary, D. Mann, J. Snowden, 2006, Acta Neuropathologica.

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Kevin F. Bieniek, B. Miller, C. Geula, 2019, Acta Neuropathologica.

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

John L. Robinson, Kevin F. Bieniek, Janna H. Neltner, 2017, Journal of neuropathology and experimental neurology.

Neuropathology of Atypical Parkinsonian Disorders 33 33

I. Mackenzie, 2004 .

Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Nick C Fox, Alan J. Thomas, D. Hernandez, 2020, Scientific Reports.

A harmonized classification system for FTLD-TDP pathology

J. Trojanowski, V. Lee, D. Mann, 2011, Acta Neuropathologica.

Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

J. Trojanowski, V. Lee, N. Cairns, 2007, Annals of neurology.

The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia

I. Mackenzie, R. Rademakers, R. Rademakers, 2008, Current opinion in neurology.

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

H. Akiyama, I. Mackenzie, M. Hasegawa, 2009, Acta Neuropathologica.

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study

Alan C. Evans, Eric E. Smith, R. Dixon, 2019, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Drusen in the Peripheral Retina of the Alzheimer's Eye.

M. Beg, G. Hsiung, I. Mackenzie, 2017, Current Alzheimer research.

Proposed research criteria for prodromal behavioural variant frontotemporal dementia

K. Rankin, B. Dickerson, B. Boeve, 2022, Brain : a journal of neurology.

Early Neuropsychological Characteristics of Progranulin Mutation Carriers

H. Feldman, C. Jacova, B. Levine, 2014, Journal of the International Neuropsychological Society.

Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia

Nick C Fox, W. M. van der Flier, S. Black, 2018, Annals of neurology.

Revised Self-Monitoring Scale

K. Rankin, B. Dickerson, B. Boeve, 2020, Neurology.

Rates of lobar atrophy in asymptomatic MAPT mutation carriers

David T. Jones, C. Jack, A. Toga, 2019, Alzheimer's & Dementia.

α-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases

J. Trojanowski, C. Duyckaerts, V. Lee, 2004, Acta Neuropathologica.

Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease

J. Trojanowski, B. Pillon, M. Grossman, 2004, Neurology.

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort

David T. Jones, A. Toga, L. Petrucelli, 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.

TDP‐43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations

N. Cairns, W. Markesbery, M. Forman, 2007, Journal of neuropathology and experimental neurology.

Neuropathology of primary lateral sclerosis

I. Mackenzie, 2020, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Fused in Sarcoma Neuropathology in Neurodegenerative Disease.

I. Mackenzie, M. Neumann, 2017, Cold Spring Harbor perspectives in medicine.

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

B. Boeve, D. Dickson, G. Hsiung, 2013, Journal of neurochemistry.

Frontotemporal Lobar Degeneration with TDP‐43 Pathology

I. Mackenzie, M. Neumann, 2011 .

Progranulin expression in the developing and adult murine brain

I. Mackenzie, S. J. Neal, P. Orban, 2010, The Journal of comparative neurology.

FUS pathology deﬁnes the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

P. Deyn, J. Trojanowski, M. Rossor, 2010 .

A new subtype of frontotemporal lobar degeneration with FUS pathology.

H. Kretzschmar, I. Mackenzie, M. Baker, 2009, Brain : a journal of neurology.

Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease

H. Feldman, B. Leavitt, S. Butland, 2006, BMC neurology.

Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID)

C. Duyckaerts, N. Cairns, E. Bigio, 2011, Journal of Neural Transmission.

The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease

C. Duyckaerts, N. Cairns, E. Bigio, 2011, Acta Neuropathologica.

Distinct pathological subtypes of FTLD-FUS

N. Cairns, H. Kretzschmar, D. Munoz, 2011, Acta Neuropathologica.

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease

H. Kretzschmar, I. Mackenzie, M. Baker, 2009, Acta Neuropathologica.

Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants

Sheng-Yang M. Goh, B. Boeve, O. Pedraza, 2020, JAMA network open.

Long‐standing multiple system atrophy‐Parkinsonism with limbic and FTLD‐type α‐synuclein pathology

D. Galasko, I. Mackenzie, D. Pizzo, 2021, Neuropathology and applied neurobiology.

Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43

N. Cairns, D. Munoz, I. Mackenzie, 2011, Journal of Molecular Neuroscience.

Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene

I. Mackenzie, A. Isaacs, I. Holm, 2009, Acta Neuropathologica.

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)

Robert V Farese, William T. Hu, J. Morris, 2013, Alzheimer's & Dementia.

The Advantages of FTD Drug Development ( Part 2 of FTD : The Next Therapeutic Frontier )

Robert V Farese, William T. Hu, J. Morris, 2013 .

C9ORF72 repeat expansions in cases with previously identified pathogenic mutations

Kevin F. Bieniek, D. Geschwind, M. Mesulam, 2013, Neurology.

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

S. Lorenzl, E. Kremmer, D. Troost, 2013, Acta Neuropathologica.

Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p

A. Eisen, I. Mackenzie, M. Baker, 2012, Acta Neuropathologica.

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia

Kevin F. Bieniek, M. Mesulam, L. Petrucelli, 2014, Acta Neuropathologica.

Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases

I. Mackenzie, M. Neumann, 2019, Acta Neuropathologica.

Achromatic neurons in the cortex of progressive supranuclear palsy

I. Mackenzie, L. Hudson, 2004, Acta Neuropathologica.

Neurofilament inclusion body disease with early onset frontotemporal dementia and primary lateral sclerosis.

H. Feldman, I. Mackenzie, 2004, Clinical neuropathology.

Detection and characterization of TDP-43 in human cells and tissues by multiple reaction monitoring mass spectrometry.

M. DeMarco, I. Mackenzie, Y. Zheng, 2019, Clinical mass spectrometry.

Brain volumetric deficits in MAPT mutation carriers: a multisite study

D. Geschwind, A. Toga, B. Dickerson, 2020, Annals of clinical and translational neurology.

The neuropathology associated with repeat expansions in the C9ORF72 gene

I. Mackenzie, M. Neumann, P. Frick, 2014, Acta Neuropathologica.

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers

L. Petrucelli, E. Kremmer, D. Troost, 2015, Acta Neuropathologica.

Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development

A. Oloumi, S. Dedhar, I. Mackenzie, 2006, The Journal of Neuroscience.

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

Nick C Fox, Jennifer M. Nicholas, J. Morris, 2019, The Lancet Neurology.

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

L. Petrucelli, D. Dickson, W. Shao, 2021, Cell reports.

The neuropathology and clinical phenotype of FTD with progranulin mutations

I. Mackenzie, 2007, Acta Neuropathologica.

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

L. Petrucelli, H. Feldman, I. Mackenzie, 2020, Molecular Neurodegeneration.

Reappraisal of TDP-43 pathology in FTLD-U subtypes

I. Mackenzie, M. Neumann, 2017, Acta Neuropathologica.

Mechanisms of Disease in FTLD: Gain of Function versus Loss of Function Effects

N. Cairns, E. Bigio, D. Mann, 2014 .

FUS‐Immunoreactive Intranuclear Inclusions in Neurodegenerative Disease

I. Mackenzie, J. Woulfe, D. Gray, 2010, Brain pathology.

TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD

H. Kretzschmar, I. Mackenzie, M. Neumann, 2008, Acta Neuropathologica.

TDP-43 pathology in primary lateral sclerosis

I. Mackenzie, H. Briemberg, 2020, Amyotrophic lateral sclerosis & frontotemporal degeneration.

The Neuropathology of FTD Associated With ALS

I. Mackenzie, 2007, Alzheimer disease and associated disorders.

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype

R. Petersen, B. Boeve, D. Knopman, 2012, Neurobiology of Aging.

Clinicopathologic Study and Review of the Literature

J. Cairncross, L. Gaspar, D. Macdonald, 1993 .

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations

H. Kretzschmar, D. Munoz, I. Mackenzie, 2012, Acta Neuropathologica.

Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases

H. Feldman, I. Mackenzie, 2003, Acta Neuropathologica.

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers

M. Oulad-Abdelghani, I. Mackenzie, J. Prudlo, 2018, Acta Neuropathologica Communications.

Severe vascular disturbance in a case of familial brain calcinosis

J. Miklossy, Z. Wszolek, P. Mcgeer, 2005, Acta Neuropathologica.

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy

Alan J. Thomas, G. Schellenberg, G. Deuschl, 2022, Movement disorders : official journal of the Movement Disorder Society.

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Nick C. Fox, Pietro Pietrini, Alexander Gerhard, 2018, Nature Medicine.

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

Kevin F. Bieniek, C. Geula, M. Mesulam, 2018, Lancet Neurology.

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

C. Broeckhoven, M. Cruts, H. Kretzschmar, 2013, Acta Neuropathologica.

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

M. Mesulam, D. Dickson, E. Bigio, 2017, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

The role of dipeptide‐repeat protein pathology in C9orf72 mutation cases

I. Mackenzie, 2016, Neuropathology and applied neurobiology.

Phenotypic Variability of Gerstmann-Straussler-Scheinker Disease is Associated with Prion Protein Heterogeneity

D. Dickson, B. Ghetti, S. Kish, 1998, Journal of neuropathology and experimental neurology.

Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis

A. Eisen, N. Graff-Radford, I. Mackenzie, 2010, Muscle & nerve.

Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability

I. Mackenzie, J. Rankin, D. Edbauer, 2014, Acta Neuropathologica.

Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS

B. Boeve, D. Dickson, W. Seeley, 2013, Neurobiology of Aging.

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis

I. Mackenzie, M. Neumann, 2012, Brain Research.

Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions

I. Mackenzie, M. Neumann, 2011 .

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation

A. Eisen, I. Mackenzie, M. Strong, 2011, Acta Neuropathologica.

A novel double mutation in FUS gene causing sporadic ALS

L. Hazrati, E. Rogaeva, I. Mackenzie, 2011, Neurobiology of Aging.

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

I. Mackenzie, M. Neumann, Rosa Rademakers, 2010, The Lancet Neurology.

FTLD-TDP pathological subtypes: clinical and mechanistic significance.

I. Mackenzie, M. Neumann, Edward B. Lee, 2021 .

Frontotemporal Lobar Degeneration TDP-43-Immunoreactive Pathological Subtypes: Clinical and Mechanistic Significance.

I. Mackenzie, Eddie B. Lee, M. Neumann, 2021, Advances in experimental medicine and biology.

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes

I. Mackenzie, E. Buratti, M. Neumann, 2020, Acta Neuropathologica.

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide‐repeat protein deposition

T. Arzberger, I. Mackenzie, C. Haass, 2016, EMBO reports.

Jump from pre-mutation to pathologic expansion in C9orf72.

D. Dickson, P. Fraser, E. Rogaeva, 2015, American journal of human genetics.

Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.

Y. T. Wang, I. Mackenzie, N. Cashman, 2011, Biochemical and biophysical research communications.

Clinicopathological phenotype of ALS with a novel G72C SOD1 gene mutation mimicking a myopathy

P. Andersen, A. Eisen, I. Mackenzie, 2006, Muscle & nerve.

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells

I. Mackenzie, N. Cashman, Edward Pokrishevsky, 2017, PloS one.

Sensitivity of the Social Behavior Observer Checklist to Early Symptoms of Patients With Frontotemporal Dementia

K. Rankin, B. Dickerson, B. Boeve, 2022, Neurology.

Grant on PREDICT-ADFTD: Multimodal Imaging Prediction of AD/FTD and Differential Diagnosis.

L. Younes, A. Toga, K. Kantarci, 2019 .

Plasma Neuro ﬁ lament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration

Sheng-Yang M. Goh, A. Toga, L. Petrucelli, 2022 .

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Jennifer M. Nicholas, Sheng-Yang M. Goh, M. Freedman, 2022, Nature Medicine.

Advances in understanding the molecular basis of frontotemporal dementia.

I. Mackenzie, M. Neumann, R. Rademakers, 2012, Nature reviews. Neurology.

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

David T. Jones, A. Fagan, L. Petrucelli, 2022, Cell reports. Medicine.

Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

M. Beg, I. Mackenzie, J. Matsubara, 2022, Acta Neuropathologica Communications.

Senile plaques, “aging” and Alzheimer's disease

I. Mackenzie, J. Foncin, K. Hachimi, 2004, Acta Neuropathologica.

Optic nerve sheath meningiomas.

R. Nugent, L. Koornneef, I. Mackenzie, 2003, Ophthalmology.

Central neurocytoma

I. Mackenzie, 1999, Cancer.

Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS).

H. Vinters, I. Mackenzie, F. Segal-gidan, 2020, Journal of neuropathology and experimental neurology.

Nonlinear Z-score modeling for improved detection of cognitive abnormality

David T. Jones, Lilah M. Besser, A. Toga, 2019, Alzheimer's & dementia.

Cysts of the neuraxis of endodermal origin.

I. Mackenzie, J. Gilbert, I R Mackenzie, 1991, Journal of neurology, neurosurgery, and psychiatry.

LATE-NC staging in routine neuropathologic diagnosis: an update

Janna H. Neltner, J. Schneider, T. Montine, 2022, Acta Neuropathologica.

Characteristics and Progress on 312 Subjects in the Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) Protocol (P3.036)

David T. Jones, A. Toga, L. Petrucelli, 2018 .

Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

S. Strittmatter, Guilin Wang, I. Mackenzie, 2022, bioRxiv.

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

S. Melquist, D. Neary, B. Boeve, 2006, Nature.

Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging

I. Mackenzie, M. Baker, M. Neumann, 2022, Acta Neuropathologica.

Neuronal Intranuclear Inclusions Distinguish Familial FTD-MND Type from Sporadic Cases

H. Feldman, I. Mackenzie, 2004, Dementia and Geriatric Cognitive Disorders.

White-matter abnormalities in presymptomatic GRN and C9orf72 mutation carriers

M. Beg, G. Hsiung, I. Mackenzie, 2022, Brain communications.

Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration

Sheng-Yang M. Goh, A. Toga, L. Petrucelli, 2021, Neurology.

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

Bradford C. Dickerson, Bruce L. Miller, Murray Grossman, 2020, Nature Medicine.

Development and validation of a novel dementia of Alzheimer's type (DAT) score based on metabolism FDG-PET imaging

Lei Wang, Mirza Faisal Beg, Karteek Popuri, 2017, NeuroImage: Clinical.

Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease.

D. Munoz, I. Mackenzie, 2001, Archives of neurology.

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

David T. Jones, Sheng-Yang M. Goh, A. Toga, 2019, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

H. Feldman, S. Strittmatter, I. Mackenzie, 2010, Neuron.

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Michelle K. Lupton, D. Geschwind, J. Haines, 2012, Human molecular genetics.

Journal of Neuroinflammation BioMed Central Review

D. Dickson, M. Hutton, I. Mackenzie, 2006 .

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

L. Petrucelli, I. Mackenzie, Jeannie Chew, 2013, Human molecular genetics.

Progranulin: normal function and role in neurodegeneration

I. Mackenzie, J. Eriksen, Jason L Eriksen, 2007, Journal of neurochemistry.

Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway

Eric N. Anderson, Nicolas L. Fawzi, D. A. Bosco, 2021, Nature Neuroscience.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis

Susan L Cotman, Shannon Leslie, Jeffrey M Gelfand, 2017, Science Translational Medicine.

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Michelle K. Cahill, Robert V Farese, Charles C. Kim, 2016, Cell.

The molecular basis of frontotemporal dementia

I. Mackenzie, M. Neumann, M. Tolnay, 2009, Expert Reviews in Molecular Medicine.

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

Li-Huei Tsai, Jessica C Jimenez, L. Tsai, 2013, Nature Neuroscience.

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

I. Mackenzie, M. Neumann, 2016, Journal of neurochemistry.

ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐mediated nuclear import

I. Mackenzie, C. Haass, M. Neumann, 2010, The EMBO journal.

Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43

D. Neary, D. Mann, J. Snowden, 2007, Acta Neuropathologica.

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

R. Petersen, S. Lincoln, B. Boeve, 2008, Human molecular genetics.

Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development

Robert V Farese, J. Morris, K. Zahs, 2013, Alzheimer's & Dementia.

Frontotemporal Degeneration , the Next Therapeutic Frontier : Molecules and Animal Models for FTD drug development ( Part 1 of 2 articles )

Sutherland, Nigel, Robert V Farese, 2013 .

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

L. Foster, I. Mackenzie, C. Cowan, 2019, The Journal of Biological Chemistry.

Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis

D. Geschwind, L. Petrucelli, R. Petersen, 2008, PLoS genetics.

Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes

Nick C Fox, Alan J. Thomas, D. Hernandez, 2021, Biological Psychiatry.

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

N. Cairns, E. Bigio, D. Mann, 2012, Acta Neuropathologica.

Advances in understanding the molecular basis of frontotemporal dementia

I. Mackenzie, M. Neumann, R. Rademakers, 2012, Nature Reviews Neurology.

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

I. Mackenzie, N. Cashman, Edward Pokrishevsky, 2012, PloS one.

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

Olaf Ansorge, Christian Haass, H. Kretzschmar, 2011, Brain : a journal of neurology.

Neuropathological background of phenotypical variability in frontotemporal dementia

J. Hodges, D. Dickson, D. Mann, 2011, Acta Neuropathologica.

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

R. Petersen, J. Trojanowski, M. Rossor, 2010, Acta Neuropathologica.

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

John Q. Trojanowski, Bernardino Ghetti, Paul G. Ince, 2009, Acta Neuropathologica.

FUS pathology in basophilic inclusion body disease

D. Munoz, I. Mackenzie, S. Terada, 2009, Acta Neuropathologica.

Synaptic dysfunction in progranulin-deficient mice

L. Raymond, H. Feldman, B. Leavitt, 2012, Neurobiology of Disease.

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

K. Blennow, B. Dickerson, D. Airey, 2020, Nature Medicine.

Progranulin Deficiency Decreases Gross Neural Connectivity But Enhances Transmission at Individual Synapses

M. Cynader, L. Raymond, I. Mackenzie, 2011, The Journal of Neuroscience.

Open peer commentary Inflammation and Alzheimer's disease

C. Finch, H. Hampel, G. Cole, 2000 .

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

M. J. Fresnadillo Martínez, H. Hakonarson, G. Schellenberg, 2010, Nature Genetics.

Thomas Wisniewski, Radoslav Matej, Colin Smith, 2015, Acta Neuropathologica.

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

M. Mesulam, L. Petrucelli, R. Petersen, 2017, Neuron.

Baylisascaris procyonis Infection in Elderly Person, British Columbia, Canada

I. Mackenzie, Tawny Hung, R. Neafie, 2012, Emerging infectious diseases.

Manson's schistosomiasis presenting as a brain tumor. Case report.

I. Mackenzie, A. Guha, 1998, Journal of neurosurgery.

The spectrum of disease and tau pathology of nodding syndrome in Uganda

I. Mackenzie, D. Kitara, M. Pollanen, 2022, Brain : a journal of neurology.

Two cases of rheumatoid meningitis

H. Vinters, I. Mackenzie, W. Pope, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17.

S. Melquist, H. Feldman, A. Sadovnick, 2006, Brain : a journal of neurology.

Xanthoma disseminatum with massive intracranial involvement.

I. Mackenzie, R. Hammond, 1995, Clinical neuropathology.

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

R. Petersen, B. Boeve, D. Knopman, 2013, Molecular Neurodegeneration.

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases

L. Petrucelli, D. Dickson, M. DeMarco, 2022, Cell.

rs5848 polymorphism and serum progranulin level

H. Feldman, G. Hsiung, I. Mackenzie, 2011, Journal of the Neurological Sciences.

The neuropathology and biochemistry of frontotemporal dementia

A. Delacourte, D. Dickson, I. Mackenzie, 2003, Annals of neurology.

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS

E. Haan, P. Pietrini, R. Petersen, 2017, Scientific Reports.

D. Hernandez, M. Nalls, L. Ferrucci, 2017, bioRxiv.

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.

William T. Hu, G. Schellenberg, J. Grafman, 2011, Archives of neurology.

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.

J. Morris, J. Trojanowski, V. Lee, 2007, The American journal of pathology.

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene.

H. Feldman, M. Hutton, G. Hsiung, 2006, Brain : a journal of neurology.

Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia.

D. Neary, D. Mann, A. Varma, 2006, Brain : a journal of neurology.

Ubiquitin Immunohistochemistry Suggests Classic Motor Neuron Disease, Motor Neuron Disease With Dementia, and Frontotemporal Dementia of the Motor Neuron Disease Type Represent a Clinicopathologic Spectrum

I. Mackenzie, Howard H. Feldman, 2005, Journal of neuropathology and experimental neurology.

Rabies encephalitis.

I. Mackenzie, Jason R. Shewchuk, Steven J. Co, 2015, Radiographics : a review publication of the Radiological Society of North America, Inc.

Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers

M. Mesulam, L. Petrucelli, R. Petersen, 2014, Neurobiology of Aging.

Frontotemporal dementia and its subtypes: a genome-wide association study

Alexander Gerhard, Adrian Danek, Luigi Ferrucci, 2014, The Lancet Neurology.

Pilot study of granulocyte colony stimulating factor (G‐CSF)‐mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS)

B. Mädler, A. MacKay, A. Eisen, 2008, Muscle & nerve.

Optic nerve sheath meningioma

I. Mackenzie, F. Gentili, I. Fayaz, 1999, Journal of neurology, neurosurgery, and psychiatry.

Symptomatic osteolipoma of the tuber cinereum.

J. Girvin, I. Mackenzie, D. Lee, 1996, Clinical neuropathology.

Meningiomas presenting with paranasal sinus involvement.

I. Mackenzie, J. Miles, P. Stell, 1990, British journal of neurosurgery.

Senile plaques in temporal lobe epilepsy

Laurie A. Miller, I. Mackenzie, L. Miller, 1994, Acta Neuropathologica.

Senile plaques do not progressively accumulate with normal aging

I. Mackenzie, 2004, Acta Neuropathologica.

Role of microglia in senile plaque formation

D. Munoz, I. Mackenzie, C. Hao, 1995, Neurobiology of Aging.

Radiation-induced Glioma Presenting as Diffuse Leptomeningeal Gliomatosis: A Case Report

W. Mason, I. Mackenzie, M. Hill, 2001, Journal of Neuro-Oncology.

The chromosome 9 ALS and FTD locus is probably derived from a single founder

M. Nalls, T. Peuralinna, J. Hardy, 2012, Neurobiology of Aging.

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

J. Trojanowski, D. Dickson, N. Cairns, 2008, Acta Neuropathologica.

Testicular degeneration in Huntington disease

M. Hayden, B. Leavitt, I. Mackenzie, 2007, Neurobiology of Disease.

Grant Report on PREDICT-ADFTD: Multimodal Imaging Prediction of AD/FTD and Differential Diagnosis

Mirza Faisal Beg, Karteek Popuri, Arthur W. Toga, 2019, Journal of psychiatry and brain science.

Novel Ubiquitin Neuropathology in Frontotemporal Dementia With Valosin-Containing Protein Gene Mutations

Charles D. Smith, J. Karlawish, A. Pestronk, 2006, Journal of neuropathology and experimental neurology.

CENTRAL NEUROCYTOMA: HISTOLOGIC ATYPIA, PROLIFERATION POTENTIAL AND CLINICAL OUTCOME

I. Mackenzie, I. Fayaz, 1998 .

Increased apolipoprotein E ϵ4 in epilepsy with senile plaques

N R Relkin, N. Relkin, D. Munoz, 1997, Annals of neurology.

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

D. Moerman, M. Hayden, I. Mackenzie, 2016, Acta Neuropathologica.

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

I. Mackenzie, S. Plotkin, Xu-biao Peng, 2019, Scientific Reports.

Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

David T. Jones, A. Toga, L. Petrucelli, 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.

alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease.

J. Trojanowski, C. Duyckaerts, V. Lee, 2004, The American journal of pathology.

FDG-PET in presymptomatic C9orf72 mutation carriers

V. Sossi, C. Jacova, M. Beg, 2021, NeuroImage: Clinical.

Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers

Mirza Faisal Beg, Karteek Popuri, Mahadev Bhalla, 2018, NeuroImage: Clinical.

Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family

B. Boeve, H. Feldman, E. McDade, 2010, Journal of Neurology, Neurosurgery & Psychiatry.

Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype

Julie S. Snowden, Robert H. Perry, Atik Baborie, 2006, Acta Neuropathologica.

Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia

K. Rankin, B. Dickerson, B. Boeve, 2021, Cortex.

Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation

I. Mackenzie, 2001, Neurobiology of Aging.

Positive CSF HSV PCR in patients with GBM: A note of caution

I. Mackenzie, Lawrence D. Recht, S. S. McDermott, 2000, Neurology.

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

D. Munoz, I. Mackenzie, 1998, Neurology.

Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases

A. Toga, L. Petrucelli, J. Trojanowski, 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.

ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion

Maxwell A. Bertolero, Matthew W Flounders, Phillip A. Cook, 2022, Nature Methods.

Prospective neuropsychological assessment of nondemented patients with biopsy proven senile plaques

I. Mackenzie, C. Kubu, L. Miller, 1996, Neurology.

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

David T. Jones, A. Toga, L. Petrucelli, 2019, Alzheimer's & Dementia.

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

David T. Jones, Sheng-Yang M. Goh, A. Toga, 2019, Alzheimer's & Dementia.

The contribution of behavioral features to caregiver burden in FTLD spectrum disorders

B. Dickerson, B. Boeve, M. Grossman, 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Evolutionary concepts in biobanking - the BC BioLibrary

Adrian Png, Samuel Aparicio, Rebecca O Barnes, 2009, Journal of Translational Medicine.

Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort

David T. Jones, A. Toga, L. Petrucelli, 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration

David T. Jones, Sheng-Yang M. Goh, A. Toga, 2019, Alzheimer's & Dementia.

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

David T. Jones, A. Toga, L. Petrucelli, 2019, Alzheimer's & Dementia.

Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye

M. Beg, G. Hsiung, I. Mackenzie, 2020, Frontiers in Neuroscience.

Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

V. Sossi, H. Feldman, C. Jacova, 2013, Neurology.

Multiple brain pathologies in dementia are common

C. Jacova, G. Hsiung, I. Mackenzie, 2010 .

The pathology and nosology of primary progressive aphasia

A. Kertesz, D. Munoz, I. Mackenzie, 1994, Neurology.

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

K. Jellinger, C. Jack, T. Montine, 2015, Acta Neuropathologica.

Neuropathology of Atypical Parkinsonian Disorders

I. Mackenzie, 2005 .

Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

David T. Jones, Robert I. Reid, C. Jack, 2019, Neurobiology of Aging.

Autosomal dominant dystonia-plus with cerebral calcifications

S. Melquist, R. Uitti, J. Allanson, 2006, Neurology.

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Nick C Fox, Alan J. Thomas, D. Hernandez, 2018, Nature Medicine.

Rapidly Progressive Dementia in a Chinese Patient due to C9ORF72 Mutation

G. Hsiung, I. Mackenzie, N. Kandiah, 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers

Nick C Fox, Alan J. Thomas, D. Hernandez, 2018, Brain : a journal of neurology.

Title Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation Permalink

Michelle K. Cahill, Robert V Farese, Charles C. Kim, 2016 .

Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration

B. Dickerson, B. Boeve, D. Knopman, 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Mutations in progranulin explain atypical phenotypes with variants in MAPT.

B. Boeve, R. Martins, P. Schofield, 2006, Brain : a journal of neurology.

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

Allissa Dillman, Ronald C Petersen, Mark R Cookson, 2010, American journal of human genetics.

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

K. Rankin, B. Dickerson, B. Boeve, 2023, Alzheimer's & dementia.

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

David T. Jones, Sheng-Yang M. Goh, A. Toga, 2019, Alzheimer's & Dementia.

Clinical Presentation of Prodromal Frontotemporal Dementia

H. Feldman, I. Mackenzie, N. Silverberg, 2008, American journal of Alzheimer's disease and other dementias.

Progressive Anomia Revisited: Focal Degeneration Associated with Progranulin Gene Mutation

Julie S. Snowden, David M. A. Mann, D. Neary, 2008, Neurocase.

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

P. Sorensen, I. Mackenzie, S. Taubert, 2018, Acta Neuropathologica Communications.

Creating the Pick’s disease International Consortium: Association study of MAPT H2 haplotype with risk of Pick’s disease

Derek H. Oakley, A. Singleton, D. Vitale, 2023, medRxiv.

Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia

A. Toga, K. Rankin, J. Graff‐Radford, 2023, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis

T. Montine, N. Cairns, M. Gearing, 2010, Journal of Neural Transmission.

Clinico‐pathological comparison of patients with autopsy‐confirmed Alzheimer's disease, dementia with Lewy bodies, and mixed pathology

I. Mackenzie, G. R. Hsiung, A. Chatterjee, 2021, Alzheimer's & dementia.

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

P. Sorensen, J. Nyengaard, I. Mackenzie, 2021, Acta Neuropathologica Communications.

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS

Nick C Fox, D. Hernandez, M. Nalls, 2017, Scientific Reports.

SEX DIFFERENCES IN THE PREVALENCE OF GENETIC MUTATIONS IN FTD AND ALS: A META-ANALYSIS

E. Rogaeva, G. Hsiung, M. Tierney, 2017, Alzheimer's & Dementia.

DIFFUSE PLAQUES DO NOT PROGRESSIVELY ACCUMULATE WITH AGING IN NON-DEMENTED INDIVIDUALS

I. Mackenzie, 1993 .

Intraparenchymal Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Report

G. Slack, I. Mackenzie, C. Haw, 2022, Cureus.

Multiple Pathologies are Common in Alzheimer Patients in Clinical Trials

B. L. Beattie, C. Jacova, G. Hsiung, 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Differentiating the frontal variant of Alzheimer's disease

Andrew Kertesz, Michael Woodward, Claudia Jacova, 2009, International journal of geriatric psychiatry.

Neuropathology of frontotemporal dementia and related disorders

B. Dickerson, I. Mackenzie, M. Neumann, 2016 .

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

M. Mesulam, L. Petrucelli, R. Petersen, 2014, Molecular Neurodegeneration.

Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study

H. Feldman, I. Mackenzie, 2004, Acta Neuropathologica.

The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease

H. Feldman, I. Mackenzie, 2003, Acta Neuropathologica.

Recent Advances in Frontotemporal Dementia

I. Mackenzie, M. Tartaglia, 2022, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Chronic myelopathy associated with human herpesvirus‐6

C. Wiley, I. Mackenzie, D. Carrigan, 1995, Neurology.

Limbic-predominant age-related TDP-43 proteinopathy (LATE-NC) is associated with abundant TMEM106B pathology

G. Hsiung, I. Mackenzie, M. Neumann, 2023, Acta Neuropathologica.

Activated microglia in dementia with Lewy bodies

I. Mackenzie, 2000, Neurology.

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

Alan J. Thomas, A. Peters, G. Schellenberg, 2021, medRxiv.

Letter to the editor [1]

N. Cairns, E. Bigio, I. Mackenzie, 2006 .

Clinicopathologic correlations in a family with a TBK1 mutation presenting as primary progressive aphasia and primary lateral sclerosis

G. Hsiung, I. Mackenzie, M. Baker, 2019, Amyotrophic lateral sclerosis & frontotemporal degeneration.

SYMPTOM ONSET IN GENETIC FRONTOTEMPORAL DEMENTIA

Jennifer M. Nicholas, B. Dickerson, J. Hodges, 2017, Alzheimer's & Dementia.

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

B. Boeve, D. Dickson, D. Knopman, 2013, Molecular Neurodegeneration.

Truncated TDP-43 proteoforms diagnostic of frontotemporal dementia with TDP-43 pathology.

L. Foster, M. DeMarco, I. Mackenzie, 2023, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Frontotemporal lobar degeneration: current perspectives

Hans Förstl, A. Kurz, J. Diehl-Schmid, 2014 .

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

M. Mesulam, D. Dickson, E. Bigio, 2017, Acta Neuropathologica Communications.

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes.

I. Mackenzie, B. Heeman, Jolien Perneel, 2023, Brain : a journal of neurology.

Progranulin in frontotemporal lobar degeneration and neuroinflammation

D. Dickson, M. Hutton, I. Mackenzie, 2007, Journal of Neuroinflammation.

British Columbia,

I. Mackenzie, Tawny Hung, R. Neafie, 2007 .

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

L. Petrucelli, B. Boeve, M. Murray, 2014, Molecular Neurodegeneration.

CXCR4 involvement in neurodegenerative diseases

O. Andreassen, G. Schellenberg, A. Dale, 2017, bioRxiv.

Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology

W. Honer, G. Hsiung, I. Mackenzie, 2023, Neuropathology and applied neurobiology.

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

I. Mackenzie, S. Plotkin, Xu-biao Peng, 2019, Scientific Reports.

M94 THE GENOMICS OF HIGHLY TREATMENT RESISTANT SCHIZOPHRENIA

P. Sullivan, J. Berg, J. Crowley, 2019, European Neuropsychopharmacology.

Correction to: Antibody against TDP-43 phosphorylated at serine 369 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes

I. Mackenzie, E. Buratti, M. Neumann, 2020, Acta Neuropathologica.

MR in temporal lobe epilepsy: analysis with pathologic confirmation.

Donald H. Lee, J. Girvin, W. Blume, 1998, AJNR. American journal of neuroradiology.

Applying the Alzheimer Disease ATN Diagnostic Framework in Atypical Dementia.

H. Feldman, M. DeMarco, I. Mackenzie, 2020, Alzheimer disease and associated disorders.

P3-176 High prevalence of multiple brain pathologies in dementia

H. Feldman, I. Mackenzie, M. Woodward, 2006, Alzheimer's & Dementia.

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

P. Pietrini, R. Desikan, J. Trojanowski, 2019, Scientific Reports.

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

D. Geschwind, R. Petersen, B. Boeve, 2011, Neuron.

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

N. Cairns, E. Bigio, D. Mann, 2012, Acta Neuropathologica.

The heritability and genetics of frontotemporal lobar degeneration

Nick C Fox, M. Rossor, S. Mead, 2009, Neurology.

K. Jellinger, T. Hortobágyi, T. Montine, 2015, Acta Neuropathologica.

Synaptic dysfunction in progranulin-deficient mice

L. Raymond, H. Feldman, B. Leavitt, 2012, Neurobiology of Disease.

Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia.

D. Neary, D. Mann, A. Varma, 2006, Brain : a journal of neurology.

Decreased Prefrontal Activation during Matrix Reasoning in Predementia Progranulin Mutation Carriers.

Dagmar Zeithamova, C. Jacova, G. Hsiung, 2018, Journal of Alzheimer's disease : JAD.

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

C. Geula, M. Mesulam, J. Grafman, 2019, Acta Neuropathologica.

Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration

A. Toga, L. Petrucelli, B. Dickerson, 2021, Neurology.

Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy

J. Nyengaard, G. Halliday, I. Mackenzie, 2021, Brain communications.

The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia

I. Mackenzie, R. Rademakers, 2008, Current opinion in neurology.

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study

Alan C. Evans, Eric E. Smith, R. Dixon, 2019, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.