P. Carlier

发表

Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors.

M. Totrov, P. Lam, Christopher J. Monceaux, 2010, Bioorganic & medicinal chemistry letters.

Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors*

Ming-tao Li, P. Carlier, Y. Pang, 2005, Journal of Biological Chemistry.

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.

P. Taylor, P. Carlier, M. Finn, 2002, Angewandte Chemie.

Voltage-Sensitive Potassium Kv2 Channels as New Targets for Insecticides

J. Bloomquist, M. Totrov, P. Carlier, 2014 .

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

P. Carlier, Y. Pang, D. Du, 1999, Bioorganic & medicinal chemistry letters.

Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.

P. Carlier, Y. Pang, N. Lee, 1999, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

Yi-fan Han, P. Carlier, Y. Pang, 2000, Neuroscience Letters.

Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant

J. Bloomquist, M. Totrov, P. Carlier, 2014, Parasites & Vectors.

N'-mono- and N, N'-diacyl derivatives of benzyl and arylhydrazines as contact insecticides against adult Anopheles gambiae.

J. Bloomquist, P. Carlier, Baonan Sun, 2017, Pesticide biochemistry and physiology.

Evaluation of novel carbamate insecticides for neurotoxicity to non-target species

J. Bloomquist, P. Carlier, F. Ekström, 2013 .

A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides.

P. Carlier, Nipa Deora, 2019, Organic & biomolecular chemistry.

Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.

J. Bloomquist, M. Totrov, P. Lam, 2013, Archives of insect biochemistry and physiology.

Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae

M. Totrov, P. Lam, P. Carlier, 2018, Insect science.

Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname

P. Carlier, D. Kingston, R. Gandour, 2005 .

Computational and Spectroscopic Structural Determination of Lithiated Benzylic Nitriles in THF/HMPA Solution

P. Carlier, A. Esker, D. Troya, 2008 .

Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones.

P. Lam, P. Carlier, C. Slebodnick, 2009, Journal of the American Chemical Society.

NOVEL CLASS OF ANTI-MALARIAL COMPOUNDS: IN VITRO NEGATIVE SELECTION TO REDUCE POTENTIAL SIDE EFFECTS IN HUMANS

M. Cassera, P. Carlier, F. Merino, 2014 .

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.

P. Carlier, Wenming Li, Yifan Han, 2013, Chemico-biological interactions.

Select Small Core Structure Carbamates Exhibit High Contact Toxicity to “Carbamate-Resistant” Strain Malaria Mosquitoes, Anopheles gambiae (Akron)

J. Bloomquist, M. Totrov, P. Lam, 2012, PloS one.

Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae.

J. Bloomquist, P. Carlier, T. Anderson, 2015, Pesticide biochemistry and physiology.

Dimeric Tacrine (10)-Hupyridone Effectively Combats Alzheimer’s Disease as A Multi-Target-Directed Ligand

P. Carlier, Yifan Han, Sheng-quan Hu, 2021 .

Inhibition ofBlattella germanicaAcetylcholinesterase byBis(n)-Tacrines: Prospects for the Molecular Design of a Selective Insecticide for a Household Pest.

J. Bloomquist, P. Carlier, T. Anderson, 2010 .

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.

Yitao Wang, P. Carlier, Y. Pang, 2008, Journal of pharmaceutical and biomedical analysis.

Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds

P. Carlier, W. Santos, P. Sobrado, 2022, Microbiology spectrum.

Stereochemical inversion of a cyano-stabilized grignard reagent: remarkable effects of the ethereal solvent structure and concentration.

P. Carlier, N. Patwardhan, Ming Gao, 2013, Journal of the American Chemical Society.

Protonated 2-methyl-1,2-epoxypropane: a challenging problem for density functional theory.

T. Crawford, P. Carlier, Nipa Deora, 2006, The Journal of organic chemistry.

Self‐Regeneration of Stereocenters (SRS) via Stereolabile Axially Chiral Intermediates

P. Carlier, D. C. Hsu, Stephanie A. Bryson, 2010 .

Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito.

J. Bloomquist, M. Totrov, P. Carlier, 2017, Current medicinal chemistry.

Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase.

J. Bloomquist, P. Carlier, F. Ekström, 2013, Pesticide biochemistry and physiology.

Structural genomics for drug design against the pathogen Coxiella burnetii

Maxim Totrov, Zhong-Ke Yao, M. Totrov, 2015, Proteins.

Effect of 2,6-disubstituted aryl groups on acyclic conformation: preference for an antiperiplanar orientation of the geminal and vicinal hydrogens.

Ian D. Williams, P. Carlier, M. M. Lo, 2006, The Journal of organic chemistry.

Synthetic optimization and structural limitations of the nitrile aldol reaction

P. Carlier, M. M. Lo, K. M. Lo, 1997 .

Anti-Selective Aldol Reaction of Benzylic Nitriles and Synthesis of .gamma.-Amino Alcohols

Ian D. Williams, P. Carlier, M. M. Lo, 1995 .

6Li/15N NMR-Based Solution Structural Determination of Et2O- and TMEDA-Solvated Lithiophenylacetonitrile and a LiHMDS Mixed Aggregate

B. Lucht, P. Carlier, D. B. Collum, 1994 .

2,3-Anti selective aldol reaction of phenylacetonitrile

P. Carlier, K. M. Lo, 1994 .

Highly enantioselective synthesis of rigid, quaternary 1,4-benzodiazepine-2,5-diones derived from proline.

P. Carlier, Stephanie L. Macquarrie-Hunter, 2005, Organic letters.

Memory of chirality trapping of low inversion barrier 1,4-benzodiazepin-2-one enolates

P. Lam, P. Carlier, Hong‐Wu Zhao, 2005 .

Memory of Chirality: An Emerging Strategy for Asymmetric Synthesis

P. Carlier, Hong‐Wu Zhao, D. C. Hsu, 2004 .

Enantioselective deprotonative ring contraction of N1-methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones.

P. Carlier, C. Slebodnick, Zhong-Ke Yao, 2014, Organic letters.

Pd-catalyzed amination as an alternative to nucleophilic aromatic substitution for the synthesis of N-alkyltacrines and analogues.

P. Carlier, Ming Ma, L. D. Williams, 2011, Tetrahedron letters.

Potent, Easily Synthesized Huperzine A‐Tacrine Hybrid Acetylcholinesterase Inhibitors.

P. Carlier, Y. Pang, D. Du, 1999 .

Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.

P. Carlier, Y. Pang, J. El Yazal, 1999, Journal of medicinal chemistry.

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.

P. Carlier, Y. Pang, H. Wong, 1999, Bioorganic & medicinal chemistry.

Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.

P. Carlier, I. Reynolds, E. Richelson, 1998, Bioorganic & medicinal chemistry letters.

Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

P. Carlier, Yifan Han, Sheng-quan Hu, 2014, Journal of Molecular Neuroscience.

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2015, Bioorganic & medicinal chemistry.

Incremental solvation precedes ion-pair separation in enantiomerization of a cyano-stabilized Grignard reagent.

P. Carlier, N. Patwardhan, Ming Gao, 2011, Chemistry.

Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations.

P. Lam, P. Carlier, 2005, The Journal of organic chemistry.

Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality.

P. Lam, P. Carlier, Hong‐Wu Zhao, 2003, Journal of the American Chemical Society.

Enhanced kinetic resolution and enzyme-like shape selectivity

P. Carlier, W. Mungall, K. Sharpless, 1988 .

Configurational stability of chiral lithiated cyclopropylnitriles: a density functional study.

P. Carlier, 2003, Chirality.

Lithium Ephedrinate Mediated Aldol Reaction of Arylacetonitriles: Thermodynamic Control of Enantioselectivity.

Ian D. Williams, P. Carlier, N. Wan, 1998, Angewandte Chemie.

Regioselective azide opening of 2,3-epoxy alcohols by [Ti(O-i-Pr)2(N3)2]: synthesis of .alpha.-amino acids

P. Carlier, K. Sharpless, K. B. Sharpless, 1988 .

Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H-1H coupling constants.

P. Carlier, M. Ghavami, Zhong-Ke Yao, 2019, Organic & biomolecular chemistry.

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

J. Bloomquist, M. Totrov, P. Lam, 2012, Bioorganic & medicinal chemistry letters.

Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro.

M. Cassera, E. F. Merino, J. H. Butler, 2022, ACS medicinal chemistry letters.

Discovery of non-zwitterionic GABA(A) receptor full agonists and a superagonist.

J. Bloomquist, P. Carlier, R. Barlow, 2002, Bioorganic & medicinal chemistry letters.

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.

Yuan-Ping Pang, Joel L Sussman, Israel Silman, 2003, Journal of the American Chemical Society.

Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi.

Fan Tong, J. Bloomquist, M. Totrov, 2013, Pesticide biochemistry and physiology.

Mode of action of the plant-derived silphinenes on insect and mammalian GABAA receptor/chloride channel complex

J. Bloomquist, P. Carlier, A. González-Coloma, 2008 .

Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates

J. Bloomquist, M. Totrov, P. Carlier, 2019, International journal of environmental research and public health.

Catalytic asymmetric synthesis of protected tryptophan regioisomers.

P. Lam, P. Carlier, D. M. Wong, 2002, The Journal of organic chemistry.

Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2008, Chemico-biological interactions.

Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

P. Carlier, Y. Pang, Wenming Li, 2021, Journal of neurochemistry.

Access to "Friedel-Crafts-restricted" tert-alkyl aromatics by activation/methylation of tertiary benzylic alcohols.

P. Carlier, Qiao-Hong Chen, Ming Ma, 2012, The Journal of organic chemistry.

Synthesis, Characterization, and Micellar Properties of Dendritic Amphiphiles

P. Carlier, T. Long, R. Gandour, 2009 .

Regioselective synthesis of aniline-derived 1,3- and Ci-symmetric 1,4-diols from trans-1,4-cyclohexadiene dioxide.

Christopher J. Monceaux, P. Carlier, 2010, Organic letters.

HMPA Promotes retro-Aldol Reaction, Resulting in syn-Selective Addition of Lithiated 1-Naphthylacetonitrile to Aromatic Aldehydes.

Ian D. Williams, P. Carlier, M. M. Lo, 2000 .

Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.

P. Carlier, E. Richelson, A. Shaw, 2007, European journal of pharmacology.

Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2013, Chemico-biological interactions.

Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs.

M. Cassera, E. F. Merino, J. H. Butler, 2017, ACS Infectious Diseases.

Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.

P. Carlier, Lixuan Liu, R. Kalathur, 2018, Structure.

Toxicity, mode of action, and synergist potential of flonicamid against mosquitoes.

J. Bloomquist, P. Carlier, F. Démares, 2018, Pesticide biochemistry and physiology.

Pharmacological Mapping of the Acetylcholinesterase Catalytic Gorge in Mosquitoes with Bis(n)-Tacrines

J. Bloomquist, P. Carlier, T. Anderson, 2009 .

Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

J. Bloomquist, M. Totrov, P. Carlier, 2018, Pesticide biochemistry and physiology.

Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.

J. Bloomquist, M. Totrov, P. Carlier, 2015, Bioorganic & medicinal chemistry letters.

Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management.

J. Bloomquist, P. Carlier, D. Swale, 2015, Pest management science.

STRUCTURAL STUDIES OF Anopheles gambiae ACETYLCHOLINESTERASE PROVIDE INSIGHT TOWARDS IMPROVED INSECTICIDES FOR MALARIA VECTOR CONTROL

M. Totrov, P. Carlier, Lixuan Liu, 2018 .

Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].

P. Carlier, Y. Pang, N. Lee, 2000, Neuroscience letters.

Protection against ischemic injury in primary cultured astrocytes of mouse cerebral cortex by bis(7)-tacrine, a novel anti-Alzheimer's agent

P. Carlier, Y. Pang, N. Lee, 2000, Neuroscience Letters.

Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease.

P. Carlier, Yifan Han, Sheng-quan Hu, 2021, ACS chemical neuroscience.

Preventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone

P. Carlier, Wenming Li, Yifan Han, 2011, Brain Research.

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.

P. Carlier, Y. Pang, Y. Han, 1999, Bioorganic & medicinal chemistry.

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Yuan-Ping Pang, Joel L Sussman, Israel Silman, 2006, Journal of medicinal chemistry.

Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product

Ian D. Williams, P. Carlier, Y. Pang, 2000 .

Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies.

M. Cassera, E. F. Merino, P. Carlier, 2015, Bioorganic & medicinal chemistry letters.

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

M. Cassera, P. Carlier, B. Striepen, 2013, Antimicrobial Agents and Chemotherapy.

Toxicology of potassium channel‐directed compounds in mosquitoes

J. Bloomquist, M. Totrov, P. Carlier, 2017, Neurotoxicology.

Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

P. Carlier, Y. Pang, N. Lee, 2000, Neuroscience Letters.

Antidepressant-Like Pharmacological Profile of a Novel Triple Reuptake Inhibitor, (1S,2S)-3-(Methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

P. Carlier, E. Richelson, A. Shaw, 2008, Journal of Pharmacology and Experimental Therapeutics.

Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action.

S. Dalal, M. Klemba, P. Carlier, 2016, Bioorganic & medicinal chemistry letters.

Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR

P. Carlier, Wenming Li, Yifan Han, 2011, Brain Research.

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

P. Carlier, Y. Pang, D. Mak, 2002, Planta medica.

Computational studies of ion-pair separation of benzylic organolithium compounds in THF: importance of explicit and implicit solvation.

P. Carlier, Nipa Deora, 2010, The Journal of organic chemistry.

Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials.

M. Cassera, M. Totrov, P. Carlier, 2022, ACS medicinal chemistry letters.

Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints.

M. Cassera, P. Carlier, C. Slebodnick, 2020, Bioorganic & medicinal chemistry letters.

Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE.

P. Carlier, Y. Pang, N. Lee, 1999, Neuroreport.

In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs.

M. Klemba, P. Carlier, Kate Fike, 2020, Bioorganic & medicinal chemistry letters.

Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.

P. Carlier, D. Du, 2004, Current pharmaceutical design.

Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.

Z. Zuo, P. Carlier, Kelvin Chan, 2009, Journal of pharmaceutical and biomedical analysis.

Threading the needle: mimicking natural toroidal catalysts.

P. Carlier, 2004, Angewandte Chemie.

Studies on the mechanism of the asymmetric epoxidation: a ligand variation approach

P. Carlier, K. B. Sharpless, 1989 .

Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.

P. Carlier, Y. Pang, H. Xue, 1999, Neuroreport.

Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

P. Carlier, Yifan Han, Sheng-quan Hu, 2015, Journal of Molecular Neuroscience.

Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2016, Chimia.

Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice

P. Carlier, Yifan Han, Hua Wei, 2018, Front. Cell. Neurosci..

Alkylene tether-length dependent γ-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

P. Carlier, Y. Pang, Wenming Li, 2007, Neuropharmacology.