Linhao Li

发表

Bioactive Terpenoids and Flavonoids from Ginkgo Biloba Extract Induce the Expression of Hepatic Drug-Metabolizing Enzymes Through Pregnane X Receptor, Constitutive Androstane Receptor, and Aryl hydrocarbon Receptor-Mediated Pathways

Linhao Li, J. Stanton, A. H. Tolson, 2009, Pharmaceutical Research.

SLC13A5 Is a Novel Transcriptional Target of the Pregnane X Receptor and Sensitizes Drug-Induced Steatosis in Human Liver

S. Heyward, Linhao Li, Hongbing Wang, 2015, Molecular Pharmacology.

Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor

S. Heyward, P. Swaan, Linhao Li, 2019, Molecular Pharmacology.

Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression

J. Polli, S. Heyward, Shiew-Mei Huang, 2020, Pharmaceutical Research.

Quantification of common and planar bile acids in tissues and cultured cells

Jace W. Jones, P. Swaan, Linhao Li, 2020, Journal of Lipid Research.

Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.

L. Birnbaum, Linhao Li, Hongbing Wang, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling

S. Kwon, X. Wang, Linhao Li, 2022, Journal of Biological Chemistry.

Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors

Linhao Li, Xian Jiang, Xueying Sun, 2016, Journal of experimental & clinical cancer research : CR.

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

Tao Chen, Linhao Li, Hongbing Wang, 2010, Journal of Pharmacology and Experimental Therapeutics.

Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice

Chaohui Yu, Linhao Li, Hongbing Wang, 2019, The Journal of Biological Chemistry.

Sphingolipid metabolism as a marker of hepatotoxicity in drug-induced liver injury.

Jace W. Jones, Linhao Li, Hongbing Wang, 2020, Prostaglandins & other lipid mediators.

An Insulin-Like Growth Factor 1 Receptor Inhibitor Induces CYP3A4 Expression through a Pregnane X Receptor-Independent, Noncanonical Constitutive Androstane Receptor-Related Mechanism

Linhao Li, Hongbing Wang, M. Sinz, 2012, Journal of Pharmacology and Experimental Therapeutics.

Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.

S. Heyward, M. Xia, Linhao Li, 2019, European journal of medicinal chemistry.

The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes

Linhao Li, Hongbing Wang, S. Ferguson, 2011, Pharmaceutical Research.

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

Ruili Huang, S. Heyward, M. Xia, 2022 .

DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor.

M. Xia, Linhao Li, Hongbing Wang, 2019, ACS medicinal chemistry letters.

The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies.

Linhao Li, Hongbing Wang, R. Gartenhaus, 2013, Blood.

Metazachlor: mode of action analysis for rat liver tumour formation and human relevance.

B. Lake, Linhao Li, Hongbing Wang, 2019, Toxicology.

The effects of intermittent fasting on liver physiology and metabolism in mice CURRENT

Linhao Li, 2020 .

Impact of miR‐140 Deficiency on Non‐Alcoholic Fatty Liver Disease

Pang-Kuo Lo, Linhao Li, Hongbing Wang, 2018, Molecular nutrition & food research.

Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor

Jace W. Jones, S. Heyward, P. Swaan, 2017, Molecular Pharmacology.

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor ( CAR ) 1 to the Xenobiotic-Sensitive Splicing Variant CAR 3

Tao Chen, Linhao Li, Hongbing Wang, 2009 .

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Ruili Huang, Menghang Xia, Srilatha Sakamuru, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes

S. Heyward, Linhao Li, Hongbing Wang, 2021, Cells.

The Peripheral Benzodiazepine Receptor Ligand 1-(2-Chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide Is a Novel Antagonist of Human Constitutive Androstane Receptor

Tao Chen, Linhao Li, Hongbing Wang, 2008, Molecular Pharmacology.

Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.

S. Heyward, P. Swaan, Linhao Li, 2014, Toxicology and applied pharmacology.

Androgen‐induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females

R. Ahima, Linhao Li, Hongbing Wang, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.

Linhao Li, Hongbing Wang, D. Ross, 2010, Biochemical pharmacology.

Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells

S. Heyward, Linhao Li, Hongbing Wang, 2016, PloS one.

Differential Activation of Pregnane X Receptor and Constitutive Androstane Receptor by Buprenorphine in Primary Human Hepatocytes and HepG2 Cells

Linhao Li, A. H. Tolson, Hongbing Wang, 2010, Journal of Pharmacology and Experimental Therapeutics.

Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

Menghang Xia, Peter W. Swaan, P. Swaan, 2012, Pharmaceutical Research.

High-content Analysis of Constitutive Androstane Receptor (CAR) Translocation Identifies Mosapride Citrate as a CAR Agonist that Represses Gluconeogenesis.

S. Heyward, M. Xia, Linhao Li, 2019, Biochemical pharmacology.

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor

Ruili Huang, S. Heyward, M. Xia, 2015, Scientific Reports.

CITCO as an Adjuvant Facilitates CHOP-Based Lymphoma Treatment in hCAR-Transgenic Mice

Linhao Li, Hongbing Wang, B. Mackowiak, 2020, Cells.

Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors

Linhao Li, Xian Jiang, Xueying Sun, 2016, Journal of experimental & clinical cancer research : CR.

Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients

S. Heyward, Linhao Li, Hongbing Wang, 2023, Hepatology communications.

Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening

Sean Ekins, Peter W Swaan, S. Ekins, 2011, Drug Metabolism and Disposition.

Identification and Validation of Novel hPXR Activators Amongst Prescribed Drugs via Ligand-Based Virtual Screening

S. Ekins, Linhao Li, Hongbing Wang, 2010 .

Hepatocyte androgen receptor in females mediates androgen-induced hepatocellular glucose mishandling and systemic insulin resistance

R. Ahima, Linhao Li, Hongbing Wang, 2021, bioRxiv.

Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

P. Swaan, M. Xia, Linhao Li, 2013, Pharmaceutical Research.

Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes

Linhao Li, Hongbing Wang, Jie Lu, 2021, Drug Metabolism and Disposition.

Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression

J. Polli, S. Heyward, Shiew-Mei Huang, 2020, Pharmaceutical Research.

Targeting CAR-Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment.

Ruili Huang, S. Heyward, M. Xia, 2022, JCI Insight.

The Peripheral Benzodiazepine Receptor Ligand 1-(2-Chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide Is a Novel Antagonist of Human Constitutive Androstane Receptor

Tao Chen, Linhao Li, Hongbing Wang, 2008, Molecular Pharmacology.

Diindoles produced from commensal microbiota metabolites function as endogenous CAR/Nr1i3 ligands

Linhao Li, Hao Li, Marina Grimaldi, 2024, Nature Communications.

The Peripheral Benzodiazepine Receptor Ligand PK 11195 is a Novel Antagonist of Human Constitutive Androstane Receptor

Linhao Li, T. Sueyoshi, M. Negishi, 2008 .

Special Section on Bile Acids, Drug Metabolism, and Toxicity Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes S

Linhao Li, Hongbing Wang, Jie Lu, 2022 .