Hongbing Wang

发表

Bioactive Terpenoids and Flavonoids from Ginkgo Biloba Extract Induce the Expression of Hepatic Drug-Metabolizing Enzymes Through Pregnane X Receptor, Constitutive Androstane Receptor, and Aryl hydrocarbon Receptor-Mediated Pathways

Linhao Li, J. Stanton, A. H. Tolson, 2009, Pharmaceutical Research.

SLC13A5 Is a Novel Transcriptional Target of the Pregnane X Receptor and Sensitizes Drug-Induced Steatosis in Human Liver

S. Heyward, Linhao Li, Hongbing Wang, 2015, Molecular Pharmacology.

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.

A. H. Tolson, Hongbing Wang, Hongbing Wang, 2010, Advanced drug delivery reviews.

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

Geraldine A Hamilton, Hongbing Wang, E. Lecluyse, 2004, Drug metabolism and disposition: the biological fate of chemicals.

High-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation.

Hongbing Wang, B. Mackowiak, 2019, Methods in molecular biology.

Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor

S. Heyward, P. Swaan, Linhao Li, 2019, Molecular Pharmacology.

Activation of xenobiotic receptors: driving into the nucleus

Hongbing Wang, Haishan Li, 2010, Expert opinion on drug metabolism & toxicology.

Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor

J. Sahi, Hongbing Wang, M. Milad, 2003, Journal of Pharmacology and Experimental Therapeutics.

The Roles of Xenobiotic Receptors: Beyond Chemical Disposition

Hongbing Wang, B. Mackowiak, J. Hodge, 2018, Drug Metabolism and Disposition.

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes.

Hongbing Wang, G. Hamilton, C. Lindley, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression

J. Polli, S. Heyward, Shiew-Mei Huang, 2020, Pharmaceutical Research.

Quantification of common and planar bile acids in tissues and cultured cells

Jace W. Jones, P. Swaan, Linhao Li, 2020, Journal of Lipid Research.

Contextualizing Hepatocyte Functionality of Cryopreserved HepaRG Cell Cultures

Jonathan P. Jackson, Hongbing Wang, S. Ferguson, 2016, Drug Metabolism and Disposition.

Fabrication of a Cell Culture Plate With a Three-Dimensional Printed Mold and Thermal Analysis of PDMS-Based Casting Process

S. Gadsden, Hongbing Wang, Liang Zhu, 2018, Journal of Thermal Science and Engineering Applications.

Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions

Hongbing Wang, H. Hassan, W. Hedrich, 2015, Pharmaceutical Research.

Modulation of UDP‐glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers

C. Smith, Hongbing Wang, S. Faucette, 2005, Journal of biochemical and molecular toxicology.

Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.

L. Birnbaum, Linhao Li, Hongbing Wang, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Deficiency of Multidrug and Toxin Extrusion 1 Enhances Renal Accumulation of Paraquat and Deteriorates Kidney Injury in Mice

Hongbing Wang, Qing Li, Yan Shu, 2011, Molecular pharmaceutics.

Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling

S. Kwon, X. Wang, Linhao Li, 2022, Journal of Biological Chemistry.

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

Tao Chen, Linhao Li, Hongbing Wang, 2010, Journal of Pharmacology and Experimental Therapeutics.

Evaluation of CYP2B6 Induction and Prediction of Clinical Drug–Drug Interactions: Considerations from the IQ Consortium Induction Working Group—An Industry Perspective

Hongbing Wang, M. Shebley, Liangfu Chen, 2016, Drug Metabolism and Disposition.

Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice.

Hongbing Wang, B. Ghanayem, B. Chanas, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice

Chaohui Yu, Linhao Li, Hongbing Wang, 2019, The Journal of Biological Chemistry.

Hepatic Bile Acid Transporters in Drug‐Induced Cholestasis

Hongbing Wang, Tao Hu, 2021, Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity.

Sphingolipid metabolism as a marker of hepatotoxicity in drug-induced liver injury.

Jace W. Jones, Linhao Li, Hongbing Wang, 2020, Prostaglandins & other lipid mediators.

Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells.

Shiew-Mei Huang, Lei Zhang, Hongbing Wang, 2020, Toxicology and applied pharmacology.

Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors.

Hongbing Wang, M. Negishi, 2003, Current drug metabolism.

Melatonin elicits protective effects on OGD/R-insulted H9c2 cells by activating PGC-1α/Nrf2 signaling

Hongbing Wang, M. Lei, Yingqiang Guo, 2020, International journal of molecular medicine.

An Insulin-Like Growth Factor 1 Receptor Inhibitor Induces CYP3A4 Expression through a Pregnane X Receptor-Independent, Noncanonical Constitutive Androstane Receptor-Related Mechanism

Linhao Li, Hongbing Wang, M. Sinz, 2012, Journal of Pharmacology and Experimental Therapeutics.

The Role of Bile Salt Export Pump Gene Repression in Drug-Induced Cholestatic Liver Toxicity

J. Polli, Shiew-Mei Huang, Lei Zhang, 2014, Drug Metabolism and Disposition.

Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.

S. Heyward, M. Xia, Linhao Li, 2019, European journal of medicinal chemistry.

Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells.

Shiew-Mei Huang, Lei Zhang, Hongbing Wang, 2015, Biochemical pharmacology.

The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes

Linhao Li, Hongbing Wang, S. Ferguson, 2011, Pharmaceutical Research.

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

Ruili Huang, S. Heyward, M. Xia, 2022 .

DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor.

M. Xia, Linhao Li, Hongbing Wang, 2019, ACS medicinal chemistry letters.

The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies.

Linhao Li, Hongbing Wang, R. Gartenhaus, 2013, Blood.

IL-25 or IL-17E Protects against High-Fat Diet–Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6

Hongbing Wang, T. Wynn, J. Urban, 2015, The Journal of Immunology.

Special Section on Drug Metabolism and Regulation — Minireview Clinical Relevance of the Constitutive Androstane Receptor

Hongbing Wang, S. Stern, Ritika Kurian, 2022 .

Metazachlor: mode of action analysis for rat liver tumour formation and human relevance.

B. Lake, Linhao Li, Hongbing Wang, 2019, Toxicology.

Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators.

M. Xia, Jinghua Zhao, Hongbing Wang, 2016, Methods in molecular biology.

Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases.

Hongbing Wang, B. Ghanayem, B. Chanas, 2003, Toxicology and applied pharmacology.

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.

M. Huang, M. Romkes, M. Jiang, 2013, Molecular endocrinology.

Impact of miR‐140 Deficiency on Non‐Alcoholic Fatty Liver Disease

Pang-Kuo Lo, Linhao Li, Hongbing Wang, 2018, Molecular nutrition & food research.

Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor

Jace W. Jones, S. Heyward, P. Swaan, 2017, Molecular Pharmacology.

Metformin Represses Drug-Induced Expression of CYP2B6 by Modulating the Constitutive Androstane Receptor Signaling

S. Heyward, Hongbing Wang, P. Shapiro, 2014, Molecular Pharmacology.

constitutive androstane receptor signaling

S. Heyward, Hongbing Wang, P. Shapiro, 2013 .

Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation

Hongbing Wang, Haishan Li, S. Ferguson, 2010, Molecular Pharmacology.

Differential effects of metformin‐mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial

J. Polli, Hongbing Wang, J. Fink, 2022, Clinical and translational science.

Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes

Tao Chen, Hongbing Wang, Haishan Li, 2009, Drug Metabolism and Disposition.

Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions

Hongbing Wang, H. Hassan, W. Hedrich, 2015, Pharmaceutical Research.

The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein

Hongbing Wang, N. Hempel, M. Negishi, 2004, Molecular Pharmacology.

Phenobarbital in Nuclear Receptor Activation: An Update

Hongbing Wang, Shuai Men, 2022, Drug Metabolism and Disposition.

A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor ( CAR ) 1 to the Xenobiotic-Sensitive Splicing Variant CAR 3

Tao Chen, Linhao Li, Hongbing Wang, 2009 .

Differential UGT 1 A 1 Induction by Chrysin in Primary Human Hepatocytes and HepG 2 Cells

C. Smith, Hongbing Wang, W. Krol, 2005 .

CYTOCHROME P 450 2 E 1 ( CYP 2 E 1 ) IS ESSENTIAL FOR ACRYLONITRILE METABOLISM TO CYANIDE : COMPARATIVE STUDIES USING CYP 2 E 1-NULL AND WILD-TYPE MICE

Hongbing Wang, B. Ghanayem, B. Chanas, 2002 .

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Ruili Huang, Menghang Xia, Srilatha Sakamuru, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

S. Shen, Hongbing Wang, Yuan Gu, 2009, Cancer research.

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme.

Hongbing Wang, Leslie M. Tompkins, 2008, Current drug metabolism.

Mechanisms of xenobiotic receptor activation: Direct vs. indirect.

Hongbing Wang, B. Mackowiak, 2016, Biochimica et biophysica acta.

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes

S. Heyward, Linhao Li, Hongbing Wang, 2021, Cells.

Molecular Mechanisms of the SLC13A5 Gene Transcription

Hongbing Wang, Zhihui Li, 2021, Metabolites.

Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells

Shiew-Mei Huang, Lei Zhang, Hongbing Wang, 2017, The Journal of Biological Chemistry.

The Peripheral Benzodiazepine Receptor Ligand 1-(2-Chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide Is a Novel Antagonist of Human Constitutive Androstane Receptor

Tao Chen, Linhao Li, Hongbing Wang, 2008, Molecular Pharmacology.

Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

Hongbing Wang, T. Sueyoshi, M. Negishi, 2007, Journal of Pharmacology and Experimental Therapeutics.

Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin*

Hongbing Wang, T. Sueyoshi, M. Negishi, 2004, Journal of Biological Chemistry.

A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression*

Hongbing Wang, T. Sueyoshi, M. Negishi, 2003, The Journal of Biological Chemistry.

Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.

S. Heyward, P. Swaan, Linhao Li, 2014, Toxicology and applied pharmacology.

Signaling control of the constitutive androstane receptor (CAR)

Hongbing Wang, Hui Yang, 2014, Protein & Cell.

Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor

C. Smith, Hongbing Wang, T. Sueyoshi, 2006, Journal of Pharmacology and Experimental Therapeutics.

Androgen‐induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females

R. Ahima, Linhao Li, Hongbing Wang, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.

Linhao Li, Hongbing Wang, D. Ross, 2010, Biochemical pharmacology.

Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells

S. Heyward, Linhao Li, Hongbing Wang, 2016, PloS one.

A Change in Bile Flow: Looking Beyond Transporter Inhibition in the Development of Drug-induced Cholestasis.

Shiew-Mei Huang, Lei Zhang, Hongbing Wang, 2019, Current drug metabolism.

A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors

Hongbing Wang, G. Narla, Z. Qiu, 2020, Cancer Research.

Role of pregnane X receptor in chemotherapeutic treatment

Hongbing Wang, W. Zhuo, Honghao Zhou, 2014, Cancer Chemotherapy and Pharmacology.

RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells

Zhefu Ma, Shunqiang Li, Hongbing Wang, 2018, Clinical Cancer Research.

Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.

Hongbing Wang, Duan-ming Wang, 2012, Acta pharmaceutica Sinica. B.

Clinical Relevance of the Constitutive Androstane Receptor

Hongbing Wang, S. Stern, Ritika Kurian, 2022, Drug Metabolism and Disposition.

Insights into CYP2B6-mediated drug–drug interactions

Hongbing Wang, H. Hassan, W. Hedrich, 2016, Acta pharmaceutica Sinica. B.

Differential Activation of Pregnane X Receptor and Constitutive Androstane Receptor by Buprenorphine in Primary Human Hepatocytes and HepG2 Cells

Linhao Li, A. H. Tolson, Hongbing Wang, 2010, Journal of Pharmacology and Experimental Therapeutics.

Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes

Hongbing Wang, Hongbing Wang, E. LeCluyse, 2003, Clinical pharmacokinetics.

Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

Menghang Xia, Peter W. Swaan, P. Swaan, 2012, Pharmaceutical Research.

High-content Analysis of Constitutive Androstane Receptor (CAR) Translocation Identifies Mosapride Citrate as a CAR Agonist that Represses Gluconeogenesis.

S. Heyward, M. Xia, Linhao Li, 2019, Biochemical pharmacology.

Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach

Hongbing Wang, R. Zuo, Kirsten Cooper, 2017, Drug Metabolism and Disposition.

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.

Hongbing Wang, T. Sueyoshi, M. Negishi, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor

Ruili Huang, S. Heyward, M. Xia, 2015, Scientific Reports.

Human PXR forms a tryptophan zipper-mediated homodimer.

L. Moore, Hongbing Wang, M. Redinbo, 2006, Biochemistry.

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Benjamin S. Freedman, J. Polli, S. Heyward, 2021, Clinical and translational science.

Antibody–Drug Conjugates: Pharmacokinetic/Pharmacodynamic Modeling, Preclinical Characterization, Clinical Studies, and Lessons Learned

Hongbing Wang, H. Ashour, H. Hassan, 2018, Clinical Pharmacokinetics.

CITCO as an Adjuvant Facilitates CHOP-Based Lymphoma Treatment in hCAR-Transgenic Mice

Linhao Li, Hongbing Wang, B. Mackowiak, 2020, Cells.

Friend or Foe: Xenobiotic Activation of Nrf2 in Disease Control and Cardioprotection

Hongbing Wang, W. Hedrich, 2021, Pharmaceutical Research.

Differential UGT1A1 Induction by Chrysin in Primary Human Hepatocytes and HepG2 Cells

C. Smith, Hongbing Wang, W. Krol, 2005, Journal of Pharmacology and Experimental Therapeutics.

Induction of Xenobiotic Receptors, Transporters, and Drug Metabolizing Enzymes by Oxycodone

Hongbing Wang, H. Hassan, N. Eddington, 2013, Drug Metabolism and Disposition.

Methadone Induces the Expression of Hepatic Drug-Metabolizing Enzymes through the Activation of Pregnane X Receptor and Constitutive Androstane Receptor

A. H. Tolson, Hongbing Wang, Haishan Li, 2009, Drug Metabolism and Disposition.

Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients

S. Heyward, Linhao Li, Hongbing Wang, 2023, Hepatology communications.

Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening

Sean Ekins, Peter W Swaan, S. Ekins, 2011, Drug Metabolism and Disposition.

Identification and Validation of Novel hPXR Activators Amongst Prescribed Drugs via Ligand-Based Virtual Screening

S. Ekins, Linhao Li, Hongbing Wang, 2010 .

EFFECT OF METHACRYLONITRILE ON CYTOCHROME P-450 2E1 (CYP2E1) EXPRESSION IN MALE F344 RATS

Hongbing Wang, B. Ghanayem, B. Chanas, 2002, Journal of toxicology and environmental health. Part A.

Nuclear Receptor-Mediated Gene Regulation in Drug Metabolism

Hongbing Wang, W. Xie, 2010 .

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

Zhihui Feng, Jinzhi Lai, Analisa Difeo, 2015, Oncogene.

Microphysiological Models for Mechanistic-Based Prediction of Idiosyncratic DILI

Hongbing Wang, N. Sadrieh, S. Stern, 2023, Cells.

Activation of the Constitutive Androstane Receptor Increases the Therapeutic Index of CHOP in Lymphoma Treatment

S. Heyward, Hongbing Wang, Junran Zhang, 2016, Molecular Cancer Therapeutics.

Hepatocyte androgen receptor in females mediates androgen-induced hepatocellular glucose mishandling and systemic insulin resistance

R. Ahima, Linhao Li, Hongbing Wang, 2021, bioRxiv.

Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches

P. Swaan, M. Xia, Linhao Li, 2013, Pharmaceutical Research.

Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes

Linhao Li, Hongbing Wang, Jie Lu, 2021, Drug Metabolism and Disposition.

Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression

J. Polli, S. Heyward, Shiew-Mei Huang, 2020, Pharmaceutical Research.

Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy.

Zhefu Ma, Q. She, Hongbing Wang, 2022, Cancer research.

Targeting CAR-Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment.

Ruili Huang, S. Heyward, M. Xia, 2022, JCI Insight.

Effects of Commonly Used Excipients on the Expression of CYP3A4 in Colon and Liver Cells

J. Polli, Hongbing Wang, S. Haidar, 2010, Pharmaceutical Research.