I. Bezprozvanny

发表

Calcium signaling and neurodegenerative diseases.

I. Bezprozvanny, 2009, Trends in molecular medicine.

Maintaining the stability of neural function: a homeostatic hypothesis.

G. Davis, I. Bezprozvanny, Ilya Bezprozvanny, 2001, Annual review of physiology.

Theoretical analysis of calcium wave propagation based on inositol (1,4,5)-trisphosphate (InsP3) receptor functional properties.

I. Bezprozvanny, Ilya Bezprozvanny, 1994, Cell calcium.

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

B. Strooper, I. Bezprozvanny, L. Serneels, 2006, Cell.

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

X. Chen, I. Bezprozvanny, Jun Wu, 2011, Molecular Neurodegeneration.

Classification of PDZ domains

I. Bezprozvanny, A. Maximov, I Bezprozvanny, 2001, FEBS letters.

An Optoelectronic Neurostimulation System with Adaptive Feedback

A. I. Erofeev, I. Bezprozvanny, M. V. Matveev, 2019, Neuroscience and Behavioral Physiology.

Software for analyzing the behavioural test “Morris Water Maze”

I. Bezprozvanny, A. Zorin, M. Bolsunovskaya, 2020, E3S Web of Conferences.

Future of Optogenetics: Potential Clinical Applications?

A. I. Erofeev, S. G. Terekhin, I. Bezprozvanny, 2016 .

Differences in Recycling of Apolipoprotein E3 and E4—LDL Receptor Complexes—A Mechanistic Hypothesis

I. Bezprozvanny, Meewhi Kim, 2021, International journal of molecular sciences.

Neurons from skin mimic brain holes

I. Bezprozvanny, S. Kiselev, 2016, Oncotarget.

Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.

I. Bezprozvanny, E. Popugaeva, E. Pchitskaya, 2018, Antioxidants & redox signaling.

Inositol 1,4,5‐trisphosphate receptors and neurodegenerative disorders

I. Bezprozvanny, P. Egorova, 2018, The FEBS journal.

Dendritic Spines Shape Analysis—Classification or Clusterization? Perspective

I. Bezprozvanny, E. Pchitskaya, 2020, Frontiers in Synaptic Neuroscience.

Disturbed Ca 2 signaling and apoptosis of medium spiny neurons in Huntington ’ s disease

R. Llinás, M. Sugimori, M. Hayden, 2005 .

Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease.

I. Bezprozvanny, J. Parys, G. Bultynck, 2021, Trends in cell biology.

Recent advances in understanding IP3R function with focus on ER-mitochondrial Ca2+ transfers

I. Bezprozvanny, G. Bultynck, M. Kerkhofs, 2020 .

Light-Sheet Microscopy of Cleared Tissues with Isotropic, Subcellular Resolution

Kevin M. Dean, Philippe Roudot, Raju Tomer, 2019, Nature Methods.

Presynaptic endoplasmic reticulum and neurotransmission.

I. Bezprozvanny, E. Kavalali, 2019, Cell calcium.

Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.

I. Bezprozvanny, O. Vlasova, E. Popugaeva, 2015, Neurodegenerative disease management.

Presenilins and Calcium Signaling—Systems Biology to the Rescue

I. Bezprozvanny, 2013, Science Signaling.

Therapeutic prospects for spinocerebellar ataxia type 2 and 3.

T. Klockgether, I. Bezprozvanny, 2009, Drugs of the future.

Crystal structure of the SH3 domain of growth factor receptor-bound protein 2.

I. Bezprozvanny, D. Luzik, O. Rogacheva, 2020, Acta crystallographica. Section F, Structural biology communications.

Erratum: G-protein-coupled receptor modulation of striatal Ca v1.3 L-type Ca2+ channels is dependent on a shank-binding domain (The Journal of Neuroscience (February 2, 2005) (1050-1062))

D. Surmeier, S. Hernández-López, E. Mugnaini, 2005 .

Molecular pathogenesis of Huntington's disease: The role of excitotoxicity

L. Raymond, M. Hayden, I. Bezprozvanny, 2006 .

Bilayer measurement of endoplasmic reticulum Ca2+ channels.

I. Bezprozvanny, 2013, Cold Spring Harbor protocols.

Activation of the calcium release channel (ryanodine receptor) by heparin and other polyanions is calcium dependent.

I. Bezprozvanny, B. Ehrlich, E. Kaftan, 1993, Molecular biology of the cell.

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

Ilya Bezprozvanny, Mark P. Mattson, M. Mattson, 2008, Trends in Neurosciences.

Alzheimer research forum live discussion: calcium in AD pathogenesis.

B. Bacskai, K. Kuchibhotla, Ivan V. Goussakov, 2009, Journal of Alzheimer's disease : JAD.

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

I. Bezprozvanny, J. Liou, M. Rosen, 2021, eLife.

The role of sigma-1 receptor in organization of endoplasmic reticulum signaling microdomains

I. Bezprozvanny, J. Liou, M. Rosen, 2020, bioRxiv.

Small-molecule activation of neuronal cell fate.

I. Bezprozvanny, Shijie Li, J. Schneider, 2008, Nature chemical biology.

Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum.

I. Bezprozvanny, B. Ehrlich, S. Bezprozvannaya, 1994, Molecular biology of the cell.

Commentary on “Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice”

I. Bezprozvanny, E. Popugaeva, 2014, Front. Cell. Neurosci..

Ca(2+)-sensor region of IP(3) receptor controls intracellular Ca(2+) signaling.

M. Iino, K. Hirose, I. Bezprozvanny, 2001, The EMBO journal.

Astrocyte Activation Markers

P. Balaban, I. Bezprozvanny, A. Salmina, 2022, Biochemistry (Moscow).

Features of the Development and Analysis of Impairments to Social Behavior and Cognitive Functions in Animals with Experimental Alzheimer’s Disease

P. Balaban, I. Bezprozvanny, A. Salmina, 2022, Neuroscience and Behavioral Physiology.

Reactions of Cyclometalated Platinum(II) [Pt(N∧C)(PR3)Cl] Complexes with Imidazole and Imidazole-Containing Biomolecules: Fine-Tuning of Reactivity and Photophysical Properties via Ligand Design.

I. Bezprozvanny, P. Chou, P. Chelushkin, 2018, Inorganic chemistry.

Light Stimulation Parameters Determine Neuron Dynamic Characteristics

A. I. Erofeev, I. Bezprozvanny, E. Gerasimov, 2019, Applied Sciences.

Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A.

I. Bezprozvanny, B. Potter, J. Falck, 2000, Molecular cell biology research communications : MCBRC.

Single-Channel Properties of Inositol (1,4,5)-Trisphosphate Receptor Heterologously Expressed in HEK-293 Cells

I. Bezprozvanny, E. Kaznacheyeva, V. Lupu, 1998, The Journal of general physiology.

Role of TRPC3 in the formation of receptor-and store-operated calcium channels in carcinoma A431 cells

I. Bezprozvanny, V. Alexeenko, E. Kaznacheyeva, 2007, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

The Store-operated Calcium Entry Pathways in Human Carcinoma A431 Cells: Functional Properties and Activation Mechanisms

I. Bezprozvanny, Zhengnan Wang, E. Kaznacheyeva, 2003 .

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

D. Corey, I. Bezprozvanny, Masayuki Matsui, 2009, Nature Biotechnology.

The effect of optogenetic activation of astrocytes on the hippocampal neurons activity

P. Balaban, I. Bezprozvanny, S. Pushkareva, 2021, Journal of Physics: Conference Series.

Homer regulation of native plasma membrane calcium channels in A431 cells.

I. Bezprozvanny, M. Ryazantseva, E. Kaznacheyeva, 2010, Cell calcium.

Alzheimer's disease - Where do we go from here?

I. Bezprozvanny, 2022, Biochemical and biophysical research communications.

The limitation of the Purkinje cells’ impulse activity in the laboratory mice's cerebellum by in vivo activation of SK channels

I. Bezprozvanny, O. Vlasova, P. Egorova, 2016 .

Presenilins: A novel link between intracellular calcium signaling and lysosomal function?

I. Bezprozvanny, 2012, The Journal of cell biology.

Plasma Membrane Calcium Channels in Human Carcinoma A431 Cells Are Functionally Coupled to Inositol 1,4,5-Trisphosphate Receptor-Phosphatidylinositol 4,5-Bisphosphate Complexes*

I. Bezprozvanny, A. Nikolaev, V. Alexeenko, 2000, The Journal of Biological Chemistry.

In Vivo Penetrating Microelectrodes for Brain Electrophysiology

I. Bezprozvanny, O. Vlasova, A. Bolshakova, 2022, Sensors.

Response to Shilling et al.

B. Strooper, I. Bezprozvanny, C. Supnet, 2012 .

Response to Shilling et al. (10.1074/jbc.M111.300491)

B. de Strooper, I. Bezprozvanny, C. Supnet, 2012, The Journal of Biological Chemistry.

Possibilities and Prospects of the Behavioral Test “Morris Water Maze”

I. Bezprozvanny, O. Vlasova, D. Chernyuk, 2021, Journal of Evolutionary Biochemistry and Physiology.

Applying the Expansion Microscopy Method in Neurobiology

I. Bezprozvanny, E. Pchitskaya, K. Derevtsova, 2021 .

Electrophysiological Studies Support Utility of Positive Modulators of SK Channels for the Treatment of Spinocerebellar Ataxia Type 2

I. Bezprozvanny, P. Egorova, 2022, The Cerebellum.

Electrophysiological Studies Support Utility of Positive Modulators of SK Channels for the Treatment of Spinocerebellar Ataxia Type 2

I. Bezprozvanny, P. Egorova, 2022, The Cerebellum.

New Approaches in Studies of the Molecular Pathogenesis of Type 2 Spinocerebellar Ataxia

I. Bezprozvanny, P. Egorova, 2020, Neuroscience and Behavioral Physiology.

New Approaches in Studies of the Molecular Pathogenesis of Type 2 Spinocerebellar Ataxia

I. Bezprozvanny, P. Egorova, 2020 .

Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2

I. Bezprozvanny, P. Egorova, 2019, Neurotherapeutics.

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

S. Feske, I. Bezprozvanny, C. White, 2014, Neuron.

G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca Channels Is Dependent on a Shank-Binding Domain

D. James Surmeier, Enrico Mugnaini, Ilya Bezprozvanny, 2005 .

Molecular basis of proton block of L-type Ca2+ channels

R. Tsien, I. Bezprozvanny, X. H. Chen, 1996, The Journal of general physiology.

Sigma-1 receptor as a potential pharmacological target for the treatment of neuropathology

A. N. Gainullina, I. Bezprozvanny, A. Bolshakova, 2016 .

Deranged Calcium Signaling in Purkinje Cells and Pathogenesis in Spinocerebellar Ataxia 2 (SCA2) and Other Ataxias

I. Bezprozvanny, A. Kasumu, 2012, The Cerebellum.

Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium

I. Bezprozvanny, B. Ehrlich, 1994, The Journal of general physiology.

The C Terminus of Bax Inhibitor-1 Forms a Ca2+-permeable Channel Pore*

I. Bezprozvanny, L. Missiaen, J. Parys, 2011, The Journal of Biological Chemistry.

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore*

B. de Strooper, A. Tolia, I. Bezprozvanny, 2011, The Journal of Biological Chemistry.

Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.

I. Bezprozvanny, Omar Nelson, C. Supnet, 2010, Journal of Alzheimer's disease : JAD.

Dopaminergic Signaling and Striatal Neurodegeneration in Huntington's Disease

Xi Chen, Jing Liu, Ilya Bezprozvanny, 2007, The Journal of Neuroscience.

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

B. de Strooper, I. Bezprozvanny, M. Bentahir, 2007, The Journal of clinical investigation.

functionofPS1,indicatingthattheobservedeffectsarediseasespecific.Ourobservationsareconsistentwith thepotentialroleofdisturbedCa 2+ homeostasisinAlzheimerdiseasepathogenesis.

B. Strooper, I. Bezprozvanny, M. Bentahir, 2007 .

The high-affinity calcium[bond]calmodulin-binding site does not play a role in the modulation of type 1 inositol 1,4,5-trisphosphate receptor function by calcium and calmodulin.

M. Iino, I. Bezprozvanny, Zhengnan Wang, 2002, The Biochemical journal.

CHAPTER 33 – InsP3 Receptor: Functional Properties and Regulation

I. Bezprozvanny, B. Ehrlich, 1994 .

Suppression of TRPC3 Leads to Disappearance of Store-operated Channels and Formation of a New Type of Store-independent Channels in A431 Cells*

I. Bezprozvanny, L. Tsiokas, V. Alexeenko, 2007, Journal of Biological Chemistry.

Functional Properties of Endogenous Receptor- and Store-operated Calcium Influx Channels in HEK293 Cells*

I. Bezprozvanny, A. Nikolaev, V. Alexeenko, 2005, Journal of Biological Chemistry.

The Store-operated Calcium Entry Pathways in Human Carcinoma A431 Cells

I. Bezprozvanny, Zhengnan Wang, E. Kaznacheyeva, 2003, The Journal of general physiology.

Activation of calcium entry in human carcinoma A431 cells by store depletion and phospholipase C- dependent mechanisms converge on ICRAC-like calcium channels.

I. Bezprozvanny, E. Kaznacheyeva, G. Mozhayeva, 2001, Proceedings of the National Academy of Sciences of the United States of America.

CaV1.2 and CaV1.3 neuronal L‐type calcium channels: differential targeting and signaling to pCREB

I. Bezprozvanny, C. Altier, J. Platzer, 2006, The European journal of neuroscience.

Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants.

G. Hasan, S. Srikanth, I. Bezprozvanny, 2004, Biophysical journal.

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.

Ilya Bezprozvanny, I. Bezprozvanny, Elena Popugaeva, 2017, Cell calcium.

ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites

I. Bezprozvanny, B. Ehrlich, 1993, Neuron.

The inositol trisphosphate receptor of Xenopus oocytes.

I. Bezprozvanny, J. Parys, Ilya Bezprozvanny, 1995, Cell calcium.

The pharmacology of intracellular Ca2+-release channels

I. Bezprozvanny, B. Ehrlich, E. Kaftan, 1994 .

The pharmacology of intracellular Ca(2+)-release channels.

I. Bezprozvanny, B. Ehrlich, E. Kaftan, 1994, Trends in pharmacological sciences.

Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling

I. Bezprozvanny, S. Birnbaum, Mou Cao, 2015, Molecular and Cellular Biology.

Mutational remodeling of di-aspartyl intramembrane proteases : uncoupling physiologically-relevant activities from those associated with Alzheimer ' s disease

E. Rogaev, I. Bezprozvanny, O. Plotnikova, 2018 .

Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.

E. Rogaev, I. Bezprozvanny, O. Plotnikova, 2017, Oncotarget.

The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease.

W. Annaert, I. Bezprozvanny, G. Bultynck, 2021, Biochimica et biophysica acta. Molecular cell research.

Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease.

Ilya Bezprozvanny, I. Bezprozvanny, C. Supnet, 2010, Journal of Alzheimer's disease : JAD.

Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2) *

J. Minna, M. Wei, M. Lerman, 2000, The Journal of Biological Chemistry.

Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2).

J. Minna, M. Wei, M. Lerman, 2000, The Journal of biological chemistry.

Association of CaV1.3 L-Type Calcium Channels with Shank

D. Surmeier, T. Tkatch, I. Bezprozvanny, 2005, The Journal of Neuroscience.

Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).

R. Tsien, I. Bezprozvanny, 1995, Molecular pharmacology.

Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease

I. Bezprozvanny, C. Van den Haute, G. Bultynck, 2023, IBRO neuroscience reports.

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

I. Bezprozvanny, E. Popugaeva, P. Egorova, 2015, Seminars in cell & developmental biology.

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

S. Pulst, I. Bezprozvanny, D. Huynh, 2009, The Journal of Neuroscience.

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3

X. Chen, R. Hammer, I. Bezprozvanny, 2008, The Journal of Neuroscience.

Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

I. Bezprozvanny, E. Pchitskaya, V. Zhemkov, 2018, Biochemistry (Moscow).

Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases

M. Hayden, I. Bezprozvanny, M. Geva, 2021, International journal of molecular sciences.

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

I. Bezprozvanny, G. Rammes, M. Geva, 2019, Neurobiology of Disease.

Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1

M. Hayden, I. Bezprozvanny, C. Wellington, 2003, Neuron.

Amyloid β perturbs elevated heme flux induced with neuronal development

I. Bezprozvanny, Keely E. Fitzgerald, Li Zhang, 2019, Alzheimer's & dementia.

Association of Neuronal Calcium Channels with Modular Adaptor Proteins*

T. Südhof, I. Bezprozvanny, A. Maximov, 1999, The Journal of Biological Chemistry.

Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

I. Bezprozvanny, J. Liou, V. Zhemkov, 2021, Contact (Thousand Oaks (Ventura County, Calif.)).

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5‐trisphosphate‐induced Ca2+ release in primary culture of striatal medium spiny neurons

I. Bezprozvanny, P. Orban, T. Tang, 2004, The European journal of neuroscience.

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

I. Bezprozvanny, Daniel A. Ryskamp, V. Zhemkov, 2019, Front. Neurosci..

Deranged Calcium Signaling in Purkinje Cells and Pathogenesis in Spinocerebellar Ataxia 2 (SCA2) and Other Ataxias

I. Bezprozvanny, A. Kasumu, 2010, The Cerebellum.

The inositol 1,4,5-trisphosphate (InsP3) receptor

I. Bezprozvanny, B. Ehrlich, Ilya Bezprozvanny, 1995, The Journal of Membrane Biology.

The dysregulation of intracellular calcium in Alzheimer disease.

I. Bezprozvanny, C. Supnet, 2010, Cell calcium.

Store-operated calcium entry into SK-N-SH human neuroblastoma cells modeling huntington’s disease

I. Bezprozvanny, E. Kaznacheyeva, G. Mozhayeva, 2012, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

R. Llinás, M. Sugimori, M. Hayden, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Reelin Modulates NMDA Receptor Activity in Cortical Neurons

I. Bezprozvanny, T. Tang, J. Herz, 2005, The Journal of Neuroscience.

Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

D. Atasoy, I. Bezprozvanny, E. Kavalali, 2021, Neuron.

Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington’s Disease and Spinocerebellar Ataxias

I. Bezprozvanny, 2011, Neurochemical Research.

Inositol 1,4,5-tripshosphate receptor, calcium signaling, and polyglutamine expansion disorders.

I. Bezprozvanny, 2010, Current topics in membranes.

Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease.

I. Bezprozvanny, I Bezprozvanny, 2007, Sub-cellular biochemistry.

Deranged neuronal calcium signaling and Huntington disease.

Ilya Bezprozvanny, M. Hayden, I. Bezprozvanny, 2004, Biochemical and biophysical research communications.

The inositol 1,4,5-trisphosphate receptors.

I. Bezprozvanny, 2005, Cell calcium.

Secondary structure of Huntingtin amino-terminal region.

Zbyszek Otwinowski, Ilya Bezprozvanny, Z. Otwinowski, 2009, Structure.

The 2.2‐Angstrom resolution crystal structure of the carboxy‐terminal region of ataxin‐3

I. Bezprozvanny, Meewhi Kim, A. Kulminskaya, 2016, FEBS open bio.

Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease.

Ilya Bezprozvanny, Suya Sun, I. Bezprozvanny, 2015, Journal of Alzheimer's disease : JAD.

Reversal of calcium dysregulation as potential approach for treating Alzheimer's Disease.

I. Bezprozvanny, D. Chernyuk, E. Popugaeva, 2020, Current Alzheimer research.

An Optogenetic Study of the Electrophysiological Properties of Hippocampal Neurons in PS1-M146V Transgenic Mice (a model of Alzheimer’s disease)

A. I. Erofeev, S. G. Terekhin, I. Bezprozvanny, 2019, Neuroscience and Behavioral Physiology.

An Optoelectronic Neurostimulation System with Adaptive Feedback

A. I. Erofeev, I. Bezprozvanny, M. V. Matveev, 2019, Neuroscience and Behavioral Physiology.

Optogenetic light pulses generator

A. I. Erofeev, S. G. Terekhin, V. Kilimnik, 2017 .

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

I. Bezprozvanny, K. Fon Tacer, O. Zakharova, 2016, The Journal of Neuroscience.

Use of optogenetic technology in cell culture models

A. I. Erofeev, S. G. Terekhin, I. Bezprozvanny, 2016 .

AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer's Disease

F. LaFerla, I. Bezprozvanny, A. Fisher, 2015, Neurodegenerative Diseases.

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

I. Bezprozvanny, T. Saido, O. Zakharova, 2015, The Journal of Neuroscience.

AF 710 B , a Novel M 1 / σ 1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer ’ s Disease

F. LaFerla, I. Bezprozvanny, A. Fisher, 2015 .

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

L. Good, I. Bezprozvanny, C. Supnet, 2014, Channels.

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.

D. Strøbæk, C. Hougaard, P. Christophersen, 2012, Chemistry & biology.

Chronic Suppression of Inositol 1,4,5-Triphosphate Receptor-Mediated Calcium Signaling in Cerebellar Purkinje Cells Alleviates Pathological Phenotype in Spinocerebellar Ataxia 2 Mice

I. Bezprozvanny, P. Egorova, X. Liang, 2012, The Journal of Neuroscience.

Role of Presenilins in Neuronal Calcium Homeostasis

B. de Strooper, I. Bezprozvanny, A. Herreman, 2010, The Journal of Neuroscience.

Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease

Ilya Bezprozvanny, I. Bezprozvanny, Elena Popugaeva, 2013, Front. Mol. Neurosci..

Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease

I. Bezprozvanny, D. Chernyuk, E. Popugaeva, 2019, Neuroscience.

STIM proteins as regulators of neuronal store-operated calcium influx.

I. Bezprozvanny, E. Popugaeva, 2018, Neurodegenerative disease management.

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

I. Bezprozvanny, E. Popugaeva, E. Pchitskaya, 2017, Biochemical and biophysical research communications.

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

I. Bezprozvanny, O. Vlasova, A. Speshilova, 2015, Molecular Neurodegeneration.

Can the Calcium Hypothesis Explain Synaptic Loss in Alzheimer's Disease?

I. Bezprozvanny, E. Popugaeva, 2013, Neurodegenerative Diseases.

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.

I. Bezprozvanny, C. Supnet, 2011, Cell calcium.

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer’s disease pathogenesis

I. Bezprozvanny, C. Supnet, 2011, Science China Life Sciences.

Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons

I. Bezprozvanny, A. Maximov, T. Tang, 2003, Molecular and Cellular Neuroscience.

Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.

I. Bezprozvanny, M. Ahlijanian, Q. Wu, 2011, Chemistry & biology.

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

I. Bezprozvanny, Daniel A. Ryskamp, V. Zhemkov, 2019, Front. Neurosci..

CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines

I. Bezprozvanny, E. Popugaeva, N. Zernov, 2022, IBRO neuroscience reports.

Derivatives of Piperazines as Potential Therapeutic Agents for Alzheimer’s Disease

A. Zaitsev, V. Poroikov, I. Bezprozvanny, 2019, Molecular Pharmacology.

Regulation of InsP3R by Ca2+ and Cytosolic Ca2+ Dynamics

V. Markin, I. Bezprozvanny, 1998 .

The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

P. Hiesinger, I. Bezprozvanny, 2013, Molecular Neurodegeneration.

Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

M. Ikura, I. Bezprozvanny, P. Stathopulos, 2014, European journal of pharmacology.

Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region.

I. Bezprozvanny, Huiping Tu, Zhengnan Wang, 2005, Biophysical journal.

Dopamine Receptor-mediated Ca2+ Signaling in Striatal Medium Spiny Neurons*

I. Bezprozvanny, T. Tang, 2004, Journal of Biological Chemistry.

Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor.

M. Iino, I. Bezprozvanny, Huiping Tu, 2003, Biophysical journal.

Modulation of Type 1 Inositol (1,4,5)-Trisphosphate Receptor Function by Protein Kinase A and Protein Phosphatase 1α

Ilya Bezprozvanny, I. Bezprozvanny, T. Tang, 2003, The Journal of Neuroscience.

Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain SII(+/-) splice variants and the Opisthotonos mutant form.

M. Iino, I. Bezprozvanny, Huiping Tu, 2002, Biophysical journal.

Ca2+‐sensor region of IP3 receptor controls intracellular Ca2+ signaling

M. Iino, K. Hirose, I. Bezprozvanny, 2001 .

Functional Coupling of Phosphatidylinositol 4,5-Bisphosphate to Inositol 1,4,5-Trisphosphate Receptor*

I. Bezprozvanny, J. Falck, E. Kaznacheyeva, 1998, The Journal of Biological Chemistry.

Inositol 1,4,5-trisphosphate-gated channels in cerebellum: presence of multiple conductance states

I. Bezprozvanny, J. Watras, B. Ehrlich, 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Association with proteasome determines pathogenic threshold of polyglutamine expansion diseases.

I. Bezprozvanny, Meewhi Kim, 2020, Biochemical and biophysical research communications.

Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands.

Ilya Bezprozvanny, Suya Sun, Yuan Luo, 2013, ACS chemical neuroscience.

Normalization of Calcium Balance in Striatal Neurons in Huntington’s Disease: Sigma 1 Receptor as a Potential Target for Therapy

I. Bezprozvanny, N. Kraskovskaya, 2021, Biochemistry (Moscow).

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

I. Bezprozvanny, M. Geva, R. Kusko, 2017, Neurobiology of Disease.

Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts

J. Repa, Quanzhen Li, I. Bezprozvanny, 2008, BMC Neuroscience.

Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons

I. Bezprozvanny, A. Maximov, 2002, The Journal of Neuroscience.

Functional impact of syntaxin on gating of N-type and Q-type calcium channels

R. Tsien, R. Scheller, R. Scheller, 1995, Nature.

Presenilins, Deranged Calcium Homeostasis, Synaptic Loss and Dysfunction in Alzheimer's Disease

Ilya Bezprozvanny, I. Bezprozvanny, C. Supnet, 2012 .

Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium.

I. Bezprozvanny, B. R. Miller, 2010, Future neurology.

Calcium Signaling and Neurodegeneration

I. Bezprozvanny, 2010, Acta naturae.

Neuroprotective Effects of Inositol 1,4,5-Trisphosphate Receptor C-Terminal Fragment in a Huntington's Disease Mouse Model

X. Chen, I. Bezprozvanny, Caixia Guo, 2009, The Journal of Neuroscience.

Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating.

R. Tsien, R. Scheller, R. Scheller, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease.

T. Kodadek, Yuan Luo, I. Bezprozvanny, 2011, Chemistry & biology.

Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels.

K. Parang, I. Bezprozvanny, H. Wulff, 2021, Journal of medicinal chemistry.

Evaluation of Dimebon in cellular model of Huntington's disease

I. Bezprozvanny, Jun Wu, Qin Li, 2008, Molecular Neurodegeneration.

Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer’s Disease

I. Bezprozvanny, Meewhi Kim, 2023, International journal of molecular sciences.

Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations

I. Bezprozvanny, Meewhi Kim, 2021, International journal of molecular sciences.

Pin1 mediates Aβ42-induced dendritic spine loss

I. Bezprozvanny, J. Malter, E. Kavalali, 2018, Science Signaling.

Possibilities of using a miniature fluorescence microscope

I. Bezprozvanny, M. Bolsunovskaya, A. Erofeev, 2020, E3S Web of Conferences.

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

I. Bezprozvanny, O. Vlasova, D. Chernyuk, 2017, Scientific Reports.

Optogenetic Activation of Astrocytes—Effects on Neuronal Network Function

I. Bezprozvanny, E. Gerasimov, O. Vlasova, 2021, International journal of molecular sciences.

Metabolic Plasticity of Astrocytes

P. Balaban, I. Bezprozvanny, O. Vlasova, 2021, Journal of Evolutionary Biochemistry and Physiology.

The rise and fall of Dimebon.

I. Bezprozvanny, 2010, Drug News and Perspectives.

Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2.

I. Bezprozvanny, P. Egorova, K. S. Marinina, 2023, Biochimica et biophysica acta. Molecular cell research.

Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid

I. Bezprozvanny, E. Pchitskaya, A. Rakovskaya, 2022, International journal of molecular sciences.

Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

I. Bezprozvanny, G. Hung, Jun Wu, 2016, The Journal of Neuroscience.

Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease

A. N. Gainullina, I. Bezprozvanny, O. Vlasova, 2017, Bulletin of Experimental Biology and Medicine.

Tetrabenazine is neuroprotective in Huntington's disease mice

X. Chen, I. Bezprozvanny, T. Tang, 2010, Molecular Neurodegeneration.

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

D. Holtzman, M. Sano, D. Westaway, 2009, Molecular Neurodegeneration.

Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

I. Bezprozvanny, E. Pchitskaya, V. Zhemkov, 2018, Biochemistry (Moscow).

“Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease

I. Bezprozvanny, Hua Zhang, 2023, Life.

Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.

I. Bezprozvanny, H. de Smedt, Huiping Tu, 2005, Biophysical journal.

Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons

I. Bezprozvanny, N. Mikhailova, M. Khotin, 2023, International journal of molecular sciences.

Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease.

I. Bezprozvanny, L. Birnbaumer, Jun Wu, 2018, Journal of Huntington's Disease.

Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease

I. Bezprozvanny, T. Tang, Jun Wu, 2006, Neuroscience Letters.

Light-sheet microscopy with isotropic, sub-micron resolution and solvent-independent large-scale imaging

Gaudenz Danuser, Kevin M. Dean, Rainer Heintzmann, 2019, bioRxiv.

Ataxic Symptoms in Huntington’s Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone

I. Bezprozvanny, P. Egorova, Aleksandra V. Gavrilova, 2020, Frontiers in Neuroscience.

Applying the Expansion Microscopy Method in Neurobiology

I. Bezprozvanny, E. Pchitskaya, K. Derevtsova, 2021, Journal of Evolutionary Biochemistry and Physiology.

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

I. Bezprozvanny, O. Vlasova, A. Speshilova, 2015, Molecular Neurodegeneration.

Simplified method to perform CLARITY imaging

I. Bezprozvanny, O. Vlasova, A. Bolshakova, 2014, Molecular Neurodegeneration.

Simplified method to perform CLARITY imaging

Ekaterina Poguzhelskaya, Dmitry Artamonov, Anastasia Bolshakova, 2014, Molecular Neurodegeneration.

Hyperexpression of STIM2 protein lowers the amount of Abeta plaques in the brain of Alzheimer's disease mouse model

I. Bezprozvanny, O. Vlasova, D. Chernyuk, 2016 .

Genetic Constructs for the Control of Astrocytes’ Activity

P. Balaban, I. Bezprozvanny, A. Salmina, 2021, Cells.

In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2.

I. Bezprozvanny, P. Egorova, Aleksandra V. Gavrilova, 2020, Cell calcium.

In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.

I. Bezprozvanny, O. Vlasova, O. Zakharova, 2016, Journal of neurophysiology.

Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer’s Disease Mice Model

I. Bezprozvanny, E. Gerasimov, O. Vlasova, 2023, International journal of molecular sciences.

Ginsenosides protect striatal neurons in a cellular model of Huntington's disease

S. Kwon, I. Bezprozvanny, Jeong-Hill Park, 2009, Journal of neuroscience research.

An automated and quantitative method to evaluate progression of striatal pathology in Huntington's disease transgenic mice.

I. Bezprozvanny, Jun Wu, P. Egorova, 2014, Journal of Huntington's disease.

Expansion Microscopy Application for Calcium Protein Clustering Imaging in Cells and Brain Tissues

I. Bezprozvanny, E. Pchitskaya, A. Rakovskaya, 2023, Current protocols.

Amyloid Goes Global

I. Bezprozvanny, 2009, Science Signaling.

PDZ domains: More than just a glue.

I. Bezprozvanny, A. Maximov, I Bezprozvanny, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

Michael R. Hayden, Ilya Bezprozvanny, M. Hayden, 2008, Neurobiology of Disease.

NeuroInfoViewer: A Software Package for Analysis of Miniscope Data

A. I. Erofeev, I. Bezprozvanny, O. Vlasova, 2021, Neuroscience and Behavioral Physiology.

Molecular Association of CaV 1 . 3 L-Type Calcium Channels with Shank

D. Surmeier, T. Tkatch, I. Bezprozvanny, 2005 .

Bidirectional regulation by “star forces”: Ionotropic astrocyte's optical stimulation suppresses synaptic plasticity, metabotropic one strikes back

M. Roshchin, I. Bezprozvanny, A. Maltsev, 2022, Hippocampus.

Misery loves company - shared features of neurodegenerative disorders.

I. Bezprozvanny, E. Carafoli, M. Sorgato, 2017, Biochemical and biophysical research communications.

An Open-Source Wireless Electrophysiological Complex for In Vivo Recording Neuronal Activity in the Rodent’s Brain

I. Bezprozvanny, E. Gerasimov, D. Kazakov, 2021, Sensors.

Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5‐trisphosphate receptor

G. Hasan, S. Srikanth, I. Bezprozvanny, 2004, FEBS letters.

Association of Type 1 Inositol 1,4,5-Trisphosphate Receptor with AKAP9 (Yotiao) and Protein Kinase A*

I. Bezprozvanny, T. Tang, Huiping Tu, 2004, Journal of Biological Chemistry.

Store-operated calcium entry into SK-N-SH human neuroblastoma cells modeling huntington’s disease

I. Bezprozvanny, E. Kaznacheyeva, G. Mozhayeva, 2012, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

Changes in the store-dependent calcium influx in a cellular model of Huntington’s disease

I. Bezprozvanny, O. Zimina, L. Glushankova, 2010, Doklady Biological Sciences.

Localization of L-type calcium channel CaV1.3 in cat lumbar spinal cord – with emphasis on motoneurons

Ilya Bezprozvanny, Hans Hultborn, Morten Møller, 2006, Neuroscience Letters.

Investigation of low amyloid level toxicity effects on the function of hippocampal neurons

I. Bezprozvanny, O. Vlasova, E. Popugaeva, 2015 .

Characterization of synaptic dysfunction in an in vitro corticostriatal model system of Huntington’s disease

I. Bezprozvanny, V. Korzhova, O. Vlasova, 2013, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

Potential direct role of synuclein in dopamine transport and its implications for Parkinson's disease pathogenesis.

I. Bezprozvanny, Meewhi Kim, 2023, Biochemical and biophysical research communications.

A chlorzoxazone–folic acid combination improves cognitive affective decline in SCA2-58Q mice

I. Bezprozvanny, P. Egorova, K. S. Marinina, 2023, Scientific reports.

Positive Allosteric Modulator of SERCA Pump NDC-1173 Exerts Beneficial Effects in Mouse Model of Alzheimer’s Disease

I. Bezprozvanny, R. Dahl, W. Koss, 2023, International journal of molecular sciences.

GCaMP, a Family of Single-Fluorophore Genetically Encoded Calcium Indicators

I. Bezprozvanny, O. Vlasova, A. Erofeev, 2023, Journal of Evolutionary Biochemistry and Physiology.

Intracellular calcium release channels.

I. Bezprozvanny, B. Ehrlich, 1994, The Chinese journal of physiology.

Calcium hypothesis of neurodegeneration - An update.

I. Bezprozvanny, 2019, Biochemical and biophysical research communications.

Inhibiting Expression of Mutant Huntingtin and Ataxin-3 by Targeting Expanded CAG Repeat RNAs

D. Corey, I. Bezprozvanny, Masayuki Matsui, 2009, Nature biotechnology.

Cognitive Decline and Mood Alterations in the Mouse Model of Spinocerebellar Ataxia Type 2

I. Bezprozvanny, P. Egorova, K. S. Marinina, 2023, Cerebellum.

G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain

D. Surmeier, S. Hernández-López, E. Mugnaini, 2005, The Journal of Neuroscience.

Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease.

I. Bezprozvanny, C. Supnet, 2010, Journal of Alzheimer's disease : JAD.

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore*

B. de Strooper, A. Tolia, I. Bezprozvanny, 2011, The Journal of Biological Chemistry.

Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.

I. Bezprozvanny, M. Ahlijanian, Q. Wu, 2011, Chemistry & biology.

Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer’s Disease Mouse Model

I. Bezprozvanny, E. Pchitskaya, A. Rakovskaya, 2023, International journal of molecular sciences.

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

I. Bezprozvanny, M. Geva, R. Kusko, 2017, Neurobiology of Disease.

Tetrabenazine is neuroprotective in Huntington's disease mice

X. Chen, I. Bezprozvanny, T. Tang, 2010, Molecular Neurodegeneration.

A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer’s Disease Mouse Models by Upregulating Neuronal Autophagy

I. Bezprozvanny, Hua Zhang, S. Chen, 2023, The Journal of Neuroscience.

Small-molecule activation of neuronal cell fate.

I. Bezprozvanny, Shijie Li, J. Schneider, 2008, Nature chemical biology.

Single-Channel Properties of Inositol (1,4,5)-Trisphosphate Receptor Heterologously Expressed in HEK-293 Cells

I. Bezprozvanny, E. Kaznacheyeva, V. Lupu, 1998, The Journal of general physiology.

In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

A. V. Gavrilova, I. Bezprozvanny, P. Egorova, 2018, The Cerebellum.

PDZ domains: evolving classification

Anton Maximov, Ilya Bezprozvanny, I. Bezprozvanny, 2002 .

Structure-Based Modeling of Sigma 1 Receptor Interactions with Ligands and Cholesterol and Implications for Its Biological Function

I. Bezprozvanny, Meewhi Kim, 2023, International journal of molecular sciences.