K. Handa

发表

Sphingosine-dependent Protein Kinase-1, Directed to 14-3-3, Is Identified as the Kinase Domain of Protein Kinase Cδ*

A. Hamaguchi, E. Suzuki, K. Murayama, 2003, Journal of Biological Chemistry.

A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis.

K. Handa, S. Hakomori, N. Radin, 1990, Biochemistry.

Cell adhesion in a dynamic flow system as compared to static system. Glycosphingolipid-glycosphingolipid interaction in the dynamic system predominates over lectin- or integrin-based mechanisms in adhesion of B16 melanoma cells to non-activated endothelial cells.

K. Handa, S. Hakomori, Y. Sadahira, 1992, The Journal of biological chemistry.

Myeloglycan, a series of E-selectin-binding polylactosaminolipids found in normal human leukocytes and myelocytic leukemia HL60 cells.

B. Reinhold, K. Handa, K. Ito, 1995, Biochemical and biophysical research communications.

Monosialogangliosides of human myelogenous leukemia HL60 cells and normal human leukocytes. 2. Characterization of E-selectin binding fractions, and structural requirements for physiological binding to E-selectin.

B. Reinhold, K. Handa, S. Hakomori, 1996, Biochemistry.

Signal Transduction Through Glyco(sphingo)lipids: Introduction and Recent Studies on Glyco(sphingo)lipid‐enriched Microdomains a

K. Handa, S. Hakomori, S. Yamamura, 1998, Annals of the New York Academy of Sciences.

Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process

K. Handa, S. Hakomori, H. Clausen, 2011, Proceedings of the National Academy of Sciences.

Regulation of Growth Factor Receptors by Glycosphingolipids

K. Handa, S. Hakomori, 2016 .

Sialosyl‐Lex expression defines invasive and metastatic properties of bladder carcinoma

K. Handa, S. Hakomori, C. Ohyama, 2002, Cancer.

Induction of epithelial‐mesenchymal transition with O‐glycosylated oncofetal fibronectin

K. Handa, S. Hakomori, L. Freire-de-Lima, 2012, FEBS letters.

Monosialogangliosides of human myelogenous leukemia HL60 cells and normal human leukocytes. 1. Separation of E-selectin binding from nonbinding gangliosides, and absence of sialosyl-Le(x) having tetraosyl to octaosyl core.

B. Reinhold, K. Handa, S. Hakomori, 1996, Biochemistry.

Reconstitution of Membranes Simulating “Glycosignaling Domain” and Their Susceptibility to Lyso-GM3*

K. Iwabuchi, K. Handa, D. Withers, 2000, The Journal of Biological Chemistry.

New insights in glycosphingolipid function: "glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules,involved in cell adhesion coupled with signaling.

K. Iwabuchi, K. Handa, S. Hakomori, 1998, Glycobiology.

GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells*

K. Iwabuchi, K. Handa, S. Hakomori, 1998, The Journal of Biological Chemistry.

A close association of GM3 with c-Src and Rho in GM3-enriched microdomains at the B16 melanoma cell surface membrane: a preliminary note.

K. Handa, S. Hakomori, S. Yamamura, 1997, Biochemical and biophysical research communications.

Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor

T. Hikita, K. Handa, S. Hakomori, 2006, Proceedings of the National Academy of Sciences.

Glycosphingolipid‐dependent cross‐talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy

K. Handa, S. Hakomori, 2002, FEBS letters.

A Specific Microdomain (“Glycosynapse 3”) Controls Phenotypic Conversion and Reversion of Bladder Cancer Cells through GM3-mediated Interaction of α3β1 Integrin with CD9*

K. Handa, S. Hakomori, M. Satoh, 2005, Journal of Biological Chemistry.

Changes of glycoconjugate expression profiles during early development

K. Handa, S. Hakomori, 2017, Glycoconjugate Journal.

Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation.

K. Handa, D. Withers, S. Hakomori, 1999, Cancer research.

Tetraspanin CD9 Is a “Proteolipid,” and Its Interaction with α3 Integrin in Microdomain Is Promoted by GM3 Ganglioside, Leading to Inhibition of Laminin-5-dependent Cell Motility*

K. Handa, D. Withers, S. Hakomori, 2002, The Journal of Biological Chemistry.

Efficient synthesis of chloro-derivatives of sialosyllactosylceramide, and their enhanced inhibitory effect on epidermal growth factor receptor activation

W. Cavenee, K. Handa, S. Hakomori, 2014, Oncology letters.

Association of MUC-1 and SPGL-1 with low-density microdomain in T-lymphocytes: a preliminary note.

K. Handa, S. Hakomori, B. Longenecker, 2001, Biochemical and biophysical research communications.

Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Le(a) and sialosyl-Le(x), and sulfated glycans modulate this binding.

K. Handa, S. Hakomori, T. Shiozawa, 1991, Biochemical and biophysical research communications.

Glycosylation affects translocation of integrin, Src, and caveolin into or out of GEM.

K. Handa, S. Hakomori, M. Ono, 2000, Biochemical and biophysical research communications.

Histo‐blood group A/B antigen deletion/ reduction vs. continuous expression in human tumor cells as correlated with their malignancy

K. Handa, S. Hakomori, D. Ichikawa, 1998, International journal of cancer.

Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine.

K. Handa, S. Hakomori, Y. Igarashi, 1991, Biochemistry.

Separation of glycosphingolipid-enriched microdomains from caveolar membrane characterized by presence of caveolin.

K. Iwabuchi, K. Handa, S. Hakomori, 2000, Methods in enzymology.

Monosialyl‐Gb5 organized with cSrc and FAK in GEM of human breast carcinoma MCF‐7 cells defines their invasive properties

M. Mareel, E. Bruyneel, K. Handa, 2002, FEBS letters.

Interaction of glycosphingolipids with signal transducers and membrane proteins in glycosphingolipid-enriched microdomains.

K. Handa, S. Hakomori, 2003, Methods in enzymology.

Carbohydrate to carbohydrate interaction in development process and cancer progression

K. Handa, S. Hakomori, 2012, Glycoconjugate Journal.

Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note.

K. Handa, S. Hakomori, L. Larue, 2007, Biochemical and biophysical research communications.

Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells.

K. Handa, D. Withers, S. Hakomori, 2000, Biochemical and biophysical research communications.

Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells

K. Handa, S. Hakomori, S. Levery, 2013, Proceedings of the National Academy of Sciences.

Effect of Ganglioside and Tetraspanins in Microdomains on Interaction of Integrins with Fibroblast Growth Factor Receptor*

E. Suzuki, K. Handa, S. Hakomori, 2005, Journal of Biological Chemistry.

Multi-recognition capability of E-selectin in a dynamic flow system, as evidenced by differential effects of sialidases and anti-carbohydrate antibodies on selectin-mediated cell adhesion at low vs. high wall shear stress: a preliminary note.

K. Handa, S. Hakomori, W. Newman, 1992, Biochemical and biophysical research communications.

Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells.

K. Handa, S. Hakomori, W. Newman, 1992, Biochemical and biophysical research communications.

Species-specific expression of sialosyl-Lex on polymorphonuclear leukocytes (PMN), in relation to selectin-dependent PMN responses

K. Handa, S. Hakomori, Kazunori Ito, 1994, Glycoconjugate Journal.

Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter

K. Handa, D. Withers, S. Hakomori, 1999, Glycoconjugate Journal.

Expression profiles of I and sialosyl-I antigens on blood cells: the sialosyl-I antigen is expressed along the monocytic differentiation.

K. Handa, S. Hakomori, K. Ozawa, 1998, Leukemia research.

Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling*

K. Iwabuchi, K. Handa, S. Hakomori, 1998, The Journal of Biological Chemistry.

Histo-blood group A/B versus H status of human carcinoma cells as correlated with haptotactic cell motility: approach with A and B gene transfection.

K. Handa, D. Withers, S. Hakomori, 1997, Cancer research.

Disialosyl galactosylgloboside as an adhesion molecule expressed on renal cell carcinoma and its relationship to metastatic potential.

K. Handa, S. Hakomori, M. Satoh, 1996, Cancer research.

The alpha 1-->3 fucosylation at the penultimate GlcNAc catalyzed by fucosyltransferase VII is blocked by internally fucosylated residue in sialosyl long-chain poly-LacNAc: enzymatic basis for expression of physiological E-selectin epitope.

K. Handa, D. Withers, S. Hakomori, 1998, Biochemical and biophysical research communications.

Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line

K. Handa, S. Hakomori, Xiaohua Huang, 2017, FEBS letters.

Cell Growth Regulation through GM3-enriched Microdomain (Glycosynapse) in Human Lung Embryonal Fibroblast WI38 and Its Oncogenic Transformant VA13*

E. Suzuki, K. Handa, S. Hakomori, 2004, Journal of Biological Chemistry.

Ganglioside GM2-Tetraspanin CD82 Complex Inhibits Met and Its Cross-talk with Integrins, Providing a Basis for Control of Cell Motility through Glycosynapse*

K. Handa, S. Hakomori, A. Todeschini, 2007, Journal of Biological Chemistry.

Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

K. Handa, D. Withers, S. Hakomori, 2001, FEBS letters.

Functional role of gangliotetraosylceramide in epithelial‐to‐mesenchymal transition process induced by hypoxia and by TGF‐β

K. Handa, S. Hakomori, L. Schaffer, 2010 .

Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.

E. Suzuki, K. Handa, S. Hakomori, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCdelta: a preliminary note.

A. Hamaguchi, E. Suzuki, K. Murayama, 2003, Biochemical and biophysical research communications.

GM3 and cancer

K. Handa, S. Hakomori, 2015, Glycoconjugate Journal.

Regulation of Epidermal Growth Factor Receptor Through Interaction of Ganglioside GM3 with GlcNAc of N-Linked Glycan of the Receptor: Demonstration in ldlD Cells

K. Handa, S. Hakomori, F. Guan, 2011, Neurochemical Research.

P-selectin-dependent adhesion of human cancer-cells - requirement for coexpression of a psgl-1-like core protein and the glycosylation process for sialosyl-le(x) or sialosyl-le(a).

K. Handa, S. Hakomori, S. Wang, 1995, International journal of oncology.

GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy.

K. Handa, D. Withers, S. Hakomori, 2001, Biochemistry.

Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines

K. Handa, S. Hakomori, F. Guan, 2009, Proceedings of the National Academy of Sciences.

Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway

K. Handa, S. Hakomori, A. Todeschini, 2008, Proceedings of the National Academy of Sciences.

Enhanced GM3 expression, associated with decreased invasiveness, is induced by brefeldin A in bladder cancer cells.

K. Handa, S. Hakomori, C. Ohyama, 2001, International journal of oncology.

Sialosyl-fucosyl Poly-LacNAc without the sialosyl-Lex epitope as the physiological myeloid cell ligand in E-selectin-dependent adhesion: studies under static and dynamic flow conditions.

K. Handa, S. Hakomori, M. Stroud, 1997, Biochemistry.

A characteristic protein highly expressed in guinea pig inner ear, defined by monoclonal antibody WH-1

E. Rubel, K. Handa, S. Hakomori, 1994, Hearing Research.

Carbohydrate to carbohydrate interaction in development process and cancer progression

K. Handa, S. Hakomori, 2012, Glycoconjugate Journal.

Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}.

K. Handa, S. Hakomori, L. Schaffer, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.

K. Handa, K. Handa, S. Sato, 1975, Gan.

Electron spin resonance study on the mode of generation of free radicals of daunomycin, adriamycin, and carboquone in NAD(P)H-microsome system.

K. Handa, M. Iwaizumi, Y. Tamura, 1977, Gan.

GM3 and cancer

K. Handa, S. Hakomori, 2015, Glycoconjugate Journal.