Feng Gu

发表

DeepCRISPR: optimized CRISPR guide RNA design by deep learning

Guohui Chuai, Hanhui Ma, Jifang Yan, 2018, Genome Biology.

Identification of a rhodopsin gene mutation in a large family with autosomal dominant retinitis pigmentosa

Feng Gu, J. Qu, Ding Chen, 2016, Scientific Reports.

Deciphering relationship between microhomology and in-frame mutation occurrence in human CRISPR-based gene knockout.

Guohui Chuai, Jifang Yan, Chi Zhou, 2016, Molecular therapy. Nucleic acids.

Can SpRY recognize any PAM in human cells?

Feng Gu, Xiaosheng Lu, Junzhao Zhao, 2022, Journal of Zhejiang University. Science. B.

Molecular Diagnosis of Putative Stargardt Disease by Capture Next Generation Sequencing

Feng Gu, J. Qu, Zi-Bing Jin, 2014, PloS one.

Identification of RPGR ORF15 mutation for X-linked retinitis pigmentosa in a large Chinese family and in vitro correction with prime editor

Feng Gu, J. Qu, W. Shi, 2022, Gene Therapy.

Human cells based directed evolution of adenine base editors

Feng Gu, Jinwei Zhang, J. Qu, 2021 .

Protective Effects of Trimetazidine in Retarding Selenite-Induced Lens Opacification

Feng Gu, Yihua Zhu, Yanghui Xiu, 2019, Current eye research.

Identification of a novel GJA3 mutation in a large Chinese family with congenital cataract using targeted exome sequencing

Feng Gu, Yihua Zhu, Junzhao Zhao, 2017, PloS one.

A Novel Mutation p.L461P in KRT5 Causing Localized Epidermolysis Bullosa Simplex

Feng Gu, Huihui Sun, Xin Jiang, 2020, Annals of dermatology.

An anti-CAPN5 intracellular antibody acts as an inhibitor of CAPN5-mediated neuronal degeneration

Feng Gu, Yan Wang, Zongming Song, 2017, Oncotarget.

A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family

Feng Gu, J. Qu, Liming Song, 2014, Scientific Reports.

High-fidelity SaCas9 identified by directional screening in human cells

Shuang Li, Feng Gu, Jinyu Wu, 2020, PLoS biology.

Identification of a novel idiopathic congenital nystagmus-causing missense mutation, p.G296C, in the FRMD7 gene

Feng Gu, Yihua Zhu, Junzhao Zhao, 2018, Molecular medicine reports.

Clinical characteristics of a KIF21A mutation in a Chinese family with congenital fibrosis of the extraocular muscles type 1

Feng Gu, Lulu Cheng, Yuanyuan Lin, 2017, Medicine.

Engineered FnCas12a with enhanced activity through directional evolution in human cells

Feng Gu, Xiaoyu Liu, Jineng Lv, 2021, The Journal of biological chemistry.

CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool

Feng Gu, J. Qu, Ding Chen, 2017, Molecular therapy. Nucleic acids.

Boosting activity of high-fidelity CRISPR/Cas9 variants using a tRNAGln-processing system in human cells

Yufei Wang, Feng Gu, Caixia Gao, 2019, The Journal of Biological Chemistry.

CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome

Feng Gu, Zhibo Wang, Xiujuan Lv, 2021, Science China Life Sciences.

CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome

Feng Gu, Bin Lu, Zhibo Wang, 2021, Science China Life Sciences.

Lb2Cas12a and its engineered variants mediate genome editing in human cells

Feng Gu, J. Qu, Xiaoyu Liu, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Efficient cleavage resolves PAM preferences of CRISPR-Cas in human cells

Feng Gu, J. Qu, Xiaoyu Liu, 2019, Cell regeneration.

Basic and Clinical Application of Adeno-Associated Virus-Mediated Genome Editing.

Feng Gu, Haihua Xie, Xiexie Liu, 2019, Human gene therapy.

[Application and optimization of CRISPR/Cas system in bacteria].

Feng Gu, Junhao Fu, Fayu Yang, 2019, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells.

Changbao Liu, Junzhao Zhao, Xiaoyu Liu, 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

A Single Multiplex crRNA Array for FnCpf1-Mediated Human Genome Editing.

Feng Gu, J. Qu, Junzhao Zhao, 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells.

Feng Gu, J. Qu, Junzhao Zhao, 2018, Biotechnology journal.

A ‘new lease of life’: FnCpf1 possesses DNA cleavage activity for genome editing in human cells

Junhao Fu, Changbao Liu, Junzhao Zhao, 2017, Nucleic acids research.

Efficient Human Genome Editing Using SaCas9 Ribonucleoprotein Complexes.

Feng Gu, Junzhao Zhao, R. Deng, 2019, Biotechnology journal.

Functional non-homologous end joining patterns triggered by CRISPR/Cas9 in human cells.

Feng Gu, J. Qu, Junzhao Zhao, 2018, Journal of genetics and genomics = Yi chuan xue bao.

Deciphering relationship between microhomology and in-frame mutation occurrence in human CRISPR-based gene knockout

Qin Ma, Chenyu Zhu, Guohui Chuai, 2016, Molecular therapy. Nucleic acids.

Development of a Simple and Quick Method to Assess Base Editing in Human Cells

Feng Gu, Yuqin Wang, Jinyu Wu, 2020, Molecular therapy. Nucleic acids.

Targeted Exome Sequencing Identified Novel USH2A Mutations in Usher Syndrome Families

Feng Gu, C. Pang, J. Qu, 2013, PloS one.

A patient with severe congenital neutropenia harbors a missense ELANE mutation due to paternal germline mosaicism.

Feng Gu, Xiaosheng Lu, Junzhao Zhao, 2021, Clinica chimica acta; international journal of clinical chemistry.

Toll-Like Receptor 3 Activation Initiates Photoreceptor Cell Death In Vivo and In Vitro.

Feng Gu, Lue Xiang, Mei-Ling Gao, 2017, Investigative ophthalmology & visual science.

DeepCRISPR: optimized CRISPR guide RNA design by deep learning

Guohui Chuai, Hanhui Ma, Jifang Yan, 2018, Genome Biology.

Recapitulating and Correcting Marfan Syndrome in a Cellular Model

Feng Gu, T. Xie, Lixia Yue, 2017, International journal of biological sciences.

Human cell based directed evolution of adenine base editors with improved efficiency

Junhao Fu, Xiujuan Lv, Qing Li, 2021, Nature Communications.

Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation

Feng Gu, Tao Xu, Ding Chen, 2018, Front. Mol. Neurosci..

Questions about NgAgo

Qiang Wu, Bin Zhou, Xiaoqun Wang, 2016, Protein & Cell.

Identification of Three Novel Mutations in the FRMD7 Gene for X-linked Idiopathic Congenital Nystagmus

Feng Gu, J. Qu, Zi-Bing Jin, 2014, Scientific Reports.

Identifcation of a Novel Mutation p.I240T in the FRMD7 gene in a Family with Congenital Nystagmus

Feng Gu, Z. Wang, Juhua Yang, 2013, Scientific Reports.

CRISPR/Cas9-AAV Mediated Knock-in at NRL Locus in Human Embryonic Stem Cells

Feng Gu, J. Qu, Ge Lin, 2016, Molecular therapy. Nucleic acids.

Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells

Feng Gu, Feng Gu, J. Qu, 2014, Scientific Reports.

Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage.

Feng Gu, Yan Wang, Zongming Song, 2018, Investigative ophthalmology & visual science.

Retinal Cell Biology Photoreceptor Cell – Derived CAPN 5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT 2 Cleavage

Feng Gu, Yan Wang, Zongming Song, 2018 .

Small-molecule compounds boost genome-editing efficiency of cytosine base editor

Feng Gu, Haoyi Wang, Xiaoyu Liu, 2021, Nucleic acids research.

Progress of application and off-target effects of CRISPR/Cas9.

Feng Gu, Wu Zheng, 2015, Yi chuan = Hereditas.

Two high-fidelity variants: efSaCas9 and SaCas9-HF, which one is better?

Feng Gu, Junzhao Zhao, Zongming Song, 2022, Gene Therapy.

SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells.

Feng Gu, J. Qu, Junzhao Zhao, 2018, Biotechnology journal.

Questions about NgAgo

Qiang Wu, Bin Zhou, Xiaoqun Wang, 2016, Protein & Cell.

Best-corrected visual acuity results facilitate molecular diagnosis of infantile nystagmus patients harboring FRMD7 mutations.

Feng Gu, Yeqin Yang, Jinling Xu, 2023, Experimental eye research.

Identification of a novel GJA3 mutation in a large Chinese family with congenital cataract using targeted exome sequencing

Feng Gu, Yihua Zhu, Junzhao Zhao, 2017, PloS one.

Advances in Split Vector Approaches for Adeno-Associated Virus Gene Therapy.

Feng Gu, 2023, Human gene therapy.