N. L. La Gruta

发表

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Bjoern Peters, D. Tscharke, J. Sidney, 2019, Proceedings of the National Academy of Sciences.

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

D. Tscharke, J. Sidney, A. Sette, 2019, Nature Communications.

Paired TCRαβ analysis of virus‐specific CD8+ T cells exposes diversity in a previously defined ‘narrow’ repertoire

Nicole L La Gruta, Paul G Thomas, Pradyot Dash, 2015, Immunology and cell biology.

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host.

Kylie M. Quinn, J. McVernon, Pengxing Cao, 2016, Journal of theoretical biology.

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity

Spencer J. Williams, G. Besra, J. Rossjohn, 2015, The Journal of Immunology.

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

N. L. La Gruta, G. Belz, R. Lundie, 2007, Proceedings of the National Academy of Sciences.

Kylie M. Quinn, Haroon Naeem, L. Loh, 2018, Cell reports.

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice.

G. McFadden, S. Gras, A. Purcell, 2020, Cell host & microbe.

Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis.

K. Laurie, N. L. La Gruta, P. Gleeson, 2002, Autoimmunity reviews.

Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection.

R. Webby, P. Doherty, K. Kedzierska, 2004, Seminars in immunology.

P. Doherty, K. Kedzierska, S. Turner, 2008, The Journal of Immunology.

Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression

P. Doherty, S. Turner, N. L. La Gruta, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The linear range for accurately quantifying antigen‐specific T‐cell frequencies by tetramer staining during natural immune responses

S. Turner, N. L. La Gruta, G. Belz, 2011, European journal of immunology.

Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells.

N. L. La Gruta, L. Cauley, S. Swain, 2002, Journal of immunological methods.

Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus

C. Szeto, S. Gras, N. L. La Gruta, 2022, Nature Communications.

A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo

N. L. La Gruta, J. Stow, P. Gleeson, 2008, Proceedings of the National Academy of Sciences.

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice

Kylie M. Quinn, J. McCaw, P. Doherty, 2016, Proceedings of the National Academy of Sciences.

The Majority of Immunogenic Epitopes Generate CD4+ T Cells That Are Dependent on MHC Class II-Bound Peptide-Flanking Residues

N. L. La Gruta, D. Woodland, D. Vignali, 2002, The Journal of Immunology.

Influenza‐induced, helper‐independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

S. Turner, N. L. La Gruta, L. Brown, 2013, Journal of leukocyte biology.

Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice

S. Loi, A. Strasser, N. L. La Gruta, 2022, Nature Cancer.

CD4+ T help promotes influenza virus-specific CD8+ T cell memory by limiting metabolic dysfunction

Kylie M. Quinn, P. Doherty, S. Turner, 2019, Proceedings of the National Academy of Sciences.

Forewarned is forearmed.

S. Turner, N. L. La Gruta, 2010, Immunity.

Evaluation of inflammation and follicle depletion during ovarian ageing in mice

N. L. La Gruta, A. Mansell, Karla J. Hutt, 2021, Scientific reports.

Architectural Changes in the TCR:CD3 Complex Induced by MHC:Peptide Ligation1

N. L. La Gruta, D. Wiest, D. Vignali, 2004, The Journal of Immunology.

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion.

P. Doherty, K. Kedzierska, P. Thomas, 2010, The Journal of clinical investigation.

A question of self‐preservation: immunopathology in influenza virus infection

P. Doherty, K. Kedzierska, N. L. La Gruta, 2007, Immunology and cell biology.

The Majority of Immunogenic Epitopes Generate CD4+ T Cells That Are Dependent on MHC Class II-Bound Peptide-Flanking Residues1

David L. Woodland, N. L. La Gruta, D. Woodland, 2002, The Journal of Immunology.

The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8+ T Cell Repertoire

Kylie M. Quinn, S. Turner, N. L. La Gruta, 2020, The Journal of Immunology.

The clock is ticking: the impact of ageing on T cell metabolism

Kylie M. Quinn, N. L. La Gruta, Clovis S Palmer, 2019, Clinical & translational immunology.

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

R. Toes, J. McCluskey, J. Rossjohn, 2013, The Journal of experimental medicine.

T cell mediated immunity to influenza: mechanisms of viral control.

S. Turner, N. L. La Gruta, 2014, Trends in immunology.

Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility

L. Notarangelo, K. Dobbs, Karin Chen, 2020, The Journal of experimental medicine.

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

N. L. La Gruta, B. Jenkins, A. Giraud, 2005, Gastroenterology.

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

D. Tscharke, J. Sidney, A. Sette, 2019, Nature Communications.

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Kylie M. Quinn, J. Rossjohn, S. Gras, 2016, Immunity.

Fixed Expression of Single Influenza Virus–Specific TCR Chains Demonstrates the Capacity for TCR α– and β–Chain Diversity in the Face of Peptide–MHC Class I Specificity

P. Doherty, E. B. Clemens, N. Gruta, 2015, The Journal of Immunology.

Effect of MHC Class I Diversification on Influenza Epitope-Specific CD8+ T Cell Precursor Frequency and Subsequent Effector Function

P. Doherty, S. Turner, N. L. La Gruta, 2011, The Journal of Immunology.

Role of CD8+ T-cell immunity in influenza infection: potential use in future vaccine development

A. Kelso, S. Turner, N. L. La Gruta, 2009, Expert review of respiratory medicine.

Killer T cells in influenza.

P. Doherty, K. Kedzierska, N. L. La Gruta, 2008, Pharmacology & therapeutics.

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.

Nicole L La Gruta, Katherine Kedzierska, P. Doherty, 2008, Molecular immunology.

Establishment and recall of CD8+ T‐cell memory in a model of localized transient infection

P. Doherty, K. Kedzierska, S. Turner, 2006, Immunological reviews.

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses.

M. Davenport, P. Doherty, K. Kedzierska, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T Cell Responses: Correlation of Cytokine Profile and TCR Avidity1

P. Doherty, S. Turner, N. L. La Gruta, 2004, The Journal of Immunology.

Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells.

P. Doherty, S. Turner, N. L. La Gruta, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

K. Laurie, M. Aban, L. Loh, 2021, Nature Communications.

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

F. Luciani, Pengxing Cao, J. McCaw, 2018, Nature Communications.

The Influenza Virus–Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells

P. Doherty, S. Turner, N. L. La Gruta, 2014, The Journal of Immunology.

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

P. Doherty, P. Thomas, S. Turner, 2014, Proceedings of the National Academy of Sciences.

A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies.

R. Webby, M. Davenport, P. Doherty, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection

Uri Hershberg, Christopher D. Scharer, S. Turner, 2021, Nature Immunology.

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

P. Doherty, K. Kedzierska, P. Thomas, 2010, PLoS pathogens.

PTPN2 attenuates T-cell lymphopenia-induced proliferation

N. L. La Gruta, T. Tiganis, F. Wiede, 2014, Nature Communications.

Unlike CD4+ T‐cell help, CD28 costimulation is necessary for effective primary CD8+ T‐cell influenza‐specific immunity

S. Turner, N. L. La Gruta, G. Belz, 2012, European journal of immunology.

Interrogating the relationship between naïve and immune antiviral T cell repertoires.

P. Thomas, N. L. La Gruta, 2013, Current opinion in virology.

Understanding the drivers of MHC restriction of T cell receptors

Nicole L La Gruta, Paul G Thomas, Jamie Rossjohn, 2018, Nature Reviews Immunology.

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Stephen J. Turner, Anthony W. Purcell, Peter C. Doherty, 2011, Proceedings of the National Academy of Sciences.

Altered CD8+ T Cell Immunodominance after Vaccinia Virus Infection and the Naive Repertoire in Inbred and F1 Mice

Yang Wang, D. Tscharke, I. Flesch, 2009, The Journal of Immunology.

Consistency in polyclonal T-cell responses to gluten between children and adults with celiac disease.

L. Greco, N. L. La Gruta, C. Gianfrani, 2015, Gastroenterology.

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

N. L. La Gruta, Claerwen M. Jones, M. Y. Hardy, 2019, Gut.

CD4+CD8β+ double‐positive T cells in skin‐draining lymph nodes respond to inflammatory signals from the skin

I. Frazer, N. L. La Gruta, Jazmina L G Cruz, 2017, Journal of leukocyte biology.

Simulation modelling for immunologists

Andreas Handel, Nicole L La Gruta, Paul G Thomas, 2019, Nature Reviews Immunology.

Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Michael J. Dagley, Eleanor C. Saunders, Kylie M. Quinn, 2020, Nature Communications.

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

N. L. La Gruta, J. Mintern, S. Ishido, 2016, The Journal of experimental medicine.

Precursor Frequency and Competition Dictate the HLA-A2–Restricted CD8+ T Cell Responses to Influenza A Infection and Vaccination in HLA-A2.1 Transgenic Mice

N. L. La Gruta, W. Zeng, D. Jackson, 2011, The Journal of Immunology.

Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

K. Gaus, C. Szeto, J. Rossjohn, 2021, Science.

MHC Restriction: Where Are We Now?

N. L. La Gruta, Pirooz Zareie, C. Farenc, 2020, Viral immunology.

Influenza Epitope-Specific CD8+ T Cell Avidity, but Not Cytokine Polyfunctionality, Can Be Determined by TCRβ Clonotype

P. Doherty, P. Thomas, S. Turner, 2010, The Journal of Immunology.

Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

P. Doherty, P. Thomas, S. Turner, 2008, Proceedings of the National Academy of Sciences.

Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

D. Tscharke, P. Thomas, J. Rossjohn, 2020, The Journal of Immunology.

Modified Vaccinia Virus Ankara Can Induce Optimal CD8+ T Cell Responses to Directly Primed Antigens Depending on Vaccine Design

D. Tscharke, Stewart A. Smith, N. L. La Gruta, 2019, Journal of Virology.

Functional implications of T cell receptor diversity.

P. Doherty, K. Kedzierska, P. Thomas, 2009, Current opinion in immunology.

Terminal Deoxynucleotidyltransferase Is Required for the Establishment of Private Virus-Specific CD8+ TCR Repertoires and Facilitates Optimal CTL Responses1

M. Davenport, P. Doherty, K. Kedzierska, 2008, The Journal of Immunology.

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations

P. Doherty, P. Thomas, A. Handel, 2013, Proceedings of the National Academy of Sciences.

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude

Kylie M. Quinn, P. Doherty, K. Kedzierska, 2017, PloS one.

In-concert immune dynamics during natural influenza virus infection and recovery in acute hospitalized patients

K. Laurie, M. Aban, L. Loh, 2020, medRxiv.

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

Jia Jia Lim, J. Rossjohn, A. Purcell, 2021, Nature Communications.

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR

Jia Jia Lim, J. Rossjohn, A. Purcell, 2021, Science Immunology.

The Role of Natural Killer Cells in the Induction of Autoimmune Gastritis

N. L. La Gruta, P. Gleeson, B. Toh, 2001, Autoimmunity.

Thymic Expression of a Gastritogenic Epitope Results in Positive Selection of Self-Reactive Pathogenic T Cells1

Nicole L La Gruta, K. Laurie, N. L. La Gruta, 2004, The Journal of Immunology.

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

F. Luciani, Pengxing Cao, L. Loh, 2018, Nature Communications.

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

D. Tscharke, J. Sidney, A. Sette, 2019, Nature Communications.

The paradox of aging: Aging-related shifts in T cell function and metabolism.

Kylie M. Quinn, N. L. La Gruta, D. Vicencio, 2023, Seminars in immunology.

Thanks for the memories: Low-avidity T cells shine against escape variants.

N. L. La Gruta, P. Zareie, 2023, Immunity.

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion.

P. Doherty, K. Kedzierska, S. Turner, 2010, The Journal of clinical investigation.

Role of CD8+ T-cell immunity in influenza infection: potential use in future vaccine development

A. Kelso, S. Turner, N. L. La Gruta, 2009, Expert review of respiratory medicine.

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

M. Mearin, J. Schweizer, J. van Bergen, 2014, Nature Structural &Molecular Biology.

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

P. Doherty, S. Turner, A. Handel, 2014, Proceedings of the National Academy of Sciences.

Consistency in polyclonal T-cell responses to gluten between children and adults with celiac disease.

L. Greco, N. L. La Gruta, C. Gianfrani, 2015, Gastroenterology.

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses.

M. Davenport, P. Doherty, K. Kedzierska, 2005, Proceedings of the National Academy of Sciences of the United States of America.

CD8+ T-Cell Memory: The Why, the When, and the How.

S. Turner, N. L. La Gruta, T. Bennett, 2021, Cold Spring Harbor perspectives in biology.