Shuning He

发表

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

H. Spaink, A. Meijer, Shuning He, 2012, The Journal of pathology.

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.

Richard A. Young, R. Young, A. Look, 2018, Cancer discovery.

Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

Colin J. Daniel, Ellen M. Langer, R. Sears, 2020, bioRxiv.

Cancer and inflammation studies using zebrafish cell lines

Shuning He, 2010 .

A ΔRaf1–ER‐inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures

Z. Gong, H. Spaink, Huiqing Zhan, 2011, The Journal of pathology.

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.

Hu Li, A. Look, C. Ung, 2017, Cell reports.

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

R. Young, A. Look, K. Stegmaier, 2022, bioRxiv.

ERK1 and ERK2 MAPK are key regulators of distinct target gene signature sets in zebrafish embryogenesis

H. Spaink, Shuning He, B. Snaar-Jagalska, 2007 .

A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing

Jeffry D. Sander, J. Joung, L. Zon, 2014, Molecular and Cellular Biology.

Integrin control of ZEB/miR-200 balance regulates tumor cell migration strategy and metastasis

Shuning He, Veerander P. S. Ghotra, B. Water, 2011 .

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells by XPO1 inhibitors

A. Look, Shuning He, N. Prutsch, 2022, bioRxiv.

Identification of P38α target genes involved in the physiological angiogenesis

H. Spaink, Shuning He, E. Snaar-Jagalska, 2014 .

Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish.

H. Spaink, A. Meijer, H. Spaink, 2004, Molecular immunology.

Discovery of a selective inhibitor of Doublecortin Like Kinase 1

Charles Y. Lin, W. Hahn, A. Look, 2020, Nature Chemical Biology.

Profile of phosphorylation events controlled by hyper-activation of the MAPK signaling pathway in zebrafish liver cells

H. Spaink, Shuning He, B. Snaar-Jagalska, 2010 .

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

A. Look, J. Epstein, Shuning He, 2016, eLife.

Malignant Peripheral Nerve Sheath Tumors.

A. Look, Shuning He, D. Ki, 2016, Advances in experimental medicine and biology.

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

Colin J. Daniel, Ellen M. Langer, R. Sears, 2021, Nature Chemical Biology.

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells

A. Look, Shuning He, Zhaodong Li, 2018, Leukemia.

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

K. Ross, A. Look, J. Aster, 2019, PLoS genetics.

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

R. Young, T. Golub, W. Hahn, 2018, Nature Genetics.

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

Traci M. Blonquist, R. Young, L. Zon, 2018, The Journal of experimental medicine.

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

Hu Li, A. Look, C. Ung, 2021, Cancer Research.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Hu Li, D. Neuberg, A. Look, 2017, Cancer cell.

Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma

R. Young, A. Look, Shuning He, 2021, bioRxiv.

Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN

R. Young, A. Look, Shuning He, 2020 .

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

Seok-Hyung Kim, A. Look, K. Ligon, 2012, Disease Models & Mechanisms.

Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model

Shuning He, B. Snaar-Jagalska, P. Dijke, 2013, Breast Cancer Research.

Automated Whole Animal Bio-Imaging Assay for Human Cancer Dissemination

H. Spaink, L. Rénia, Shuning He, 2012, PloS one.

Characterization and expression patterns of the MAPK family in zebrafish.

H. Spaink, Shuning He, B. Snaar-Jagalska, 2006, Gene expression patterns : GEP.

β1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer

Bob van de Water, Sylvia E. Le Dévédec, B. Ewa Snaar-Jagalska, 2014, Science Signaling.

Genetic and transcriptome characterization of model zebrafish cell lines.

H. Spaink, A. Meijer, Shuning He, 2006, Zebrafish.

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

A. Look, N. Gray, Jinhua Wang, 2020, Cell.

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

C. Bourque, A. Look, Y. Houvras, 2016, Nature Communications.

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

K. Ross, A. Look, J. Aster, 2020, Disease Models & Mechanisms.

suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma.

K. Ross, A. Look, J. Aster, 2020, Disease models & mechanisms.

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors

A. Look, Shuning He, N. Prutsch, 2020, Leukemia.

Title: c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification Authors:

R. Young, A. Look, Beisi Xu, 2017 .

SYK is a candidate kinase target for the treatment of advanced prostate cancer.

Esther I Verhoef, Bob van de Water, Guido Jenster, 2015, Cancer research.

1 SYK is a candidate kinase target for the treatment of advanced prostate cancer

G. Jenster, Shuning He, Veerander P. S. Ghotra, 2014 .

IN VIVO RNAI IDENTIFIES SYK AS A CANDIDATE DRUG TARGET FOR PROSTATE CANCER

G. Jenster, Shuning He, Veerander P. S. Ghotra, 2013 .

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

L. Zon, C. Kaufman, A. Look, 2021, Oncogene.

In vivo magnetic resonance imaging to detect malignant melanoma in adult zebrafish.

Adam Hurlstone, H. Spaink, Shuning He, 2010, Zebrafish.

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

H. Spaink, T. Schmidt, A. Meijer, 2008, Developmental biology.

Distinct functions for ERK 1 and ERK 2 in cell migration processes during zebra fi sh gastrulation

H. Spaink, T. Schmidt, A. Meijer, 2008 .

ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis

H. Spaink, Shuning He, B. Snaar-Jagalska, 2008, BMC Genomics.

Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish.

H. Spaink, W. Dunn, Shuning He, 2019, Cancer research.

Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model.

H. Spaink, A. Meijer, Shuning He, 2016, Methods in molecular biology.

MST1R SUPPORTS PROSTATE CANCER INVASION, DISSEMINATION AND FORMATION OF BONE METASTASES

G. Jenster, Shuning He, Veerander P. S. Ghotra, 2013 .

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

R. Young, T. Golub, W. Hahn, 2018, Nature Genetics.

Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model

Shuning He, B. Snaar-Jagalska, P. ten Dijke, 2013, Breast Cancer Research.

Zebrafish models of leukemia.

A. Look, Shuning He, Chang-Bin Jing, 2017, Methods in cell biology.

Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

A. Look, Shuning He, S. Rodig, 2016, Oncogene.

Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

A. Look, Shuning He, S. Rodig, 2016, Oncogene.

Supplemental Methods PCR analysis on genomic translocations Genomic

R. Young, A. Look, Beisi Xu, 2017 .

Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome

Francine E. Garrett-Bakelman, Y. Houvras, Shuning He, 2023, Frontiers in hematology.

Synthetic lethal targeting of TET2‐mutant haematopoietic stem and progenitor cells by XPO1 inhibitors

Shuning He, N. Prutsch, Y. Landesman, 2023, British journal of haematology.