David Barros

发表

Testing Tuberculosis Drug Efficacy in a Zebrafish High-Throughput Translational Medicine Screen

Robert H Bates, T. Hankemeier, A. Ordas, 2014, Antimicrobial Agents and Chemotherapy.

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

Alfonso Mendoza, Benigno Crespo, David Barros, 2013, ChemMedChem.

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

George Papadatos, John P. Overington, Tom L. Blundell, 2017, Front. Pharmacol..

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

G. Besra, J. Lelièvre, David Barros, 2016, Scientific Reports.

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

George Papadatos, John P. Overington, Grace Mugumbate, 2015, PloS one.

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

Robert H Bates, David Barros, C. Chung, 2018, ChemMedChem.

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.

David Barros, L. Ballell-Pages, C. Chung, 2016, European journal of medicinal chemistry.

Discovery of a Potent and Speci fi c M . tuberculosis Leucyl-tRNA Synthetase Inhibitor : ( S ) ‐ 3-( Aminomethyl )

David Barros, J. Plattner, Esther Pérez-Herrán, 2017 .

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

David Barros, J. Plattner, Esther Pérez-Herrán, 2017, Journal of medicinal chemistry.

4‐Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween‐80 in vitro Dependent Families of Antitubercular Agents with Moderate in vivo Activity

David Barros, Lluís Ballell, Jaime. Escribano, 2011, ChemMedChem.

Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular Drugs

J. Lavandera, David Barros, Lluís Ballell, 2015, Antimicrobial Agents and Chemotherapy.

throughput translational medicine screen 2

Robert H Bates, T. Hankemeier, A. Ordas, 2014 .

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

Robert H Bates, N. Fotouhi, G. Besra, 2022, bioRxiv.

University of Birmingham Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

N. Loman, C. Constantinidou, M. Pallen, 2012 .

Repurposing clinically approved cephalosporins for tuberculosis therapy

C. Thompson, Fraser Cunningham, David Barros, 2016, Scientific Reports.

Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity*

Araceli, V. J. Winter, S. Croft, 2004, Journal of Biological Chemistry.

Hydrolysis of Clavulanate by Mycobacterium tuberculosis β-Lactamase BlaC Harboring a Canonical SDN Motif

H. van Tilbeurgh, David Barros, J. Mainardi, 2015, Antimicrobial Agents and Chemotherapy.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, G. Drewes, 2016, Nature Communications.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

G. Drewes, M. Bantscheff, G. Besra, 2016, Nature Microbiology.

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.

Christophe M. L. Vande Velde, Robert H Bates, Fraser Cunningham, 2018, Journal of medicinal chemistry.

Plasmodium falciparum: stage specific effects of a selective inhibitor of lactate dehydrogenase.

S. Croft, J. Lavandera, David Barros, 2005, Experimental parasitology.

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

N. Loman, C. Constantinidou, M. Pallen, 2013, PloS one.

Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.

S. Turk, David Barros, L. Ballell-Pages, 2015, Journal of medicinal chemistry.

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable β-Lactam Antibiotic

David Barros, J. Mckinney, N. Dhar, 2014, Antimicrobial Agents and Chemotherapy.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Christopher B. Cooper, Lisa K. Woolhiser, J. Sacchettini, 2016, Antimicrobial Agents and Chemotherapy.

Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities

J. Cechetto, David Barros, A. Garcia‐Bennett, 2014, Nanomaterials.

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

J. Sacchettini, E. Alvarez, J. Lavandera, 2016, EBioMedicine.

Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target

N. Loman, G. Besra, David Barros, 2014, PloS one.

Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in Mycobacterium tuberculosis by the Novel Drug Candidate GSK2556286

David Barros, B. VanderVen, L. Eltis, 2023, Antimicrobial agents and chemotherapy.

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

N. Loman, G. Besra, David Barros, 2017, Scientific Reports.

An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS.

José María Bueno, Esther Fernández, Simon J F Macdonald, 2011, ACS medicinal chemistry letters.

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.

S. Ekins, J. Lelièvre, David Barros, 2017, ACS infectious diseases.

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

N. Loman, C. Constantinidou, M. Pallen, 2012, PloS one.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, M. Bantscheff, 2016, Nature Communications.