H. Nikaido

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Properties of AdeABC and AdeIJK Efflux Systems of Acinetobacter baumannii Compared with Those of the AcrAB-TolC System of Escherichia coli

E. Sugawara, H. Nikaido, 2014, Antimicrobial Agents and Chemotherapy.

The BaeSR Two-Component Regulatory System Activates Transcription of the yegMNOB (mdtABCD) Transporter Gene Cluster in Escherichia coli and Increases Its Resistance to Novobiocin and Deoxycholate

H. Nikaido, N. Baranova, 2002, Journal of bacteriology.

Hiroshi Nikaido Deoxycholate Its Resistance to Novobiocin and and Increases Escherichia coli Cluster in ) Transporter Gene mdtABCD ( yegMNOB System Activates Transcription of the The BaeSR Two-Component Regulatory

H. Nikaido, N. Baranova, 2002 .

Extended deletions in the histidine-rough-B region of the Salmonella chromosome.

K. Nikaido, H. Nikaido, M. Levinthal, 1967, Proceedings of the National Academy of Sciences of the United States of America.

Outer membrane barrier as a mechanism of antimicrobial resistance

H. Nikaido, 1989, Antimicrobial Agents and Chemotherapy.

Molecular Basis of Bacterial Outer Membrane Permeability Revisited

H. Nikaido, 2003, Microbiology and Molecular Biology Reviews.

Christian Raetz: scientist and friend extraordinaire.

H. Nikaido, J. Stubbe, W. Wickner, 2013, Annual review of biochemistry.

The envelope of mycobacteria.

H. Nikaido, P. Brennan, 1995, Annual review of biochemistry.

Multidrug efflux pumps of gram-negative bacteria

H. Nikaido, 1996, Journal of bacteriology.

Quantitative lipid composition of cell envelopes of Corynebacterium glutamicum elucidated through reverse micelle extraction

H. Nikaido, Ritu Bansal-Mutalik, 2011, Proceedings of the National Academy of Sciences.

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.

H. Nikaido, J. Pagés, 2012, FEMS microbiology reviews.

Prevention of drug access to bacterial targets: permeability barriers and active efflux.

H. Nikaido, H Nikaido, 1994, Science.

Outer membrane of Salmonella typhimurium: accessibility of phospholipid head groups to phospholipase c and cyanogen bromide activated dextran in the external medium.

H. Nikaido, Y. Kamio, H Nikaido, 1976, Biochemistry.

Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa

H. Nikaido, X. Li, K. Poole, 1995, Antimicrobial agents and chemotherapy.

Biochemistry and Regulation of a NovelEscherichia coli K-12 Porin Protein, OmpG, Which Produces Unusually Large Channels

Rajeev Misra, Hiroshi Nikaido, E. Sugawara, 1998, Journal of bacteriology.

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

Hiroshi Nikaido, H. Nikaido, Xian-Zhi Li, 2015, Clinical Microbiology Reviews.

Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coli

J. Hearst, H. Nikaido, N. Pon, 1995, Molecular microbiology.

Multidrug Efflux Pump AcrAB of Salmonella typhimuriumExcretes Only Those β-Lactam Antibiotics Containing Lipophilic Side Chains

Hiroshi Nikaido, H. Nikaido, Vy Nguyen, 1998, Journal of bacteriology.

Molecular basis of bacterial outer membrane permeability.

H. Nikaido, M. Vaara, H Nikaido, 1985, Microbiological reviews.

CHAPTER 4 – Isolation and Chemical and Immunological Characterization of Bacterial Lipopolysaccharides

H. Nikaido, O. Westphal, O. Lüderitz, 1971 .

Proceedings of the 14th Symposium on Bacterial Toxins-International Session

J. Porath, H. Nikaido, N. Grecz, 1967 .

How are the ABC transporter

H. Nikaido, 2016 .

Contributions of MexAB-OprM and an EmrE Homolog to Intrinsic Resistance of Pseudomonas aeruginosa to Aminoglycosides and Dyes

H. Nikaido, K. Poole, Xian-Zhi Li, 2003, Antimicrobial Agents and Chemotherapy.

Sensitivity of Escherichia coli to various β‐lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β‐lactamases: a quantitative predictive treatment

H. Nikaido, S. Normark, Hiroshi Nikaido, 1987, Molecular microbiology.

Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide

H. Nikaido, Ying Zhang, A. Scorpio, 1999, Journal of bacteriology.

Specificity of diffusion channels produced by lambda phage receptor protein of Escherichia coli.

H. Nikaido, M. Luckey, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Specificity of the glucose channel formed by protein D1 of Pseudomonas aeruginosa.

H. Nikaido, J. Trias, E. Rosenberg, 1988, Biochimica et biophysica acta.

Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein

H. Nikaido, D. Bertenthal, E. Rosenberg, 2003, Molecular microbiology.

Mycolic Acid Structure Determines the Fluidity of the Mycobacterial Cell Wall*

J. Liu, G. Besra, H. Nikaido, 1996, The Journal of Biological Chemistry.

Fluidity of the lipid domain of cell wall from Mycobacterium chelonae.

H. Nikaido, E. Rosenberg, J. Liu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

PhoPQ-Mediated Regulation Produces a More Robust Permeability Barrier in the Outer Membrane of Salmonella enterica Serovar Typhimurium

Samuel I. Miller, H. Nikaido, T. Murata, 2007, Journal of bacteriology.

AcrD of Escherichia coli Is an Aminoglycoside Efflux Pump

H. Nikaido, D. Ma, E. Rosenberg, 2000, Journal of bacteriology.

Functional reconstitution of lens gap junction proteins into proteoliposomees

H. Nikaido, E. Rosenberg, 2005, The Journal of Membrane Biology.

In Pseudomonas aeruginosa ethidium bromide does not induce its own degradation or the assembly of pumps involved in its efflux.

A. Babayan, H. Nikaido, 2004, Biochemical and biophysical research communications.

Transport proteins in bacteria: common themes in their design.

M. Saier, H. Nikaido, M. Saier, 1992, Science.

Role, Structure, and Function of Multidrug Efflux Pumps in Gram-Negative Bacteria

H. Nikaido, 2005 .

Two modes of ligand binding in maltose-binding protein of Escherichia coli. Functional significance in active transport.

A. Ganesan, H. Nikaido, J. Chen, 1997, The Journal of biological chemistry.

Permeability of the mycobacterial cell wall.

H. Nikaido, V. Jarlier, 1991, Research in microbiology.

Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump

H. Nikaido, H. Takiff, J. Liu, 1996, Journal of bacteriology.

Structure and mechanism of RND-type multidrug efflux pumps.

H. Nikaido, 2011, Advances in enzymology and related areas of molecular biology.

Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins

H. Nikaido, X. Li, Xian-Zhi Li, 1997, Journal of bacteriology.

Identification of a cytoplasmic membrane-associated component of the maltose transport system of Escherichia coli.

M. Hofnung, H. Nikaido, P. Bavoil, 1980, The Journal of biological chemistry.

Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01.

R. Hancock, H. Nikaido, G. Decad, 1979, Biochimica et biophysica acta.

Membrane Permeability and Transport in Mycobacterium tuberculosis

N. Connell, H. Nikaido, 1994 .

Hydrophilic Solutes in Mycobacterium chelonei

H. Nikaido, Vincent JARLIERl, 2005 .

Galactose-sensitive mutants of Salmonella. I. Metabolism of galactose.

H. Nikaido, Hiroshi Nikaido, Hiroshi Nikaido, 1961, Biochimica et biophysica acta.

Formation of ‘Protoplasts’ in Mutant Strains of Salmonella induced by Galactose

T. Fukasawa, H. Nikaido, 1959, Nature.

Galactose-sensitive Mutants of Salmonella

T. Fukasawa, H. Nikaido, 1959, Nature.

Studies on the biosynthesis of cell-wall polysaccharide in mutant strains of Salmonella. I.

H. Nikaido, 1962, Proceedings of the National Academy of Sciences of the United States of America.

Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium

H. Nikaido, Y. Funahara, Yoshinori FUNAHARAt, 1980, Journal of bacteriology.

Hiroshi Nikaido and to Aminoglycosides aeruginosa Pseudomonas the Natural Resistance of Involvement of an Active Efflux System in

H. Nikaido, T. Köhler, J. Aires, 1999 .

Involvement of an Active Efflux System in the Natural Resistance of Pseudomonas aeruginosa to Aminoglycosides

H. Nikaido, T. Köhler, J. Aires, 1999, Antimicrobial Agents and Chemotherapy.

Protein Composition of the Outer Membrane of Salmonella typhimurium: Effect of Lipopolysaccharide Mutations

G. Ames, E. Spudich, H. Nikaido, 1974, Journal of bacteriology.

Interplay of cell wall barrier and beta-lactamase activity determines high resistance to beta-lactam antibiotics in Mycobacterium chelonae

H. Nikaido, L. Gutmann, V. Jarlier, 1991, Antimicrobial Agents and Chemotherapy.

Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis?

H. Nikaido, S. Kocagöz, C. Hackbarth, 1995, Antimicrobial agents and chemotherapy.

Outer membrane of gram-negative bacteria. XVII. Secificity of transport process catalyzed by the lambda-receptor protein in Escherichia coli.

H. Nikaido, K. von Meyenburg, K. Meyenburg, 1977, Biochemical and biophysical research communications.

Outer membranes of gram-negative bacteria. XIX. Isolation from Pseudomonas aeruginosa PAO1 and use in reconstitution and definition of the permeability barrier

R. Hancock, W. RobertE., H. Nikaido, 1978, Journal of bacteriology.

Proteins forming large channels from bacterial and mitochondrial outer membranes: porins and phage lambda receptor protein.

H. Nikaido, 1983, Methods in enzymology.

Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli.

H. Nikaido, A. Davidson, 1991, The Journal of biological chemistry.

Biosynthesis of Saccharides From Glycopyranosyl Esters of Nucleoside Pyrophosphates “Sugar Nucleotides”

H. Nikaido, W. Hassid, 1971 .

Physical interaction between lipid A and phospholipids: a study with spin-labeled phospholipids.

H. Nikaido, Y. Takeuchi, 1984, Reviews of infectious diseases.

Covalently Linked Trimer of the AcrB Multidrug Efflux Pump Provides Support for the Functional Rotating Mechanism

H. Nikaido, Y. Takatsuka, 2008, Journal of bacteriology.

Mutants of Escherichia coli That Are Resistant to Certain Beta-Lactam Compounds Lack the ompF Porin

H. Nikaido, M. Matsuhashi, Karen J. Harder, 1981, Antimicrobial Agents and Chemotherapy.

Biosynthesis of cell wall lipopolysaccharide in gram-negative enteric bacteria.

H. Nikaido, 1968, Advances in enzymology and related areas of molecular biology.

Biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. 3. Transfer of L-rhamnose and D-galactose.

H. Nikaido, 1965, Biochemistry.

Rough Mutants of Salmonella Typhimurium (3) Enzymatic Synthesis of Nucleotide-Sugar Compounds

K. Nikaido, H. Nikaido, B. Stocker, 1964, Nature.

Biosynthesis of Cell Wall Lipopolysaccharide in Mutants of Salmonella V. A Mutant of Salmonella typhimurium Defective in the Synthesis of Cytidine Diphosphoabequose

H. Nikaido, M. Levinthal, R. Yuasa, 1969, Journal of bacteriology.

Isolation of cytidine diphosphate 3,6-dideoxyhexoses from Salmonella.

H. Nikaido, K. Jokura, 1961, Biochemical and biophysical research communications.

Lipopolysaccharide in the taxonomy of Enterobacteriaceae

H. Nikaido, 1970 .

Genetic Determination of Enzymes Synthesizing O-Specific Sugars of Salmonella Lipopolysaccharides

K. Nikaido, H. Nikaido, P. Mäkelä, 1966, Journal of bacteriology.

Studies on the biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. II.

H. Nikaido, 1962, Proceedings of the National Academy of Sciences of the United States of America.

A Mycobacterium smegmatis mutant with a defective inositol monophosphate phosphatase gene homolog has altered cell envelope permeability

J. Liu, H. Nikaido, T. Parish, 1997, Journal of bacteriology.

Biosynthesis of uridine diphosphate N-acetylmannosaminuronic acid in rff mutants of Salmonella tryphimurium

H. Nikaido, P. Mäkelä, H. Lew, 1978, Journal of bacteriology.

Galactose-sensitive mutants of Salmonella. II. Bacteriolysis induced by galactose.

T. Fukasawa, H. Nikaido, Toshio Fukasawa, 1961, Biochimica et biophysica acta.

Existence and purification of porin heterotrimers of Escherichia coli K12 OmpC, OmpF, and PhoE proteins.

H. Nikaido, K. Gehring, 1989, The Journal of biological chemistry.

Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins

H. Nikaido, A. Raimondi, A. Traverso, 1991, Antimicrobial Agents and Chemotherapy.

Restoring permeability barrier function to outer membrane.

H. Nikaido, 2005, Chemistry & biology.

Outer membrane permeability and beta-lactamase stability of dipolar ionic cephalosporins containing methoxyimino substituents

W. Liu, H. Nikaido, W. Liu, 1990, Antimicrobial Agents and Chemotherapy.

Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams

H. Nikaido, H. Vu, 1985, Antimicrobial Agents and Chemotherapy.

Consequences of deletion mutations joining two operons of opposite polarity.

H. Nikaido, M. Levinthal, 1969, Journal of molecular biology.

Galactose mutants of Salmonella typhimurium.

T. Fukasawa, H. Nikaido, 1961, Genetics.

Glucosylation of lipopolysaccharide in Salmonella: biosynthesis nof O antigen factor n12 2 . II. Structure of the lipid intermediate.

K. Nikaido, H. Nikaido, 1971, The Journal of biological chemistry.

Can Penicillins and Other (cid:98) -Lactam Antibiotics Be Used To Treat Tuberculosis?

H. Nikaido, S. Kocagöz, C. Hackbarth, 1995 .

The role of outer membrane and efflux pumps in the resistance of gram-negative bacteria. Can we improve drug access?

H. Nikaido, Hiroshi Nikaido, 1998, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Outer membrane of Salmonella typhimurium. Electron spin resonance studies.

H. Nikaido, T. Nakae, S. Ohnishi, 1977, Biochimica et biophysica acta.

Outer membrane of Salmonella typhimurium: chemical analysis and freeze-fracture studies with lipopolysaccharide mutants

H. Nikaido, J. Smit, Y. Kamio, 1975, Journal of bacteriology.

A mutant form of maltose-binding protein of Escherichia coli deficient in its interaction with the bacteriophage lambda receptor protein

H. Nikaido, M. Schwartz, P. Bavoil, 1983, Journal of bacteriology.

Formation of phage receptors induced by galactose in a galactose-sensitive mutant of Salmonella.

T. Fukasawa, H. Nikaido, Toshio Fukasawa, 1960, Virology.

BIOSYNTHESIS OF CELL WALL POLYSACCHARIDE IN MUTANT STRAINS OF SALMONELLA. IV. SYNTHESIS OF S-SPECIFIC SIDE-CHAIN.

K. Nikaido, H. Nikaido, 1965, Biochemical and biophysical research communications.

SEMIROUGH STRAINS OF SALMONELLA.

H. Nikaido, B. Stocker, R. Wilkinson, 1965, Proceedings of the National Academy of Sciences of the United States of America.

Structure of cell wall lipopolysaccharide from Salmonella typhimurium. IV. Anomeric configuration of L-rhamnose residues and its taxonomic implications.

H. Kita, H. Nikaido, K. Nakane, 1970, Journal of bacteriology.

Biosynthesis of T1 Antigen in Salmonella: Origin of d-Galactofuranose and d-Ribofuranose Residues

M. Sarvas, H. Nikaido, 1971, Journal of bacteriology.

Biosynthesis of the 0-Antigenic Side-Chains of Lipopolysaccharide in Salmonella -Its Biochemistry and Genetics (Abstract)

H. Nikaido, M. Levinthal, 1967 .

BIOSYNTHESIS OF O‐ANTIGENIC POLYSACCHARIDES IN SALMONELLA

H. Nikaido, P. Mäkelä, Y. Naide, 1966, Annals of the New York Academy of Sciences.

Structure of cell wall lipopolysaccharide from Salmonella typhimurium. I. Linkage between o side chains and R core.

H. Nikaido, 1969, The Journal of biological chemistry.

Biosynthesis of enterobacterial common antigen requires dTDPglucose pyrophosphorylase determined by a Salmonella typhimurium rfb gene and a Salmonella montevideo rfe gene

H. Nikaido, H. Mayer, P. Mäkelä, 1986, Journal of bacteriology.

Structure and functions of the cell envelope of gram-negative bacteria.

H. Nikaido, 1988, Reviews of infectious diseases.

Enterobacterial common antigen in rfb deletion mutants of Salmonella typhimurium

H. Nikaido, G. Schmidt, H. Mayer, 1976, Journal of bacteriology.

Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance

H. Nikaido, 1989 .

Outer membrane of Salmonella typhimurium. Identification of proteins exposed on cell surface.

H. Nikaido, Y. Kamio, Hiroshi Nikaido, 1977, Biochimica et biophysica acta.

Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances.

H. Nikaido, Hiroshi Nikaido, 1976, Biochimica et biophysica acta.

Structure of cell wall lipopolysaccharide from Salmonella typhimurium. Further studies on the linkage between O side chains and R core.

H. Nikaido, 1970, European journal of biochemistry.

Structure of Cell Wall Lipopolysaccharide from Salmonella typhimurium IV. Anomeric Configuration of l-Rhamnose Residues and Its Taxonomic Implications

H. Kita, H. Nikaido, 1973 .

Cross-Linked Complex between Oligomeric Periplasmic Lipoprotein AcrA and the Inner-Membrane-Associated Multidrug Efflux Pump AcrB from Escherichia coli

H. Nikaido, H. Zgurskaya, 2000, Journal of bacteriology.

Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane

H. Nikaido, N. Masuda, J. Trias, 1993, Antimicrobial Agents and Chemotherapy.

Cell-Free System

M. Sarvas, H. Nikaido, 2020 .

Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.

H. Nikaido, A. Vargiu, A. Kinana, 2013, Biochemistry.

Determinants of OmpF porin antigenicity and structure.

H. Nikaido, S. Singh, T. Abdullah, 1990, The Journal of biological chemistry.

Maltose transport and starch binding in phage-resistant point mutants of maltoporin. Functional and topological implications.

M. Hofnung, H. Nikaido, K. Gehring, 1988, Journal of molecular biology.

CHAPTER 4 – Outer Membrane Permeability of Pseudomonas aeruginosa

H. Nikaido, 1986 .

Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin.

H. Nikaido, D. Gidalevitz, T. M. Nobre, 2015, Biophysical journal.

Chapter 27 Diffusion of inhibitors across the cell wall

H. Nikaido, 1994 .

Uptake of iron-siderophore complexes across the bacterial outer membrane.

H. Nikaido, 1993, Trends in microbiology.

Substrate path in the AcrB multidrug efflux pump of Escherichia coli

H. Nikaido, Fasahath Husain, 2010, Molecular microbiology.

Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates

H. Nikaido, J. Bohnert, Brian Karamian, 2010, Antimicrobial Agents and Chemotherapy.

Role of permeability barriers in resistance to β-lactam antibiotics

H. Nikaido, 1985 .

Persistence of segregated phospholipid domains in phospholipid--lipopolysaccharide mixed bilayers: studies with spin-labeled phospholipids.

H. Nikaido, Y. Takeuchi, 1981, Biochemistry.

To the happy few.

H. Nikaido, 2011, Annual review of microbiology.

Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides

Samuel I. Miller, F. Fang, H. Nikaido, 2003, Molecular microbiology.

Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes

F. Yoshimura, H. Nikaido, Fuminobu YOSHIMURAt, 1982, Journal of bacteriology.

Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra

H. Nikaido, T. Kocagöz, C. Hackbarth, 1996, Antimicrobial agents and chemotherapy.

Transport through the outer membrane of bacteria.

H. Nikaido, 1986, Methods in enzymology.

Export of autotransported proteins proceeds through an oligomeric ring shaped by C‐terminal domains

V. de Lorenzo, E. Sugawara, H. Nikaido, 2002, The EMBO journal.

ISOLATION OF URIDINE DIPHOSPHOGALACTOSE FROM ESCHERICHIA COLI MUTANT CELLS.

H. Nikaido, N. Morikawa, Y. Imae, 1964, Journal of Biochemistry (Tokyo).

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

P. Ruggerone, H. Nikaido, A. Vargiu, 2014, Antimicrobial Agents and Chemotherapy.

Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli

H. Nikaido, Fasahath Husain, Mihir Bikhchandani, 2011, Journal of bacteriology.

It takes three to tango

H. Nikaido, H. Zgurskaya, O. Lomovskaya, 2002, Nature Biotechnology.

AcrAB and related multidrug efflux pumps of Escherichia coli.

H. Nikaido, H. Zgurskaya, Hiroshi Nikaido, 2001, Journal of molecular microbiology and biotechnology.

Site-Directed Disulfide Cross-Linking Shows that Cleft Flexibility in the Periplasmic Domain Is Needed for the Multidrug Efflux Pump AcrB of Escherichia coli

H. Nikaido, Y. Takatsuka, 2007, Journal of bacteriology.

Site-Directed Disulﬁde Cross-Linking Shows that Cleft Flexibility in the Periplasmic Domain Is Needed for the Multidrug Efﬂux Pump AcrB of Escherichia coli (cid:1)

H. Nikaido, Y. Takatsuka, 2007 .

lrnrnunochernical structure of the OmpD porin f rorn Salmonella typhimurium

Kenneth, Stephanie I. Miller, Shiva, 2008 .

Nonspecific and specific diffusion channels in the outer membrane of Escherichia coli.

H. Nikaido, M. Luckey, E. Rosenberg, 1980, Journal of supramolecular structure.

Antibiotic efflux mechanisms.

H. Nikaido, H. Zgurskaya, Hiroshi Nikaido, 1999, Current opinion in infectious diseases.

Multidrug resistance in bacteria.

H. Nikaido, 2009, Annual review of biochemistry.

Kinetic Parameters of Efﬂux of Penicillins by the Multidrug Efﬂux Transporter AcrAB-TolC of Escherichia coli (cid:1)

H. Nikaido, S. Lim, 2010 .

A MATE Family Multidrug Efflux Transporter Pumps out Fluoroquinolones in Bacteroides thetaiotaomicron

F. Yoshimura, H. Nikaido, Yoshinobu Tanaka, 2001, Antimicrobial Agents and Chemotherapy.

High-Level Fluoroquinolone-Resistant Clinical Isolates of Escherichia coli Overproduce Multidrug Efflux Protein AcrA

H. Nikaido, G. Cornaglia, A. Mazzariol, 2000, Antimicrobial Agents and Chemotherapy.

Covalently Linked Trimers of RND (Resistance-Nodulation-Division) Efflux Transporters to Study Their Mechanism of Action: Escherichia coli AcrB Multidrug Exporter as an Example.

H. Nikaido, 2018, Methods in molecular biology.

Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups

H. Nikaido, E. Rosenberg, Hiroshi Nikaido, 1990, Journal of bacteriology.

Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to cephalosporins during therapy.

A. Medeiros, H. Nikaido, T. O'Brien, 1987, The Journal of infectious diseases.

Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.

H. Nikaido, A. Vargiu, A. Kinana, 2016, Biochemical and biophysical research communications.

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

H. Nikaido, N. Peet, T. Opperman, 2015, Bioorganic & medicinal chemistry.

Active Efflux of Norfloxacin byBacteroides fragilis

F. Yoshimura, H. Nikaido, Yoshinobu Tanaka, 1998, Antimicrobial Agents and Chemotherapy.

Identification and characterization of porins in Pseudomonas aeruginosa.

K. Nikaido, H. Nikaido, S. Harayama, 1991, The Journal of biological chemistry.

Pseudomonas aeruginosa. proteins OmpA of Escherichia coli and OprF of Secondary structure of the outer membrane

E. Sugawara, H. Nikaido, M. Steiert, 2013 .

Mutation in Serratia marcescens AmpC β-Lactamase Producing High-Level Resistance to Ceftazidime and Cefpirome

H. Nikaido, A. Raimondi, F. Sisto, 2001, Antimicrobial Agents and Chemotherapy.

Active Efﬂux of Fluoroquinolones in Mycobacterium smegmatis Mediated by LfrA, a Multidrug Efﬂux Pump

H. Nikaido, H. Takiff, Jun Liu, 1996 .

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

Hiroshi Nikaido, H. Nikaido, K. Nagano, 2009, Proceedings of the National Academy of Sciences.

Ligand‐transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay

H. Nikaido, C. Su, E. Yu, 2007, FEBS letters.

Biosynthesis of T1 Antigen in Salmonella: Biosynthesis in a Cell-Free System

M. Sarvas, H. Nikaido, 1971, Journal of Bacteriology.

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

H. Nikaido, Ritu Bansal-Mutalik, 2014, Proceedings of the National Academy of Sciences.

Antibiotic resistance caused by gram-negative multidrug efflux pumps.

H. Nikaido, 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples

H. Nikaido, D. Thanassi, 1993, Antimicrobial Agents and Chemotherapy.

Diffusion of beta-lactam antibiotics through the porin channels of Escherichia coli K-12

F. Yoshimura, H. Nikaido, Fuminobu YOSHIMURAt, 1985, Antimicrobial Agents and Chemotherapy.

Porin channels in Escherichia coli: studies with beta-lactams in intact cells

H. Nikaido, J. Foulds, E. Rosenberg, 1983, Journal of bacteriology.

Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa

H. Nikaido, J. Trias, 1990, Antimicrobial Agents and Chemotherapy.

Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins.

H. Nikaido, A. Davidson, H. Shuman, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Active efflux of bile salts by Escherichia coli

H. Nikaido, D. Thanassi, L. Cheng, 1997, Journal of bacteriology.

The Outer Membrane of Gram-negative Bacteria

H. Nikaido, T. Nakae, 1980 .

The C-Terminal Domain of Salmonella enterica Serovar Typhimurium OmpA Is an Immunodominant Antigen in Mice but Appears To Be Only Partially Exposed on the Bacterial Cell Surface

Stephanie I. Miller, H. Nikaido, Y. U. Williams, 2003, Infection and Immunity.

Phospholipid as a possible component of carrier system in beta-galactoside permease of Escherichia coli.

H. Nikaido, 1962, Biochemical and biophysical research communications.

Antimicrobial Drug Efflux Pumps in Escherichia coli

H. Nikaido, Xian-Zhi Li, Xian-Zhi Li, 2016 .

Efflux-Mediated Drug Resistance in Bacteria

Hiroshi Nikaido, H. Nikaido, Xian-Zhi Li, 2012, Drugs.

Stimulation of glutamine transport by osmotic stress in Escherichia coli K-12

M. Hofnung, H. Nikaido, K. Gehring, 1990, Journal of bacteriology.

Efflux-Mediated Drug Resistance in Bacteria

H. Nikaido, Xian-Zhi Li, Xian-Zhi Li, 2009, Drugs.

Diffusion of 1-Lactam Antibiotics Through the Porin Channels of Escherichia coli K-12

H. Nikaido, Fuminobu YOSHIMURAt, 2022 .

Role of ,B-Lactam Hydrolysis in the Mechanism of Resistance of a 3-Lactamase-Constitutive Enterobacter cloacae Strain to Expanded-Spectrum r-Lactams

H. Nikaido, 2022 .

Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli

H. Nikaido, S. Lim, 2010, Antimicrobial Agents and Chemotherapy.

Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli.

H. Nikaido, H. Zgurskaya, 1999, Proceedings of the National Academy of Sciences of the United States of America.

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants

H. Nikaido, D. Ma, H. Okusu, 1996, Journal of bacteriology.

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

P. Ruggerone, H. Nikaido, A. Vargiu, 2016, Proceedings of the National Academy of Sciences of the United States of America.

Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump

H. Nikaido, A. Vargiu, A. Kinana, 2016, Proceedings of the National Academy of Sciences.

, with Other Inhibitors Multidrug Efflux Pump and Comparison Inhibition of Escherichia coli AcrB Molecular Mechanism of MBX 2319

P. Ruggerone, H. Nikaido, A. Vargiu, 2014 .

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

Attilio V Vargiu, Hiroshi Nikaido, H. Nikaido, 2012, Proceedings of the National Academy of Sciences.

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

Hiroshi Nikaido, H. Nikaido, Yumiko Takatsuka, 2010, Proceedings of the National Academy of Sciences.

Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria.

I. Paulsen, M. Saier, M. Sliwinski, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Active efflux of antimicrobial agents in wild-type strains of enterococci

H. Nikaido, P. Courvalin, C. Lynch, 1997, Antimicrobial agents and chemotherapy.

Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance

D. Livermore, H. Nikaido, X. Li, 1994, Antimicrobial Agents and Chemotherapy.

Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin

D. Livermore, H. Nikaido, X. Li, 1994, Antimicrobial Agents and Chemotherapy.

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

J. Hearst, H. Nikaido, N. Pon, 1993, Journal of bacteriology.

Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli.

H. Nikaido, Hong-Suk Kim, 2012, Biochemistry.

Mechanisms of RND multidrug efflux pumps.

H. Nikaido, Y. Takatsuka, 2009, Biochimica et biophysica acta.

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

H. Nikaido, S. D’Souza, G. Walker, 2013, Antimicrobial Agents and Chemotherapy.

Contributions of the AmpC β-Lactamase and the AcrAB Multidrug Efflux System in Intrinsic Resistance of Escherichia coli K-12 to β-Lactams

H. Nikaido, G. Cornaglia, A. Mazzariol, 2000, Antimicrobial Agents and Chemotherapy.

Role of permeability barriers in resistance to beta-lactam antibiotics.

H. Nikaido, 1985, Pharmacology & therapeutics.

A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study

G. McDermott, H. Nikaido, J. Aires, 2005, Journal of bacteriology.

Multidrug resistance mechanisms: drug efflux across two membranes

Hiroshi Nikaido, H. Nikaido, H. Zgurskaya, 2000, Molecular microbiology.

The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump

H. Nikaido, W. Pan, M. Viñas, 1997, Journal of bacteriology.

AcrA is a highly asymmetric protein capable of spanning the periplasm.

H. Nikaido, H. Zgurskaya, Hiroshi Nikaido, 1999, Journal of molecular biology.

Multiple antibiotic resistance and efflux.

H. Nikaido, Hiroshi Nikaido, 1998, Current opinion in microbiology.

Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli

H. Nikaido, D. Thanassi, Greg S B Suh, 1995, Journal of bacteriology.

Aminoglycosides Are Captured from both Periplasm and Cytoplasm by the AcrD Multidrug Efflux Transporter of Escherichia coli

H. Nikaido, J. Aires, 2005, Journal of bacteriology.

Mechanistic parallels in bacterial and human multidrug efflux transporters.

H. Nikaido, H. Zgurskaya, 2002, Current protein and peptide science.

Contributions of the AmpC b -Lactamase and the AcrAB Multidrug Efﬂux System in Intrinsic Resistance of Escherichia coli K-12 to b -Lactams

H. Nikaido, G. Cornaglia, A. Mazzariol, 2000 .

The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals

J. Hearst, H. Nikaido, M. Alberti, 1996, Molecular microbiology.

The effect of mutation in a structural gene on the inducibility of the enzymes controlled by other genes of the same operon.

T. Fukasawa, H. Nikaido, T. Fukasawa, 1961, Biochemical and biophysical research communications.

Outer membranes of Gram‐negative bacteria are permeable to steroid probes

H. Nikaido, P. Plésiat, 1992, Molecular microbiology.

Efflux pumps and drug resistance in gram-negative bacteria.

J. Hearst, H. Nikaido, D. N. Cook, 1994, Trends in microbiology.

Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins

H. Nikaido, H Nikaido, E Y Rosenberg, 1983, Journal of bacteriology.

Chimeric Analysis of AcrA Function Reveals the Importance of Its C-Terminal Domain in Its Interaction with the AcrB Multidrug Efflux Pump

C. Elkins, H. Nikaido, 2003, Journal of bacteriology.

Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides.

H. Nikaido, J. Trias, 1990, The Journal of biological chemistry.

Porins and specific channels of bacterial outer membranes

H. Nikaido, Hiroshi Nikaido, 1992, Molecular microbiology.

Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria.

H. Nikaido, 2001, Seminars in cell & developmental biology.

Outer membrane of gram-negative bacteria. XVIII. Electron microscopic studies on porin insertion sites and growth of cell surface of Salmonella typhimurium

H. Nikaido, J. Smit, Hiroshi Nikaido, 1978, Journal of bacteriology.

Outer membrane of gram-negative bacteria. XII. Molecular-sieving function of cell wall

H. Nikaido, G. Decad, 1976, Journal of bacteriology.

Porins and specific diffusion channels in bacterial outer membranes.

H. Nikaido, Hiroshi Nikaido, 1994, The Journal of biological chemistry.

Mycobacterial cell wall: structure and role in natural resistance to antibiotics.

H. Nikaido, V. Jarlier, H Nikaido, 1994, FEMS microbiology letters.

Efflux Pump-Mediated Intrinsic Drug Resistance in Mycobacterium smegmatis

H. Nikaido, Xian-Zhi Li, Li Zhang, 2004, Antimicrobial Agents and Chemotherapy.

Overview of bacterial ABC transporters.

H. Nikaido, J. Hall, Hiroshi Nikaido, 1998, Methods in enzymology.

Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin

H. Nikaido, S. Raina, C. Dartigalongue, 2000, The EMBO journal.

Physical organization of lipids in the cell wall of Mycobacterium chelonae

Sung-Hou Kim, H. Nikaido, E. Rosenberg, 1993, Molecular microbiology.

Permeability barrier to hydrophilic solutes in Mycobacterium chelonei

H. Nikaido, V. Jarlier, H Nikaido, 1990, Journal of bacteriology.

How are the ABC transporters energized?

H. Nikaido, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Microbial Biotechnology: Fundamentals of Applied Microbiology

Alexander N. Glazer, Hiroshi Nikaido, H. Nikaido, 1995 .

Protein I of Neisseria gonorrhoeae outer membrane is a porin

H. Nikaido, J. Douglas, Michael D. Lee, 1981 .

Porins of Brucella species

H. Nikaido, A. Winter, J. Douglas, 1984, Infection and immunity.

High Salt Concentrations Increase Permeability through OmpC Channels of Escherichia coli*

S. Kojima, H. Nikaido, 2014, The Journal of Biological Chemistry.

contributing factor to beta-lactam resistance. Pseudomonas aeruginosa: active efflux as a Role of efflux pump(s) in intrinsic resistance of

D. Livermore, H. Nikaido, 2013 .

Two modes of ligand binding in maltose-binding protein of Escherichia coli. Correlation with the structure of ligands and the structure of binding protein.

H. Nikaido, K. Gehring, J. Hall, 1997, The Journal of biological chemistry.

Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels

Seiji Kojima, Hiroshi Nikaido, S. Kojima, 2013, Proceedings of the National Academy of Sciences.

Partitioning of hydrophobic probes into lipopolysaccharide bilayers.

H. Nikaido, M. Vaara, W. Plachy, 1990, Biochimica et biophysica acta.

Lipopolysaccharide structure required for in vitro trimerization of Escherichia coli OmpF porin

H. Nikaido, K. Sen, 1991, Journal of bacteriology.

Microdermatology: Cell Surface in the Interaction of Microbes with the External World

H. Nikaido, 1999, Journal of bacteriology.

Sequence of the malK gene in E.coli K12.

E. Gilson, M. Hofnung, H. Nikaido, 1982, Nucleic acids research.

Physical interaction between the phage lambda receptor protein and the carrier-immobilized maltose-binding protein of Escherichia coli.

H. Nikaido, P. Bavoil, 1981, The Journal of biological chemistry.

Diffusion of solutes through channels produced by phage lambda receptor protein of Escherichia coli: inhibition by higher oligosaccharides of maltose series.

H. Nikaido, M. Luckey, 1980, Biochemical and biophysical research communications.

Outer membrane of Salmonella XIV. Reduced transmembrane diffusion rates in porin-deficient mutants.

H. Nikaido, L. Shaltiel, M. Nurminen, 1977, Biochemical and biophysical research communications.

Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding.

F A Quiocho, F. Quiocho, H. Nikaido, 2001, Journal of molecular biology.

Pseudomonas aeruginosa PORIN OprF: PROPERTIES OF THE CHANNEL

E. Sugawara, H. Nikaido, S. Bezrukov, 2006 .

Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC

S. Kojima, E. Sugawara, H. Nikaido, 2016, Journal of bacteriology.

Accessibility of lysyl residues of Escherichia coli B/r porin (OmpF) to covalent labeling reagents of different sizes. An approach for a three-dimensional structure of a channel-forming protein.

H. Nikaido, S. Ichihara, J. Schlaeppi, 1985, The Journal of biological chemistry.

Stoichiometry of maltodextrin-binding sites in LamB, an outer membrane protein from Escherichia coli

H. Nikaido, K. Gehring, B. Jap, 1991, Journal of bacteriology.

In vitro trimerization of OmpF porin secreted by spheroplasts of Escherichia coli.

H. Nikaido, K. Sen, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Substrate Specificity of the RND-Type Multidrug Efflux Pumps AcrB and AcrD of Escherichia coli Is Determined Predominately by Two Large Periplasmic Loops

C. Elkins, H. Nikaido, 2002, Journal of bacteriology.

Trimerization of an in vitro synthesized OmpF porin of Escherichia coli outer membrane.

H. Nikaido, K. Sen, 1991, The Journal of biological chemistry.

Bacteriophage Lambda Receptor Protein in Escherichia coli K-12: Lowered Affinity of Some Mutant Proteins for Maltose-Binding Protein In Vitro

H. Nikaido, M. Luckey, 1983, Journal of bacteriology.

Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli

H. Nikaido, H Nikaido, E Y Rosenberg, 1981, The Journal of general physiology.

Specificity of diffusion channels produced by X phage receptor protein of Escherichia coli (liposomes/reconstitution/outer membrane/facilitated diffusion/maltose)

H. Nikaido, M. Luckey, 1980 .

Pseudomonas aeruginosa Porin OprF Exists in Two Different Conformations*

E. Sugawara, H. Nikaido, S. Bezrukov, 2006, Journal of Biological Chemistry.

Permeability of the outer membrane of bacteria.

H. Nikaido, Hiroshi Nikaido, 1979, Angewandte Chemie.

Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa

H. Nikaido, J. Trias, R. Lévesque, 1989, Antimicrobial Agents and Chemotherapy.

Regulation of the maltose transport system of Escherichia coli by the glucose-specific enzyme III of the phosphoenolpyruvate-sugar phosphotransferase system. Characterization of inducer exclusion-resistant mutants and reconstitution of inducer exclusion in proteoliposomes.

M. Saier, H. Nikaido, D. Dean, 1990, The Journal of biological chemistry.

Amino acid sequence homology among the major outer membrane proteins of Escherichia coli.

H. Nikaido, H. C. Wu, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Purification and properties of Pseudomonas aeruginosa porin.

F. Yoshimura, H. Nikaido, L. Zalman, 1983, The Journal of biological chemistry.

OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii

E. Sugawara, H. Nikaido, 2012, Journal of bacteriology.

, Etsuko Channels OmpG , Which Produces Unusually Large K-12 Porin Protein , Escherichia coli Biochemistry and Regulation of a Novel

E. Sugawara, H. Nikaido, R. Misra, 1998 .

Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa

E. Sugawara, H. Nikaido, M. Steiert, 1996, Journal of bacteriology.

Outer Membrane Permeability of Gram-Negative Bacteria in their Interaction with the Outside World

H. Nikaido, 1984 .

Structural and Functional Analyses of the Major Outer Membrane Protein of Chlamydia trachomatis

E. Sugawara, H. Nikaido, E. Peterson, 2007, Journal of bacteriology.

Glucosylation of lipopolysaccharide in Salmonella: biosynthesis of O antigen factor 12 2 . I. Over-all reaction.

K. Nikaido, H. Nikaido, T. Nakae, 1971, The Journal of biological chemistry.

Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein

H. Nikaido, K. Gehring, D. Dean, 1989, Journal of bacteriology.

Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli

Keith D. Morrison, H. Nikaido, Jon W. Weeks, 2015, Journal of bacteriology.

Extensive homology between membrane-associated components of histidine and maltose transport systems of Salmonella typhimurium and Escherichia coli.

E. Gilson, M. Hofnung, C. Higgins, 1982, The Journal of biological chemistry.

Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane.

H. Nikaido, J. Hellman, H Nikaido, 1988, The Journal of biological chemistry.

A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates.

H. Nikaido, J. Liu, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Pleiotropic transport mutants of Escherichia coli lack porin, a major outer membrane protein

H. Nikaido, K. Meyenburg, P. Bavoil, 1977, Molecular and General Genetics MGG.

[Bacterial lipopolysaccharides].

H. Nikaido, 1967, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Transport across the bacterial outer membrane

H. Nikaido, 1993, Journal of bioenergetics and biomembranes.

Bacterial resistance to antibiotics as a function of outer membrane permeability.

H. Nikaido, Hiroshi Nikaido, 1988, The Journal of antimicrobial chemotherapy.

Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway

G. McDermott, H. Nikaido, Ming Li, 2006, Journal of bacteriology.

AcrB Multidrug Efflux Pump of Escherichia coli: Composite Substrate-Binding Cavity of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity

H. Nikaido, J. Aires, E. Yu, 2003, Journal of bacteriology.

Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa

E. Sugawara, H. Nikaido, K. Nagano, 2012, The FEBS journal.

Preparation and reconstitution of membrane-associated maltose transporter complex of Escherichia coli.

H. Nikaido, A. Davidson, J. Hall, 1998, Methods in enzymology.

Two modes of ligand binding in maltose-binding protein of Escherichia coli. Electron paramagnetic resonance study of ligand-induced global conformational changes by site-directed spin labeling.

T. Thorgeirsson, J. Liu, H. Nikaido, 1997, The Journal of biological chemistry.

Overproduction, solubilization, and reconstitution of the maltose transport system from Escherichia coli.

H. Nikaido, A. Davidson, 1990, The Journal of biological chemistry.

Maltose transport in membrane vesicles of Escherichia coli is linked to ATP hydrolysis.

H. Nikaido, D. Dean, A. Davidson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

Gerry McDermott, Helen I Zgurskaya, Hiroshi Nikaido, 2003, Science.

Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump.

E. Nogales, K. Downing, H. Nikaido, 2001, Journal of structural biology.

3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm.

C. Elkins, H. Nikaido, 2003, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

RND transporters in the living world.

H. Nikaido, 2018, Research in microbiology.

Maltose transport system of Escherichia coli: An ABC‐type transporter

H. Nikaido, 1994, FEBS letters.

Interaction between maltose‐binding protein and the membrane‐associated maltose transporter complex in Escherichia coli

H. Nikaido, L. Hor, D. Dean, 1992, Molecular microbiology.

Pore-forming activity of OmpA protein of Escherichia coli.

E. Sugawara, H. Nikaido, H Nikaido, 1992, The Journal of biological chemistry.

The role of ATP as the energy source for maltose transport in Escherichia coli.

H. Nikaido, D. Dean, A. Davidson, 1990, Research in microbiology.

[19] Isolation of epimeraseless mutants

H. Nikaido, 1966 .

Threonine-978 in the Transmembrane Segment of the Multidrug Efflux Pump AcrB of Escherichia coli Is Crucial for Drug Transport as a Probable Component of the Proton Relay Network

H. Nikaido, Y. Takatsuka, 2006, Journal of bacteriology.

Outer Membrane, Gram-Negative Bacteria

H. Nikaido, 2019, Reference Module in Life Sciences.

Isolation of outer membranes.

H. Nikaido, Hiroshi Nikaido, 1994, Methods in enzymology.

Biosynthesis of T1 Antigen in Salmonella: Biosynthesis in a Cell-Free System

M. Sarvas, H. Nikaido, 1971, Journal of bacteriology.

Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses in Salmonella.

K. Nikaido, H. Nikaido, 1966, The Journal of biological chemistry.

How do exported proteins and antibiotics bypass the periplasm in Gram-negative bacterial cells?

H. Nikaido, 2000, Trends in microbiology.

Seiji Kojima and Hiroshi Nikaido Escherichia coli High Salt Concentrations Increase Permeability through OmpC Channels

S. Kojima, H. Nikaido, 2014 .

X-ray diffraction studies of outer membranes of Salmonella typhimurium.

H. Nikaido, T. Mitsui, T. Ueki, 1979, Journal of biochemistry.

Porins ofBrucella Species

H. Nikaido, 1984 .

Proteins Forming Large Channels in Biological Membranes

H. Nikaido, 1982 .

Factors Affecting the Folding of Pseudomonas aeruginosa OprF Porin into the One-Domain Open Conformer

E. Sugawara, H. Nikaido, K. Nagano, 2010, mBio.

Microbial Biotechnology: Microbial Biotechnology: Scope, Techniques, Examples

H. Nikaido, A. Glazer, 2007 .

Microbial Biotechnology: Fundamentals of Applied Microbiology

H. Nikaido, A. Glazer, Hiroshi Nikaido, 1995 .

Multidrug Efflux Pump MdtBC of Escherichia coli Is Active Only as a B2C Heterotrimer

H. Nikaido, D. Nagore, Hong-Suk Kim, 2009, Journal of bacteriology.

Involvement of an Active Efflux System in the Natural Resistance of Pseudomonas aeruginosa to Aminoglycosides

H. Nikaido, T. Köhler, J. Aires, 1999 .

Evolutionary origins of multidrug and drug‐specific efflux pumps in bacteria

I. Paulsen, M. Saier, H. Nikaido, 1998 .

Acinetobacter baumanii Compared with Those of AcrAB-TolC

E. Sugawara, H. Nikaido, 2014 .

Immunochemical structure of the OmpD porin from Salmonella typhimurium.

K. Rudd, H. Nikaido, S. Singh, 1996, Microbiology.

Vestibules Are Part of the Substrate Path in the Multidrug Efﬂux Transporter AcrB of Escherichia coli (cid:1)

H. Nikaido, Fasahath Husain, Mihir Bikhchandani, 2011 .

Christian Raetz: scientist and friend extraordinaire.

H. Nikaido, J. Stubbe, W. Wickner, 2013, Annual review of biochemistry.

Biosynthesis of thymidine diphosphate L-rhamnose in Escherichia coli K-12.

K. Nikaido, H. Nikaido, A. Rapin, 1965, Biochimica et biophysica acta.

Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli

H. Nikaido, E. Rosenberg, 1981, The Journal of general physiology.

An NMR study of ligand binding by maltodextrin binding protein

D. Wemmer, H. Nikaido, K. Gehring, 1998 .

Site-directed disulfide cross-linking to probe conformational changes of a transporter during its functional cycle: Escherichia coli AcrB multidrug exporter as an example.

H. Nikaido, Y. Takatsuka, 2010, Methods in molecular biology.

Phage lambda receptor protein from Escherichia coli

H. Nikaido, H. Sandermann, P. Bavoil, 1978, FEBS letters.

Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway

G. McDermott, H. Nikaido, Ming Li, 2006, Journal of bacteriology.

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

H. Nikaido, Ritu Bansal-Mutalik, 2014, Proceedings of the National Academy of Sciences.

Crossing the envelope: how cephalosporins reach their targets.

H. Nikaido, 2000, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Multidrug Efflux Pump MdtBC of Escherichia coli Is Active Only as a B2C Heterotrimer

H. Nikaido, D. Nagore, Hong-Suk Kim, 2009, Journal of bacteriology.

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

H. Nikaido, N. Peet, T. Opperman, 2015, Bioorganic & medicinal chemistry.