D. Santi

D. Santi, G. Ashley, B. Malcolm, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The mechanism of pseudouridine synthase I as deduced from its interaction with 5-fluorouracil-tRNA.

D. Santi, Y. Liu, X. Gu, 1999, Proceedings of the National Academy of Sciences of the United States of America.

5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase.

A. Matsuda, D. Santi, J. Wu, 1988, Biochemistry.

A rapid method for determination of endoproteinase substrate specificity: Specificity of the 3C proteinase from hepatitis A virus (proteinase/Edman

D. Jewell, J. Kirsch, D. Santi, 2022 .

A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts.

D. Santi, C. Garrett, 1979, Analytical biochemistry.

Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.

D. Santi, W. Washtien, 1979, Cancer research.

Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system

S. Pfaff, D. Santi, G. Ashley, 2018, Journal of controlled release : official journal of the Controlled Release Society.

On the mechanism of DNA-adenine methylase.

D. Santi, A. Ono, A. Pogolotti, 1988, The Journal of biological chemistry.

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site.

D. Santi, P. Danenberg, 1971, Biochemistry.

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site.

D. Santi, P. Danenberg, K. Montgomery, 1971, Biochemistry.

Order of substrate binding to tyrosyl‐tRNA synthetase of Escherichia coli B

D. Santi, V. A. Pena, 1971, FEBS letters.

Recognition of the T-arm of tRNA by tRNA (m5U54)-methyltransferase is not sequence specific.

D. Santi, K. Ivanetich, X. Gu, 1996, Biochemistry.

Cloning, expression, purification, and characterization of 2'-deoxyuridylate hydroxymethylase from phage SPO1.

D. Santi, L. Livi, U. Schellenberger, 1995, Protein expression and purification.

Identification of the catalytic nucleophile of tRNA (m5U54)methyltransferase.

D. Santi, J. Kealey, 1991, Biochemistry.

Folylpolyglutamates in Leishmania major.

D. Santi, B. Shane, P. Nolan, 1987, Biochemical and biophysical research communications.

Pneumocystis carinil Pneumonia Treated With a-Difluoromethylorn ithi ne A Prospective Study Among Patients With the Acquired Immunodeficiency Syndrome

J. Golden, A. Sjoerdsma, D. Santi, 2004 .

Model studies of thymidylate synthetase. Intramolecular catalysis of 5-hydrogen exchange and 5-hydroxymethylation of 1-substituted uracils.

D. Santi, C. Brewer, 1973, Biochemistry.

Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme.

D. Santi, R. Duncan, M. Trujillo, 1997, Protein engineering.

Reaction of 5-ethynyl-2'-deoxyuridylate with thiols and thymidylate synthetase.

P. Barr, D. Santi, M. Robins, 1983, Biochemistry.

[6] Use of secondary α-hydrogen isotope effects in reactions of pyrimidine nucleoside/nucleotide metabolism: Thymidylate synthetase

Y. Wataya, D. Santi, T. W. Bruice, 1980 .

Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?

D. Santi, F. Bidard, L. Cabel, 2021, Annals of translational medicine.

A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst.

D. Santi, L. Huang, M. Pookanjanatavip, 1998, Biochemistry.

Irreversible Enzyme Inhibitors LXIX: Candidate Active-Site-Directed Irreversible Inhibitors of Dihydrofolic Reductase III. Bromoacyl Derivatives of 5-(p-Aminophenoxypropyl)-2,4,6-Triaminopyrimidines

D. Santi, B. R. Baker, 1967 .

Analogs of tetrahydrofolic acid. XXXIX . selective bromoacylation of polyfunctional molecules for synthesis of active-site-directed irreversible enzyme inhibitors†

D. Santi, J. Jordaan, J. Coward, 1966 .

Thymidylate synthetase. Model studies of inhibition by 5-trifluoromethyl-2'-deoxyuridylic acid.

D. Santi, T. Sakai, 1971, Biochemistry.

High‐throughput, aseptic production of injectable Tetra‐PEG hydrogel microspheres for delivery of releasable covalently bound drugs

D. Santi, G. Ashley, Jeff Henise, 2020, Engineering Reports.

Heterodimeric thymidylate synthases with C-terminal deletion on one subunit.

D. Santi, C. Carreras, P. M. Costi, 1994, The Journal of biological chemistry.

Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.

R M Stroud, R. Stroud, K. M. Perry, 1993, Biochemistry.

Secondary alpha-hydrogen isotope effects on the interaction of 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate with thymidylate synthetase.

D. Santi, T. W. Bruice, 1982, Biochemistry.

Molecular modeling and crystal structure of ERK2-hypothemycin complexes.

Giulio Rastelli, G. Rastelli, R. Rosenfeld, 2008, Journal of structural biology.

Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains.

John R Carney, D. Santi, S. Chandran, 2006, Chemistry & biology.

A multiplasmid approach to preparing large libraries of polyketides.

C R Hutchinson, D. Santi, G. Ashley, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Perspective on the design and biochemical pharmacology of inhibitors of thymidylate synthetase.

D. Santi, 1980, Journal of medicinal chemistry.

Metabolism and mechanism of action of formycin B in Leishmania.

D. Santi, P. Rainey, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Tyrosyl transfer ribonucleic acid synthetase from Escherichia coli B. Analysis of tyrosine and adenosine 5'-triphosphate binding sites.

D. Santi, V. A. Pena, 1973, Journal of medicinal chemistry.

The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I

Robert M. Stroud, R. Stroud, D. Santi, 2000, Nature Structural Biology.

Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages

J. Berman, D. Santi, P. Rainey, 1983, The Journal of experimental medicine.

Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.

R. Reid, D. Santi, J. Kennedy, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid.

D. Santi, B. Ho, J. Coward, 1966, Journal of pharmaceutical sciences.

Nuclcophilic substitution reactions of 5-acetoxymethyl-and 5-p-nitrophenoxymethyluraeils †

D. Santi, A. L. Pogololti, 1971 .

Oxygen-alkyl ester cleavage of 5 -acetoxymethyl uracils

D. Santi, A. Pogolotti, 1968 .

Semisynthesis and Cytotoxicity of Hypothemycin Analogues

D. Santi, B. Hearn, Jonah Cannoy, 2007, ChemMedChem.

Analogs of tetrahydrofolic acid XXIV. Further observations on the mode of pyrimidyl binding to dihydrofolic reductase and thymidylate synthetase by the 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol type of inhibitor.

D. Santi, B. R. Baker, 1965, Journal of pharmaceutical sciences.

Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.

Y. Wataya, D. Santi, M. Saneyoshi, 1980, Journal of medicinal chemistry.

Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines.

D. Santi, B. R. Baker, H. O. Beng-Thong, 1965, Journal of pharmaceutical sciences.

ANALOGS OF TETRAHYDROFOLIC ACID. X. SYNTHETIC AND ENZYMIC STUDIES ON THE CONTRIBUTION OF THE P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES.

D. Santi, B. R. Baker, P. Almaula, 1964, Journal of medicinal chemistry.

Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

Y. Wataya, D. Santi, T. James, 1976, Biochemical and biophysical research communications.

INHIBITORS OF THYMIDYLATE SYNTHETASE

Y. Wataya, A. Matsuda, D. Santi, 1979 .

Studies on the preparation and exchange reactions of 5‐deuterated uracils

D. Santi, C. Brewer, D. Farber, 1970 .

Partial purification of a glucocorticoid receptor.

D. Santi, G. Tomkins, D. Failla, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli B. Potent inhibition by analogues of N-benzyl-2-phenylethylamine.

D. Santi, R. Anderson, 1976, Journal of medicinal chemistry.

Interaction of thymidylate synthetase with 5-nitro-2'-deoxyuridylate.

Y. Wataya, A. Matsuda, D. Santi, 1980, The Journal of biological chemistry.

5-Nitro-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.

Y. Wataya, A. Matsuda, D. Santi, 1978, Biochemical and biophysical research communications.

Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.

C. Hansch, Y. Wataya, D. Santi, 1977, Journal of medicinal chemistry.

Irreversible inhibition of thymidylate synthetase by 5-formyl-2'-deoxyuridylic acid.

D. Santi, T. Sakai, 1972, Biochemical and biophysical research communications.

Inhibition of thymidylate synthetase by 5-formyl- and 5-hydroxymethyl-2'-deoxyuridylate.

D. Santi, T. Sakai, 1971, Biochemical and biophysical research communications.

Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.

A. Sjoerdsma, D. Santi, P. Schechter, 1984, Transactions of the Association of American Physicians.

Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi

M. Sogin, J. Kovacs, H. Masur, 1988, Nature.

Ribosomal RNA genes of Pneumocystis carinii.

M. Sogin, J. Kovacs, H. Masur, 1989, The Journal of Protozoology.

Isolation and expression of the Pneumocystis carinii thymidylate synthase gene.

D. Santi, J. Edman, B. Lundgren, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.

A. Sjoerdsma, D. Santi, J. A. Golden, 1984, The Western journal of medicine.

Thermodynamic analysis of the binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate to thymidylate synthase over a range of temperatures.

P. Reche, D. Santi, O. López-Mayorga, 1995, European journal of biochemistry.

Thymidylate synthetase: studies on peptide containing covalently bound 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

D. Santi, K. Ivanetich, A. Pogolotti, 1976, Biochemical and biophysical research communications.

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

D. Santi, C. McHenry, H. Sommer, 1974, Biochemistry.

Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.

C. Hansch, W. Sirawaraporn, D. Santi, 1988, Molecular and biochemical parasitology.

Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts.

P. Barr, D. Santi, J. Kealey, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Development and screening of a polyketide virtual library for drug leads against a motilide pharmacophore.

I D Kuntz, A G Skillman, I. Kuntz, 2000, Journal of molecular graphics & modelling.

A simple method for quantitating ligands covalently bound to agarose beads.

D. Santi, D. Failla, 1973, Analytical biochemistry.

A sensitive and robust method for quantification of intracellular short-chain coenzyme A esters.

J. Galazzo, D. Santi, M. Shimazu, 2004, Analytical biochemistry.

Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli.

C. Khosla, D. Santi, J. Carney, 2002, Biochemistry.

High-pressure liquid chromatography--ultraviolet analysis of intracellular nucleotides.

D. Santi, A. Pogolotti, 1982, Analytical biochemistry.

Nonclassical antimetabolites. XXV. Inhibitors of thymidine kinase. I. A new spectrophotometric assay. Inhibition by nucleoside derivatives.

D. Santi, B. R. Baker, T. Schwan, 1966, Journal of medicinal chemistry.

Thymidylate synthetase catalyzed exchange of tritiumfrom [5-3H]-2'-deoxyuridylate for protons of water.

D. Santi, C. Weill, A. Pogolotti, 1979, Biochemistry.

Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase.

J. Vederas, D. Santi, B. Malcolm, 1995, Biochemistry.

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

S. Beverley, R. Schimke, D. Santi, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Thymidylate synthetase catalyzed dehalogenation of 5-bromo-and 5-iodo-2'-deoxyuridylate.

Y. Wataya, D. Santi, 1975, Biochemical and biophysical research communications.

Atomic structure of thymidylate synthase: target for rational drug design.

R M Stroud, R. Stroud, J. Finer-Moore, 1987, Science.

A C-terminal conformational equilibrium in thymidylate synthase observed by electron paramagnetic resonance spectroscopy.

R. Cooke, D. Santi, C. Carreras, 1994, Biochemistry.

Biochemical studies on the mode of action of cytochalasin B. Preparation of (3H)cytochalasin B and studies on its binding of cells.

J. Spudich, D. Santi, S. Lin, 1974, The Journal of biological chemistry.

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition.

D. Santi, P. Danenberg, P. Satterly, 1971, Biochemistry.

Cloning and Expression of Mycobacterium tuberculosis and Mycobacterium leprae Dihydropteroate Synthase in Escherichia coli

W. Sirawaraporn, D. Santi, Vanida Nopponpunth, 1999, Journal of bacteriology.

On the mechanism of the acid-catalyzed hydrolysis of uridine to uracil. Evidence for 6-hydroxy-5,6-dihydrouridine intermediates.

D. Santi, J. J. Prior, 1984, Journal of Biological Chemistry.

A facile synthesis of 3-alkyluracils and thymines

D. Santi, A. Pogolotti, D. Failla, 1972 .

β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols.

R. Reid, D. Santi, G. Ashley, 2013, Bioconjugate chemistry.

A facile synthesis of 5-substituted 1-methyluracils and cytosine

D. Santi, T. Sakai, A. Pogolotti, 1968 .

trans-5-(3,3,3-Trifluoro-1-propenyl-)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.

Y. Wataya, A. Matsuda, D. Santi, 1979, Journal of medicinal chemistry.

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine.

D. Santi, C. Garrett, A. Norment, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Model studies of thymidylate synthetase. Neighboring-group facilitation of electrophilic substitution reactions of uracil furanosides.

D. Santi, C. Brewer, 1968, Journal of the American Chemical Society.

5,6-dihydropyrimidine adducts in the reactions and interactions of pyrimidines with proteins.

D. Santi, K. Ivanetich, 1992, Progress in nucleic acid research and molecular biology.

On the mechanism of 2'-deoxyuridylate hydroxymethylase.

D. Santi, M. Kunitani, 1980, Biochemistry.

On the structure of the cofactor in the complex formed with thymidylate synthetase, 5,10-methylenetetrahy-drofolate and 5-fluoro-2'-deoxyuridylate.

D. Santi, V. A. Pena, S. S. Lam, 1976, Biochimica et biophysica acta.

A sulfhydryl group is not the covalent catalyst in the thymidylate synthetase reaction.

D. Santi, C. McHenry, 1974, Biochemical and biophysical research communications.

Model studies of the thymidylate synthetase reaction. Nucleophilic displacement of 5-p-nitrophenoxymethyluracils.

D. Santi, A. Pogolotti, 1974, Biochemistry.

Requirement of reduced folate cofactors for cytotoxicity of 5-fluoro-2'-deoxyuridine. Abstr.

D. Santi, M. Lee, D. Martin, 1977 .

A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant.

D. Santi, C. McHenry, E. Perriard, 1974, Biochemistry.

Inosine Analogs as Anti-Leishmanial Agents

R. K. Robins, D. Santi, L. Townsend, 1985, Pharmaceutical Research.

Experimental Combination Chemotherapy with Thymidylate Synthetase and Ribonucleotide Reductase Inhibitors

D. Santi, T. Hoshino, Shū Kobayashi, 1984, Pharmaceutical Research.

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.

D. Santi, P. Danenberg, A. Pogolotti, 1986, Journal of medicinal chemistry.

A continuous spectrophotometric assay for thymidine and deoxycytidine kinases.

D. Santi, Y. Liu, 1998, Analytical biochemistry.

5-Fluoro-2'-deoxycytidine 5'-monophosphate is a mechanism-based inhibitor of thymidylate synthase.

D. Santi, L. Liu, 1994, Biochimica et biophysica acta.

The catalytic mechanism and structure of thymidylate synthase.

D. Santi, D V Santi, C. Carreras, 1995, Annual review of biochemistry.

Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase.

D. Santi, E. Garvey, A. Pogolotti, 1984, Journal of medicinal chemistry.

Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase.

D. Santi, L. Liu, 1992, Biochemistry.

m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts.

D. Santi, Y. Liu, Y Liu, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.

D. Santi, J. Kealey, J. Eckstein, 1995, Chemistry & biology.

Enzymatic mechanism of tRNA (m5U54)methyltransferase.

D. Santi, J. Kealey, X. Gu, 1994, Biochimie.

High-level expression of Escherichia coli tRNA (m5U54)-methyltransferase.

D. Santi, X. Gu, 1990, DNA and cell biology.

A secondary isotope effect in the cysteine-Promoted dehalogenation of 5-bromo-2'-deoxyuridine. evidence for transient 5,6-dihydropyrimidine intermediates.

Y. Wataya, D. Santi, 1977, Journal of the American Chemical Society.

Thymidylate Synthetase: Interaction with 5-Fluoro and 5-Trifluoromethyl-2′-Deoxyuridylic Acid

Y. Wataya, D. Santi, T. James, 1976 .

Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation.

S. Climie, D. Santi, C. Carreras, 1992, Biochemistry.

Separation of 5-substituted 2'-deoxyuridines and deoxyuridylates by high-pressure anion-exchange liquid chromatography.

D. Santi, C. Garrett, A. Pogolotti, 1977, Analytical biochemistry.

Syntheses of some analogs of a possible intermediate formed in the thymidylate synthetase reaction

D. Santi, 1967 .

The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs

R. Stroud, J. Finer-Moore, D. Santi, 2013, Nucleic acids research.

On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2'-deoxycytidine 5'-monophosphate.

D. Santi, C. Mathews, Y. Wang, 1989, Archives of biochemistry and biophysics.

Active-site labeling of thymidylate synthetase with 5-fluoro-2'-deoxyuridylate.

Y. Wataya, D. Santi, 1977, Methods in enzymology.

Kinetic and catalytic mechanism of HhaI methyltransferase.

D. Santi, J. Wu, 1987, The Journal of biological chemistry.

Simultaneous measurement of charging levels of multiple aminoacyl-tRNAs.

R. A. Smith, D. Santi, 1979, Analytical biochemistry.

A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models

A. Ashworth, P. Houghton, D. Santi, 2020, Cancer Research.

Irreversible enzyme inhibitors. XCIV. inhibition of dihydrofolic reductase with derivatives of 2,6-diaminopurines†

D. Santi, B. R. Baker, 1967 .

A Conserved Aspartate of tRNA Pseudouridine Synthase Is Essential for Activity and a Probable Nucleophilic Catalyst

D. Santi, Lixuan L. Huang, M. Pookanjanatavip, 1998 .

The dynamic NMR structure of the TΨC-loop: Implications for the specificity of tRNA methylation

T. L. James, D. Santi, J. Kealey, 1997, Journal of biomolecular NMR.

Interaction of tRNA (uracil-5-)-methyltransferase with NO2Ura-tRNA.

A. Matsuda, D. Santi, K. Ivanetich, 1996, Nucleic acids research.

Covalent adducts between tRNA (m5U54)-methyltransferase and RNA substrates.

D. Santi, X. Gu, 1992, Biochemistry.

Long-term stabilization of maleimide-thiol conjugates.

Louise Robinson, R. Reid, D. Santi, 2015, Bioconjugate chemistry.

Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.

C. Hansch, C. Selassie, D. Santi, 1987, Journal of medicinal chemistry.

Thymidylate synthase and fluorouracil.

D. Santi, K. Ivanetich, 1988, Advances in experimental medicine and biology.

Metabolism and mechanism of action of 5-fluorodeoxycytidine.

D. Santi, E. Newman, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Purification methods for recombinant Lactobacillus casei thymidylate synthase and mutants: a general, automated procedure.

D. Santi, J. Kealey, 1992, Protein expression and purification.

Irreversible Enzyme Inhibitors. LXXVII.(1,2) Inhibitors of Thymidine Phosphorylase. III.(2) Hydrophobic Bonding by 1-Substituted Uracils Containing Additional Substituents at the 5 and 6 Positions.

D. Santi, B. R. Baker, M. Kawazu, 1967, Journal of medicinal chemistry.

Irreversible enzyme inhibitors. LXXIV. Inhibitors of guanine deaminase. II. Studies on bulk tolerance within enzyme-inhibitor complexes.

D. Santi, B. R. Baker, 1967, Journal of medicinal chemistry.

Mechanism of action of 5-nitro-2'-deoxyuridine.

D. Santi, W. Washtien, 1982, Journal of medicinal chemistry.

Reaction of 5-trifluoromethyl-2′-deoxyuridine and 1-methyl-5-trifluoromethyluracil with methoxyamine: model studies for the interaction between thymidylate synthetase and 5-trifluoromethyl-2′-deoxyuridine 5′-phosphate

M. Aida, Y. Wataya, D. Santi, 1987 .

Hydrolysis of hydroxybenzotrifluorides and fluorinated uracil derivatives. A general mechanism for carbon-fluorine bond labilization.

D. Santi, T. Sakai, 1973, Journal of medicinal chemistry.

TRANS-5-(3,3,3-TRIFLUORO-1-PROPENYL)-2′-DEOXYURIDYLATE: A MECHANISM-BASED INHIBITOR OF THYMIDYLATE SYNTHETASE

Y. Wataya, A. Matsuda, D. Santi, 1979 .

The metabolism and cytotoxic effects of Formycin B in Trypanosoma cruzi.

D. Santi, C. Garrett, P. Rainey, 1983, Biochemical pharmacology.

Prospective use of the single-mouse experimental design for the evaluation of PLX038A

P. Houghton, Siyuan Zheng, D. Santi, 2020, Cancer Chemotherapy and Pharmacology.

Purification and characterization of recombinant Pneumocystis carinii thymidylate synthase.

D. Santi, S. Minkin, P. Greene, 1991, Protein expression and purification.

A long-acting C-natriuretic peptide for achondroplasia

R. Reid, D. Santi, G. Ashley, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

D. Caput, D. Santi, R. Grumont, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.

R. Stroud, D. Santi, U. Schellenberger, 1998, Biochemistry.

Identification of two Escherichia coli pseudouridine synthases that show multisite specificity for 23S RNA.

D. Santi, L. Huang, P. Greene, 1998, Biochemistry.

Molecular recognition of tRNA by tRNA pseudouridine 55 synthase.

D. Santi, M. Yu, K. Ivanetich, 1998, Biochemistry.

Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes.

D. Santi, C. Gustafsson, D V Santi, 1996, Nucleic acids research.

Adducts across the 5,6-double bond of pyrimidines. The mechanism of dehydration of 1-substituted uracil photohydrates.

D. Santi, J. J. Prior, J. Maley, 1984, The Journal of biological chemistry.

Using Chemobiosynthesis and Synthetic Mini-Polyketide Synthases To Produce Pharmaceutical Intermediates in Escherichia coli

Yong Li, John R Carney, D. Santi, 2010, Applied and Environmental Microbiology.

Migration properties of circular DNAs using orthogonal‐field‐alternation gel electrophoresis

D. Santi, R. Hightower, 1989, Electrophoresis.

Cloning, sequencing, and expression of the Lactobacillus casei thymidylate synthase gene.

D. Santi, V. Davisson, K. Pintér, 1988, DNA.

A very long-acting IL-15: implications for the immunotherapy of cancer

John A. Hangasky, T. Waldmann, R. Reid, 2022, Journal for ImmunoTherapy of Cancer.

An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster.

B. Roe, D. Santi, D. Kupfer, 2000, Gene.

Effect of amino acid substitutions at the subunit interface on the stability and aggregation properties of a dimeric protein: Role of Arg 178 and Arg 218 at the dimer interface of thymidylate synthase

D. Santi, P. Balaram, B. Gopal, 1999, Proteins.

The T-arm of tRNA is a substrate for tRNA (m5U54)-methyltransferase.

D. Santi, X. Gu, 1991, Biochemistry.

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

D. Santi, E. Garvey, T. Meek, 1985, Biochemistry.

In vivo inhibitors of Escherichia coli phenylalanyl-tRNA synthetase.

D. Santi, S. Cunnion, R. Anderson, 1979, Journal of medicinal chemistry.

Phenylalanyl transfer ribonucleic acid synthetase from rat liver. Analysis of phenylalanine and adenosine 5'-triphosphate binding sites and comparison to the enzyme from Escherichia coli.

D. Santi, R. Webster, 1976, Journal of medicinal chemistry.

Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain.

P. Reche, D. Santi, D. González-Pacanowska, 1996, Molecular and biochemical parasitology.

Formycin B resistance in Leishmania.

D. Santi, P. Rainey, 1984, Biochemical pharmacology.

Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp 90

R. Stroud, G. Rastelli, D. Santi, 2006 .

Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide.

R. Reid, D. Santi, G. Ashley, 2016, Bioconjugate chemistry.

Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi.

P. Reche, D. Santi, D. González-Pacanowska, 1994, Molecular and biochemical parasitology.

ANALOGS OF TETRAHYDROFOLIC ACID. XIV. FACILE SYNTHETIC ROUTE TO THE 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE INHIBITOR.

D. Santi, H. Shapiro, B. R. Baker, 1964, Journal of pharmaceutical sciences.

Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis.

W. Sirawaraporn, W. Jacobs, D. Santi, 1991, Experimental parasitology.

Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major.

W. Sirawaraporn, D. Santi, R. Grumont, 1988, Biochemistry.

Analysis of amplified DNAs from drug-resistant Leishmania by orthogonal-field-alternation gel electrophoresis. The effect of size and topology on mobility.

N. Cozzarelli, D. Santi, J. Bliska, 1989, The Journal of biological chemistry.

The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.

Maria Paola Costi, R. Stroud, J. Finer-Moore, 2003, Protein engineering.

Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase.

R. Stroud, J. Finer-Moore, D. Santi, 2000, Protein engineering.

Disulfide engineering at the dimer interface of lactobacillus casei thymidylate synthase: Crystal structure of the T155C/E188C/C244T mutant

S. Parthasarathy, D. Santi, S. Ray, 2008, Protein science : a publication of the Protein Society.

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.

R. Stroud, D. Santi, S. Ghelli, 1999, Journal of medicinal chemistry.

Covalent tethering of the dimer interface annuls aggregation in thymidylate synthase

D. Santi, P. Balaram, S. Agarwalla, 1996, Protein science : a publication of the Protein Society.

Expression, purification, and characterization of thymidylate synthase from Lactococcus lactis

C. Schiffer, D. Santi, P. Greene, 1994, Protein science : a publication of the Protein Society.

Partial restoration of activity to Lactobacillus casei thymidylate synthase following inactivation by domain deletion.

B. Shoichet, D. Santi, P. Balaram, 1994, Biochemistry.

Cloning, expression and characterization of thymidylate synthase from Crypto coccus neoformans

D. Santi, L. Livi, P. Greene, 1994 .

Interaction of thymidylate synthase with pyridoxal 5'-phosphate as studied by UV/visible difference spectroscopy and molecular modeling.

D. Santi, T. Ouyang, C. Carreras, 1993, Biochemistry.

Catalytically active cross-species heterodimers of thymidylate synthase.

F. Maley, D. Santi, J. Pedersen-Lane, 1993, Biochemistry.

Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase.

D. Santi, L. Liu, 1993, Biochemistry.

Subunit complementation of thymidylate synthase.

D. Santi, Y. Yuthavong, P. Greene, 1992, Biochemistry.

Crystallization of human thymidylate synthase.

R. Stroud, C. Schiffer, D. Santi, 1991, Journal of molecular biology.

Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase.

R. Raines, D. Santi, C. McHenry, 1987, Biochemistry.

Limited proteolysis of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica.

D. Santi, E. Garvey, 1985, Proceedings of the National Academy of Sciences of the United States of America.

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa.

S. Beverley, D. Santi, E. Garvey, 1984, Molecular and biochemical parasitology.

A deae-cellulose filter disk assay for aminoacyl-tRNA.

D. Santi, R. Anderson, 1974, Analytical biochemistry.

Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.

S. Pfaff, R. Reid, D. Santi, 2016, Bioconjugate chemistry.

In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates

Donghui Wang, B. Hann, S. Pfaff, 2019, International Journal of Polymer Science.

A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist.

S. Pfaff, N. Vrang, R. Reid, 2017, ACS chemical biology.

Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide.

R. Reid, D. Santi, G. Ashley, 2016, Bioconjugate chemistry.

A once-monthly GLP-1 receptor agonist for treatment of diabetic cats.

D. Santi, G. Ashley, D. Parkes, 2019, Domestic animal endocrinology.

Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster

R. Reid, M. Welch, D. Santi, 2005, Journal of Industrial Microbiology and Biotechnology.

Rational design and assembly of synthetic trimodular polyketide synthases.

John R Carney, D. Santi, J. Carney, 2007, Chemistry & biology.

The synthesis of blocked triplet-phosphoramidites and their use in mutagenesis.

A. Matsuda, D. Santi, A. Ono, 1995, Nucleic acids research.

Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.

D. Roos, D. Santi, R. Donald, 1996, Biochemistry.

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.

Giulio Rastelli, Robert M Stroud, R. Stroud, 2003, Chemistry & biology.

Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme.

F. Gamarro, D. Santi, J. Zhao, 1995, Molecular and biochemical parasitology.

Affinity chromatography of Escherichia coli (m5U54)-methyltransferase on tRNA-agarose.

D. Santi, X. Gu, 1991, Protein expression and purification.

Expression of human thymidylate synthase in Escherichia coli.

W. Sirawaraporn, D. Santi, V. Davisson, 1989, The Journal of biological chemistry.

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.

Yaoquan Liu, R. Stroud, J. Finer-Moore, 2006, Biochemistry.

Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2'-deoxyuridine 5'-monophosphate.

P. Schultz, D. Santi, Y. Liu, 1999, Biochemistry.

Active site general catalysts are not necessary for some proton transfer reactions of thymidylate synthase.

D. Santi, W. Huang, 1997, Biochemistry.

[57] Peptidyl-tRNA analogs as affinity labeling agents☆

D. Santi, S. Cunnion, 1974 .

Macromolecular affinity labeling agents. Reaction of N-bromoacetylisoleucyl transfer ribonucleic acid with isoleucyl transfer ribonucleic acid synthetase.

D. Santi, S. Cunnion, 1974, Biochemistry.

Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant.

W. Sirawaraporn, D. Santi, Y. Yuthavong, 1997, Experimental parasitology.

Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum.

A. Cowman, W. Sirawaraporn, D. Santi, 1990, Biochemistry.

Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

P. Prapunwattana, W. Sirawaraporn, D. Santi, 1996, Molecular and biochemical parasitology.

[Biocytin13]Dynorphin A 1-13 Amide: A Potential Probe for the κ-Opioid Receptor

W. Sadee, D. Santi, G. Hochhaus, 1988, Pharmaceutical Research.

Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase.

D. Santi, R. Mirmira, L. Liu, 1997, Chemistry & biology.

Kinetics of aminoacyl-tRNA synthetases catalyzed ATP-PPi exchange.

W. Cleland, D. Santi, R. Webster, 1974, Methods in enzymology.

The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants.

P. Prapunwattana, W. Sirawaraporn, D. Santi, 1993, The Journal of biological chemistry.

Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate.

J. Finer-Moore, Y. Wataya, D. Santi, 1994, Biochemistry.

Analytical and Simulation-Based Models for Drug Release and Gel-Degradation in a Tetra-PEG Hydrogel Drug-Delivery System

A. Sali, M. Sgobba, G. Rastelli, 2015 .

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.

R M Stroud, R. Stroud, K. M. Perry, 1993, Journal of molecular biology.

Surgical sealants with tunable swelling, burst pressures, and biodegradation rates.

D. Santi, T. Sakai, G. Ashley, 2017, Journal of biomedical materials research. Part B, Applied biomaterials.

Effects of 1,7- and 1,10-phenanthroline dione on tissue culture cells.

D. Santi, T. C. Bruice, T. Eckert, 1983, Biochemical pharmacology.

PLX038: a long-acting topoisomerase I inhibitor with robust anti-tumor activity in ATM deficient tumors and potent synergy with PARP inhibitors.

Y. Pommier, F. Feng, D. Santi, 2022, Molecular Cancer Therapeutics.

Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay.

D. Santi, M. Siani, C. Carreras, 2002, Analytical biochemistry.

DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.

D. Santi, R. Grumont, W. Washtien, 1985, Journal of Biological Chemistry.

A filter technique for measurement of steroid-receptor binding.

D. Santi, J. Baxter, G. Rousseau, 1975, Methods in enzymology.

Mechanism of action of 2',5-difluoro-1-arabinosyluracil.

D. Santi, J. Coderre, J. Fox, 1983, Journal of medicinal chemistry.

Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.

J. Apfeld, R. Stroud, J. Finer-Moore, 1998, Journal of molecular biology.

Preparation of equimolar mixtures of peptides by adjustment of activated amino acid concentrations.

D. Santi, K. Ivanetich, 1996, Methods in enzymology.

Peptoids: a modular approach to drug discovery.

L Wang, Bartlett, F. Cohen, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli.

D. Santi, C. Gustafsson, M. Yu, 1999, Biochemistry.

(protozoan parasite/drug resistance/gene amplification)

D. Santi, J. Coderre, Stephen M. BEVERLEYt, 2016 .

Expression of human thymidylate synthase in Escherichia coli.

W. Sirawaraporn, D. Santi, V. Davisson, 1994, Journal of Biological Chemistry.

Expression of Human Thymidylate Synthase in

W. Sirawaraporn, D. Caput, D. Santi, 1989 .

Purification of the araC protein.

D. Santi, G. Wilcox, E. Englesberg, 1971, Proceedings of the National Academy of Sciences of the United States of America.

The role of polyamines in the aminoacyl transfer ribonucleic acid synthetase reactions. Demonstration of the requirement for magnesium ion and a secondary stimulatory effect of spermine.

D. Santi, R. Webster, 1975, The Journal of biological chemistry.

Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.

R. Stroud, E. Fauman, J. Finer-Moore, 1996, Protein engineering.