J. Lubkowski

发表

DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis.

D. Hoover, J. Lubkowski, 2002, Nucleic acids research.

Structural basis of interaction between urokinase-type plasminogen activator and its receptor.

D. Shaw, J. Lubkowski, A. Mazar, 2006, Journal of molecular biology.

The Conserved Salt Bridge in Human α-Defensin 5 Is Required for Its Precursor Processing and Proteolytic Stability*♦

Jacek Lubkowski, J. Lubkowski, M. Pazgier, 2008, Journal of Biological Chemistry.

Studies of the Biological Properties of Human β-Defensin 1*

Jacek Lubkowski, D. Hoover, J. Lubkowski, 2007, Journal of Biological Chemistry.

Human neutrophil α‐defensin 4 inhibits HIV‐1 infection in vitro

Jacek Lubkowski, J. Lubkowski, Wuyuan Lu, 2005 .

The Structure of Human β-Defensin-2 Shows Evidence of Higher Order Oligomerization*

Robert Blumenthal, Anu Puri, Oleg Chertov, 2000, The Journal of Biological Chemistry.

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.

D. Hoover, J. Lubkowski, J. Oppenheim, 2003, Journal of leukocyte biology.

Antimicrobial characterization of human beta-defensin 3 derivatives.

Jacek Lubkowski, D. Hoover, J. Lubkowski, 2003, Antimicrobial agents and chemotherapy.

Inhibition of pathologic retinal neovascularization by α-defensins

H. Hammes, K. Preissner, J. Lubkowski, 2005 .

Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase.

A Wlodawer, A. Wlodawer, J. Lubkowski, 2001, Biochemistry.

Generalized enzymatic mechanism of catalysis by tetrameric l-asparaginases from mesophilic bacteria

A. Wlodawer, J. Lubkowski, M. Dyba, 2020, Scientific Reports.

Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.

A. Wlodawer, A. Olson, G. Morris, 1997, Biochemistry.

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

J. Konvalinka, J. Lubkowski, C. Bařinka, 2009, The FEBS journal.

Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization.

M. Pomper, J. Lubkowski, A. Kozikowski, 2008, Journal of medicinal chemistry.

Crystal structures of human α‐defensins HNP4, HD5, and HD6

J. Lubkowski, Wuyuan Lu, De Yang, 2006, Protein science : a publication of the Protein Society.

A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules.

W. L. Jorgensen, J. Michel, J. Lubkowski, 2010, Journal of the American Chemical Society.

Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies.

M. Pomper, J. Lubkowski, Youngjoo Byun, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, features and thermal decomposition of hexachlorostannates and hexachloroplatinates of tris(2,2′-dipyridyl)metal(II) and tris(1,10-phenanthroline)metal(II) (metal=Ru, Fe, Ni)

J. Lubkowski, J. Błażejowski, A. Bujewski, 1992 .

Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities

J. Lubkowski, J. Černý, C. Bařinka, 2016, The FEBS journal.

Synthesis and characterization of human alpha-defensins 4-6.

J. Lubkowski, Bryan Ericksen, K. Tucker, 2004, The journal of peptide research : official journal of the American Peptide Society.

Human β‐defensin‐3 structure motifs that are important in CXCR4 antagonism

G. Dubyak, J. Lubkowski, Zhimin Feng, 2013, The FEBS journal.

Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL).

A. Wlodawer, J. Lubkowski, B. O’Keefe, 2015, Acta crystallographica. Section F, Structural biology communications.

The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.

D. Hoover, J. Lubkowski, Wuyuan Lu, 2002, The Journal of biological chemistry.

Inhibition of pathologic retinal neovascularization by alpha-defensins.

H. Hammes, K. Preissner, J. Lubkowski, 2005, Blood.

Human defensins: synthesis and structural properties.

J. Lubkowski, M. Pazgier, Wuyuan Lu, 2007, Current pharmaceutical design.

Opportunistic complexes of E. coli L-asparaginases with citrate anions

A. Wlodawer, J. Lubkowski, W. Chan, 2019, Scientific Reports.

Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II.

M. Pomper, J. Lubkowski, J. Černý, 2014, Bioorganic & medicinal chemistry letters.

The Structure of the Extracellular Domain of Triggering Receptor Expressed on Myeloid Cells Like Transcript-1 and Evidence for a Naturally Occurring Soluble Fragment*

J. Lubkowski, J. Gattis, A. Szyk, 2006, Journal of Biological Chemistry.

Crystallization and preliminary X-ray studies of thymus and activation-regulated chemokine (TARC).

D. Hoover, J. Lubkowski, Wuyuan Lu, 2003, Acta crystallographica. Section D, Biological crystallography.

Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis.

J. Lubkowski, Yan Cai, John K. Zehmer, 2014, American journal of physiology. Lung cellular and molecular physiology.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Preclinical evaluation of human secretoglobin 3 A 2 in mouse models of lung development and fibrosis

J. Lubkowski, Yan Cai, John K. Zehmer, 2013 .

Soluble TLT-1 modulates platelet–endothelial cell interactions and actin polymerization

J. Lubkowski, J. Gattis, A. Washington, 2010, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Reconstruction of the Conserved β-Bulge in Mammalian Defensins Using d-Amino Acids*

J. Lubkowski, Weiyue Lu, Wuyuan Lu, 2005, Journal of Biological Chemistry.

Crystal structure and amino acid sequence of Wolinella succinogenes L-asparaginase.

A. Wlodawer, G. Gilliland, J. Lubkowski, 1996, European journal of biochemistry.

Heme-Protein Interactions in Horse Heart Myoglobin at Neutral pH and Exposed to Acid Investigated by Time-resolved Fluorescence in the Pico- to Nanosecond Time Range (*)

J. Lubkowski, Z. Gryczynski, E. Bucci, 1995, The Journal of Biological Chemistry.

Lattice energy of organic ionic crystals and its importance in analysis of features, behaviour and reactivity of solid-state systems

J. Lubkowski, J. Błażejowski, 1992 .

Crystal lattice energy of ammonium and methanaminium chlorides

J. Lubkowski, J. Błażejowski, 1990 .

Many chemokines including CCL20/MIP‐3α display antimicrobial activity

D. Hoover, J. Lubkowski, J. Oppenheim, 2003 .

Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES.

A. Wlodawer, S. Kent, D. Hoover, 1999, Chemistry & biology.

Human α-defensins block papillomavirus infection

D. Lowy, J. Lubkowski, J. Schiller, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.

A Wlodawer, A. Wlodawer, A. Plückthun, 1999, Structure.

TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

A. Dutra, J. Lubkowski, P. Schwartzberg, 2009, The Journal of clinical investigation.

Human beta-defensins.

D. Hoover, J. Lubkowski, M. Pazgier, 2006, Cellular and molecular life sciences : CMLS.

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.

D. Hoover, J. Lubkowski, A. Biragyn, 2004, Annual review of immunology.

Human β-defensins

D. Hoover, J. Lubkowski, M. Pazgier, 2006, Cellular and Molecular Life Sciences CMLS.

Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation.

J. Lubkowski, Wuyuan Lu, J. Alexandratos, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Structural and biochemical properties of L‐asparaginase

A. Wlodawer, J. Lubkowski, 2021, The FEBS journal.

REVIEW Structural and biochemical properties of L-asparaginase

A. Wlodawer, J. Lubkowski, 2021 .

Geometric considerations support the double‐displacement catalytic mechanism of l‐asparaginase

A. Wlodawer, J. Lubkowski, 2019, Protein science : a publication of the Protein Society.

Toward Understanding the Cationicity of Defensins

J. Lubkowski, Chong Li, M. Pazgier, 2007, Journal of Biological Chemistry.

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3

D. Hoover, J. Lubkowski, Wuyuan Lu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.

A. Wlodawer, J. Lubkowski, Di Zhang, 2016, Journal of molecular biology.

The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions

J. Lubkowski, G. Bujacz, L. Boqué, 1997, Nature Structural Biology.

Toward a universal inhibitor of retroviral proteases: Comparative analysis of the interactions of LP‐130 complexed with proteases from HIV‐1, FIV, and EIAV

K Y Hui, A Wlodawer, A. Wlodawer, 1998, Protein science : a publication of the Protein Society.

A covalently bound catalytic intermediate in Escherichia coli asparaginase : Crystal structure of a Thr‐89‐Val mutant

A. Wlodawer, J. Lubkowski, G. Palm, 1996, FEBS letters.

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.

A Wlodawer, T R Burke, Y. Pommier, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Time-resolved fluorescence of hemoglobin species.

J. Lubkowski, I. Gryczynski, Z. Gryczynski, 1997, Biophysical chemistry.

Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2

S. Smirnov, A. Wlodawer, J. Lubkowski, 2018, The Journal of Immunology.

Efficient and versatile one-step affinity purification of in vivo biotinylated proteins: expression, characterization and structure analysis of recombinant human glutamate carboxypeptidase II.

J. Konvalinka, J. Lubkowski, C. Bařinka, 2012, Protein expression and purification.

The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.

D. Hoover, J. Lubkowski, O. Chertov, 2001, The Journal of biological chemistry.

Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth

A. Wlodawer, J. Lubkowski, J. Gildersleeve, 2017, The FEBS journal.

Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity.

M. Pomper, J. Konvalinka, J. Lubkowski, 2011, Journal of medicinal chemistry.

Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

J. Konvalinka, J. Lubkowski, P. Mlcochova, 2007, Journal of medicinal chemistry.

Structural and biochemical characterization of the folyl‐poly‐γ‐l‐glutamate hydrolyzing activity of human glutamate carboxypeptidase II

J. Konvalinka, J. Lubkowski, C. Bařinka, 2014, The FEBS journal.

Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.

J. Konvalinka, J. Lubkowski, P. Mlcochova, 2009, Biochemistry.

Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.

J. Konvalinka, J. Lubkowski, M. Dauter, 2008, Journal of molecular biology.

Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli.

W. Lockau, J. Lubkowski, Mahdi Hejazi, 2004, Acta Crystallographica Section D: Biological Crystallography.

The Structure of Human Macrophage Inflammatory Protein-3α/CCL20

D. Hoover, J. Lubkowski, Wuyuan Lu, 2002, The Journal of Biological Chemistry.

A comparison of the crystal structures of bacterial l-asparaginases

M. Gribskov, A. Wlodawer, J. Lubkowski, 1996 .

Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).

J. Lubkowski, C. Bařinka, A. Prahl, 2008, Acta crystallographica. Section D, Biological crystallography.

Structures of thymus and activation-regulated chemokine (TARC).

D. Hoover, J. Lubkowski, Wuyuan Lu, 2003, Acta crystallographica. Section D, Biological crystallography.

Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur.

J. Lubkowski, Wuyuan Lu, A. Szyk, 2004, Journal of structural biology.

Antimicrobial Characterization of Human β-Defensin 3 Derivatives

Jacek Lubkowski, D. Hoover, J. Lubkowski, 2003, Antimicrobial Agents and Chemotherapy.

Electrostatic energy in inorganic and organic hexahalogenoplatinate lattices

J. Lubkowski, P. Dokurno, J. Błażejowski, 1993 .

COULOMBIC ENERGY IN HEXAHALOGENOSTANNATES CONTAINING INORGANIC AND ORGANICCATIONS

J. Lubkowski, P. Dokurno, J. Błażejowski, 1992 .

Electrostatic Energy in Inorganic and Organic Salts Containing Octahedral SnCl62- Ion

J. Lubkowski, P. Dokurno, J. Błażejowski, 1991 .

Intrinsic fluorescence of hemoglobins and myoglobins.

J. Lubkowski, Z. Gryczynski, E. Bucci, 1997, Methods in enzymology.

Effect of disordered hemes and dimerization in isolated a-subunits of hemoglobin detected by time-resolved fluorescence spectroscopy in the picosecond range

Enrico Gratton, Zygmunt Gryczynski, Enrico Bucci, 1994, Photonics West - Lasers and Applications in Science and Engineering.

A high-resolution structure of ligand-free human glutamate carboxypeptidase II.

J. Konvalinka, J. Lubkowski, C. Bařinka, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Electrostatic energy in chloride salts of mononitrogen organic bases

J. Lubkowski, J. Błażejowski, 1991 .

Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu?

A. Wlodawer, J. Lubkowski, K. Aghaiypour, 2001, Biochimica et biophysica acta.

Mass spectrometry as a tool for studying the action of human aspartic proteases on peptides and proteins.

J. Lubkowski, C. Michejda, B. Green, 1998, Advances in experimental medicine and biology.

The E. coli L‐asparaginase V27T mutant: structural and functional characterization and comparison with theoretical predictions

A. Wlodawer, J. Lubkowski, P. Strzelczyk, 2022, FEBS letters.

The dimeric form of bacterial l‐asparaginase YpAI is fully active

A. Wlodawer, J. Lubkowski, J. Alexandratos, 2022, The FEBS journal.

The mechanism of catalysis by L-asparaginase.

J. Weinstein, A. Wlodawer, D. Fushman, 2020, Biochemistry.

Fluorescence and Monte Carlo conformational studies of the (1-15) galanin amide fragment.

S. Ołdziej, J. Lubkowski, W. Wiczk, 1996, Biophysical chemistry.

Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus

Alexander Wlodawer, Li Zhang, Ben M. Dunn, 1995, Nature Structural Biology.

Expression and purification of recombinant human alpha-defensins in Escherichia coli.

J. Lubkowski, M. Pazgier, 2006, Protein expression and purification.

Homology modeling and molecular dynamics simulations of lymphotactin

R. Nussinov, B. Ma, J. Lubkowski, 2000, Protein science : a publication of the Protein Society.

Structure of the D30N active site mutant of FIV proteinase complexed with a statine-based inhibitor

A. Wlodawer, A. Gustchina, J. Lubkowski, 1997 .

Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.

J. Lubkowski, Wuyuan Lu, E. D. de Leeuw, 2008, Journal of molecular biology.

From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain.

J. Lubkowski, A. Prahl, Bryan Ericksen, 2003, The journal of peptide research : official journal of the American Peptide Society.

Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.

J. Lubkowski, Wuyuan Lu, R. Lehrer, 2005, FEBS Letters.

Sometimes It Takes Two to Tango

J. Lubkowski, H. Szmacinski, M. Pazgier, 2012, The Journal of Biological Chemistry.

The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p

A. Wlodawer, A. Plückthun, J. Lubkowski, 1998, Nature Structural Biology.

Atomic resolution structure of Erwinia chrysanthemi L-asparaginase.

A. Wlodawer, Z. Dauter, J. Lubkowski, 2002, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of XMRV protease differs from the structures of other retropepsins

David Baker, Frank DiMaio, Zbigniew Dauter, 2010, Nature Structural &Molecular Biology.

Impact of Pro Segments on the Folding and Function of Human Neutrophil α-Defensins

J. Lubkowski, Chong Li, Wuyuan Lu, 2007, Journal of Molecular Biology.

Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine*

J. Konvalinka, J. Lubkowski, M. Hubálek, 2015, The Journal of Biological Chemistry.

Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR.

Y. Zhang, J. Lubkowski, Wuyuan Lu, 2010, Journal of molecular biology.

The Structure of Human MIP-3 (cid:1) /CCL20: Linking Antimicrobial and CCR6 Receptor Binding Activities with Human (cid:2) -Defensins

D. Hoover, J. Lubkowski, Wuyuan Lu, 2002 .

Novel Peptides Based on HIV-1 gp120 Sequence with Homology to Chemokines Inhibit HIV Infection in Cell Culture

Ning Zhang, Michele A. Kutzler, Oleg Chertov, 2011, PloS one.

Resonance Assignment and Three-Dimensional Structure Determination of a Human α-Defensin, HNP-1,

Y. Zhang, J. Lubkowski, Wuyuan Lu, 2010 .

Human β-defensin 4 - defensin without the "twist".

J. Lubkowski, M. Pazgier, J. Alexandratos, 2016, Postepy biochemii.

Structural characterization of Pseudomonas 7A glutaminase-asparaginase.

A Wlodawer, A. Wlodawer, J. Lubkowski, 1994, Biochemistry.

HUMAN BETA-DEFENSIN-1

D. Hoover, J. Lubkowski, 2001 .

The oligomerization domain of p53: Crystal structure of the trigonal form

A. Gronenborn, G. Clore, H. Sakamoto, 1996, FEBS letters.

The Crystal Structure of the Chemokine Domain of Fractalkine Shows a Novel Quaternary Arrangement*

D. Hoover, J. Lubkowski, T. Handel, 2000, The Journal of Biological Chemistry.

Electronic Reprint Biological Crystallography Structures of Two Highly Homologous Bacterial L-asparaginases: a Case of Enantiomorphic Space Groups Biological Crystallography Structures of Two Highly Homologous Bacterial L-asparaginases: a Case of Enantiomorphic Space Groups

M. Jaskólski, A. Wlodawer, M. Kozak, 2022 .

Human alpha-defensins block papillomavirus infection.

D. Lowy, J. Lubkowski, J. Schiller, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Structure of Human β-Defensin-1

Oleg Chertov, Jacek Lubkowski, D. Hoover, 2001, The Journal of Biological Chemistry.

Decamers observed in the crystals of bovine pancreatic trypsin inhibitor.

A. Wlodawer, J. Lubkowski, 1999, Acta crystallographica. Section D, Biological crystallography.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and ﬁbrosis

J. Lubkowski, Yan Cai, John K. Zehmer, 2013 .

Structural studies of medically-interesting protease inhibitors and lectins that belong to the β-trefoil family

A. Wlodawer, A. Gustchina, J. Lubkowski, 2016 .