M. Kowala

发表

Prospective identification of biologically active structures by topomer shape similarity searching.

R. Cramer, M. Poss, M. Hermsmeier, 1999, Journal of medicinal chemistry.

Fibrinogen deficiency is compatible with the development of atherosclerosis in mice.

D. Witte, M. Kowala, M. Valentine, 1998, The Journal of clinical investigation.

The T- and L-Type Calcium Channel Blocker (CCB) Mibefradil Attenuates Leg Edema Induced by the L-Type CCB Nifedipine in the Spontaneously Hypertensive Rat: A Novel Differentiating Assay

Serguei Liachenko, M. Kowala, T. Major, 2008, Journal of Pharmacology and Experimental Therapeutics.

The Guinea Pig as a Preclinical Model for Demonstrating the Efficacy and Safety of Statins

M. Blanar, M. Kowala, Rongan Zhang, 2008, Journal of Pharmacology and Experimental Therapeutics.

The popliteal lymph node of the mouse: internal architecture, vascular distribution and lymphatic supply.

M. Kowala, G. Schoefl, 1986, Journal of anatomy.

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Natesan Murugesan, S. Chong, J. Barrish, 2002, Journal of medicinal chemistry.

Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.

W. Humphreys, J. Macor, M. Kowala, 2005, Journal of medicinal chemistry.

Chapter 7. Advances in the understanding and treatment of congestive heart failure (HF)

J. Macor, M. Kowala, 2000 .

Distinct hemodynamic responses to (Pyr)Apelin-13 in large animal models.

M. Kowala, J. Tune, J. Noblet, 2020, American journal of physiology. Heart and circulatory physiology.

Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol.

M. Kowala, M. Valentine, P. Stein, 1995, The American journal of pathology.

Modified Hematoxylin and Eosin Stain for Elastic Fibers in Rat Carotid and Pig Coronary Arteries After Balloon Injury

M. Kowala, M. Valentine, T. Jenkins-West, 1997 .

Effect of dietary fat saturation and cholesterol on LDL composition and metabolism. In vivo studies of receptor and nonreceptor-mediated catabolism of LDL in cebus monkeys.

E. Schaefer, M. Kowala, R. Nicolosi, 1990, Arteriosclerosis.

Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.

B. Tait, M. Kowala, G. Lu, 2007, Bioorganic & medicinal chemistry letters.

Identification and Characterization of a Major Liver Lysophosphatidylcholine Acyltransferase*

D. Bredt, M. Kowala, D. Moller, 2008, Journal of Biological Chemistry.

Identification and Characterization of a Lysophosphatidylcholine Acyltransferase That is Primarily Expressed in Metabolic Tissues

D. Bredt, M. Kowala, D. Moller, 2008 .

Development of a high-throughput assay for aldosterone synthase inhibitors using high-performance liquid chromatography-tandem mass spectrometry.

M. Kowala, M. Kuo, Lan Yu, 2014, Analytical biochemistry.

Regression of Early Atherosclerosis in Hyperlipidemic Hamsters Induced by Fosinopril and Captopril

M. Kowala, S. Beyer, S. Beyer, 1995, Journal of cardiovascular pharmacology.

Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE.

M. Kowala, M. Valentine, S. Beyer, 2000, Atherosclerosis.

Captopril decreases accelerated atherosclerosis in hypertensive one kidney one clip rats fed cholesterol

M. Kowala, 1993 .

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.

D. Witte, M. Kowala, M. Valentine, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Effects of prazosin on hemodynamics, hemostasis, and serum lipid and lipoprotein levels in normal and hypercholesterolemic monkeys.

M. Kowala, R. Nicolosi, R. Graham, 1989, The American journal of medicine.

Novel Regulators of Low-Density Lipoprotein Receptor and Circulating LDL-C for the Prevention and Treatment of Coronary Artery Disease

M. Kowala, Guoqing Cao, R. Konrad, 2012 .

Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats.

F. Haj, M. Kowala, B. Cummings, 2012, Endocrinology.

Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.

Y. Qian, M. Kowala, R. Schmidt, 2008, Biochemical and biophysical research communications.

Inhibitors of angiotensin converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma cholesterol and captopril inhibits macrophage-foam cell accumulation independently of blood pressure and plasma lipids.

M. Kowala, R. Grove, G. Åberg, 1994, Atherosclerosis.

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice.

M. Kowala, R. Panek, W. Rosebury, 2008, Pharmacological research.

Low density lipoprotein heterogeneity in the cebus monkey.

V. Schumaker, M. Kowala, R. Nicolosi, 1989, Journal of lipid research.

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet–Induced Obese Rats

M. Kowala, Xiaohong Yu, C. Reidy, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Abstract 538: A PCSK9 Antibody that Blocks Binding to LDLR while Allowing Normal PCSK9 Inactivation by Furin is Afforded a Reduced Clearance Rate and a Longer Duration of Effect in Mice

M. Kowala, V. Wroblewski, R. Hansen, 2015, Arteriosclerosis, Thrombosis, and Vascular Biology.

Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models

Brian E. Mattioni, M. Kowala, Xiaohong Yu, 2022, Pharmacology research & perspectives.

Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.

M. Kowala, M. Valentine, C. Molloy, 1997, Journal of Clinical Investigation.

Intimal changes in the aorta of prehypertensive rats.

M. Kowala, R. Nicolosi, G. Majno, 1988, Experimental and molecular pathology.

Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension

M. Kowala, I. Joris, J. Nunnari, 1988 .

Cellular changes during hypertension: a quantitative study of the rat aorta.

M. Kowala, G. Majno, I. Joris, 1986, Experimental and molecular pathology.

Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice.

M. Kowala, M. Valentine, M. French, 2000, Kidney international.

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.

Bo Feng, David B Duignan, Bruce Auerbach, 2011, Bioorganic & medicinal chemistry letters.

Abstract 3922: A Potent Anti-Inflammatory CCR2/CCR5 Dual Antagonist Abrogates Adipose Inflammation and Glucose Intolerance, and Reduces Fat Mass in a Preclinical Model of Diet Induced Obesity

M. Kowala, C. Hamdouchi, Xiaohong Yu, 2008 .

Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.

J. Macor, M. Kowala, M. Valentine, 2003, Bioorganic & medicinal chemistry letters.

Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.

Yuntao Song, Bruce Auerbach, Lisa Dillon, 2008, Bioorganic & medicinal chemistry letters.

The role of endothelin in the pathogenesis of atherosclerosis.

M. Kowala, 1997, Advances in pharmacology.

Effect of Doxazosin on Plasma Lipids and Atherogenesis: A Preliminary Report

M. Kowala, R. Nicolosi, Robert J. Nicolosi, 1989, Journal of cardiovascular pharmacology.

Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice

M. Kowala, Zhi-zhong Ma, Yansheng Du, 2017, Scientific Reports.

A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy

J. Krieger, M. Kowala, M. Rodrigues, 2017, Scientific Reports.

A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes

M. Kowala, T. Major, C. Okerberg, 2008, Cardiovascular Drugs and Therapy.

Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors.

P. M. Davis, J. Murray, M. Kowala, 2001, International immunopharmacology.

Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats

Jaehyoung Kim, Fangrui Ma, F. Haj, 2012, Disease Models & Mechanisms.

Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB), is currently the most effective treatment for obesity and often results in type 2 diabetes resolution and possibly type 2 diabetes prevention

Jaehyoung Kim, Fangrui Ma, F. Haj, 2013 .

Acute SGLT-2i treatment improves cardiac efficiency during myocardial ischemia independent of Na+/H+ exchanger-1.

M. Kowala, L. Fliegel, J. Tune, 2022, International journal of cardiology.

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]

M. Kowala, V. Wroblewski, R. Hansen, 2015, Journal of Lipid Research.

Novel Dual Action AT1 and ETA Receptor Antagonists Reduce Blood Pressure in Experimental Hypertension

J. Barrish, J. Macor, M. Kowala, 2004, Journal of Pharmacology and Experimental Therapeutics.

Doxazosin and cholestyramine similarly decrease fatty streak formation in the aortic arch of hyperlipidemic hamsters.

M. Kowala, R. Nicolosi, J. Nunnari, 1991, Atherosclerosis.

Prostacyclin agonists reduce early atherosclerosis in hyperlipidemic hamsters. Octimibate and BMY 42393 suppress monocyte chemotaxis, macrophage cholesteryl ester accumulation, scavenger receptor activity, and tumor necrosis factor production.

M. Kowala, G. Warr, C. Mazzucco, 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

Section Review Cardiovascular & Renal: Endothelin receptors and atherosclerosis: a potential target for therapeutic intervention

M. Kowala, 1996 .

Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.

Bruce Auerbach, Lisa Dillon, Jeffrey A Pfefferkorn, 2008, Journal of medicinal chemistry.

Leukotriene B4 Levels in Human Atherosclerotic Plaques and Abdominal Aortic Aneurysms

P. Quax, F. Moll, M. Kowala, 2014, PloS one.

Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway[S]

D. Glahn, L. Almasy, R. Duggirala, 2019, Journal of Lipid Research.

Enhanced reduction of atherosclerosis in hamsters treated with pravastatin and captopril: ACE in atheromas provides cellular targets for captopril.

M. Kowala, M. Valentine, S. Beyer, 1998, Journal of cardiovascular pharmacology.

Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation

M. Rekhter, M. Kowala, F. Willard, 2020, Frontiers in Physiology.

Genome-wide Screen for Modulation of Hepatic Apolipoprotein A-I (ApoA-I) Secretion

P. Yu, M. Kowala, J. Calley, 2013, The Journal of Biological Chemistry.

Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice

M. Kowala, Yansheng Du, Nicole Du, 2017, Scientific Reports.