D. Davies

发表

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.

S. Bromidge, S. Dabbs, D. Davies, 1998, Journal of medicinal chemistry.

Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides

S. Dabbs, D. Davies, R. Markwell, 2010 .

Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.

D. Davies, L. Czaplewski, I. Collins, 2014, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

I. Morrissey, D. Davies, S. Magnet, 2018, Antimicrobial Agents and Chemotherapy.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

D. Middlemiss, S. Lightowler, S. Bromidge, 2000, Journal of medicinal chemistry.

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors.

A. K. Forrest, D. Davies, M. Lemonnier, 2021, ACS medicinal chemistry letters.

A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin.

D. Davies, M. Helliwell, D. Procter, 2011, Organic & biomolecular chemistry.

A flexible, stereoselective approach to the decorated cis-hydrindane skeleton: synthesis of the proposed structure of faurinone.

D. Davies, D. Procter, David Sucunza, 2008, Chemistry.

The chemistry of Pseudomonic acid. 15. Synthesis and antibacterial activity of a series of 5-alkyl, 5-alkenyl, and 5-heterosubstituted oxazoles.

D. Davies, P. Brown, J. Wilson, 1996, Journal of medicinal chemistry.

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, E. Minthorn, 2016, Bioorganic & medicinal chemistry letters.

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, E. Minthorn, 2013, Bioorganic & medicinal chemistry letters.

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, Susanne Eyrisch, 2011, Bioorganic & medicinal chemistry letters.

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, T. Gallagher, 2011, Bioorganic & medicinal chemistry letters.

A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones.

James M. Morrell, D. Davies, S. Coles, 2007, Chemical communications.

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.

J. Palmer, D. Davies, C. Morton, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Edward M. Tyndall, J. Palmer, D. Davies, 2013, Bioorganic & medicinal chemistry letters.

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target.

D. Davies, M. Everett, 2021, Drug discovery today.

Preparation of N-Heterocycles by Radical Cyclisation of Enamides Mediated by Manganese(III) or Copper(I). A Comparison of Cyclisation Methods

D. Davies, A. Parsons, N. Kapur, 2000 .

The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

S. Dabbs, D. Davies, Christopher W. Barfoot, 2010 .

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity.

C. Fishwick, D. Davies, L. Czaplewski, 2014, European journal of medicinal chemistry.

The Synthesis of Dehydroamino Acids from Pyruvic Acid

D. Davies, M. O’Brien, A. Parsons, 1997 .

Isosteric replacement of the indole nucleus by benzothiophene in a series of pyrido[2,3-b]indoles with potential anxiolytic activity

D. Davies, I. Forbes, T. Blackburn, 1995 .

A second synthesis of 7,9-bisdeoxycarminomycinone from 5-hydroxyquinizarin

D. Davies, P. Jones, J. K. Sutherland, 1983 .

Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales

I. Morrissey, D. Davies, M. Lemonnier, 2021, Antimicrobial Agents and Chemotherapy.

Designing Inhibitors of β-Lactamase Enzymes to Overcome Carbapenem Resistance in Gram-Negative Bacteria.

D. Davies, M. Everett, 2021, Accounts of chemical research.

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.

I. Morrissey, D. Davies, S. Mangani, 2020, Journal of medicinal chemistry.

ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae.

D. Davies, S. Mangani, P. Warn, 2020, ACS infectious diseases.

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

N. Jennings, D. Davies, S. Mangani, 2018, ACS infectious diseases.

The design of efficient and selective routes to a key 1,4-cis-substituted cyclohexylamide intermediate

D. Davies, M. McGuire, R. Markwell, 2010 .

Aromatic Heterocyclic Chemistry

D. Davies, 1992 .

Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6 alpha-formamido penicillin.

S. J. Knott, D. Davies, R. Southgate, 1990, The Journal of antibiotics.

Synthesis and biological activity of a series of piperazine-2,3-dione containing penicillins and 6 alpha-formamidopenicillins. I. Derivatives substituted at C(5) or C(6) of the piperazine ring.

S. J. Knott, D. Davies, R. Southgate, 1989, The Journal of antibiotics.

The synthesis of anthracyclinones-ii : The synthesis of 7,9-bisdeoxycarminomycinone and -daunomycinone

D. Davies, A. Ashcroft, J. K. Sutherland, 1984 .

Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

D. Davies, M. Lemonnier, Doris L. LaRock, 2023, ACS infectious diseases.

Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT(2C/2B) receptor antagonists.

S. Bromidge, S. Dabbs, D. Davies, 1999, Bioorganic & medicinal chemistry.

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, Susanne Eyrisch, 2011, Bioorganic & medicinal chemistry letters.