D. Duckworth

发表

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.

S. Bromidge, S. Dabbs, D. Davies, 1998, Journal of medicinal chemistry.

In silico identification of novel therapeutic targets.

P. Sanseau, D. Duckworth, 2002, Drug discovery today.

A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).

P J Lovell, J. Hagan, D. Middlemiss, 2000, Journal of medicinal chemistry.

The impact of genomics on drug discovery.

C. Southan, D. Duckworth, D M Duckworth, 2000, Progress in medicinal chemistry.

Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5‐HT2C/2B Receptor Antagonists.

Frank E. Blaney, S. Dabbs, D. Duckworth, 1997 .

Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.

S. Dabbs, D. Duckworth, I. Forbes, 1996, Journal of medicinal chemistry.

(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.

P J Lovell, J. Hagan, A. Brown, 1998, Journal of medicinal chemistry.

The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.

J. Hagan, D. Middlemiss, G. W. Price, 1998, Journal of medicinal chemistry.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

D. Middlemiss, S. Lightowler, S. Bromidge, 2000, Journal of medicinal chemistry.

The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK

P. Murdock, G. Rennie, D. Duckworth, 2001, Brain Research.

Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family.

D. Duckworth, L. Beeley, M. Barnes, 1998, Trends in pharmacological sciences.

Kinetic modification of the α1I subunit‐mediated T‐type Ca2+ channel by a human neuronal Ca2+ channel γ subunit

M. Pangalos, D. Duckworth, A. Medhurst, 2001 .

Co-cyclizations of nitrogen-containing acetylenes induced by a nickel triphenylphosphine complex to give aminoindane, isoindoline and isoindolinone derivatives

Edward H. Smith, David J. Williams, A. Slawin, 1996 .

Antiviral 9-[2-(phosphonomethoxy)alkoxy]purines

D. Duckworth, D. N. Planterose, R. Perkins, 1991 .

Biogenetically Patterned Synthesis of Cadambine

D. Duckworth, C. A. Santos, R. T. Brown, 1990 .

The impact of genomics on drug design

D. Duckworth, L. Beeley, 1996 .

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

S. Topp, P. Murdock, R. Prinjha, 2000, Pain.

9-[2-(Phosphonomethoxy)alkoxy]purines, A New Series of Antiviral Acyclonucleotides

D. Duckworth, D. N. Planterose, M. R. Harnden, 1991 .

Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT(2C/2B) receptor antagonists.

S. Bromidge, S. Dabbs, D. Davies, 1999, Bioorganic & medicinal chemistry.

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

S. Topp, P. Murdock, R. Prinjha, 2000, Pain.