P. Ham

发表

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.

S. Bromidge, S. Dabbs, D. Davies, 1998, Journal of medicinal chemistry.

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.

I. Forbes, P. Ham, T. Blackburn, 1995, Journal of medicinal chemistry.

Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5‐HT2C/2B Receptor Antagonists.

Frank E. Blaney, S. Dabbs, D. Duckworth, 1997 .

Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.

S. Dabbs, D. Duckworth, I. Forbes, 1996, Journal of medicinal chemistry.

The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.

J. Hagan, D. Middlemiss, G. W. Price, 1998, Journal of medicinal chemistry.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

D. Middlemiss, S. Lightowler, S. Bromidge, 2000, Journal of medicinal chemistry.

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.

F E Blaney, S. Bromidge, I. Forbes, 1997, Journal of medicinal chemistry.

The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration.

P. Ham, Stephen A. Smith, R. Buckingham, 1994 .

In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties

I. Forbes, P. Ham, T. Blackburn, 1996, British journal of pharmacology.

Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT(2C/2B) receptor antagonists.

S. Bromidge, S. Dabbs, D. Davies, 1999, Bioorganic & medicinal chemistry.

N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist.

P. Ham, G. Kennett, M. Wood, 1993, Journal of medicinal chemistry.