P. Wyman

发表

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.

S. Bromidge, S. Dabbs, D. Davies, 1998, Journal of medicinal chemistry.

Rational synthesis of low-polydispersity block copolymer vesicles in concentrated solution via polymerization-induced self-assembly.

S. Armes, P. Wyman, O. Mykhaylyk, 2014, Journal of the American Chemical Society.

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.

Paul W Smith, I. Forbes, P. Wyman, 2010, Bioorganic & medicinal chemistry letters.

SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist

Paul W Smith, C. Langmead, J. Hagan, 2006, Neuropharmacology.

SB‐272183, a selective 5‐HT1A, 5‐HT1B and 5‐HT1D receptor antagonist in native tissue

C. Davies, D. Middlemiss, C. Scott, 2001, British journal of pharmacology.

Phosphate diester hydrolysis within a highly reactive dinuclear cobalt(III) complex. Ligand effect on reactivity, transition state and dissociation

P. Wyman, Nicholas H Williams, 2001 .

The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.

J. Hagan, D. Middlemiss, G. W. Price, 1998, Journal of medicinal chemistry.

Cell Adhesion to Polymethacrylate Networks Prepared by Photopolymerization and Functionalized with GRGDS Peptide or Fibrinogen

S. MacNeil, N. Fullwood, P. Wyman, 2010 .

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.

D. Middlemiss, S. Lightowler, S. Bromidge, 2000, Journal of medicinal chemistry.

(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.

F. King, S. Starr, P. Wyman, 1993, Journal of medicinal chemistry.

SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor.

D. Middlemiss, C. Scott, G. W. Price, 1999, European journal of pharmacology.

Synthesis and anti-arthritic activity of a series of 1-aryl-3-dimethylamino-1,4-dihydroisoquinolines

P. Wyman, Stephen A. Smith, E. Karran, 1993 .

Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor.

F E Blaney, P. Wyman, F. Blaney, 1991, Journal of medicinal chemistry.

New quinoline NK3 receptor antagonists with CNS activity.

Paul W Smith, P. Wyman, Zining Wu, 2009, Bioorganic & medicinal chemistry letters.

7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents.

P. Wyman, S. Smith, R. Markwell, 1986, Journal of Medicinal Chemistry.

The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA.

R. Wolfenden, P. Wyman, Nicholas H Williams, 2006, Proceedings of the National Academy of Sciences of the United States of America.

7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic Acids and 7-Benzoyl-2,3- dihydrobenzo[b]thiophene-3-carboxylic Acids as Analgesic Agents.

P. Wyman, Stephen A. Smith, R. Markwell, 1986 .

Mononuclear Co(III)-complex promoted phosphate diester hydrolysis: dependence of reactivity on the leaving group†

P. Wyman, Nicholas H Williams, M. Padovani, 2004 .

Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist

C. Davies, P. Wyman, C. Gill, 2004, Neuropharmacology.

Synthesis of ethyl 1-azabicyclo[2.2.1]hept-4-yl carboxylate

P. Wyman, F. King, H. Wadsworth, 1991 .

N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity.

F. King, P. Wyman, G. Sanger, 1995, Journal of medicinal chemistry.

Amine-functionalization of glycidyl methacrylate-containing emulsion-templated porous polymers and immobilization of proteinase K for biocatalysis

P. Wyman, N. Cameron, Scott Kimmins, 2014 .

Synthesis of functional photopolymerized macroporous polyHIPEs by atom transfer radical polymerization surface grafting

P. Wyman, A. Heise, J. Thies, 2007 .

Flame‐retarding effects of dialkyl‐p‐vinylbenzyl phosphonates in copolymers with acrylonitrile

P. Wyman, P. Joseph, J. Ebdon, 2006 .

Improved synthesis of phosphorus-containing styrenic monomers

P. Wyman, J. Ebdon, B. Hunt, 2004 .

Addition of water to an alcoholic RAFT PISA formulation leads to faster kinetics but limits the evolution of copolymer morphology

S. Armes, P. Wyman, M. Semsarilar, 2016 .

The influence of comonomers on the degradation and flammability of polyacrylonitrile: Design input for a new generation of flame retardants

P. Wyman, P. Joseph, J. Ebdon, 2010 .

Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.

S. Bromidge, P. Wyman, G. Riley, 1992, Journal of medicinal chemistry.

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.

A. Brown, D. Middlemiss, S. Bromidge, 1999, Journal of medicinal chemistry.

How Do Spherical Diblock Copolymer Nanoparticles Grow during RAFT Alcoholic Dispersion Polymerization?

S. Armes, P. Wyman, O. Mykhaylyk, 2015, Macromolecules.

Hydrophilic coatings for biomedical applications in and ex vivo

P. Wyman, 2012 .

Discovery of small molecule antagonists of TRPV1.

P. Wyman, A. Randall, M. Gunthorpe, 2004, Bioorganic & medicinal chemistry letters.

Azabicyclic indole esters as potent 5-HT4 receptor antagonists.

F. King, P. Wyman, L. Gaster, 1996, Bioorganic & medicinal chemistry.

The discovery and development of 5-HT-terminal autoreceptor antagonists.

D. Middlemiss, F. King, P. Wyman, 2003, Progress in medicinal chemistry.

The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, on in vivo extracellular 5-HT levels in the freely-moving guinea-pig

J. Hagan, D. Middlemiss, P. Wyman, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Photopolymerised methacrylate-based emulsion-templated porous polymers

P. Wyman, N. Cameron, Scott Kimmins, 2012 .

Identification of a potent and selective 5-HT1B receptor antagonist.

Paul W Smith, C. Scott, G. W. Price, 2005, Bioorganic & medicinal chemistry letters.

Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells.

S. MacNeil, N. Fullwood, P. Wyman, 2007, Biomaterials.

Polymethacrylate Networks as Substrates for Cell Culture

S. MacNeil, N. Fullwood, P. Wyman, 2007 .

Base catalysed phosphate diester hydrolysis

P. Wyman, Nicholas H Williams, 2001 .