C. Parker

发表

Application of Nearest‐Neighbor and Cluster Analyses in Pharmaceutical Lead Discovery.

D. T. Stanton, T. Morris, S. Roychoudhury, 1999 .

Differentiation and Visualization of Diverse Cellular Phenotypic Responses in Primary High-Content Screening

P. Selzer, C. Parker, Y. Ibig-Rehm, 2012, Journal of biomolecular screening.

Dark chemical matter as a promising starting point for drug lead discovery.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2015, Nature chemical biology.

High‐Throughput Screening for Small‐Molecule Drug Discovery

C. Parker, J. Zhang, 2011 .

Comparison of Multivariate Data Analysis Strategies for High-Content Screening

Anne Kümmel, Hanspeter Gubler, Martin Beibel, 2011, Journal of biomolecular screening.

Latent hit series hidden in high-throughput screening data.

Ansgar Schuffenhauer, Christian N Parker, Thibault Varin, 2012, Journal of medicinal chemistry.

Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

H. Naegeli, C. Parker, R. Morris, 2009, Journal of the American Chemical Society.

Understanding False Positives in Reporter Gene Assays: in Silico Chemogenomics Approaches To Prioritize Cell-Based HTS Data

Andreas Bender, Meir Glick, Jeremy L. Jenkins, 2007, J. Chem. Inf. Model..

Activation of Yap-Directed Transcription by Knockdown of Conserved Cellular Functions

T. Bouwmeester, V. Myer, C. Mickanin, 2016, Journal of biomolecular screening.

Inhibition of bacterial IF2 binding to fMet-tRNA((fMet)) by aminoglycosides.

C. Parker, R. Sarver, J. M. Evans, 2003, Bioorganic & medicinal chemistry letters.

Novel oxazolidinone-quinolone hybrid antimicrobials.

J. Gage, C. Parker, D. Patel, 2003, Bioorganic & medicinal chemistry letters.

Recommendations for the reduction of compound artifacts in time-resolved fluorescence resonance energy transfer assays.

C. Parker, Vincent Unterreiner, Hanspeter Gubler, 2007, Assay and drug development technologies.

Characterization and inhibition study of MurA enzyme by capillary electrophoresis.

C. Parker, J. J. Bao, H. Dai, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Glucocorticoid receptor ligands modulate Cardiovirus encephalomyocarditis virus internal ribosome entry site activity.

Frederick J. King, D. Selinger, A. Schuffenhauer, 2013, Assay and drug development technologies.

A High Throughput Screen for Inhibitors of Fungal Cell Wall Synthesis

C. Parker, P. Zaworski, Jonathan M Evans, 2002, Journal of biomolecular screening.

Multiplexed Reporter Gene Assays: Monitoring the Cell Viability and the Compound Kinetics on Luciferase Activity

Frederick J. King, C. Parker, S. Serafini, 2011, Journal of biomolecular screening.

The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry.

K L Morand, T. Morris, C. Parker, 2001, Bioorganic & medicinal chemistry letters.

Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase

Christian N. Parker, Richard A. Houghten, Sylvie E. Blondelle, 2004, Molecular Diversity.

Stereoselectivity of DNA catenane fusion by resolvase

C. Parker, S. Halford, W. Stark, 1994, Nature.

Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis

T. Reinheckel, R. Backofen, C. Kreutz, 2023, Science Signaling.

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

Mathias Frederiksen, S. Reinker, S. Schuierer, 2015, Nature Communications.

Identification of the C3a Receptor (C3AR1) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells

E. Oakeley, J. Hamon, M. Beibel, 2013, The Journal of Biological Chemistry.

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

I. Clay, H. Ruffner, T. Bouwmeester, 2012, PloS one.

Multiparametric Analysis of Screening Data

Christian N Parker, Xian Zhang, C. Parker, 2014, Journal of biomolecular screening.

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

A. Bauer, H. Ruffner, T. Bouwmeester, 2015, Hepatology.

A novel HERC4-dependent glue degrader targeting STING

F. Nigsch, C. Parker, D. Bonenfant, 2023, bioRxiv.

Characterization of a High-Throughput Screening Assay for Inhibitors of Elongation Factor P and Ribosomal Peptidyl Transferase Activity

Christian N Parker, C. Parker, Zhigang Wang, 2006, Journal of biomolecular screening.

Identification of Cardiac Glycoside Molecules as Inhibitors of c-Myc IRES-Mediated Translation

D. Selinger, V. Myer, A. Schuffenhauer, 2013, Journal of biomolecular screening.

Dynamics of long-range interactions on DNA: The speed of synapsis during site-specific recombination by resolvase

Christian N. Parker, Stephen E. Halford, C. Parker, 1991, Cell.

A Review of Methods to Monitor the Modulation of mRNA Stability

C. Parker, D. Cheneval, T. Kastelic, 2010, Journal of biomolecular screening.

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

T. Reinheckel, R. Backofen, C. Parker, 2022, bioRxiv.

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

M. Schirle, P. Couttet, N. Schmiedeberg, 2023, bioRxiv.

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.

John A. Tallarico, S. Schuierer, J. Tallarico, 2017, Microbiological research.

Requirements of skin tissue models for high-throughput screening

Christian N. Parker, Stephanie Mathes, C. Parker, 2018 .

MiR-210 promotes sensory hair cell formation in the organ of corti

T. Bouwmeester, M. Beibel, C. Parker, 2016, BMC Genomics.

Site-specific recombination by mutants of Tn21 resolvase with DNA recognition functions from Tn3 resolvase.

C. Parker, S. Halford, P. Avila, 1990, Journal of molecular biology.

Data Shaving: A Focused Screening Approach

Suzanne K. Schreyer, Christian N. Parker, Gerald M. Maggiora, 2004, J. Chem. Inf. Model..

Application of Nearest-Neighbor and Cluster Analyses in Pharmaceutical Lead Discovery

David T. Stanton, Timothy W. Morris, Christian N. Parker, 1999, J. Chem. Inf. Comput. Sci..

“Plate Cherry Picking”: A Novel Semi-Sequential Screening Paradigm for Cheaper, Faster, Information-Rich Compound Selection

Andreas Bender, Meir Glick, Christian N Parker, 2007, Journal of biomolecular screening.

The Interweaving of Cheminformatics and HTS.

Anne Kümmel, Christian N Parker, C. Parker, 2011, Methods in molecular biology.

Review : Recent advances in quantitative high throughput and high content data analysis

Christian N Parker, Ioannis K Moutsatsos, C. Parker, 2016 .

An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p

Jeffrey A. Porter, Mathias Frederiksen, S. Reinker, 2012, Antimicrobial Agents and Chemotherapy.

Application of Chemoinformatics to High-Throughput Screening

Christian N. Parker, Suzanne K. Schreyer, C. Parker, 2004 .

Multiplexing Nuclear Receptors for Agonist Identification in a Cell-Based Reporter Gene High-Throughput Screen

C. Parker, D. Lala, B. Turner, 2003, Journal of biomolecular screening.

Development of a Method for the High‐Throughput Quantification of Cellular Proteins

D. Housman, C. Parker, P. Paganetti, 2009, Chembiochem : a European journal of chemical biology.

Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds

Christian N Parker, Shilpa Parakh, C. Parker, 2006, Journal of biomolecular screening.

A Screen for Enhancers of Clearance Identifies Huntingtin as a Heat Shock Protein 90 (Hsp90) Client Protein*

C. Parker, M. Bibel, P. Paganetti, 2011, The Journal of Biological Chemistry.

Compound Set Enrichment: A Novel Approach to Analysis of Primary HTS Data

Peter Ertl, Ansgar Schuffenhauer, Christian N. Parker, 2010, J. Chem. Inf. Model..

Integration of Multiple Readouts into the Z' Factor for Assay Quality Assessment

Anne Kümmel, Hanspeter Gubler, Patricia Gehin, 2010, Journal of biomolecular screening.

Towards Unified Compound Screening Strategies: A Critical Evaluation of Error Sources in Experimental and Virtual High‐Throughput Screening

Jürgen Bajorath, Christian N. Parker, J. Bajorath, 2006 .

Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform

Xian Zhang, Jeremy L. Jenkins, Imtiaz Hossain, 2016, SLAS discovery : advancing life sciences R & D.

Computational methods to support high-content screening: from compound selection and data analysis to postulating target hypotheses

Andreas Bender, Anne Kümmel, Daniela Gabriel, 2009, Expert opinion on drug discovery.

MiR-210 promotes sensory hair cell formation in the organ of corti

T. Bouwmeester, M. Beibel, C. Parker, 2016, BMC Genomics.

McMaster University Data-Mining and Docking Competition

Christian N Parker, C. Parker, 2005, Journal of biomolecular screening.

Measure, mine, model, and manipulate: the future for HTS and chemoinformatics?

Christopher P Austin, Jürgen Bajorath, Christian N Parker, 2006, Drug discovery today.

Development of a Quantitative Structure-Activity Relationship Model for Inhibition of Gram-positive Bacterial Cell Growth by Biarylamides

David T. Stanton, Prakash J. Madhav, Larry J. Wilson, 2004, J. Chem. Inf. Model..

Compound Set Enrichment: A Novel Approach to Analysis of Primary HTS Data

P. Raman, A. Schuffenhauer, P. Ertl, 2010, J. Chem. Inf. Model..

Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension

C. Parker, Yann Abraham, Xian Zhang, 2014 .

Recent advances in quantitative high throughput and high content data analysis

C. Parker, I. Moutsatsos, 2016, Expert opinion on drug discovery.

Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

H. Naegeli, C. Parker, R. Morris, 2009, Journal of the American Chemical Society.

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

Florian Nigsch, Martin Beibel, Heinz Ruffner, 2017, SLAS discovery : advancing life sciences R & D.

A High Throughput Screen for Inhibitors of Fungal Cell Wall Synthesis

C. Parker, P. Zaworski, Jonathan M Evans, 2002, Journal of biomolecular screening.