P. Seneci

发表

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

F. Vasile, D. Potenza, L. Belvisi, 2012, Organic & biomolecular chemistry.

Drug Design and Discovery in Alzheimer’s Disease

Kenneth J. Witt, M. Z. Ahmad, Eric A. Owens, 2014 .

Combinatorial chemistry and high-throughput screening in drug discovery: Different strategies and formats

Stanislav Miertus, Pierfausto Seneci, P. Seneci, 2004, Molecular Diversity.

Targeting the Protein Quality Control (PQC) Machinery

P. Seneci, 2015 .

Protein Misfolding, Neurodegeneration and Tau

P. Seneci, 2015 .

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents.

P. Seneci, D. Lecis, A. Bossi, 2016, Bioorganic & medicinal chemistry letters.

Proapoptotic Activity of a Monomeric Smac Mimetic on Human Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

M. Truzzi, P. Seneci, F. Ingegnoli, 2014, Inflammation.

Application of Combinatorial Technologies for Catalyst Design and Development

P. Seneci, S. Miertus, F. Gennari, 2000 .

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Alex M. Ascensión, M. Araúzo-Bravo, M. Gorospe, 2020, The Journal of clinical investigation.

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis

P. Seneci, D. Delia, C. Carlo-Stella, 2011, Investigational New Drugs.

Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus.

A. Prandi, P. Seneci, G. Fassina, 2012, Bioorganic & medicinal chemistry.

The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review

P. Seneci, G. Fassina, S. Miertus, 2014 .

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

P. Seneci, M. Christodoulou, D. Passarella, 2019, Pharmaceutics.

HIGH THROUGHPUT PURIFICATION METHODS IN COMBINATORIAL SOLUTION PHASE SYNTHESIS

P. Seneci, R. Ferritto, 1998 .

Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries

P. Seneci, C. Sizemore, K. Islam, 1996 .

DFG-in and DFG-out homology models of TrkB kinase receptor: induced-fit and ensemble docking.

P. Seneci, A. Bernardi, Č. Podlipnik, 2010, Journal of molecular graphics & modelling.

Targeting the Protein Quality Control (PQC) Machinery: The neuronal Salvation Army

P. Seneci, 2015 .

Regiospecific synthesis of mono-N-substituted indolopyrrolocarbazoles.

P. Seneci, T. Braxmeier, L. Casiraghi, 2005, Organic letters.

Intracisternal delivery of PEG-coated gold nanoparticles results in high brain penetrance and long-lasting stability

G. Martino, P. Seneci, P. Podini, 2019, Journal of Nanobiotechnology.

Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

P. Seneci, D. Arosio, L. Polito, 2022, Pharmaceutics.

Trehalose-based neuroprotective autophagy inducers.

P. Seneci, D. Arosio, L. Polito, 2021, Bioorganic & medicinal chemistry letters.

Targeting Assembly and Disassembly of Protein Aggregates

P. Seneci, 2015 .

Further information on the steric course of the baker's yeast reduction of 4-substituted-3-oxobutanoates

P. Seneci, C. Fuganti, P. Grasselli, 1986 .

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

M. Gaestel, P. Seneci, A. Provenzani, 2015, Scientific Reports.

Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes

P. Seneci, F. Ingegnoli, D. lattuada, 2016, Mediators of inflammation.

Synthesis and antimicrobial activity of oxazolidin-2-ones and related heterocycles

P. Seneci, R. Ciabatti, F. Ripamonti, 1994 .

Proapoptotic Activity of a Monomeric Smac Mimetic on Human Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

M. Truzzi, P. Seneci, F. Ingegnoli, 2014, Inflammation.

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL).

A. Neri, P. Seneci, D. Delia, 2013, Leukemia research.

Application of Combinatorial Technologies for Catalyst Design and Development

P. Seneci, S. Miertus, F. Gennari, 2000 .

A combinatorial approach to [1,5]benzothiazepine derivates as potential antibacterial agents.

P. Seneci, A. Pozzan, F. Micheli, 2001, Journal of combinatorial chemistry.

Detecting drugs in dry bone: a pilot study of skeletal remains with a post-mortem interval over 23 years

P. Seneci, C. Cattaneo, D. Candia, 2021, International Journal of Legal Medicine.

3.33 – Combinatorial Chemistry

P. Seneci, P. Seneci, 2007 .

SOLUTION PHASE LIBRARY OF PERHYDROOXAZIN-4-ONES

P. Seneci, M. Panunzio, T. Rossi, 1998 .

Trialkylsilyl Cyanide, Polymer‐supported

P. Seneci, 2003 .

Synthesis of Mono- and Disubstituted 1H-Imidazo [1,2-B] Pyrazoles

P. Seneci, G. Resnati, E. Vanotti, 1999 .

New polymer-bound haloarene chromium dicarbonyl isocyanide complexes: a successful study validating their use in solid-phase chemistry

P. Seneci, S. Provera, C. Baldoli, 2000 .

Immobilized benzylpenicillin acylase: Application to the synthesis of optically active forms of carnitin and propranalol

P. Seneci, S. Servi, C. Fuganti, 1986 .

Solid-Phase Synthesis and Combinatorial Technologies

Pierfausto Seneci, P. Seneci, 2000 .

Solid-Supported Nitrile Oxides as Stable and Valuable Reactive Intermediates

P. Seneci, G. Faita, M. Mella, 2002 .

Allylic Functionalization of 2,5- and 2,4-Cyclo-Hexadiene-1,3-Dicarboxylates

P. Seneci, S. Lociuro, L. Carrano, 1998 .

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

P. Seneci, A. Bernardi, D. Arosio, 2001, The Journal of organic chemistry.

Synthesis of non glycosidic nucleobase-sugar mimetics

P. Seneci, A. Bernardi, D. Arosio, 2010 .

Synthesis of polymer-bound fischer chromium alkoxy and aminocarbene complexes

P. Seneci, A. Papagni, S. Provera, 1999 .

Solid supported chiral auxiliaries in asymmetric synthesis. Part 2: Catalysis of 1,3-dipolar cycloadditions by Mg(II) cation

P. Seneci, G. Faita, P. Quadrelli, 2001 .

Stereoselective alkenylation of aldehydes with phosphorus carbanions: Preparation of E- and Z-2-alkoxy- and 2-aryloxy-2-alkenoates

P. Seneci, M. Souchet, G. Nadler, 1997 .

Cyclative cleavage via solid-phase supported stabilized sulfur ylides: synthesis of macrocyclic lactones

P. Seneci, S. Provera, C. Gennari, 2002 .

Peptide aldehydes as inhibitors of HIV protease

P. Seneci, N. Peet, M. Denaro, 1993, FEBS letters.

d‐Glucose as a Regioselectively Addressable Scaffold for Combinatorial Chemistry on Solid Phase

F. Nicotra, P. Seneci, F. Peri, 2003 .

Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Vladimir Frecer, Stanislav Miertus, Pierfausto Seneci, 2011, J. Comput. Aided Mol. Des..

(4S)-p-Hydroxybenzyl-1,3-oxazolidin-2-one as a solid-supported chiral auxiliary in asymmetric 1,3-dipolar cycloadditions

P. Seneci, G. Faita, P. Quadrelli, 2000 .

Synthesis of 2,5- and 2,4-Cyclohexadiene-1,3-dicarboxylates via Reductive Alkylation of Isophthalates

P. Seneci, S. Lociuro, L. Carrano, 1997 .

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

G. Comi, G. Martino, P. Seneci, 2020, Nature Communications.

Chemical diversity as a driving force to design and put in practice synthetic strategies leading to combinatorial libraries for lead discovery and lead optimization

Pierfausto Seneci, P. Seneci, 2002 .

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

F. Vasile, D. Potenza, L. Belvisi, 2014, Molecular pharmaceutics.

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

M. Colombo, P. Seneci, D. Delia, 2013, Cell Death and Disease.

Structure‐based design and molecular profiling of Smac‐mimetics selective for cellular IAPs

F. Cossu, P. Seneci, A. Corti, 2018, The FEBS journal.

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

M. Bolognesi, F. Cossu, P. Seneci, 2012, PloS one.

Recognition of Smac‐mimetic compounds by the BIR domain of cIAP1

M. Bolognesi, G. Canevari, F. Cossu, 2010, Protein science : a publication of the Protein Society.

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.

M. Bolognesi, G. Canevari, F. Cossu, 2009, Journal of molecular biology.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.

M. Bolognesi, F. Cossu, P. Seneci, 2009, Biochemical and biophysical research communications.

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.

Carlo Scolastico, Vincenzo Rizzo, Martino Bolognesi, 2008, Journal of molecular biology.

Targets and Small Molecules Against Tauopathies. Part 1: From Genes to Soluble, Aggregation-Prone Tau Proteins

P. Seneci, 2014 .

Studies on the novel anti-staphyloccal compound nematophin.

P. Seneci, P. Cavallini, F. Micheli, 2000, Bioorganic & medicinal chemistry letters.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis.

F. Vasile, D. Potenza, L. Belvisi, 2012, Bioorganic & medicinal chemistry.

Small molecules as pro-apoptotic anticancer agents.

P. Seneci, 2012, Pharmaceutical patent analyst.

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.

P. Seneci, D. Lecis, E. Mastrangelo, 2012, Bioorganic & medicinal chemistry letters.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

M. Bolognesi, M. Marizzoni, F. Vasile, 2009, Bioorganic & medicinal chemistry.

Targeting Unselective Autophagy of Cellular Aggregates

P. Seneci, 2015 .

Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors.

E. Novellino, P. Seneci, B. Pagano, 2021, Journal of medicinal chemistry.

Assembly and Disassembly of Protein Aggregates

P. Seneci, 2015 .

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

M. Bolognesi, P. Seneci, D. Delia, 2010, British Journal of Cancer.

Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau: What is not Covered Next

P. Seneci, 2015 .

Proteasomal Degradation of Soluble, Misfolded Proteins: Throwing out the Bath Water, but Where's the Baby?

P. Seneci, 2015 .

NEURODEGENERATIVE DISEASES AND TAU: PATHOLOGICAL EVENTS AND MOLECULAR TARGETS

P. Seneci, 2012 .

Polymer-supported silyl cyanide and silyl azide: useful reagents for solid-phase applications.

P. Seneci, M. Panunzio, T. Rossi, 2000, Biotechnology and bioengineering.

Solid-supported benzotriazoles. 2. Synthetic auxiliaries and traceless linkers for the combinatorial synthesis of unsymmetrical ureas.

P. Seneci, A. Paio, M. Ciraco, 2001, Journal of combinatorial chemistry.

Solid-Supported Benzotriazoles: Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Amine Libraries1

P. Seneci, A. Zaramella, A. Paio, 1999 .

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.

N. Plesnila, D. Dickson, M. Hutton, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

A. Ashworth, A. Bardelli, P. Seneci, 2015, Oncotarget.

Selective Disposal of Insoluble Protein Aggregates

P. Seneci, 2015 .

Unselective Disposal of Cellular Aggregates: Engulf, Devour and Digest to Recycle

P. Seneci, 2015 .

Regulation of HuR structure and function by dihydrotanshinone-I

M. Gorospe, E. Novellino, C. Luchinat, 2017, Nucleic acids research.

DIRECT DECONVOLUTION TECHNIQUES FOR POOL LIBRARIES OF SMALL ORGANIC MOLECULES*

P. Seneci, 2001, Journal of receptor and signal transduction research.

Stimulus-responsive liposomes for biomedical applications.

P. Seneci, D. Passarella, S. Pellegrino, 2021, Drug discovery today.

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.

E. Novellino, C. Luchinat, P. Seneci, 2018, Journal of medicinal chemistry.

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models.

P. Seneci, L. Cerofolini, M. Fragai, 2021, Advanced drug delivery reviews.

HuR modulation with tanshinone mimics impairs LPS response in murine macrophages

P. Seneci, S. Piazza, M. Fragai, 2023, bioRxiv.

Targeting Selective Autophagy of Insoluble Protein Aggregates: The Sniper’s Philosophy

P. Seneci, 2015 .

Dual Functionalized Liposomes for Selective Delivery of Poorly Soluble Drugs to Inflamed Brain Regions

P. Seneci, B. Vergani, G. Paglia, 2022, Pharmaceutics.

Targeting Proteasomal Degradation of Soluble, Misfolded Proteins

P. Seneci, 2015, Chemical Modulators of Protein Misfolding and Neurodegenerative Disease.

Raman Spectroscopy Characterization of Multi-Functionalized Liposomes as Drug-Delivery Systems for Neurological Disorders

P. Seneci, M. Bedoni, F. Re, 2023, Nanomaterials.

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.

M. Bolognesi, M. Civera, F. Vasile, 2012, Bioorganic & medicinal chemistry.

Transport of the antibacterial agent oxazolidin-2-one and derivatives across intestinal (Caco-2) and renal (MDCK) epithelial cell lines

W. Guba, P. Seneci, G. Ranaldi, 1996, Antimicrobial agents and chemotherapy.

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles

P. Seneci, D. Passarella, M. Colombo, 2022, RSC advances.

Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

P. Seneci, L. Cerofolini, M. Fragai, 2023, Computational and structural biotechnology journal.

2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles

P. Seneci, D. Passarella, L. Dalla Via, 2023, Pharmaceuticals.

Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates.

P. Seneci, M. Christodoulou, D. Passarella, 2019, ACS medicinal chemistry letters.

Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation

P. Seneci, V. Broccoli, D. Passarella, 2023, Pharmaceutics.

ENCODING TECHNIQUES FOR POOL LIBRARIES OF SMALL ORGANIC MOLECULES*

P. Seneci, 2001, Journal of receptor and signal transduction research.

DFG-in and DFG-out homology models of TrkB kinase receptor: induced-fit and ensemble docking.

P. Seneci, A. Bernardi, Č. Podlipnik, 2010, Journal of molecular graphics & modelling.

Drugs against avian influenza a virus: design of novel sulfonate inhibitors of neuraminidase N1.

P. Seneci, T. Rungrotmongkol, S. Miertus, 2014, Current pharmaceutical design.

Glibenclamide-Loaded Engineered Nanovectors (GNVs) Modulate Autophagy and NLRP3-Inflammasome Activation

P. Seneci, M. Saresella, I. Marventano, 2023, Pharmaceuticals.

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.

E. Novellino, C. Luchinat, P. Seneci, 2018, Journal of Medicinal Chemistry.

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

P. Seneci, M. Rizzi, D. Lecis, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

P. Seneci, D. Lecis, D. Arosio, 2014, Organic & biomolecular chemistry.

Anti-inflammatories: small molecule approaches - CHI's inaugural event.

P. Seneci, 2010, IDrugs : the investigational drugs journal.

Dansyl and dabsyl analytical constructs as tools for the accurate estimation of compounds in solid-phase synthesis.

P. Seneci, A. Zaramella, A. Paio, 2001, Journal of combinatorial chemistry.

Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands.

G. Terstappen, P. Seneci, M. Deal, 2000, Bioorganic & Medicinal Chemistry Letters.

Smac mimetics-Zn 2 + chelators as dual action antitumoral agents

P. Seneci, D. Lecis, D. Arosio, 2017 .

Concepts of Combinatorial Chemistry and Combinatorial Technologies

Pierfausto Seneci, Stanislav Miertus, Giorgio Fassina, 2000 .

Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface

P. Seneci, E. Mastrangelo, D. Gornati, 2024, Computational and structural biotechnology journal.

Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes

P. Seneci, G. Mobbili, Cristina Minnelli, 2023, Molecules.