D. Rossi

发表

Diffusion‐Ordered Spectroscopy and Saturation Transfer Difference NMR Spectroscopy Studies of Selective Interactions between ELAV Protein Fragments and an mRNA Target

F. Vasile, D. Potenza, D. Rossi, 2014 .

Chiral Flavanones from Amygdalus lycioides Spach: Structural Elucidation and Identification of TNFalpha Inhibitors by Bioactivity-guided Fractionation

D. Rossi, S. Collina, M. Christodoulou, 2012, Molecules.

TNF-α Blocker Effect of Naringenin-Loaded Sericin Microparticles that Are Potentially Useful in the Treatment of Psoriasis

M. Marazzi, D. Rossi, S. Collina, 2014, International journal of molecular sciences.

Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist.

D. Rossi, S. Collina, G. Cavaletti, 2016, Future medicinal chemistry.

An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-α,β-unsaturated Esters

D. Rossi, S. Collina, O. Azzolina, 2010, Molecules.

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

D. Rossi, S. Collina, A. Pascale, 2015 .

Sigma Receptors as Endoplasmic Reticulum Stress “Gatekeepers” and their Modulators as Emerging New Weapons in the Fight Against Cancer

A. Tesei, D. Rossi, S. Collina, 2018, Front. Pharmacol..

Are sigma receptor modulators a weapon against multiple sclerosis disease?

D. Rossi, S. Collina, G. Cavaletti, 2017, Future medicinal chemistry.

Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents.

A. Tesei, D. Rossi, S. Collina, 2016, European journal of medicinal chemistry.

A step forward in the sigma enigma: a role for chirality in the sigma1 receptor–ligand interaction?

D. Rossi, S. Collina, E. Laurini, 2015 .

Optimal graph‐based and Simplified Molecular Input Line Entry System‐based descriptors for quantitative structure–activity relationship analysis of arylalkylaminoalcohols, arylalkenylamines, and arylalkylamines as σ1 receptor ligands

Julio Caballero, D. Rossi, S. Collina, 2015 .

Sigma receptor modulators: a patent review

D. Rossi, S. Collina, A. Bassi, 2013, Expert opinion on therapeutic patents.

Models of the pharmacophoric pattern and affinity trend of methyl 2-(aminomethyl)-1-phenylcyclopropane-1-carboxylate derivatives as σ1 ligands

Julio Caballero, D. Rossi, S. Collina, 2012 .

Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site.

D. Rossi, S. Collina, E. Laurini, 2009, European journal of medicinal chemistry.

Enantioselective chromatography and absolute configuration of N,N-dimethyl-3-(naphthalen-2-yl)-butan-1-amines: potential sigma1 ligands.

D. Rossi, S. Collina, M. Urbano, 2006, Chirality.

Sigma-1 Receptor Agonists Acting on Aquaporin-Mediated H2O2 Permeability: New Tools for Counteracting Oxidative Stress

U. Laforenza, D. Rossi, S. Collina, 2021, International journal of molecular sciences.

Dual Aquaporin and Sigma1 Receptor (DAS) Modulators: New Tools for Counteracting Oxidative Stress

U. Laforenza, D. Rossi, S. Collina, 2020 .

Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R)

U. Laforenza, G. Colombo, D. Rossi, 2020, International journal of molecular sciences.

Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer

A. Tesei, D. Rossi, S. Collina, 2019, Front. Pharmacol..

Studies on the enantiomers of RC-33 as neuroprotective agents: isolation, configurational assignment, and preliminary biological profile.

D. Rossi, S. Collina, B. Wünsch, 2013, Chirality.

Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability.

D. Rossi, S. Collina, E. Laurini, 2013, Bioorganic & medicinal chemistry.

Chemical, Pharmacological, and in vitro Metabolic Stability Studies on Enantiomerically Pure RC‐33 Compounds: Promising Neuroprotective Agents Acting as σ1 Receptor Agonists

D. Rossi, S. Collina, E. Laurini, 2013, ChemMedChem.

Are sigma modulators an effective opportunity for cancer treatment? A patent overview (1996-2016)

A. Tesei, D. Rossi, S. Collina, 2017, Expert opinion on therapeutic patents.

Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists.

D. Rossi, S. Collina, L. Maggi, 2016, Biomedical chromatography : BMC.

Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment

D. Rossi, S. Collina, Marta Rui, 2016, Molecules.

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

D. Rossi, S. Collina, M. Salmona, 2014, Neurobiology of Disease.

Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines.

D. Rossi, S. Collina, K. Liedl, 2017, Bioorganic & medicinal chemistry.

(R)-(−)-Aloesaponol III 8-Methyl Ether from Eremurus persicus: A Novel Compound against Leishmaniosis

D. Rossi, S. Collina, L. Maggi, 2017, Molecules.

The use of a microwave-assisted solvent extraction coupled with HPLC-UV/PAD to assess the quality of Marrubium vulgare L. (white horehound) herbal raw material.

D. Rossi, S. Collina, G. Marrubini, 2019, Phytochemical analysis : PCA.

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties

D. Rossi, S. Collina, S. Rossi, 2017, Molecules.

The role of chirality in a set of key intermediates of pharmaceutical interest, 3‐aryl‐substituted‐&ggr;‐butyrolactones, evidenced by chiral HPLC separation and by chiroptical spectroscopies

D. Rossi, S. Collina, G. Mazzeo, 2017, Journal of pharmaceutical and biomedical analysis.

Urea-based anticancer agents. Exploring 100-years of research with an eye to the future

D. Rossi, S. Collina, P. Linciano, 2022, Frontiers in Chemistry.

Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents

A. Tesei, D. Rossi, S. Collina, 2020, Frontiers in Chemistry.

The sigma-1 receptor antagonists, promising players in fighting neuropathic pain.

D. Rossi, S. Collina, P. Linciano, 2020, Pharmaceutical patent analyst.

Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer

A. Tesei, D. Rossi, S. Collina, 2022, Molecules.

Enantiomeric Resolution and Absolute Configuration of a Chiral δ-Lactam, Useful Intermediate for the Synthesis of Bioactive Compounds

D. Rossi, S. Collina, M. Boiocchi, 2020, Molecules.

The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis*

Aurélien Grosdidier, Olivier Michielin, Vincent Zoete, 2007, Journal of Biological Chemistry.

Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.

D. Rossi, S. Collina, G. Cavaletti, 2018, European journal of medicinal chemistry.

Identification of Peptides with ELAV‐like mRNA‐Stabilizing Effect: An Integrated In Vitro/In Silico Approach

D. Rossi, S. Collina, E. Laurini, 2013, Chemical biology & drug design.

Stereospecific effects of benzo[d]isothiazolyloxypropanolamine derivatives at beta-adrenoceptors: synthesis, chiral resolution, and biological activity in vitro.

D. Rossi, S. Collina, M. Incerti, 2009, Chirality.

From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells

D. Rossi, S. Collina, M. Miloso, 2022, International journal of molecular sciences.

Influence of in vitro simulated gastroduodenal digestion on the antibacterial activity, metabolic profiling and polyphenols content of green tea (Camellia sinensis).

D. Rossi, L. Mannina, A. Sobolev, 2014 .

Dynamics of biomarkers across the stages of traumatic spinal cord injury - implications for neural plasticity and repair.

A. Nardone, D. Rossi, T. Begenisic, 2021, Restorative neurology and neuroscience.

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies.

A. Dömling, F. Vasile, D. Potenza, 2019, ACS medicinal chemistry letters.

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discovering New Hit Compounds

D. Rossi, S. Collina, Marta Rui, 2018, Molecules.

Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).

C. Laggner, D. Rossi, S. Collina, 2007, Bioorganic & medicinal chemistry.

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

D. Rossi, S. Collina, G. Barone, 2019, Molecules.

"Fit-for-purpose" development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ1 receptor agonist.

D. Rossi, S. Collina, Marta Rui, 2016, Journal of pharmaceutical and biomedical analysis.

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

Giacomo Rossino, Ivana Orellana, Julio Caballero, 2019, J. Chem. Inf. Model..

New Perspectives in Cancer Therapy: The Biotin-Antitumor MoleculeConjugates

D. Rossi, S. Collina, Marta Rui, 2014 .

Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy.

E. Novellino, B. Cosimelli, G. Greco, 2016, Chirality.

Identification and quantification of α-dicarbonyl compounds in balsamic and traditional balsamic vinegars and their cytotoxicity against human cells

G. Maga, D. Rossi, A. Amoroso, 2013 .

Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L.

D. Rossi, S. Collina, J. Žilić, 2014, Chemistry and physics of lipids.

Approaches for multi-gram scale isolation of enantiomers for drug discovery

Giacomo Rossino, Marta Rui, Simona Collina, 2017, Expert opinion on drug discovery.

Microwave-Assisted Extraction and HPLC-UV-CD Determination of (S)-usnic Acid in Cladonia foliacea

D. Rossi, S. Collina, G. Marrubini, 2021, Molecules.

PKC in Regenerative Therapy: New Insights for Old Targets

D. Rossi, S. Collina, Marta Rui, 2017, Pharmaceuticals.

Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In In Vitro Pancreatic Cancer Model

A. Tesei, D. Rossi, S. Collina, 2020, International journal of molecular sciences.

Synthesis and biological evaluation of new aryl-alkyl ( alkenyl )-4-benzylpiperidines , novel Sigma Receptor ( SR ) modulators , as potential anticancer-agent

Simona, Sabrina, A. Tesei, 2016 .

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

D. Rossi, S. Collina, A. Pascale, 2017, Journal of medicinal chemistry.

Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities

D. Rossi, S. Collina, J. Kirchmair, 2020, Journal of medicinal chemistry.

Identification of Compounds Targeting HuD: Another Brick in the Wall of Neurodegenerative Disease Treatment.

F. Vasile, D. Rossi, S. Collina, 2021, Journal of medicinal chemistry.

Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization.

Julio Caballero, D. Rossi, S. Collina, 2021, Journal of medicinal chemistry.

Identification of a potent and selective σ₁ receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.

M. Fernández, Julio Caballero, L. Fernández, 2011, Bioorganic & medicinal chemistry.

Challenges and Opportunities of Targeting Astrocytes to Halt Neurodegenerative Disorders

D. Rossi, L. Brambilla, C. F. Valori, 2021, Cells.

Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.

A. Tesei, S. Franchini, D. Rossi, 2023, European journal of medicinal chemistry.

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

F. Vasile, D. Potenza, D. Rossi, 2018, Scientific Reports.

Influence of the extraction mode on the yield of hyperoside, vitexin and vitexin-2''-O-rhamnoside from Crataegus monogyna Jacq. (hawthorn).

D. Rossi, S. Collina, F. Bracco, 2008, Phytochemical analysis : PCA.

Chemical and biological profile of racemic and optically active dialkylaminoalkylnaphthalenes with analgesic activity

D. Rossi, S. Collina, O. Azzolina, 2002 .

Discovery of small peptides derived from embryonic lethal abnormal vision proteins structure showing RNA-stabilizing properties.

D. Rossi, S. Collina, S. Govoni, 2009, Journal of medicinal chemistry.

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

C. Brullo, F. Vasile, E. Parisini, 2020, Molecules.

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells.

D. Rossi, S. Collina, S. Govoni, 2013, Pharmacological research.

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2018, MedChemComm.

BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application.

F. Vasile, D. Rossi, S. Collina, 2020, ACS medicinal chemistry letters.

Binding Studies and Quantitative Structure–Activity Relationship of 3‐Amino‐1H‐Indazoles as Inhibitors of GSK3β

Julio Caballero, Simona Collina, William Tiznado, 2011, Chemical biology & drug design.

Chiral 2-phenyl-3-hydroxypropyl esters as PKC-alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies.

F. Vasile, D. Potenza, D. Rossi, 2021, Chirality.

Cell-Penetrating Peptides as Valuable Tools for Nose-to-Brain Delivery of Biological Drugs

D. Rossi, L. Brambilla, L. B. De Martini, 2023, Cells.

Preliminary study on TNFα-blocker activity of Amygdalus lycioides spach extracts.

D. Rossi, S. Collina, F. Bracco, 2010 .

Enantioselective Modulatory Effects of Naringenin Enantiomers on the Expression Levels of miR-17-3p Involved in Endogenous Antioxidant Defenses

D. Rossi, S. Collina, M. Daglia, 2017, Nutrients.

A step forward in the identification of compounds interfering with the Embryonic Lethal Abnormal Vision (ELAV) protein - RNA complexes

F. Vasile, D. Potenza, D. Rossi, 2017 .

Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid?

D. Rossi, S. Collina, A. Pascale, 2023, International journal of molecular sciences.

Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization.

F. Vasile, D. Rossi, S. Collina, 2021, Bioorganic chemistry (Print).

Identification of a novel extracellular inhibitor of FGF2/FGFR signaling axis by combined virtual screening and NMR spectroscopy approach.

D. Rossi, S. Collina, H. Molinari, 2023, Bioorganic chemistry.

An Eco‐Friendly Enantioselective Access to (R)‐Naringenin as Inhibitor of Proinflammatory Cytokine Release

D. Rossi, S. Collina, M. Daglia, 2013, Chemistry & biodiversity.

Quick development of an analytical enantioselective high performance liquid chromatography separation and preparative scale-up for the flavonoid Naringenin.

D. Rossi, S. Collina, B. Mannucci, 2011, Journal of chromatography. A.

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

U. Laforenza, A. Tesei, D. Rossi, 2023, Pharmaceuticals.

Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines.

D. Rossi, S. Collina, K. Liedl, 2017, Bioorganic & medicinal chemistry.

Structural Insights into the Ligand–LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents

D. Rossi, S. Collina, A. Pellegrini, 2023, Molecules.

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

F. Vasile, D. Potenza, D. Rossi, 2018, Scientific Reports.