J. Angulo

发表

Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts

S. Monaco, L. Tailford, N. Juge, 2017, Angewandte Chemie.

Ligand-receptor binding affinities from saturation transfer difference (STD) NMR spectroscopy: the binding isotherm of STD initial growth rates.

J. Angulo, P. Enriquez-Navas, P. Nieto, 2010, Chemistry.

Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7

J. Angulo, Stefan Bidula, B. Cromer, 2019, Scientific Reports.

FUT8-Directed Core Fucosylation of N-glycans Is Regulated by the Glycan Structure and Protein Environment

J. Angulo, S. Vakhrushev, H. Clausen, 2021, ACS catalysis.

Fucosyltransferase-specific inhibition via next generation of fucose mimetics.

S. Monaco, J. Angulo, R. Hurtado-Guerrero, 2021, Chemical communications.

Fucosidases from the human gut symbiont Ruminococcus gnavus

S. Monaco, N. Juge, J. Angulo, 2020, Cellular and Molecular Life Sciences.

Surfactant controlled zwitterionic cellulose nanofibril dispersions.

J. Angulo, K. Edler, J. Muñoz-García, 2018, Soft matter.

Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization.

J. Angulo, P. Nieto, Giuseppe Macchione, 2013, Organic & biomolecular chemistry.

Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR.

J. Angulo, P. Nieto, J. Jiménez-Barbero, 2013, ACS chemical biology.

Synthesis of amine-functionalized heparin oligosaccharides for the investigation of carbohydrate-protein interactions in microtiter plates.

J. Angulo, P. Nieto, Giuseppe Macchione, 2012, Organic & biomolecular chemistry.

Dynamic properties of biologically active synthetic heparin-like hexasaccharides.

M. Gairí, J. Angulo, P. Nieto, 2005, Glycobiology.

The Activation of Fibroblast Growth Factors (FGFs) by Glycosaminoglycans: Influence of the Sulfation Pattern on the Biological Activity of FGF‐1

M. Redondo-Horcajo, J. Angulo, P. Nieto, 2004, Chembiochem : a European journal of chemical biology.

Interaction of heparin with Ca2+: A model study with a synthetic heparin‐like hexasaccharide

J. Angulo, P. Nieto, M. Martín-Lomas, 2000 .

Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria

G. Thomas, J. Naismith, S. Monaco, 2020, The Journal of Biological Chemistry.

Elucidation of a unique sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

Jan Claesen, G. Thomas, N. Juge, 2019, Nature Microbiology.

Unravelling the Specificity of Laminaribiose Phosphorylase from Paenibacillus sp. YM‐1 towards Donor Substrates Glucose/Mannose 1‐Phosphate by Using X‐ray Crystallography and Saturation Transfer Difference NMR Spectroscopy

J. Angulo, R. Field, C. Stevenson, 2018, Chembiochem : a European journal of chemical biology.

Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors.

S. Monaco, J. Angulo, A. Hemmings, 2018, Chemistry.

Mechanically Robust Gels Formed from Hydrophobized Cellulose Nanocrystals.

S. Eichhorn, R. Harniman, J. Angulo, 2018, ACS applied materials & interfaces.

The Activation of Fibroblast Growth Factors by Heparin: Synthesis, Structure, and Biological Activity of Heparin‐Like Oligosaccharides

M. Redondo-Horcajo, J. Angulo, P. Nieto, 2001, Chembiochem : a European journal of chemical biology.

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

A. Varki, G. Taylor, S. Monaco, 2017, Nature Communications.

The Heparin−Ca2+ Interaction: Structure of the Ca2+ Binding Site

J. Angulo, P. Nieto, M. Martín-Lomas, 2002 .

Assembling different antennas of the gp120 high mannose-type glycans on gold nanoparticles provides superior binding to the anti-HIV antibody 2G12 than the individual antennas.

J. Angulo, P. Enriquez-Navas, S. Penadés, 2015, Carbohydrate research.

Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design.

A. Bernardi, J. Angulo, P. Nieto, 2013, Journal of the American Chemical Society.

Spin Saturation Transfer Difference NMR (SSTD NMR): A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes

J. Angulo, C. Macdonald, M. Muñoz, 2016, Journal of visualized experiments : JoVE.

NMR Techniques for the Study of Transient Intermolecular Interactions

M. Martín-Pastor, J. Angulo, P. Nieto, 2014 .

Thermosensitive supramolecular and colloidal hydrogels via self-assembly modulated by hydrophobized cellulose nanocrystals

S. Eichhorn, R. Harniman, J. Angulo, 2019, Cellulose.

Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics.

J. Angulo, P. Nieto, J. Muñoz-García, 2013, Glycobiology.

NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery

J. Angulo, P. Hardwidge, R. Hurtado-Guerrero, 2021, Chemical science.

Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR.

Philip A. Gale, M. Facciotti, J. Angulo, 2016, Soft matter.

Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.

J. Angulo, P. Nieto, R. Lozano, 2005, Journal of the American Chemical Society.

Deriving ligand orientation on weak protein-ligand complexes by DEEP-STD NMR in the absence of protein chemical shift assignment

L. Tailford, N. Juge, J. Angulo, 2018 .

Synthesis, biological evaluation, WAC and NMR studies of S-galactosides and non-carbohydrate ligands of cholera toxin based on polyhydroxyalkylfuroate moieties.

J. Angulo, S. Ohlson, I. Robina, 2013, Chemistry.

Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules.

J. Angulo, D. Blaas, Hannelore Peters, 2005, Virology.

Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment

L. Tailford, N. Juge, J. Angulo, 2018, Chembiochem : a European journal of chemical biology.

Spin diffusion transfer difference (SDTD) NMR: An advanced method for the characterisation of water structuration within particle networks.

J. Angulo, K. Edler, J. Muñoz-García, 2020, Journal of colloid and interface science.

Understanding heat driven gelation of anionic cellulose nanofibrils: Combining saturation transfer difference (STD) NMR, small angle X-ray scattering (SAXS) and rheology.

J. Angulo, K. Edler, J. Muñoz-García, 2019, Journal of colloid and interface science.

Sensitization of the Escherichia coli cyclic AMP receptor protein to trypsin cleavage by polydeoxyribonucleotides and polyribonucleotides.

J. Angulo, J. Krakow, 1986, The Journal of biological chemistry.

The heparin-Ca(2+) interaction: Structure of the Ca(2+) binding site

J. Angulo, P. Nieto, R. Lucas, 2002 .

Insights into molecular recognition of Lewis(X) mimics by DC-SIGN using NMR and molecular modelling.

F. Doro, A. Bernardi, J. Angulo, 2011, Organic & biomolecular chemistry.

Solution NMR structure of a human FGF‐1 monomer, activated by a hexasaccharide heparin‐analogue

J. Angulo, P. Nieto, B. López-Méndez, 2006, The FEBS journal.

The heparin-Ca(2+) interaction: the influence of the O-sulfation pattern on binding.

J. Angulo, P. Nieto, R. Lucas, 2004, Carbohydrate research.

sp2-Iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; implications for glycosidase inhibition.

J. Angulo, P. Nieto, C. Ortiz Mellet, 2012, Chemistry.

The activation of fibroblast growth factors by heparin: Synthesis and structural study of rationally modified heparin-like oligosaccharides

J. Angulo, P. Nieto, R. Ojeda, 2002 .

Saturation Transfer Difference (STD) NMR Spectroscopy Characterization of Dual Binding Mode of a Mannose Disaccharide to DC‐SIGN

J. Angulo, P. Nieto, J. Rojo, 2008, Chembiochem : a European journal of chemical biology.

Carbohydrate-carbohydrate interaction prominence in 3D supramolecular self-assembly.

J. Angulo, P. Enriquez-Navas, F. Briones, 2008, The journal of physical chemistry. B.

Hydrophobization of cellulose nanocrystals for aqueous colloidal suspensions and gels.

S. Eichhorn, J. Angulo, K. Edler, 2020, Biomacromolecules.

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

Zoë A. E. Waller, J. Angulo, M. O'Connell, 2017, Inorganic chemistry.

Bottom-up Chemoenzymatic Synthesis Towards Novel Fluorinated Cellulose-like Materials

S. Eichhorn, R. Harniman, Peterson de Andrade, 2020 .

Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy

J. Angulo, G. Lloyd, K. Nartowski, 2017, Chemistry.

STD-NMR: application to transient interactions between biomolecules—a quantitative approach

J. Angulo, P. Nieto, 2011, European Biophysics Journal.

Langerin-heparin interaction: two binding sites for small and large ligands as revealed by a combination of NMR spectroscopy and cross-linking mapping experiments.

A. Imberty, J. Angulo, P. Nieto, 2015, Journal of the American Chemical Society.

Chemoenzymatic Synthesis of Fluorinated Cellodextrins Identifies a New Allomorph for Cellulose‐Like Materials

S. Eichhorn, R. Harniman, J. Angulo, 2020, Chemistry.

Blood group B galactosyltransferase: insights into substrate binding from NMR experiments.

B. Meyer, J. Angulo, N. Krishna, 2006, Journal of the American Chemical Society.

Structures of glycans bound to receptors from saturation transfer difference (STD) NMR spectroscopy: quantitative analysis by using CORCEMA-ST.

J. Angulo, P. Enriquez-Navas, P. Nieto, 2015, Methods in molecular biology.

Synthesis and structural study of two new heparin-like hexasaccharides.

J. Angulo, P. Nieto, R. Lucas, 2003, Organic & biomolecular chemistry.

Fragment-based Screening of the Donor Substrate Specificity of Human Blood Group B Galactosyltransferase Using Saturation Transfer Difference NMR*

J. Angulo, M. Palcic, Hannelore Peters, 2006, Journal of Biological Chemistry.

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

S. Monaco, N. Juge, J. Angulo, 2021, PLoS biology.

Tunable Supramolecular Gel Properties by Varying Thermal History.

Yousef M. Abul-Haija, Pim W. J. M. Frederix, J. Angulo, 2019, Chemistry.

Kinetics of intramolecular chemical exchange by initial growth rates of spin saturation transfer difference experiments (SSTD NMR).

J. Angulo, M. Muñoz, M. Quirós, 2015, Chemical communications.

Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods

M. Martín-Pastor, J. Angulo, P. Nieto, 2006, Journal of biomolecular NMR.

Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering.

A. Bernardi, J. Angulo, P. Nieto, 2016, Organic & biomolecular chemistry.

NMR studies on carbohydrate interactions with DC-SIGN towards a quantitative STD analysis

J. Angulo, P. Enriquez-Navas, P. Nieto, 2013 .

Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design† †Electronic supplementary information (ESI) available: Experimental procedures, spectra and processed biophysical assay data. See DOI: 10.1039/c9sc00059c

J. Angulo, S. Walpole, M. O'Connell, 2019, Chemical science.

Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

A. Imberty, J. Angulo, P. Nieto, 2014, Glycobiology.

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

A. Kamali, E. Karita, S. Monaco, 2022, Cell reports.

The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain

M. Gorospe, Je-Hyun Yoon, M. Gunzburg, 2014, RNA biology.

Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe–host interactions

N. Juge, J. Angulo, A. P. Gunning, 2018, Proceedings of the National Academy of Sciences.

Effect of the substituents of the neighboring ring in the conformational equilibrium of iduronate in heparin-like trisaccharides.

J. Angulo, P. Nieto, Irene Díaz-Contreras, 2012, Chemistry.

STD NMR Study of the Interactions between Antibody 2G12 and Synthetic Oligomannosides that Mimic Selected Branches of gp120 Glycans

J. Angulo, P. Enriquez-Navas, M. Marradi, 2012, Chembiochem : a European journal of chemical biology.

Gold nanoparticles coated with oligomannosides of HIV-1 glycoprotein gp120 mimic the carbohydrate epitope of antibody 2G12.

J. Angulo, P. Enriquez-Navas, E. Yuste, 2011, Journal of molecular biology.

A solution NMR study of the interactions of oligomannosides and the anti-HIV-1 2G12 antibody reveals distinct binding modes for branched ligands.

J. Angulo, P. Enriquez-Navas, D. Padro, 2011, Chemistry.

A self-correcting method for the measurement of free calcium and magnesium concentrations by 1H NMR.

J. Angulo, M. Wallace, Y. Khimyak, 2019, Analytical chemistry.

The conformational behaviour of α,β-trehalose-like disaccharides and their C-glycosyl, imino-C-glycosyl and carbagalactose analogues depends on the chemical nature of the modification: an NMR investigation

J. Angulo, F. Cañada, J. L. Asensio, 2005 .

Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

S. Monaco, J. Angulo, I. Robina, 2022, Pharmaceuticals.

Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding

H. Sitte, J. Angulo, C. Macdonald, 2020, Scientific Reports.

NMR analysis of carbohydrate-protein interactions.

Thomas Peters, Francisco Parra, J. Angulo, 2006, Methods in enzymology.

Ginsenosides Act As Positive Modulators of P2X4 Receptors

M. Stebbing, J. Angulo, Stefan Bidula, 2018, Molecular Pharmacology.

Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

A. Velázquez‐Campoy, J. Carrodeguas, J. Denu, 2020, The Journal of biological chemistry.

Exploring Multi‐Subsite Binding Pockets in Proteins: DEEP‐STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B

S. Monaco, J. Angulo, M. Bergström, 2020, Chemistry.

Glycosaminoglycans: What Remains To Be Deciphered?

F. Lisacek, J. Angulo, P. Nieto, 2023, JACS Au.

Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions

S. Monaco, J. Angulo, Y. Khimyak, 2019, Natural Product Communications.

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

Young Hun Kim, S. Monaco, J. Angulo, 2018, Nature Communications.

Molecular Recognition of Natural and Non‐Natural Substrates by Cellodextrin Phosphorylase from Ruminiclostridium Thermocellum Investigated by NMR Spectroscopy

Peterson de Andrade, J. Angulo, R. Field, 2021, Chemistry.

Cover Picture: The Activation of Fibroblast Growth Factors (FGFs) by Glycosaminoglycans: Influence of the Sulfation Pattern on the Biological Activity of FGF‐1 (ChemBioChem 1/2004)

M. Redondo-Horcajo, J. Angulo, P. Nieto, 2004 .

Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB

J. Angulo, A. Cameron, E. Fullam, 2019, bioRxiv.

3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.

J. Angulo, P. Nieto, J. D. de Paz, 2013, Organic & biomolecular chemistry.

A STD-NMR Study of the Interaction of the Anabaena Ferredoxin-NADP+ Reductase with the Coenzyme

J. Angulo, P. Nieto, M. Medina, 2014, Molecules.

Selective targeting of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) with mannose-based glycomimetics: synthesis and interaction studies of bis(benzylamide) derivatives of a pseudomannobioside.

A. Bernardi, J. Angulo, J. Weiser, 2013, Chemistry.

Multifrequency STD NMR Unveils the Interactions of Antibiotics With Burkholderia multivorans Biofilm Exopolysaccharide

S. Monaco, J. Angulo, R. Rizzo, 2021, Frontiers in Molecular Biosciences.

J. Angulo, S. Walpole, M. O'Connell, 2019, Chemical science.

Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.

J. Angulo, L. Howell, M. Searcey, 2016, Chemistry.

Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter

C. Brown, J. Angulo, P. Stansfeld, 2021, The Journal of biological chemistry.

Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery.

J. Angulo, C. Morris, A. Checcucci, 2020, Colloids and surfaces. B, Biointerfaces.

Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics.

J. Angulo, P. Nieto, J. D. de Paz, 2013, Glycobiology.

A molecular dynamics description of the conformational flexibility of the L-iduronate ring in glycosaminoglycans.

J. Angulo, P. Nieto, M. Martín‐Lomas, 2003, Chemical communications.

Langerin-heparin interaction: two binding sites for small and large ligands as revealed by a combination of NMR spectroscopy and cross-linking mapping experiments.

A. Imberty, J. Angulo, P. Nieto, 2015, Journal of the American Chemical Society.

3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.

J. Angulo, P. Nieto, J. D. de Paz, 2013, Organic & biomolecular chemistry.

Unravelling the mechanisms of drugs partitioning phenomena in micellar systems via NMR spectroscopy.

S. Monaco, J. Angulo, K. Nartowski, 2023, Journal of colloid and interface science.

Bug Off Pain: An Educational Virtual Reality Game on Spider Venoms and Chronic Pain for Public Engagement

J. Angulo, S. Walpole, L. Stokes, 2019, Journal of Chemical Education.

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

Young Hun Kim, S. Monaco, J. Angulo, 2018, Nature Communications.

Serine-rich repeat protein adhesins from Lactobacillus reuteri display strain specific glycosylation profiles

J. Walter, N. Juge, J. Angulo, 2018, Glycobiology.