G. Ghosh

发表

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views.

F. E. Chen, G. Ghosh, F. Chen, 1999, Oncogene.

Regulation of DNA binding by Rel/NF-κB transcription factors: structural views

G. Ghosh, F. Chen, 1999, Oncogene.

Structure and mechanism in NF-kappa B/I kappa B signaling.

G. Ghosh, S. Malek, T. Huxford, 1999, Cold Spring Harbor symposia on quantitative biology.

Transcriptional regulation via the NF-kappaB signaling module.

A. Hoffmann, G. Natoli, G. Ghosh, 2006, Oncogene.

Transcriptional regulation via the NF-κB signaling module

A. Hoffmann, G. Natoli, G. Ghosh, 2006, Oncogene.

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase

G. Ghosh, Aditi Chawla, Sutapa Chakrabarti, 2011, The Journal of cell biology.

Enhanced intracellular mobility and nuclear accumulation of DNA plasmids associated with a karyophilic protein.

G. Ghosh, V. Kišš, A. Mesika, 2005, Human gene therapy.

Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.

P. Sigler, G. Ghosh, G. V. Van Duyne, 1996, Journal of molecular biology.

The X-ray Crystal Structure of the NF-κB p50·p65 Heterodimer Bound to the Interferon β-κB Site*

P. Sigler, G. Ghosh, B. Berkowitz, 2002, The Journal of Biological Chemistry.

Regulation of protein kinases; controlling activity through activation segment conformation.

Susan S. Taylor, G. Ghosh, B. Nolen, 2004, Molecular cell.

IκBα Functions through Direct Contacts with the Nuclear Localization Signals and the DNA Binding Sequences of NF-κB*

G. Ghosh, S. Malek, T. Huxford, 1998, The Journal of Biological Chemistry.

Mass Spectrometric and Kinetic Analysis of ASF/SF2 Phosphorylation by SRPK1 and Clk/Sty*

Xiang-Dong Fu, Xiang-Dong Fu, Huilin Zhou, 2005, Journal of Biological Chemistry.

Exonic unpaired elements modulate pre-mRNA structure for splice site recognition

R. Spitale, G. Ghosh, W. England, 2018 .

The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box.

P B Sigler, B. DeDecker, P. Sigler, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A structural basis for selective dimerization by NF-κB RelB.

G. Ghosh, De-bin Huang, Annapurna Vemu, 2013, Journal of molecular biology.

Crystal Structure of a Free κB DNA: Insights into DNA Recognition by Transcription Factor NF-κB

G. Ghosh, C. Phelps, De-bin Huang, 2005 .

IKAPPABALPHA/NF-KAPPAB COMPLEX

G. Ghosh, S. Malek, T. Huxford, 1999 .

Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation.

E. Komives, G. Ghosh, T. Huxford, 2002, Journal of molecular biology.

A fourth IkappaB protein within the NF-kappaB signaling module.

Hana Kim, Alexander Hoffmann, Vinay Tergaonkar, 2007, Cell.

p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation

C. Ware, G. Ghosh, Kushol Gupta, 2014, Proceedings of the National Academy of Sciences.

Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity.

G. Ghosh, C. Phelps, 2004, Oncogene.

Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer.

G. Ghosh, T. Huxford, De-bin Huang, 2004, Current opinion in structural biology.

Flexible Regions within IκBα Create the Ubiquitin-independent Degradation Signal*

E. Komives, G. Ghosh, Lily Wang, 2010, The Journal of Biological Chemistry.

Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin)

J. M. Schilling, D. Sahoo, G. van den Bogaart, 2021, Hypertension.

The 20 S proteasome processes NF-j B 1 p 105 into p 50 in a translation-independent manner

G. Ghosh, V. Wang, O. Savinova, 2013 .

The 20S proteasome processes NF‐κB1 p105 into p50 in a translation‐independent manner

G. Ghosh, V. Wang, O. Savinova, 2006, The EMBO journal.

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

S. Knapp, O. Fedorov, B. Turk, 2009, Structure.

Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography.

J. Adams, G. Ghosh, Sutapa Chakrabarti, 2003, Biochemistry.

NF-κB Potentiates Caspase Independent Hydrogen Peroxide Induced Cell Death

A. Hoffmann, G. Ghosh, M. Asagiri, 2011, PloS one.

A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity.

G. Ghosh, M. Sen, 2016, Molecular cell.

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing

R. Spitale, G. Ghosh, W. England, 2020, bioRxiv.

Construction, expression, purification and functional analysis of recombinant NFkappaB p50/p65 heterodimer.

F. E. Chen, G. Ghosh, C. Phelps, 1999, Protein engineering.

Structural Basis for the Activation of IKK1/α

I. Verma, G. Ghosh, D. Lyumkis, 2016, Cell reports.

The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100

C. Ware, G. Ghosh, V. Wang, 2016, Science Signaling.

NF-j B dictates the degradation pathway of I j B a

A. Hoffmann, G. Ghosh, Ellen L O'Dea, 2008 .

Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-κB through a targetable second interaction with upstream activator IKK2

G. Ghosh, T. Huxford, Smarajit Polley, 2022, The Journal of biological chemistry.

A Structural Guide to Proteins of the NF- k B Signaling Module

G. Ghosh, T. Huxford, 2009 .

The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection

D. Sahoo, A. Chakraborty, G. Ghosh, 2022, Research square.

X-ray Structure of a NF- κ B p50/RelB/DNA Complex Reveals Assembly of Multiple Dimers on Tandem κ B Sites

G. Ghosh, V. Wang, De-bin Huang, 2014 .

PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB

G. Stark, M. Miyagi, G. Ghosh, 2013, Proceedings of the National Academy of Sciences.

Discovery of an IKK2 Site that Allosterically Controls Its Activation

Rommie E. Amaro, D. Siegel, G. Ghosh, 2021, bioRxiv.

Structural Aspects of NF-_B and I_B Proteins

G. Ghosh, T. Huxford, A. Moorthy, 2006 .

Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB.

G. Ghosh, S. Malek, T. Huxford, 1998, The Journal of biological chemistry.

Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma.

M. Karin, G. Ghosh, E. Shimada, 2007, Biochemistry.

Inhibitor ?B Kinase Binding by Inhibitor ?B Kinase ?

M. Karin, G. Ghosh, E. Shimada, 2007 .

Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

G. Ghosh, V. Wang, V. Meshcheryakov, 2022, bioRxiv.

Immune Response to COVID-19 in India through Vaccination and Natural Infection

G. Ghosh, D. Chattopadhyay, Kaushik Saha, 2022, Fortune journal of health sciences.

p105·IκBγ and Prototypical IκBs Use a Similar Mechanism to Bind but a Different Mechanism to Regulate the Subcellular Localization of NF-κB*

G. Ghosh, A. Moorthy, 2003, The Journal of Biological Chemistry.

X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex

S. Ghosh, G. Ghosh, T. Huxford, 2002 .

Thermodynamics Reveal that Helix Four in the NLS of NF-κB p65 Anchors IκBα, Forming a Very Stable Complex

E. Komives, G. Ghosh, T. Huxford, 2006 .

Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases.

J. Adams, G. Ghosh, Brandon E. Aubol, 2002, Biochemistry.

Pieces of the puzzle: assembling the preinitiation complex of Pol II.

G. Ghosh, G. V. Van Duyne, 1996, Structure.

Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly

G. Ghosh, Kaushik Saha, 2022, bioRxiv.

U1 snRNP regulates early spliceosome assembly by disrupting the interaction between SR proteins and the pre-mRNA

G. Ghosh, Kaushik Saha, 2022 .

UNIVERSITY OF CALIFORNIA SAN DIEGO Splice Site Recognition During Early Spliceosome Assembly A Thesis submitted in partial satisfaction of the requirements for the degree Master of Science in Chemistry

G. Ghosh, Charles Leonard, Mallari Lumba, 2019 .

Interferon Response Elements by NF-{ kappa } B p 50 The Specificity of Innate Immune Responses Is Enforced by Repression of

A. Hoffmann, J. Ponomarenko, C. Benedict, 2011 .

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

S. Joseph, G. Ghosh, Kaushik Saha, 2018, bioRxiv.

Role of lysine methylation of NF-κB in differential gene regulation

G. Stark, G. Ghosh, Han-Song Wei, 2013, Proceedings of the National Academy of Sciences.

Pre-folding I κ B α alters control of NF- κ B signaling

G. Ghosh, S. M. Truhlar, Carla F. Cervantes, 2008 .

κB-Ras Binds to the Unique Insert within the Ankyrin Repeat Domain of IκBβ and Regulates Cytoplasmic Retention of IκBβ·NF-κB Complexes*

G. Ghosh, Yi Chen, Joann Wu, 2003, Journal of Biological Chemistry.

Inhibition of Transcription Factor NF-?B Activation by ?B-Ras

G. Ghosh, T. Huxford, 2006 .

Editorial overviewProtein kinases: Catalysis and regulation

Susan S. Taylor, G. Ghosh, 2006 .

KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes.

G. Ghosh, Yi Chen, Joann Wu, 2003, The Journal of biological chemistry.

Structural insights into NF-κB/IκB signaling

G. Ghosh, T. Huxford, De-bin Huang, 2000 .

Intrapulmonary administration of purified NEIL2 abrogates NF-κB–mediated inflammation

A. Chakraborty, G. Ghosh, I. Boldogh, 2021, The Journal of biological chemistry.

Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes

G. van den Bogaart, G. Ghosh, K. Tang, 2022, Frontiers in Endocrinology.

Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB.

G. Ghosh, C. Phelps, De-bin Huang, 2005, Journal of molecular biology.

The Specificity of Innate Immune Responses Is Enforced by Repression of Interferon Response Elements by NF-κB p50

A. Hoffmann, J. Ponomarenko, C. Benedict, 2011, Science Signaling.

A structural guide to proteins of the NF-kappaB signaling module.

G. Ghosh, T. Huxford, 2009, Cold Spring Harbor perspectives in biology.

NF-κB, IκB, and IKK: Integral Components of Immune System Signaling.

G. Ghosh, T. Huxford, M. C. Mulero, 2019, Advances in experimental medicine and biology.

Recognition of Nucleic Acids by Transcription Factor NF-κB

G. Ghosh, T. Huxford, De-bin Huang, 2010 .

A novel DNA recognition mode by the NF-κB p65 homodimer

S. Ghosh, G. Ghosh, Yong-qing Chen, 1998, Nature Structural Biology.

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

G. Ghosh, F. Chen, De-bin Huang, 1998, Nature.

Structure of NF-κB p50 homodimer bound to a κB site

P. Sigler, S. Ghosh, G. Ghosh, 1998, Nature.

Structure of NF-kappa B p50 homodimer bound to a kappa B site.

P B Sigler, P. Sigler, G. Ghosh, 1995, Nature.

Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.

Xiang-Dong Fu, J. Adams, G. Ghosh, 2009, Genes & development.

Deletion of the N-terminus of SF2/ASF Permits RS-Domain-Independent Pre-mRNA Splicing

A. Krainer, G. Ghosh, Sutapa Chakrabarti, 2007, PloS one.

Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis

A. Chakraborty, T. Ashizawa, G. Ghosh, 2020, Proceedings of the National Academy of Sciences.

The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes.

A. Hoffmann, G. Ghosh, O. Savinova, 2009, Molecular cell.

Pho5p and Newly Identified Nucleotide Pyrophosphatases/ Phosphodiesterases Regulate Extracellular Nucleotide Phosphate Metabolism in Saccharomyces cerevisiae

G. Ghosh, E. Kennedy, L. Pillus, 2005, Eukaryotic Cell.

Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics

A. Hoffmann, R. Spreafico, G. Ghosh, 2020, Cell reports.

B-Ras κ Association with in β B κ B Activity by I κ Inhibition of NF-

J. Sondek, G. Ghosh, Yi Chen, 2014 .

NF‐κB regulation: lessons from structures

G. Ghosh, V. Wang, De-bin Huang, 2012, Immunological reviews.

Understanding the logic of IκB:NF-κB regulation in structural terms.

Alexander Hoffmann, A. Hoffmann, G. Ghosh, 2011, Current topics in microbiology and immunology.

Kinetic enhancement of NF-κB·DNA dissociation by IκBα

Elizabeth A. Komives, Simon Bergqvist, Alexander Hoffmann, 2009, Proceedings of the National Academy of Sciences.

The IκBα/NF‐κB complex has two hot spots, one at either end of the interface

E. Komives, G. Ghosh, S. Bergqvist, 2008, Protein science : a publication of the Protein Society.

Transcriptional Outcome of Wnt-Frizzled Signal Transduction in Inflammation: Evolving Concepts

G. Ghosh, M. Sen, 2008, The Journal of Immunology.

Pre-folding IkappaBalpha alters control of NF-kappaB signaling.

Elizabeth A Komives, E. Komives, G. Ghosh, 2008, Journal of molecular biology.

NF‐κB dictates the degradation pathway of IκBα

A. Hoffmann, G. Ghosh, Ellen L O'Dea, 2008, The EMBO journal.

Stabilization of RelB Requires Multidomain Interactions with p100/p52*

A. Hoffmann, G. Ghosh, O. Savinova, 2008, Journal of Biological Chemistry.

Evolving Concepts Signal Transduction in Inflammation: Transcriptional Outcome of Wnt-Frizzled

G. Ghosh, M. Sen, 2008 .

X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites.

G. Ghosh, V. Wang, De-bin Huang, 2007, Journal of molecular biology.

Structural Analysis of NF-κB and IκB Proteins

G. Ghosh, T. Huxford, 2006 .

κB-RAS: A Small Gtpase That Influences NF-κB Signaling

G. Ghosh, T. Huxford, A. Moorthy, 2006 .

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

A. Hoffmann, S. Saccani, G. Natoli, 2005, Genes & development.

NF-κB RelB Forms an Intertwined Homodimer

G. Ghosh, De-bin Huang, D. Vu, 2005 .

Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers

B. Aronow, A. Jegga, M. Karin, 2004 .

Biophysical characterization of the free IκBα ankyrin repeat domain in solution

E. Komives, G. Ghosh, T. Huxford, 2004 .

Inhibition of NF-κB Activity by IκBβ in Association with κB-Ras

J. Sondek, G. Ghosh, Yi Chen, 2004, Molecular and Cellular Biology.

Discreet mutations from c-Rel to v-Rel alter κB DNA recognition, IκBα binding, and dimerization: implications for v-Rel oncogenicity

G. Ghosh, C. Phelps, 2004, Oncogene.

Molecular mimicry of the NF-κB DNA target site by a selected RNA aptamer

G. Ghosh, T. Huxford, De-bin Huang, 2004 .

Crystal structure of NF-κB (p50)2 complexed to a high-affinity RNA aptamer

Jeff Zimmerman, L. Cassiday, L. J. Maher, 2003, Proceedings of the National Academy of Sciences of the United States of America.

X-ray Crystal Structure of an IκBβ·NF-κB p65 Homodimer Complex*

S. Ghosh, G. Ghosh, S. Malek, 2003, Journal of Biological Chemistry.

The Structural Biology of NF-κB

G. Ghosh, T. Huxford, 2003 .

Solvent Exposed Non-contacting Amino Acids Play a Critical Role in NF-κB/IκBα Complex Formation

E. Komives, G. Ghosh, T. Huxford, 2002 .

IκBβ, but Not IκBα, Functions as a Classical Cytoplasmic Inhibitor of NF-κB Dimers by Masking Both NF-κB Nuclear Localization Sequences in Resting Cells*

G. Ghosh, S. Malek, T. Huxford, 2001, The Journal of Biological Chemistry.

X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.

G. Ghosh, C. Phelps, De-bin Huang, 2001, Structure.

Preparation and Crystallization of Dynamic NF-κB·IκB Complexes*

G. Ghosh, S. Malek, T. Huxford, 2000, The Journal of Biological Chemistry.

Mechanism of IκBα Binding to NF-κB Dimers*

G. Ghosh, T. Huxford, C. Phelps, 2000, The Journal of Biological Chemistry.

NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets

G. Ghosh, Gourisankar Ghosh, Yong-Qing Chen, 2000 .

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

S. Joseph, G. Ghosh, Kaushik Saha, 2021, bioRxiv.

Mechanisms of splicing substrate definition by modulation of pre-mRNA 3D structural scaffolds

G. Ghosh, Kaushik Saha, 2021 .

Mechanisms of modulation of pre-mRNA 3D structural scaffolds for splicing substrate definition

G. Ghosh, Kaushik Saha, 2021 .

A Fourth IκB Protein within the NF-κB Signaling Module

Hana Kim, Alexander Hoffmann, Vinay Tergaonkar, 2007, Cell.

Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution.

G. Ghosh, T. Huxford, A. Bobkov, 2020, Biochimica et biophysica acta. Proteins and proteomics.

A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

A. Hoffmann, I. Verma, G. Ghosh, 2013, PLoS biology.

Genome reading by the NF-κB transcription factors.

G. Ghosh, T. Huxford, V. Wang, 2019, Nucleic acids research.

Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor κB RelA Subunit.

Rommie E. Amaro, G. Ghosh, R. Amaro, 2018, Biochemistry.

Regulated cellular partitioning of SR protein-specific kinases in mammalian cells.

Xiang-Dong Fu, J. Adams, G. Ghosh, 2005, Molecular biology of the cell.

Identification of Functionally Distinct Regions That Mediate Biological Activity of the Protein Kinase A Homolog Tpk2*

G. Ghosh, E. Kennedy, L. Pillus, 2008, Journal of Biological Chemistry.

Identifying Critical Non-Catalytic Residues that Modulate Protein Kinase A Activity

Susan S. Taylor, Jie Yang, G. Ghosh, 2009, PloS one.

Contribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase A*

Susan S. Taylor, Michael S. Deal, Jian Wu, 2009, Journal of Biological Chemistry.

ReviewRegulation of Protein Kinases : Controlling Activity through

Susan S. Taylor, G. Ghosh, B. Nolen, 2004 .

Probing Kinase Activation and Substrate Specificity with an Engineered Monomeric IKK2

W. E. Rogers, G. Ghosh, T. Huxford, 2014, Biochemistry.

A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.

P. Dorrestein, Xiang-Dong Fu, J. Adams, 2008, Molecular cell.

SR protein kinase 1 is resilient to inactivation.

J. Mccammon, Xiang-Dong Fu, J. Adams, 2007, Structure.

Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.

Xiang-Dong Fu, Sutapa Chakrabarti, Xiang-Dong Fu, 2005, Molecular cell.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

D. Sahoo, G. Ghosh, N. Webster, 2020 .

Structurally Unique Yeast and Mammalian Serine-Arginine Protein Kinases Catalyze Evolutionarily Conserved Phosphorylation Reactions*

Xiang-Dong Fu, J. Adams, G. Ghosh, 2007, Journal of Biological Chemistry.

Processive phosphorylation of alternative splicing factor/splicing factor 2

Xiang-Dong Fu, Sutapa Chakrabarti, Jennifer Shaffer, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

G. Ghosh, S. Malek, T. Huxford, 1998, Cell.

The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs

G. Ghosh, Sutapa Chakrabarti, De-bin Huang, 2011, Nucleic acids research.

Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly

A. Krainer, Rahul Sinha, Xiang-Dong Fu, 2011, Proceedings of the National Academy of Sciences.

Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1.

Xiang-Dong Fu, Xiang-Dong Fu, J. Adams, 2008, Journal of molecular biology.

Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex.

E. Komives, G. Ghosh, T. Huxford, 2006, Journal of molecular biology.

Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution.

E. Komives, G. Ghosh, T. Huxford, 2004, Protein science : a publication of the Protein Society.

The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.

G. Ghosh, S. Malek, T. Huxford, 1998, Cell.

The Transcriptional Specificity of NF-κB Dimers Is Coded within the κB DNA Response Elements

A. Hoffmann, C. Glass, N. Spann, 2012, Cell reports.

Kinetic control of negative feedback regulators of NF-κB/RelA determines their pathogen- and cytokine-receptor signaling specificity

Alexander Hoffmann, A. Hoffmann, G. Ghosh, 2009, Proceedings of the National Academy of Sciences.

Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-κB-Driven Transcription

A. Hoffmann, P. Wright, M. Behar, 2013, PLoS biology.

Mechanism of κB DNA binding by Rel/NF-κB dimers*

G. Ghosh, S. Malek, C. Phelps, 2000, The Journal of Biological Chemistry.

Mechanism of kappa B DNA binding by Rel/NF-kappa B dimers.

G. Ghosh, S. Malek, C. Phelps, 2000, The Journal of biological chemistry.

Mechanism of I kappa B alpha binding to NF-kappa B dimers.

G. Ghosh, T. Huxford, C. Phelps, 2000, The Journal of biological chemistry.

Phosphorylation mechanism and structure of serine‐arginine protein kinases

J. Adams, G. Ghosh, 2011, The FEBS journal.

Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1.

Xiang-Dong Fu, P. Jennings, J. Adams, 2008, Journal of molecular biology.

The structure of Sky1p reveals a novel mechanism for constitutive activity

Chung F. Wong, J. Mccammon, Xiang-Dong Fu, 2001, Nature Structural Biology.

Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1.

Xiang-Dong Fu, J. Adams, G. Ghosh, 2010, Journal of molecular biology.

Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.

J. Adams, G. Ghosh, J. Hagopian, 2009, Biochemistry.

Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1.

Xiang-Dong Fu, J. Adams, G. Ghosh, 2009, Journal of molecular biology.

Origin of the Functional Distinctiveness of NF-κB/p52

G. Ghosh, V. Wang, 2021, Frontiers in Cell and Developmental Biology.

NF‐κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes

G. Ghosh, V. Wang, De-bin Huang, 2009, EMBO reports.

A Fourth IkB Protein within the NF-kB Signaling Module

A. Hoffmann, C. Benedict, C. Ware, 2007 .

The κB DNA Sequence from the HIV Long Terminal Repeat Functions as an Allosteric Regulator of HIV Transcription*

G. Ghosh, D. Thanos, De-bin Huang, 2002, The Journal of Biological Chemistry.

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.

B. Aronow, A. Jegga, M. Karin, 2004, The EMBO journal.

The RGG domain of Npl3p recruits Sky1p through docking interactions.

J. Adams, G. Ghosh, B. Nolen, 2007, Journal of molecular biology.

NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.

A. Hoffmann, M. Behar, G. Ghosh, 2012, Molecular cell.

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer

Alexander Hoffmann, Jeffrey D. Kearns, Rachel Tsui, 2015, Nature Communications.

Chromogranin A plays a crucial role in the age-related development of insulin resistance and hypertension

G. van den Bogaart, G. Ghosh, K. Tang, 2021 .

PKR and eIF2α: Integration of Kinase Dimerization, Activation, and Substrate Docking

Susan S. Taylor, G. Ghosh, N. Haste, 2005, Cell.

PABP1 Drives the Selective Translation of Influenza A Virus mRNA.

S. Joseph, G. Ghosh, Taryn M. Lucas, 2022, Journal of molecular biology.

Structural Basis for the Activation of IKK1/ alpha.

I. Verma, G. Ghosh, D. Lyumkis, 2016 .

N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation.

Ryan M. Plocinik, Xiang-Dong Fu, J. Adams, 2014, The Biochemical journal.

Characterization of the dimer interface of transcription factor NFkappaB p50 homodimer.

G. Ghosh, E. Anderson, De-bin Huang, 1999, Journal of molecular biology.

NF-kappaB RelB forms an intertwined homodimer.

G. Ghosh, De-bin Huang, D. Vu, 2005, Structure.

DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated

G. Ghosh, H. Nguyen, V. Wang, 2017, The Journal of Biological Chemistry.

An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

A. Hoffmann, G. Ghosh, S. Mitchell, 2019, Front. Immunol..

A novel DNA recognition mode by the NF-kappa B p65 homodimer.

G. Ghosh, S. Ghosh, Y. Chen, 1998, Nature structural biology.

The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.

G. Ghosh, T. Huxford, De-bin Huang, 1997, Structure.

Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.

G. Ghosh, M. Ghassemian, V. Wang, 2017, Molecular cell.

NF-kappaB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets.

G. Ghosh, L. L. Sengchanthalangsy, Y. Chen, 2000, Structure.

Chemical Clamping Allows for Efficient Phosphorylation of the RNA Carrier Protein Npl3*

J. Adams, G. Ghosh, Brandon E. Aubol, 2004, Journal of Biological Chemistry.

IkBb enhances the generation of the low-affinity NFkB/RelA homodimer

A. Hoffmann, G. Ghosh, Candace L. Lynch, 2015 .

15-Deoxy- D 12,14 -prostaglandin J 2 inhibits multiple steps in the NF- k B signaling pathway

C. Glass, J. Welch, C. Hsiang, 2000 .

I k B b enhances the generation of the low-affinity NF k B / RelA homodimer

A. Hoffmann, G. Ghosh, Candace L. Lynch, 2015 .

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells.

G. Ghosh, S. Malek, T. Huxford, 2001, The Journal of biological chemistry.

p105.Ikappa Bgamma and prototypical Ikappa Bs use a similar mechanism to bind but a different mechanism to regulate the subcellular localization of NF-kappa B.

G. Ghosh, A. Moorthy, 2003, Journal of Biological Chemistry.

Dynamic association of IκBα to chromatin is regulated by acetylation and cleavage of histone H4

G. Ghosh, L. Espinosa, A. Bigas, 2021, bioRxiv.

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

C. Glass, J. Welch, C. Hsiang, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of 2 substrate I  B  without requiring ATP

G. Ghosh, T. Huxford, Smarajit Polley, 2023 .

Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4

G. Ghosh, L. Espinosa, A. Bigas, 2021, EMBO reports.

Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p.

J. Adams, G. Ghosh, J. Shaffer, 2003, Biochemistry.

Structural analysis of the TBP/TFIIB/ DNA complex from the hyperthermophilic archaea Pyrococcus woesei

P. Sigler, G. Ghosh, P. Kóša, 1996 .

X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.

G. Ghosh, T. Huxford, De-bin Huang, 2003, The Journal of biological chemistry.

15-Deoxy-Δ12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway

G. Ghosh, L. L. Sengchanthalangsy, Mei Li, 2000 .

Supplemental Information Structural Basis for the Activation of IKK1/a

I. Verma, G. Ghosh, D. Lyumkis, 2016 .

Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.

L. Cassiday, L. J. Maher, G. Ghosh, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

G. Ghosh, T. Huxford, Smarajit Polley, 2023, bioRxiv.

Structural Basis for the Activation of IKK1/α

I. Verma, G. Ghosh, D. Lyumkis, 2016, Cell reports.

Stabilization of RelB Requires Multidomain Interactions with p100/p52*

A. Hoffmann, G. Ghosh, O. Savinova, 2008, Journal of Biological Chemistry.

Transient interactions modulate the affinity of NF-κB transcription factors for DNA.

G. Ghosh, O. Tsodikov, V. Wang, 2024, Proceedings of the National Academy of Sciences of the United States of America.