W. Simonds

F. Collins, S. Libutti, W. Simonds, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reoperation for hyperparathyroidism in multiple endocrine neoplasia type 1.

S. Libutti, J. Norton, D. Fraker, 2001, Surgery.

Probability of Positive Genetic Testing Results in Patients with Family History of Primary Hyperparathyroidism.

W. Simonds, E. Kebebew, A. Tirosh, 2018, Journal of the American College of Surgeons.

Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure

W. Simonds, E. Kebebew, S. Marx, 2018, Surgery.

The G protein connection: molecular basis of membrane association.

W. Simonds, P. Backlund, A. Spiegel, 1991, Trends in biochemical sciences.

Familial isolated hyperparathyroidism Mini-review

W. Simonds, 2006 .

Surveillance for Early Detection of Aggressive Parathyroid Disease: Carcinoma and Atypical Adenoma in Familial Isolated Hyperparathyroidism Associated With a Germline HRPT2 Mutation

W. Simonds, A. F. Stewart, A. Arnold, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Hyperparathyroidism-Jaw Tumor Syndrome: Results of surgical management

W. Simonds, E. Kebebew, S. Marx, 2014 .

Receptor and effector interactions of Gs Functional studies with antibodies to the αs carboxyl‐terminal decapeptide

W. Simonds, A. Spiegel, P. Goldsmith, 1989, FEBS letters.

Nontruncated amino‐terminal parathyroid hormone overproduction in two patients with parathyroid carcinoma: a possible link to HRPT2 gene inactivation

M. Rubin, J. Bilezikian, W. Simonds, 2011, Clinical endocrinology.

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

W. Simonds, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

The Gβγ Complex of the Yeast Pheromone Response Pathway

J. Hirschman, W. Simonds, D. Jenness, 1997, The Journal of Biological Chemistry.

Ruling out a suspect: the role of beta-catenin mutation in benign parathyroid neoplasia.

W. Simonds, 2007, The Journal of clinical endocrinology and metabolism.

Imaging to Detect Early Endocrine Cancers

W. Simonds, S. Marx, 2006 .

Immunological Probes of the Structure, Function, and Expression of Heterotrimeric GTP-Binding Proteins

W. Simonds, T. L. Jones, A. Spiegel, 1992 .

The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.

F. Collins, W. Simonds, L. Weinstein, 2007, The Journal of clinical endocrinology and metabolism.

BRIEF REPORT The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other than p27 Kip1 Mutations

F. Collins, W. Simonds, L. Weinstein, 2007 .

Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma.

R. Jensen, G. Hobbs, W. Simonds, 2004, The Journal of clinical endocrinology and metabolism.

Molecular Pathology of the MEN1 Gene

F. Collins, S. Libutti, M. Mullendore, 2004, Annals of the New York Academy of Sciences.

Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73

W. Simonds, L. Lin, E. Seigneur, 2010, Cell Death and Differentiation.

Nuclear Localization of the Parafibromin Tumor Suppressor Protein Implicated in the Hyperparathyroidism-Jaw Tumor Syndrome Enhances Its Proapoptotic Function

W. Simonds, L. Nini, M. Czapiga, 2007, Molecular Cancer Research.

Guanine nucleotides inhibit binding of agonists and antagonists to soluble opiate receptors.

G. Koski, W. Simonds, W. Klee, 1981, The Journal of biological chemistry.

Differential Modulation of Adenylyl Cyclases I and II by Various Gβ Subunits*

Z. Vogel, W. Simonds, T. Avidor-Reiss, 1998, The Journal of Biological Chemistry.

Development of MEKA (phosducin), Gβ, Gγ and S-antigen in the rat pineal gland and retina

W. Simonds, D. Klein, T. Shinohara, 1992, Brain Research.

A central role for R7bp in the regulation of itch sensation

Poorni R. Adikaram, Claire M. Kittock, R. Neubig, 2017, Pain.

Nuclear localization of the G protein β5/R7–regulator of G protein signaling protein complex is dependent on R7 binding protein

W. Simonds, K. Martemyanov, E. Posokhova, 2010, Journal of neurochemistry.

Inhibition of adenylyl cyclase isoforms V and VI by various Gβγ subunits

Z. Vogel, W. Simonds, T. Avidor-Reiss, 1998 .

Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism

W. Simonds, E. Kebebew, L. Weinstein, 2016, Annals of Surgical Oncology.

Antibodies as Probes of G-Protein Structure and Function

W. Simonds, A. Spiegel, P. Goldsmith, 1990 .

Signal transduction by guanine nucleotide-binding proteins.

M. Brann, W. Simonds, A. Spiegel, 1988, Recent progress in hormone research.

Dual Regulation of Akt/Protein Kinase B by Heterotrimeric G Protein Subunits*

W. Simonds, R. K. Bommakanti, Shaveta Vinayak, 2000, The Journal of Biological Chemistry.

The molecular basis of opioid receptor function.

W. Simonds, 1988, Endocrine reviews.

Solubilization of active opiate receptors.

G. Koski, W. Simonds, W. Klee, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Parathyroid cancer and the CDC73 tumor suppressor gene

W. Simonds, 2014 .

Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia.

W. Simonds, G. Hendy, S. Marx, 2005, Human molecular genetics.

G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.

W. Simonds, N. Gautam, A. Spiegel, 1991, The Journal of biological chemistry.

Membrane attachment of recombinant G-protein α-subunits in excess of βγ subunits in a eukaryotic expression system

M. Brann, W. Simonds, A. Spiegel, 1989 .

G Protein-Regulated Signaling Dysfunction in Human Disease

W. Simonds, 2003, Journal of Investigative Medicine.

Hereditary hormone excess: genes, molecular pathways, and syndromes.

W. Simonds, S. Marx, 2005, Endocrine reviews.

G protein regulation of adenylate cyclase.

W. Simonds, 1999, Trends in pharmacological sciences.

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

P. Crespo, W. Simonds, J. Gutkind, 1994, Nature.

Familial Syndromes of Primary Hyperparathyroidism

W. Simonds, 2020, Calcium Disorders, Hypercalcemia and Hypocalcemia - Recent Advances, New Perspectives and Treatments [Working Title].

Clinical and Molecular Genetics of Primary Hyperparathyroidism

W. Simonds, William F. Simonds, 2020, Hormone and Metabolic Research.

Evolution of Endocrine Calcium Homeostasis in Vertebrates

W. Simonds, 2020 .

Genetics of Hyperparathyroidism, Including Parathyroid Cancer.

W. Simonds, 2017, Endocrinology and metabolism clinics of North America.

Clinical and molecular genetics of parathyroid neoplasms.

W. Simonds, J. Sharretts, 2010, Best practice & research. Clinical endocrinology & metabolism.

Long-term remission of disseminated parathyroid cancer following immunotherapy

E. Friedman, W. Simonds, A. Bradwell, 2019, Endocrine.

CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.

Mark W. Ball, P. Meltzer, W. Linehan, 2019, Urology.

Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome.

J. Carpten, C. Robbins, W. Simonds, 2004, The Journal of clinical endocrinology and metabolism.

HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome

J. Carpten, E. Gillanders, J. Trent, 2002, Nature Genetics.

Multiple endocrine neoplasia type 1: new clinical and basic findings

W. Simonds, M. Skarulis, A. Burns, 2001, Trends in Endocrinology & Metabolism.

Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome.

M. Hill, W. Simonds, J. Segars, 2012, Fertility and sterility.

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

P. Crespo, W. Simonds, J. Gutkind, 1994, Nature.

Familial Hyperparathyroidism

W. Simonds, J. Blau, 2021, Frontiers in Endocrinology.

Genotype of CDC73 germline mutation determines risk of parathyroid cancer.

Poorni R. Adikaram, W. Simonds, L. Weinstein, 2020, Endocrine-related cancer.

Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.

W. Simonds, T. Burke, K. Rice, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a M r 58 000 glycoprotein subunit of the opiate receptor

W. Simonds, T. Burke, K. Rice, 1982, FEBS letters.

Gαq/11 Coupled to Mammalian Phospholipase C β3-like Enzyme Mediates the Ginsenoside Effect on Ca2+-activated Cl− Current in theXenopus Oocyte*

S. Nah, Seong-Woo Jeong, W. Simonds, 2001, The Journal of Biological Chemistry.

Familial Isolated Hyperparathyroidism: Clinical and Genetic Characteristics of 36 Kindreds

W. Simonds, G. Hendy, M. Skarulis, 2002, Medicine.

Assays of Nuclear Localization of R7/Gβ5 Complexes

W. Simonds, Jian-hua Zhang, G. Woodard, 2004 .

New dimensions in G protein signalling: Gβ5 and the RGS proteins

W. Simonds, Jian-hua Zhang, 2000 .

Copurification of Brain G-Protein β5 with RGS6 and RGS7

W. Simonds, Jian-hua Zhang, 2000, The Journal of Neuroscience.

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3

W. Simonds, S. Marx, S. Agarwal, 2008, Molecular Cancer.

Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice

W. Simonds, WeiPing Chen, C. Chen, 2011, Journal of neurochemistry.

Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction.

W. Simonds, A. Spiegel, T. Murakami, 1992, Biochemistry.

The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome

P. Dagur, W. Simonds, E. Seigneur, 2012, Cell Death and Disease.

Utility of rapid intraoperative parathyroid hormone assay to predict severe postoperative hypocalcemia after reoperation for hyperparathyroidism.

S. Libutti, D. Venzon, W. Simonds, 2002, Surgery.

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

W. Simonds, Ling Lin, Jian-hua Zhang, 2008, Proceedings of the National Academy of Sciences.

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

W. Simonds, A. Spiegel, J. Codina, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.

P. Dagur, W. Simonds, Jian-hua Zhang, 2010, Endocrine-related cancer.

HRPT2, a marker of parathyroid cancer.

W. Simonds, L. Weinstein, 2003, The New England journal of medicine.

Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter.

Y. Mo, P. Dagur, W. Simonds, 2014, Journal of biotechnology.

Clinical presentation and management of primary ovarian neuroendocrine tumor in multiple endocrine neoplasia type 1

W. Simonds, M. Ahlman, S. Agarwal, 2019, Endocrinology, diabetes & metabolism case reports.

Development of R7BP inhibitors through cross-linking coupled mass spectrometry and integrated modeling

Poorni R. Adikaram, Jian-Hua Zhang, Claire M. Kittock, 2019, Communications Biology.

The PH domain of Ras-GAP is sufficient forin Vitro binding toβγ subunits of heterotrimeric G proteins

W. Simonds, J. Gutkind, D. Mahadevan, 1996, Cellular and Molecular Neurobiology.

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway (*)

W. Simonds, J. Gutkind, H. Teramoto, 1996, The Journal of Biological Chemistry.

High prevalence of chronic kidney disease in patients with multiple endocrine neoplasia type 1 and improved kidney function after parathyroidectomy

W. Simonds, E. Kebebew, L. Weinstein, 2019, Surgery.

Gγ Subunit-selective G Protein β5Mutant Defines Regulators of G Protein Signaling Protein Binding Requirement for Nuclear Localization*

W. Simonds, C. Combs, Jian-hua Zhang, 2003, The Journal of Biological Chemistry.

Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.

W. Simonds, O. Moe, U. Hopfer, 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1.

David S. Sharlin, D. Sharlin, D. Forrest, 2013, Endocrinology.

Antibodies against synthetic peptides as probes of G protein structure and function.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Society of General Physiologists series.

F009 Regulation of Na+/H+ exchanger-3 (NHE-3) by G-protein subunits in renal brush border membranes

W. Simonds, O. Moe, U. Hopfer, 1998 .

Regulation of NHE 3 activity by G protein subunits in renal brush-border membranes

W. Simonds, O. Moe, U. Hopfer, 2000 .

Patients with MEN1 are at an increased risk for venous thromboembolism VTE risk in MEN1.

W. Simonds, A. Tirosh, L. Weinstein, 2020, The Journal of clinical endocrinology and metabolism.

18F-FDOPA PET/CT accurately identifies MEN1-associated pheochromocytoma

W. Simonds, L. Weinstein, K. Pacak, 2020, Endocrinology, diabetes & metabolism case reports.

Adenylyl cyclase type-VIII activity is regulated by Gβγ subunits

Z. Vogel, W. Simonds, E. Schallmach, 2006 .

Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus

R. Jensen, W. Simonds, D. Schrump, 2021, Endocrine-related cancer.

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

M. Brann, W. Simonds, T. L. Jones, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity.

W. Simonds, T. Burke, K. Rice, 1986, Journal of medicinal chemistry.

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome

N. Guex, J. Chrast, A. Reymond, 2020, Journal of Medical Genetics.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Nicolas Guex, Arthur A M Wilde, Alexandre Reymond, 2016, American journal of human genetics.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Nicolas Guex, Arthur A M Wilde, Alexandre Reymond, 2016, American journal of human genetics.

The G beta gamma complex of the yeast pheromone response pathway. Subcellular fractionation and protein-protein interactions.

J. Hirschman, W. Simonds, D. Jenness, 1997, Journal of Biological Chemistry.

Gβγ Affinity for Bovine Rhodopsin Is Determined by the Carboxyl-terminal Sequences of the γ Subunit*

Sanford P. Markey, William F. Simonds, Jeffrey A. Kowalak, 2001, The Journal of Biological Chemistry.

A patient with MEN1 typical features and MEN2-like features.

W. Simonds, L. Weinstein, S. Marx, 2016, International journal of endocrine oncology.

Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.

S. Libutti, W. Simonds, A. Remaley, 2012, The Journal of clinical endocrinology and metabolism.

Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor.

J. Chiorini, W. Simonds, S. Rosenzweig, 2021, New England Journal of Medicine.

Adenylyl cyclase type-VIII activity is regulated by G(betagamma) subunits.

Z. Vogel, W. Simonds, E. Schallmach, 2006, Cellular signalling.

Identification of a Discrete Region of the G Protein γ Subunit Conferring Selectivity in βγ Complex Formation (*)

W. Simonds, Chunghee Lee, T. Murakami, 1995, The Journal of Biological Chemistry.

Pitfalls of using denosumab preoperatively to treat refractory severe hypercalcaemia

W. Simonds, A. Manni, C. Fan, 2020, BMJ Case Reports.

Myristoylation of an inhibitory GTP-binding protein a subunit is essential for its membrane attachment ( site-directed mutagenesis / immunoprecipitation / signal transduction / P 8-y subunits )

W. Simonds, T. L. Jones, A. Spiegel, 2022 .

Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas.

W. Simonds, E. Kebebew, L. Weinstein, 2018, Endocrine-related cancer.

The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.

W. Simonds, J. Gutkind, D. Mahadevan, 1996, Cellular and molecular neurobiology.

Carboxyl methylation and COOH-terminal processing of the brain G-protein gamma-subunit.

W. Simonds, P. Backlund, A. Spiegel, 1990, The Journal of biological chemistry.

Ultrastructural localization of G-protein Gs in the organ of Corti

K. Iwasa, W. Simonds, K. Mizuta, 1995, Neuroscience Letters.

R7-binding protein targets the G protein β5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain

W. Simonds, A. Waheed, L. Nini, 2007, BMC Biochemistry.

Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-Jaw Tumor Syndrome.

W. Simonds, D. Bell, L. Weinstein, 2023, The Journal of clinical endocrinology and metabolism.

Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Biochemical Society symposium.

A C-terminal Mutant of the G Protein β Subunit Deficient in the Activation of Phospholipase C-β*

W. Simonds, J. Gutkind, O. Coso, 1996, The Journal of Biological Chemistry.

Expressions of Cushing’s syndrome in multiple endocrine neoplasia type 1

W. Simonds, 2023, Frontiers in endocrinology.

RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex.

V. Arshavsky, A. Bohm, N. Skiba, 2001, The Journal of biological chemistry.

Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina.

W. Simonds, D. Klein, T. Shinohara, 1992, Brain Research.

Parathyroid cancer.

W. Simonds, E. Kebebew, J. Sharretts, 2010, Seminars in oncology.

Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway.

W. Simonds, J. Gutkind, H. Teramoto, 1996, The Journal of biological chemistry.

The coiled-coil region of the G protein beta subunit. Mutational analysis of Ggamma and effector interactions.

W. Simonds, S. Zhang, A. Garritsen, 1997, The Journal of biological chemistry.

Nuclear Localization of G Protein β5 and Regulator of G Protein Signaling 7 in Neurons and Brain*

V. Barr, W. Simonds, Jian-hua Zhang, 2001, The Journal of Biological Chemistry.

G proteins and beta ARK: a new twist for the coiled coil.

H. Manji, A. Lupas, W. Simonds, 1993, Trends in biochemical sciences.

Inhibition of adenylyl cyclase isoforms V and VI by various Gbetagamma subunits.

Z. Vogel, W. Simonds, T. Avidor-Reiss, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells

W. Simonds, L. Nini, Jian-hua Zhang, 2012, Endocrine.

Familial isolated hyperparathyroidism

W. Simonds, 2006 .

Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer.

W. Simonds, L. Weinstein, S. Jha, 2022, Journal of the Endocrine Society.

Molecular and Clinical Spectrum of Primary Hyperparathyroidism.

W. Simonds, S. Jha, 2023, Endocrine reviews.

New dimensions in G protein signalling: G beta 5 and the RGS proteins.

W. Simonds, J. H. Zhang, 2000, Pharmaceutica acta Helvetiae.

THYROID DISORDERS CASE REPORTS II An Atypical Presentation of Severe Hypothyroidism, a Case of Large Posterior Pericardial Effusion Without Hemodynamic Compromise

W. Simonds, A. Tirosh, P. Piaggi, 2020 .

Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors

Poorni R. Adikaram, Claire M. Kittock, W. Simonds, 2023, JCI insight.

The N-terminal coiled-coil domain of beta is essential for gamma association: a model for G-protein beta gamma subunit interaction.

W. Simonds, A. Garritsen, P. J. van Galen, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Copurification of brain G-protein beta5 with RGS6 and RGS7.

W. Simonds, J. H. Zhang, 2000, Journal of Neuroscience.

Metastatic Grade 3 Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Expressing Somatostatin Receptors.

E. Levy, W. Simonds, L. Weinstein, 2022, Journal of the Endocrine Society.

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

W. Simonds, A. Nakagawara, A. Hata, 2005, Oncogene.

A new look at vitamin D metabolism and "idiopathic" hypercalcemia.

W. Simonds, 2012, The Journal of clinical endocrinology and metabolism.