J. Lyons

发表

Prospective phenotyping of NGLY1-CDDG, the first congenital disorder of deglycosylation

Ellen F. Macnamara, C. Toro, W. Gahl, 2016, Genetics in Medicine.

Hymenoptera venom-induced anaphylaxis and hereditary alpha-tryptasemia.

J. Lyons, M. O’Connell, 2020, Current opinion in allergy and clinical immunology.

Clinical Approach to a Patient with Elevated Serum Tryptase: Implications of Acute Versus Basally Elevated Levels

J. Lyons, L. Schwartz, 2019 .

Mast cell activation in the context of elevated basal serum tryptase: genetics and presentations

J. Lyons, P. Khoury, 2019, Current Allergy and Asthma Reports.

Correction: ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans

J. Hughes, J. McElwee, J. Lyons, 2017, The Journal of experimental medicine.

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans

J. Hughes, J. McElwee, Yuan Zhang, 2017, The Journal of experimental medicine.

Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference.

A. Órfão, S. Galli, H. Kluin-Nelemans, 2021, The Journal of allergy and clinical immunology.

A common haplotype containing functional CACNA1H variants is frequently coinherited with increased TPSAB1 copy number

L. Biesecker, J. Lyons, K. Stone, 2017, Genetics in Medicine.

Clinical relevance of inherited genetic differences in human tryptases: Hereditary alpha-tryptasemia and beyond.

P. Korošec, J. Lyons, J. Milner, 2021, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment.

J. Hughes, J. McElwee, D. Reich, 2014, The Journal of allergy and clinical immunology.

Autosomal recessive PGM3 mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

J. Hughes, J. McElwee, S. Holland, 2014 .

The genetic basis and clinical impact of hereditary alpha-tryptasemia.

J. Lyons, Andrew A. White, K. Luskin, 2021, The journal of allergy and clinical immunology. In practice.

The clinical and mechanistic intersection of primary atopic disorders and inborn errors of growth and metabolism

J. Lyons, J. Milner, 2019, Immunological reviews.

Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review.

G. Nilsson, M. Triggiani, A. Órfão, 2021, The journal of allergy and clinical immunology. In practice.

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities.

J. Lyons, K. Stone, J. Milner, 2014, The Journal of allergy and clinical immunology.

Distinct Small Intestine Mast Cell Histologic Changes in Patients With Hereditary Alpha-tryptasemia and Mast Cell Activation Syndrome.

P. Novak, J. Lyons, J. Hornick, 2021, The American journal of surgical pathology.

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

J. Lyons, J. Milner, D. Metcalfe, 2019, The Journal of experimental medicine.

Skewed lymphocyte subpopulations and associated phenotypes in patients with mastocytosis.

S. Rosenzweig, J. Lyons, D. Metcalfe, 2019, The journal of allergy and clinical immunology. In practice.

Routine KIT p.D816V screening identifies clonal mast cell disease in Hymenoptera allergic patients regularly missed using baseline tryptase levels alone.

P. Korošec, J. Lyons, M. Košnik, 2021, The Journal of allergy and clinical immunology.

Clinical Impact of Inherited and Acquired Genetic Variants in Mastocytosis

J. Lyons, A. Reiter, P. Valent, 2021, International journal of molecular sciences.

Patients with mast cell activation symptoms and elevated baseline serum tryptase have unique bone marrow morphology.

G. Pinkus, J. Lyons, J. Hornick, 2020, The Journal of allergy and clinical immunology.

Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome

M. Triggiani, J. Lyons, P. Valent, 2019, International Archives of Allergy and Immunology.

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1.

P. Korošec, J. Lyons, J. Milner, 2020, The Journal of allergy and clinical immunology.

Hereditary Alpha-Tryptasemia: a Commonly Inherited Modifier of Anaphylaxis

J. Lyons, Richard Wu, 2021, Current Allergy and Asthma Reports.

Usefulness of Testing for Hereditary Alpha Tryptasemia in Symptomatic Patients with Elevated Tryptase.

J. Lyons, J. Milner, P. Vadas, 2020, The journal of allergy and clinical immunology. In practice.

First Identification of an Inherited TPSAB1 Quintuplication in a Patient with Clonal Mast Cell Disease

J. Lyons, J. Milner, D. Ebo, 2018, Journal of Clinical Immunology.

Editorial: Stressing out mast cells via CRF1

J. Lyons, K. Druey, H. Rosenberg, 2017, Journal of leukocyte biology.

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

Yuan Zhang, S. Holland, D. Barber, 2017, The Journal of experimental medicine.

Clinical response to omalizumab in patients with hereditary alpha tryptasemia.

J. Lyons, K. Stone, J. Milner, 2019, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

GATA-2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in human subjects.

M. Pirooznia, S. Holland, J. Lyons, 2019, The Journal of allergy and clinical immunology.

Hereditary alpha-tryptasemia modifies clinical phenotypes among individuals with congenital hypermobility disorders

J. Lyons, J. Milner, M. Ritelli, 2022, HGG advances.

Primary atopic disorders

J. Lyons, J. Milner, 2018, The Journal of experimental medicine.

On the complexities of tryptase genetics and impact on clinical phenotypes.

J. Lyons, 2021, The Journal of allergy and clinical immunology.

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

Andrew J. Oler, Ryan J. Carlson, J. Hughes, 2016, Nature Genetics.

Distinct Cutaneous Manifestations and Cold-Induced Leukocyte Activation Associated With PLCG2 Mutations.

J. Lyons, J. Milner, D. Kuhns, 2015, JAMA dermatology.

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early onset autoinflammatory syndrome

J. Mullikin, Yuan Zhang, D. Kastner, 2015, Nature Genetics.

Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology

S. Rosenzweig, J. Lyons, J. Milner, 2015, Front. Pediatr..

Atopic dermatitis in children: clinical features, pathophysiology, and treatment.

J. Lyons, K. Stone, J. Milner, 2015, Immunology and allergy clinics of North America.

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.

S. Snapper, E. Fiebiger, J. Lyons, 2016, The Journal of clinical investigation.

Germline hypomorphic CARD11 mutations in severe atopic disease

J. McElwee, Yuan Zhang, E. Meffre, 2017, Nature Genetics.

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.

V. Hox, S. Holland, D. Tweardy, 2016, The Journal of allergy and clinical immunology.

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

Phillip A. Richmond, A. Hoischen, J. Casanova, 2022, medRxiv.

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.

Elisha D O Roberson, Carol J. Saunders, Lina Karam, 2015, Blood.

Targeted IL-4Rα blockade ameliorates refractory allergic eosinophilic inflammation in a patient with dysregulated TGF-β signalling due to ERBIN deficiency.

J. Lyons, J. Milner, A. Freeman, 2022, The journal of allergy and clinical immunology. In practice.

Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia.

Mohammad H. Hasan, S. Snapper, J. Lyons, 2021, The Journal of allergy and clinical immunology.

Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal

G. Nilsson, M. Triggiani, A. Órfão, 2021, HemaSphere.

Targeting Mast Cells with Biologics.

J. Lyons, D. Metcalfe, 2020, Immunology and allergy clinics of North America.

Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8-deficient patients.

J. Lyons, K. Stone, A. Freeman, 2016, The Journal of allergy and clinical immunology.

Food Allergies Can Persist After Myeloablative Hematopoietic Stem Cell Transplantation in DOCK8-Deficient Patients

J. Lyons, K. Stone, A. Freeman, 2016 .

Detection of phosphoglucomutase-3 deficiency by lectin-based flow cytometry.

Ryan J. Carlson, S. Holland, S. Rosenzweig, 2017, The Journal of allergy and clinical immunology.

Persistent tryptase elevation in a patient with Gaucher disease.

J. Lyons, J. Milner, Julie Wang, 2017, The journal of allergy and clinical immunology. In practice.

Chromosomal microarray analysis supplements exome sequencing to diagnose children with suspected inborn errors of immunity

Andrew J. Oler, E. Karlins, J. Lyons, 2023, Frontiers in Immunology.

Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features.

J. Lyons, 2018, Immunology and allergy clinics of North America.

Standards of Pathology in the Diagnosis of Systemic Mastocytosis: Recommendations of the EU-US Cooperative Group.

M. Triggiani, A. Órfão, J. Panse, 2022, The journal of allergy and clinical immunology. In practice.

Incorporating tryptase genotyping into the workup and diagnosis of mast cell diseases and reactions.

J. Lyons, D. Metcalfe, G. Hoermann, 2022, The journal of allergy and clinical immunology. In practice.

Standards of Genetic Testing in the Diagnosis and Prognostication of Systemic Mastocytosis in 2022: Recommendations of the EU-US Cooperative Group.

M. Triggiani, A. Órfão, H. Kluin-Nelemans, 2022, The journal of allergy and clinical immunology. In practice.

Novel PGM3 compound heterozygous variants with IgE‐related dermatitis, lymphopenia, without syndromic features

J. Lyons, X. Solanich, A. Vlagea, 2020, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Proposed ECNM-AIM Response Criteria in Advanced Systemic Mastocytosis.

M. Triggiani, A. Órfão, J. Lyons, 2022, The journal of allergy and clinical immunology. In practice.

Mast cell tryptases in allergic inflammation and immediate hypersensitivity.

J. Lyons, T. Yi, 2021, Current opinion in immunology.

Global Classification of Mast Cell Activation Disorders An ICD-10-CM-Adjusted Proposal of the ECNM-AIM Consortium.

M. Triggiani, A. Órfão, H. Kluin-Nelemans, 2022, The journal of allergy and clinical immunology. In practice.

Assessment of Osteoporosis and Fracture Risk in Mastocytosis within a North American Cohort.

J. Lyons, L. Scott, D. Metcalfe, 2021, The journal of allergy and clinical immunology. In practice.

Immune deficiencies, infection, and systemic immune disordersAutosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

J. Hughes, D. Reich, S. Holland, 2014 .

Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms

J. Hughes, J. McElwee, P. Korošec, 2022, medRxiv.

Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker

J. Lyons, M. O’Connell, 2022, Current opinion in allergy and clinical immunology.

First Identification of an Inherited TPSAB1 Quintuplication in a Patient with Clonal Mast Cell Disease

J. Lyons, J. Milner, D. Ebo, 2018, Journal of Clinical Immunology.

Elevated basal serum tryptase: disease distribution and variability in a regional health system.

J. Lyons, N. Boggs, Benjamin J. Rosen, 2022, The journal of allergy and clinical immunology. In practice.

Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis.

J. Lyons, D. Metcalfe, E. Brittain, 2021, The Journal of allergy and clinical immunology.

Angioedema and High Tryptase: To Marrow or Not to Marrow?

J. Lyons, S. Saini, Larisa B. Fritz, 2019, The Journal of Allergy and Clinical Immunology: In Practice.

Compound Heterozygous PGM3 Mutations in a Thai Patient with a Specific Antibody Deficiency Requiring Monthly IVIG Infusions

J. Lyons, J. Milner, S. Benjaponpitak, 2019, Journal of Clinical Immunology.

Systemic hypersensitivity reaction mimicking anaphylaxis after first filgrastim administration in a healthy donor

J. Lyons, K. Baird, Ashok Tholpady, 2013, Transfusion.

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

Phillip A. Richmond, A. Hoischen, W. Wasserman, 2023, The Journal of experimental medicine.

The normal range of baseline tryptase should be 1-15 ng/ml and covers healthy individuals with hereditary alpha tryptasemia.

M. Triggiani, A. Órfão, S. Galli, 2023, The journal of allergy and clinical immunology. In practice.

Severe food allergy reactions are associated with α-tryptase.

J. Lyons, P. Frischmeyer-Guerrerio, J. Pongracic, 2023, The Journal of allergy and clinical immunology.

Refined Treatment Response Criteria for Indolent Systemic Mastocytosis proposed by the ECNM-AIM Consortium.

M. Triggiani, A. Órfão, J. Lyons, 2022, The journal of allergy and clinical immunology. In practice.

Atopic dermatitis in children: clinical features, pathophysiology, and treatment.

J. Lyons, K. Stone, J. Milner, 2015, Immunology and allergy clinics of North America.

Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

Samuel R. LaMunion, A. Mammen, S. Hassanzadeh, 2024, Nature communications.

Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology

G. Pinkus, J. Lyons, J. Hornick, 2022 .

Clinically accessible amplitude-based multiplex ddPCR assay for tryptase genotyping.

J. Lyons, M. Rijavec, J. Šelb, 2024, Scientific reports.

Distinct Cutaneous Manifestations and Cold-Induced Leukocyte Activation Associated With PLCG2 Mutations.

J. Lyons, J. Milner, D. Kuhns, 2015, JAMA dermatology.

Distinct CutaneousManifestations and Cold-Induced Leukocyte Activation AssociatedWith PLCG 2 Mutations

J. Lyons, J. Milner, D. Kuhns, 2015 .

Hereditary alpha-tryptasemia despite normal tryptase-encoding gene copy number due to copy number loss in trans.

J. Lyons, S. Glover, Alexander Carlyle, 2021, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.