J. Ladbury

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Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.

L. Kavraki, A. Dhanik, J. McMurray, 2015, Journal of medicinal chemistry.

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

Franca Fraternali, Roger George, John E. Ladbury, 2008, Nucleic acids research.

Substitution of charged residues into the hydrophobic core of Escherichia coli thioredoxin results in a change in heat capacity of the native protein.

J. Ladbury, R. Wynn, J. Thomson, 1995, Biochemistry.

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

Y. Shamoo, J. Ladbury, M. Davlieva, 2015, Nucleic acids research.

Survey of the year 2005: literature on applications of isothermal titration calorimetry

J. Ladbury, Adessamad Ababou, John E Ladbury, 2007, Journal of molecular recognition : JMR.

A complex of Shc and Ran-GTPase localises to the cell nucleus

J. Ladbury, R. George, J. Timms, 2009, Cellular and Molecular Life Sciences.

Identification of novel fragment compounds targeted against the pY pocket of v‐Src SH2 by computational and NMR screening and thermodynamic evaluation

W. Pitt, Mark A. Williams, J. Ladbury, 2007, Proteins.

The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.

Tjelvar S. G. Olsson, W. Pitt, Mark A. Williams, 2008, Journal of molecular biology.

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions.

D. Braun, J. Joseph, A. Simeonov, 2013, Methods.

A Landscape of Driver Mutations in Melanoma

A. Sivachenko, K. Cibulskis, S. Gabriel, 2012, Cell.

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

L. Pearl, P. Piper, J. Ladbury, 1997, Cell.

The thermodynamics of formation of a three-strand, DNA three-way junction complex.

N. Leontis, J. Ladbury, J. Sturtevant, 1994, Biochemistry.

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

L. Pearl, P. Piper, J. Ladbury, 1999, Journal of medicinal chemistry.

Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes

J. Ladbury, A. S. Alshawli, H. Wurdak, 2020, Molecular genetics & genomic medicine.

Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.

J. Ladbury, 1996, Chemistry & biology.

A ribonuclease S-peptide antagonist discovered with a bacteriophage display library.

G. P. Smith, D. Schultz, J. Ladbury, 1993, Gene.

Crystallographic and calorimetric analysis of peptide binding to OppA protein.

J. Tame, J. Ladbury, A. Wilkinson, 1999, Journal of molecular biology.

Isothermal titration calorimetry: Application to structure-based drug design

J. Ladbury, 2001 .

Adding calorimetric data to decision making in lead discovery: a hot tip

Gerhard Klebe, John E. Ladbury, G. Klebe, 2010, Nature Reviews Drug Discovery.

Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions.

J. Ladbury, B. Chowdhry, J E Ladbury, 1996, Chemistry & biology.

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing

Yu Li, Xin Gao, S. Arold, 2018, Nucleic acids research.

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

J. Schlessinger, J. Ladbury, M. Lemmon, 1995, Proceedings of the National Academy of Sciences of the United States of America.

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

E. Miska, A. Lamond, J. Ladbury, 2020, Nature Communications.

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

E. Miska, A. Lamond, J. Ladbury, 2019, bioRxiv.

Structure, dynamics, and binding thermodynamics of the v‐Src SH2 domain: Implications for drug design

Mark A. Williams, J. Ladbury, A. Ababou, 2008, Proteins.

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

M. Hung, C. Logothetis, J. Ladbury, 2013, Cell.

Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design

J. Ladbury, S. Gražulis, Lina Baranauskienė, 2018, Quarterly Reviews of Biophysics.

Plakophilin-3 Catenin Associates with the ETV1/ER81 Transcription Factor to Positively Modulate Gene Activity

Moonsup Lee, William A. Muñoz, H. Ji, 2014, PloS one.

Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling.

J. Ladbury, L. O'Rourke, 2003, Accounts of chemical research.

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering

Benoit H. Dessailly, C. Orengo, D. Stuart, 2010, The Journal of Biological Chemistry.

Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction

J. Ladbury, L. Roberts, A. Rohwedder, 2021, Scientific reports.

Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.

J. M. Bradshaw, G. Waksman, R. Grucza, 1998, Biochemistry.

A structural characterization of the interactions between titin Z-repeats and the alpha-actinin C-terminal domain.

A. Pastore, S. Martin, J. Ladbury, 2001, Biochemistry.

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

G. Poncet-Montange, S. Arold, J. Ladbury, 2018, The international journal of biochemistry & cell biology.

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

J. Ladbury, P. Leonard, Z. Ahmed, 2014, Nature Structural &Molecular Biology.

Letter to the Editor: Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

L. Pearl, R. Salek, Mark A. Williams, 2002, Journal of Biomolecular NMR.

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

G. Poncet-Montange, Gilbert R. Lee, J. Ladbury, 2015, The Biochemical journal.

Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII

Wen-Yih Chen, J. Ladbury, S. Gražulis, 2021, ChemistryOpen.

Halophilic adaptation of protein-DNA interactions.

J. Ladbury, R. O'brien, S. Bergqvist, 2003, Biochemical Society transactions.

Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48*

D. Stuart, J. Ladbury, E. Davies, 2006, Journal of Biological Chemistry.

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

J. Schlessinger, J. Ladbury, V. Mandiyan, 1994, The Journal of biological chemistry.

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function

M. Hollstein, J. Ladbury, A. Odell, 2019, Biology Open.

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

Gilbert R. Lee, J. Ladbury, Z. Ahmed, 2015, Nature Communications.

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.

J. Ladbury, R. George, Richard Harris, 2008, Journal of molecular biology.

Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR

J. Ladbury, C. Baldari, J. Telford, 2000, European journal of immunology.

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands.

J. Ladbury, Sanjay Nilapwar, F. Gomez, 2007, Talanta.

Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides.

J. Ladbury, Sanjay Nilapwar, F. Gomez, 2006, Journal of capillary electrophoresis and microchip technology.

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

G. Poncet-Montange, S. Arold, J. Ladbury, 2020, bioRxiv.

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex.

W. Earnshaw, J. Ladbury, R. George, 2009, Biochemistry.

The toolbox is open, but who should pay for the job?

J. Ladbury, J. Skidmore, Adrian Hall, 2014, Nature Reviews Drug Discovery.

Expansion microscopy reveals subdomains in C. elegans germ granules

J. Ladbury, K. M. Suen, Chi-Chuan Lin, 2022, bioRxiv.

Title : T ( H ) 17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

S. Watowich, Yong‐jun Liu, S. Arold, 2022 .

Drug–DNA recognition: energetics and implications for design

J. Ladbury, I. Haq, John Ladbury, 2000, Journal of molecular recognition : JMR.

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

Tjelvar S. G. Olsson, J. Ladbury, S. Ono, 2005, The Biochemical journal.

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

J. Ladbury, Z. Ahmed, D. Lewis, 2013, The Biochemical journal.

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation*

J. Ladbury, H. Schneider, C. Rudd, 2013, The Journal of Biological Chemistry.

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

G. Parkinson, J. Ladbury, S. Perkins, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.

C. Higgins, J. Ladbury, P. Driscoll, 2002, Journal of molecular biology.

The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation

P. Quirke, J. Ladbury, C. Seiler, 2022, Communications Biology.

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

J. Ladbury, K. Suhling, J. Levitt, 2013, The Journal of cell biology.

A survey of the year 2002 literature on applications of isothermal titration calorimetry.

J. Ladbury, M. Cliff, 2003, Journal of molecular recognition : JMR.

Identification of a Novel Proline-Arginine Motif Involved in CIN85-dependent Clustering of Cbl and Down-regulation of Epidermal Growth Factor Receptors*

J. Ladbury, I. Dikic, Katarzyna Kowanetz, 2003, Journal of Biological Chemistry.

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and downregulation of EGF receptors

J. Ladbury, I. Dikic, Katarzyna Kowanetz, 2003 .

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.

J. Ladbury, A. Ababou, M. Pfuhl, 2009, Journal of molecular biology.

The binding stoichiometry of CIN85 SH3 domain A and Cbl-b

J. Ladbury, A. Ababou, M. Pfuhl, 2008, Nature Structural &Molecular Biology.

Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.

J. Ladbury, M. Okumura, Misaki Kinoshita, 2018, Chemical communications.

Extent of enthalpy–entropy compensation in protein–ligand interactions

Tjelvar S. G. Olsson, Mark A. Williams, J. Ladbury, 2011, Protein science : a publication of the Protein Society.

Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies.

J. Chaires, J. Ladbury, B. Chowdhry, 1997, Journal of molecular biology.

Biocalorimetry: Applications of Calorimetry in the Biological Sciences

J. Ladbury, B. Chowdhry, B. Z. Chowdhry, 2005 .

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors† †Electronic supplementary information (ESI) available: Experimental procedures, metallopeptide characterization, and assay details. See DOI: 10.1039/c5sc01602a Click here for additional data file.

J. Ladbury, P. Leonard, Z. Ball, 2015, Chemical science.

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems.

S. Arold, J. Ladbury, Loren J. Stagg, 2012, Journal of the American Chemical Society.

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design.

J. Ladbury, 2010, Biochemical Society transactions.

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

J. Ladbury, 2004, BioTechniques.

Molecular design using electrostatic interactions. 1. Synthesis and properties of flexible tripodand tri- and hexa-cations with restricted conformations. Molecular selection of ferricyanide from ferrocyanide

J. Ladbury, R. O'brien, M. Hursthouse, 1998 .

Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction

J. Ladbury, 2006, Acta crystallographica. Section D, Biological crystallography.

Intrinsic Thermodynamics of Protein-Ligand Binding by Isothermal Titration Calorimetry as Aid to Drug Design.

J. Ladbury, D. Matulis, Asta Zubrienė, 2019, Methods in molecular biology.

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

J. Ladbury, K. Strebhardt, C. Rudd, 2010, Immunity.

Isothermal titration calorimetry: A tutorial.

J. Ladbury, J. Thomson, 2005 .

The extended interface: measuring non-local effects in biomolecular interactions.

Mark A. Williams, J. Ladbury, Mark A Williams, 2004, Current opinion in structural biology.

Heat capacity effects of water molecules and ions at a protein-DNA interface.

Mark A. Williams, J. Ladbury, R. O'brien, 2004, Journal of molecular biology.

Specific DNA recognition by the type II restriction endonuclease MunI: the effect of pH.

J. Ladbury, R. O'brien, I. Haq, 2001, Biochemistry.

Comparison of binding energies of SrcSH2‐phosphotyrosyl peptides with structure‐based prediction using surface area based empirical parameterization

R M Jackson, R. Jackson, J. Ladbury, 2000, Protein science : a publication of the Protein Society.

Water mediated protein‐DNA interactions: The relationship of thermodynamics to structural detail

J. Ladbury, C. Morton, 1996, Protein science : a publication of the Protein Society.

Isothermal titration calorimetry of biomolecules

J. Ladbury, R. O'brien, J. Tame, 1998 .

Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity.

J. Ladbury, P. Carey, M. Weiss, 2004, Biochemistry.

Molecular anchoring of duplex and triplex DNA by disubstituted anthracene-9,10-diones: Calorimetric, UV melting, and competition dialysis studies

J. Ladbury, B. Chowdhry, T. C. Jenkins, 1996 .

A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis*

Anupama E. Gururaj, O. Bogler, J. Ladbury, 2015, The Journal of Biological Chemistry.

Hydrogen Bonds in Protein-Ligand Complexes

Mark A. Williams, J. Ladbury, 2008 .

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

I. Campbell, D. Heinegård, J. Ladbury, 2000, Structure.

Two EGF molecules contribute additively to stabilization of the EGFR dimer

D. Engelman, I. Lax, J. Schlessinger, 1997, The EMBO journal.

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

G. Montelione, R. Krug, J. Ladbury, 2014, Structure.

ThermoML -An XML-based approach for storage and exchange of experimental and critically evaluated thermophysical and thermochemical property data. 4. biomaterials

Michael D. Frenkel, Vladimir Diky, Kenneth N. Marsh, 2003 .

Drug Resistance in Glioma Cells Induced by a Mesenchymal–Amoeboid Migratory Switch

J. Ladbury, S. Lawler, M. Nowicki, 2021, Biomedicines.

A novel workflow for three-dimensional analysis of tumour cell migration

Sophie Ketchen, Arndt Rohwedder, Sabine Knipp, 2020, Interface Focus.

Faculty Opinions recommendation of Phase Transitions in the Assembly and Function of Human miRISC.

J. Ladbury, 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer

Samuel W. Brady, M. Hung, J. Hsu, 2015, Molecular oncology.

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.

A. Fire, B. Liu, J. Ladbury, 2014, Developmental cell.

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

E. Miska, J. Heeney, J. Ladbury, 2019, Molecular cell.

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.

C. Tregidgo, J. Ladbury, K. Suhling, 2008, The Biochemical journal.

Molecular basis for TPR domain‐mediated regulation of protein phosphatase 5

D. Barford, Mark A. Williams, J. Ladbury, 2005, The EMBO journal.

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

M. Jaye, I. Lax, J. Schlessinger, 1994, Cell.

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

L. Pearl, P. Piper, J. Ladbury, 1998, The EMBO journal.

Grb2 binding induces phosphorylation-independent activation of Shp2

J. Ladbury, Z. Ahmed, K. M. Suen, 2019, bioRxiv.

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

J. Grandis, M. Hung, Yueh-Fu Fang, 2015, The Journal of clinical investigation.

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.

J. Ladbury, R. George, K. Suhling, 2010, Cellular signalling.

The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N‐terminal domains

Chrisostomos Prodromou, Ronan O'Brien, Giuliano Siligardi, 2000, The EMBO journal.

Calcium-binding protein S100A6 interaction with VEGF receptors integrates signaling and trafficking pathways

J. Ladbury, J. Findlay, G. Kinsella, 2021, bioRxiv.

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

S. Arold, J. Ladbury, Z. Ahmed, 2012, Cell.

Noise in cellular signaling pathways: causes and effects.

S. Arold, J. Ladbury, John E Ladbury, 2012, Trends in biochemical sciences.

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling.

S. Arold, J. Ladbury, John E Ladbury, 2011, Methods in enzymology.

The role of alternative splicing in CEP290-related disease pathogenesis

J. Ladbury, M. Peckham, J. Poulter, 2022, medRxiv.

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.

S. Arold, P. Franken, M. Strub, 1998, Biochemistry.

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

John E. Ladbury, Anthony J. Wilkinson, J. Tame, 1996, Nature Structural Biology.

Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling

J. Ladbury, 2005 .

Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck.

J. Ladbury, M. Lemmon, M A Lemmon, 1994, Biochemistry.

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

M. Andreeff, S. Arold, J. Ladbury, 2016, Oncotarget.

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones

Chrisostomos Prodromou, Lynne Regan, Ronan O'Brien, 1999, The EMBO journal.

Erythropoietin Stimulates Tumor Growth via EphB4.

Jie Huang, Bulent Ozpolat, David B Jackson, 2015, Cancer cell.

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

E. Miska, J. Ladbury, S. Evans, 2022, Molecular cell.

TCR binding to peptide-MHC stabilizes a flexible recognition interface.

B K Jakobsen, G. Gao, J. Bell, 1999, Immunity.

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43

C. Xiong, Chun Xing Li, P. Fox, 2016, Oncotarget.

H-NS forms a superhelical protein scaffold for DNA condensation

John E. Ladbury, Stefan T. Arold, G. Parkinson, 2010, Proceedings of the National Academy of Sciences.

Oligomerization of the chromatin‐structuring protein H‐NS

C. Higgins, J. Ladbury, M. Layton, 2000, Molecular microbiology.

The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon.

B. DeDecker, P. Sigler, J. Ladbury, 1998, Journal of molecular biology.

The hidden thermodynamics of a zinc finger.

J. Ladbury, M. Weiss, N. Phillips, 2002, Journal of Molecular Biology.

Structural basis for recognition of dipeptides by peptide transporters.

J. Ladbury, R. O'brien, G. Payne, 2000, Archives of biochemistry and biophysics.

Structure and Interactions of the Human Programmed Cell Death 1 Receptor*

John E. Ladbury, Mark D. Carr, Vaclav Veverka, 2013, The Journal of Biological Chemistry.

Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85.

J. Ladbury, A. Ababou, R. Ghosh, 2011, Biochemistry.

Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS.

C. Higgins, J. Ladbury, P. Driscoll, 2001, Journal of molecular biology.

Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.

I D Campbell, I. Campbell, M. Waterfield, 1996, Biochemistry.

Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.

H. Hellinga, J. Ladbury, R. Wynn, 1994, Biochemistry.

Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.

A. M. Riley, B V Potter, M. Saraste, 1999, Structure.

Probing the nature of interactions in SH2 binding interfaces–evidence from electrospray ionization mass spectrometry

C. Robinson, J. Ladbury, C. Morton, 1999, Protein science : a publication of the Protein Society.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer

G. Mills, Yiling Lu, M. Hung, 2016, Oncogene.

T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation

J. Ladbury, C. Baldari, S. John, 2010, The Biochemical journal.

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

Klaus Suhling, James A Levitt, J. Ladbury, 2008, The Biochemical journal.

Alternative modes of binding of proteins with tandem SH2 domains

M. Waterfield, J. Ladbury, P. Driscoll, 2008, Protein science : a publication of the Protein Society.

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

J. Ladbury, P. Leonard, Z. Ball, 2015 .

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity.

T. Ikegami, J. Ladbury, C. Kojima, 2016, The Biochemical journal.

Molecular recognition via coupled folding and binding in a TPR domain.

D. Barford, Mark A. Williams, J. Ladbury, 2005, Journal of molecular biology.

The high‐resolution crystal structure of a 24‐kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

A. Breeze, D. Wigley, J. Ladbury, 1997, Proteins.

Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry.

C. Robinson, J. Tame, J. Ladbury, 2000, Journal of molecular biology.

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli

S. Arold, J. Ladbury, Swathi Arur, 2013, Nature Structural &Molecular Biology.

Thermodynamics of Biomolecular Interactions

J. Ladbury, 2018, Encyclopedia of Biophysics.

Characterization of sequence-specific DNA binding by the transcription factor Oct-1.

B. Luisi, J. Ladbury, T. Lundbäck, 2000, Biochemistry.

A thermodynamic study of the trp repressor-operator interaction.

J M Sturtevant, P B Sigler, P. Sigler, 1994, Journal of molecular biology.

Corrigendum: Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

John E. Ladbury, J. Ladbury, Z. Ahmed, 2015, Nature Communications.

Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II

James C. Campbell, B. Sankaran, T. Link, 2015, BMC Pharmacology and Toxicology.

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

G. Richardson, J. Ladbury, Z. Ahmed, 2018, Proceedings of the National Academy of Sciences.

Application of isothermal titration calorimetry in exploring the extended interface.

John Edward Simon Durham Ladbury, Mark A. Williams, Mark A. Williams, 2007 .

Site-specific cation binding mediates TATA binding protein-DNA interaction from a hyperthermophilic archaeon.

J. Ladbury, R. O'brien, S. Bergqvist, 2001, Biochemistry.

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.

J. Ladbury, S. Gražulis, Lina Baranauskienė, 2014, Journal of medicinal chemistry.

Conformational changes in the AAA ATPase p97–p47 adaptor complex

R. Isaacson, P. Freemont, J. Ladbury, 2006, The EMBO journal.

Inhibitor Binding to Carbonic Anhydrases by Isothermal Titration Calorimetry

Wen-Yih Chen, J. Ladbury, S. Keller, 2019, Carbonic Anhydrase as Drug Target.

Dynamics of a monomeric insulin analogue: testing the molten-globule hypothesis.

J. Ladbury, M. Weiss, J E Ladbury, 1993, Biochemistry.

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains.

C. Robinson, B. Luisi, J. Ladbury, 2002, Journal of molecular biology.

Survey of the year 2004: literature on applications of isothermal titration calorimetry

J. Ladbury, A. Ababou, 2006, Journal of molecular recognition : JMR.

Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat.

N. Juge, J. Ladbury, J. Berrin, 2002, The Biochemical journal.

ThermoML: an XML-Based Approach for Storage and Exchange of Experimental and Critically Evaluated Thermophysical and Thermochemical Property Data. 5. Speciation and Complex Equilibria

Peter A. Williams, J. Ladbury, A. Goodwin, 2011 .

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

S. Watowich, S. Arold, J. Ladbury, 2015, Nature Immunology.

Extension of ThermoML: The IUPAC standard for thermodynamic data communications (IUPAC Recommendations 2011)

Vladimir Diky, Kenneth N. Marsh, John H. Dymond, 2011 .

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

L. Pearl, Mark A. Williams, J. Ladbury, 2009, Journal of molecular biology.

Phase separation enhances probability of receptor signalling and drug targeting.

J. Ladbury, K. M. Suen, Chi-Chuan Lin, 2023, Trends in biochemical sciences.

Catalysis and regulation.

M. Noble, J. Ladbury, 2009, Current Opinion in Structural Biology.

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

D. Barford, Mark A. Williams, J. Ladbury, 2006, Structure.

Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides.

J. M. Bradshaw, G Waksman, M. Zvelebil, 1998, Structure.

Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.

H. Hellinga, J. Ladbury, R. Wynn, 1993, Biochemistry.

Regulation of microRNA expression by the adaptor protein GRB2

E. Miska, J. Ladbury, Z. Ahmed, 2023, Scientific reports.

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.

Xin Hu, I. Wistuba, J. Lee, 2015, American journal of cancer research.

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation.

J. Ladbury, Z. Ahmed, Annika C Schüller, 2008, The Biochemical journal.

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling

J. Ladbury, K. M. Suen, L. Wieteska, 2019, Cancer letters.

The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases*

I. Campbell, M. Noble, S. Arold, 2001, The Journal of Biological Chemistry.

The combined action of the intracellular regions regulates FGFR2 kinase activity

G. Poncet-Montange, S. Arold, J. Ladbury, 2023, Communications biology.

Receptor tyrosine kinases regulate signal transduction through a liquid–liquid phase separated state

E. Miska, J. Ladbury, Z. Ahmed, 2019, bioRxiv.

Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice

J. Ladbury, M. Weiss, Rupinder Singh, 2004, Protein science : a publication of the Protein Society.

Biophysical characterization of VEGF-aHt DNA aptamer interactions.

J. Ladbury, Wen-Hsiang Chen, K. Kourentzi, 2013, International journal of biological macromolecules.

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors.

Mark A. Williams, J. Ladbury, C. Baldari, 2005, Journal of molecular biology.

PLBD: protein–ligand binding database of thermodynamic and kinetic intrinsic parameters

H. Schiöth, J. Ladbury, S. Gražulis, 2023, Database J. Biol. Databases Curation.

Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy.

Mark A. Williams, J. Ladbury, R. O'brien, 2002, Structure.

Searching for specificity in SH domains.

J. Ladbury, J E Ladbury, S Arold, 2000, Chemistry & biology.

Redox-state-dependent complex formation between pseudoazurin and nitrite reductase.

J. Ladbury, M. Ubbink, A. Impagliazzo, 2007, Journal of the American Chemical Society.

The adaptability of Escherichia coli thioredoxin to non‐conservative amino acid substitutions

K. Plaxco, J. Ladbury, P. Driscoll, 1997, Protein science : a publication of the Protein Society.

A survey of the year 2003 literature on applications of isothermal titration calorimetry

J. Ladbury, M. Cliff, A. Gutierrez, 2004, Journal of molecular recognition : JMR.

StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI

J. Ladbury, D. Dryden, P. Leonard, 2005, Nucleic acids research.

Application of DSC for the measurement of the thermal conductivity of elastomeric materials

J. Ladbury, J. Parsonage, J. Horder, 1990 .

Investigation of the self‐association and hetero‐association interactions of H‐NS and StpA from Enterobacteria

J. Ladbury, S. Perkins, P. Leonard, 2009, Molecular microbiology.

Counting the calories to stay in the groove.

J. Ladbury, J E Ladbury, J. E. Ladbury, 1995, Structure.

Probing Cocaine-Antibody Interactions in Buffer and Human Serum

J. Ladbury, T. Kosten, B. Kinsey, 2012, PloS one.

Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: implications for regulation of tyrosine kinase activity.

I. Campbell, G. Panayotou, J. Ladbury, 1996, Biochemistry.

INTERACTION OF PORPHYRIN WITH G-QUADRUPLEX STRUCTURES

J. Ladbury, G. Barone, C. Giancola, 2005, Nucleosides, nucleotides & nucleic acids.

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function

M. Hollstein, J. Ladbury, A. Odell, 2019, Biology Open.

Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid*

J. Ladbury, J. Di Domizio, W. Cao, 2011, The Journal of Biological Chemistry.

Expansion microscopy reveals subdomains in C. elegans germ granules

J. Ladbury, K. M. Suen, Chi-Chuan Lin, 2023, Life Science Alliance.

Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding.

B. Luisi, J. Ladbury, M. Gstaiger, 1999, Journal of molecular biology.

Turning Up the Heat On Rational Drug Design

J. Ladbury, R. Peters, 1994, Bio/Technology.