J. Hancock

发表

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding

Amit K. Gupta, C. Pagba, Priyanka Prakash, 2019, ACS omega.

Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters.

J. Hancock, Liron Belanis, S. Plowman, 2008, Molecular biology of the cell.

Signalling ballet in four dimensions

B. Kholodenko, W. Kolch, J. Hancock, 2017 .

Signalling ballet in space and time

Boris N. Kholodenko, Walter Kolch, B. Kholodenko, 2010, Nature Reviews Molecular Cell Biology.

Signalling ballet in four dimensions Supplementary Information

B. Kholodenko, W. Kolch, J. Hancock, 2022 .

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

Tianhai Tian, Robert G. Parton, Angus Harding, 2007, Nature Cell Biology.

Ras proteins: different signals from different locations

J. Hancock, John F. Hancock, 2003, Nature Reviews Molecular Cell Biology.

Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger*

Sandrine Roy, Jun Yan, J. Hancock, 1997, The Journal of Biological Chemistry.

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase*

J. Hancock, S. Roy, J. Yan, 1998, The Journal of Biological Chemistry.

Biogenesis of caveolae: a structural model for caveolin-induced domain formation

J. Hancock, R. Parton, M. Hanzal-Bayer, 2006, Journal of Cell Science.

Ras nanoclusters: molecular structure and assembly.

A. Gorfe, J. Hancock, D. Abankwa, 2007, Seminars in cell & developmental biology.

Co-Regulation of Cell Polarization and Migration by Caveolar Proteins PTRF/Cavin-1 and Caveolin-1

J. Hancock, M. Parat, R. Parton, 2012, PloS one.

Activation of the MAPK module from different spatial locations generates distinct system outputs.

J. Hancock, S. Plowman, A. Harding, 2008, Molecular biology of the cell.

Activation of Raf as a result of recruitment to the plasma membrane.

J. Hancock, D. Stokoe, M. Symons, 1994, Science.

Identifying Optimal Lipid Raft Characteristics Required To Promote Nanoscale Protein-Protein Interactions on the Plasma Membrane

Dan V. Nicolau, Kevin Burrage, Robert G. Parton, 2006, Molecular and Cellular Biology.

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

Amit K. Gupta, C. Pagba, Priyanka Prakash, 2018, bioRxiv.

Binding hotspots on K‐ras: Consensus ligand binding sites and other reactive regions from probe‐based molecular dynamics analysis

Priyanka Prakash, A. Gorfe, J. Hancock, 2015, Proteins.

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

Khozirah Shaari, Harrison J. Hocker, Nandini Rambahal, 2013, Proceedings of the National Academy of Sciences.

A novel switch region regulates H‐ras membrane orientation and signal output

J Andrew McCammon, Daniel Abankwa, Robert G Parton, 2008, The EMBO journal.

Constitutive Formation of Caveolae in a Bacterium

Kai Simons, Robert G. Parton, Nicholas Ariotti, 2012, Cell.

On the use of Ripley's K-function and its derivatives to analyze domain size.

J. Hancock, A. Kenworthy, M. Kiskowski, 2009, Biophysical journal.

K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.

Tianhai Tian, Nicholas Ariotti, T. Tian, 2008, Cancer research.

Lipid rafts and plasma membrane microorganization: insights from Ras.

Robert G Parton, J. Hancock, R. Parton, 2004, Trends in cell biology.

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Robert G. Parton, J. Hancock, I. Prior, 2003, The Journal of cell biology.

Reticulocyte lysate assay for in vitro translation and posttranslational modification of Ras proteins.

J. Hancock, 1995, Methods in enzymology.

Anti-Ras drugs come of age

J. Hancock, 1993, Current Biology.

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gαq and Gα11 and kill uveal melanoma cells

J. Kirkwood, J. Hancock, P. Dent, 2019, Cancer biology & therapy.

VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking

Yong Zhou, J. Hancock, M. Philips, 2016, The Journal of cell biology.

C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution.

J. Hancock, I. Prior, M. Hansen, 2003, Biochemical and biophysical research communications.

Mathematical modeling of K-Ras nanocluster formation on the plasma membrane.

T. Tian, J. Hancock, S. Plowman, 2010, Biophysical journal.

Lipidomic atlas of mammalian cell membranes reveals hierarchical variation induced by culture conditions, subcellular membranes, and cell lineages.

Jeffrey T. Chang, M. Waxham, Kwang-jin Cho, 2020, Soft matter.

The Nonsteroidal Anti-Inflammatory Drug Indomethacin Induces Heterogeneity in Lipid Membranes: Potential Implication for Its Diverse Biological Action

J. Hancock, L. Lichtenberger, Yong Zhou, 2010, PloS one.

Correction: The Nonsteroidal Anti-Inflammatory Drug Indomethacin Induces Heterogeneity in Lipid Membranes: Potential Implication for Its Diverse Biological Action

J. Hancock, L. Lichtenberger, Yong Zhou, 2010, PLoS ONE.

Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange.

J. Hancock, E. Porfiri, P. Chardin, 1994, The Journal of biological chemistry.

Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?

Melissa J. Davis, J. Hancock, R. Parton, 2012, Developmental cell.

Reassessing the Role of Phosphocaveolin‐1 in Cell Adhesion and Migration

J. Hancock, L. Huber, M. Parat, 2007, Traffic.

The Linker Domain of the Ha-Ras Hypervariable Region Regulates Interactions with Exchange Factors, Raf-1 and Phosphoinositide 3-Kinase*

J. Hancock, Jun Yan, Judith Sluimer, 2002, The Journal of Biological Chemistry.

Therapeutic Levels of the Hydroxmethylglutaryl-Coenzyme A Reductase Inhibitor Lovastatin Activate Ras Signaling via Phospholipase D2

Kwang-jin Cho, J. Hancock, Sravanthi Chigurupati, 2011, Molecular and Cellular Biology.

Clustering of Rac1: Selective Lipid Sorting Drives Signaling.

Yong Zhou, J. Hancock, Kelsey N Maxwell, 2018, Trends in biochemical sciences.

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization

J. de Gunzburg, J. Hancock, H. Paterson, 1994, Molecular and cellular biology.

Compartmentalization of Ras proteins.

J. Hancock, I. Prior, Ian A. Prior, 2001, Journal of cell science.

Summary Compartmentalization of Ras proteins

J. Hancock, I. Prior, 2001 .

Which Ras rides the raft? - Reply

J. Hancock, I. Prior, R. Parton, 2001, Nature Cell Biology.

Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs.

Douglas B. Litwin, Priyanka Prakash, Suparna Sarkar-Banerjee, 2019, Biophysical journal.

DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18

J. Hancock, A. Hoffbrand, E. Porfiri, 1993 .

Flotillin-1/Reggie-2 Traffics to Surface Raft Domains via a Novel Golgi-independent Pathway

D. James, J. Hancock, I. Prior, 2002, The Journal of Biological Chemistry.

Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers

Wei Chen, Hongyang Li, Priyanka Prakash, 2017, Scientific Reports.

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

Travis L. Rodkey, Yong Zhou, J. Hancock, 2014, The Journal of cell biology.

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

J. Hancock, A. Harding, R. Parton, 1999, Nature Cell Biology.

Caveolin Interacts with the Angiotensin II Type 1 Receptor during Exocytic Transport but Not at the Plasma Membrane*

J. Hancock, I. Prior, R. Parton, 2003, Journal of Biological Chemistry.

Inhibition of Lipid Raft-dependent Signaling by a Dystrophy-associated Mutant of Caveolin-3*

J. Hancock, I. Prior, R. Parton, 2002, The Journal of Biological Chemistry.

Caveolin and Ras function.

J. Hancock, R. Parton, 2001, Methods in enzymology.

Characterization of RasGRP2, a Plasma Membrane-targeted, Dual Specificity Ras/Rap Exchange Factor*

N. Hayward, S. Grimmond, J. Hancock, 2000, The Journal of Biological Chemistry.

System output of the MAPK module is spatially regulated

J. Hancock, K. Inder, Kerry L. Inder, 2008, Communicative & integrative biology.

Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1

Yong Zhou, J. Hancock, Xiaodong Cheng, 2016, Scientific Reports.

Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning.

M. Westerfield, J. Hancock, R. Parton, 2005, Human molecular genetics.

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

J. Hancock, H. Paterson, S. Macdonald, 1994, Molecular and cellular biology.

Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters

Travis L. Rodkey, Hong Liang, Yong Zhou, 2013, Molecular and Cellular Biology.

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis*

S. Grinstein, M. Gold, R. Harrison, 2009, The Journal of Biological Chemistry.

Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis.

J. Hancock, L. Gutiérrez, A. Magee, 1989, The EMBO journal.

The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure

Priyanka Prakash, A. Gorfe, Hong Liang, 2021, Proceedings of the National Academy of Sciences.

Targeting of oncoproteins to membranes by fatty acylation

C. Marshall, J. Hancock, L. Gutiérrez, 1989, Journal of Cell Science.

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.

Amy M. Hurwitz, G. Wahl, J. Gray, 2019, Cell reports.

Lipid modifications and function of the ras superfamily of proteins.

J. Armstrong, J. Hancock, A. Magee, 1992, Biochemical Society transactions.

An N-Terminal Polybasic Motif of Gαq Is Required for Signaling and Influences Membrane Nanodomain Distribution

J. Hancock, D. Abankwa, Marykate Crouthamel, 2010, Molecular Pharmacology.

The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase*

J. Hancock, D. Matusica, D. Abankwa, 2012, The Journal of Biological Chemistry.

Staurosporine: A new tool for studying phosphatidylserine trafficking.

Kwang-jin Cho, J. Hancock, Jin-Hee Park, 2013, Communicative & integrative biology.

Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains*

Hong Liang, Yong Zhou, J. Hancock, 2013, The Journal of Biological Chemistry.

DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18.

J. Hancock, E. Porfiri, A. V. Hoffbrand, 1993, Blood.

Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function

C. Marshall, J. Hancock, D. Huang, 1993, Molecular and cellular biology.

Neratinib augments the lethality of [regorafenib + sildenafil]

J. Hancock, P. Dent, A. Lalani, 2018, Journal of cellular physiology.

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

C. Marshall, M. Houslay, J. Hancock, 1988, Oncogene.

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

Hong Liang, Yong Zhou, J. Hancock, 2021, The Journal of cell biology.

Dissecting the nanoscale lipid profile of caveolae

Hong Liang, Yong Zhou, J. Hancock, 2020, bioRxiv.

Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output

Priyanka Prakash, Alemayehu A. Gorfe, Priyanka Prakash, 2017, Cell.

Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours

J. Hancock, P. Dent, L. Booth, 2022, European Medical Journal.

Building insights into KRAS signaling complexes

A. Gorfe, J. Hancock, 2021, Nature Structural & Molecular Biology.

Lipid sorting and the activity of Arf signaling complexes

Yong Zhou, J. Hancock, 2017, Proceedings of the National Academy of Sciences.

Purification of baculovirus-expressed recombinant Ras and Rap proteins.

J. Hancock, G. Bollag, E. Porfiri, 1995, Methods in enzymology.

PA promoted to manager

J. Hancock, 2007, Nature Cell Biology.

Prenylation of ras and ras-Related Proteins

J. Armstrong, C. Marshall, J. Hancock, 1991 .

Stimulation of nucleotide exchange on Ras- and Rho-related proteins by small GTP-binding protein GDP dissociation stimulator.

J. Hancock, E. Porfiri, 1995, Methods in enzymology.

Prenylation and palmitoylation analysis.

J. Hancock, John F. Hancock, 1995, Methods in enzymology.

Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling.

S. Grimmond, M. Waters, J. Hancock, 2013, Cell reports.

The Anti-inflammatory Drug Indomethacin Alters Nanoclustering in Synthetic and Cell Plasma Membranes*

J. Hancock, S. Plowman, L. Lichtenberger, 2010, The Journal of Biological Chemistry.

Human Papillomavirus Type 6b Virus-Like Particles Are Able To Activate the Ras-MAP Kinase Pathway and Induce Cell Proliferation

J. Hancock, N. McMillan, M. Bowles, 2001, Journal of Virology.

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

Astrid Magenau, Nicholas Ariotti, Kirill Alexandrov, 2014, eLife.

Six point mutations that cause factor XI deficiency.

J. Hancock, R. Pugh, J. McVey, 1995, Blood.

A molecular genetic study of factor XI deficiency.

D. Cooper, J. Hancock, V. Kakkar, 1991, Blood.

Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib.

D. V. Von Hoff, Yong Zhou, J. Hancock, 2021, Biochemical pharmacology.

Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.

Kwang-jin Cho, J. Hancock, E. Lacey, 2014, Organic letters.

All ras proteins are polyisoprenylated but only some are palmitoylated

C. Marshall, J. Hancock, A. Magee, 1989, Cell.

Evolutionary analysis and molecular dissection of caveola biogenesis

M. Kirkham, F. Brodsky, J. Hancock, 2008, Journal of Cell Science.

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21 ras to the plasma membrane

C. Marshall, J. Hancock, H. Paterson, 1990, Cell.

H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output

Sarah J. Plowman, Hong Liang, J. Hancock, 2010, PloS one.

Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission

Dharini van der Hoeven, Kwang-jin Cho, J. Hancock, 2012, Molecular and Cellular Biology.

Staurosporine

Kwang-jin Cho, J. Hancock, Jin-Hee Park, 2013, Communicative & Integrative Biology.

H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway

J. Hancock, M. Lindsay, I. Prior, 2000, Molecular and Cellular Biology.

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

Michael X. Zhu, Dharini van der Hoeven, Hongzhen Hu, 2015, Science.

Oligomycins as inhibitors of K-Ras plasma membrane localisation.

J. Hancock, E. Lacey, R. Capon, 2016, Organic & biomolecular chemistry.

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

C J Marshall, J. Hancock, H. Paterson, 1991, The EMBO journal.

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer

E. Dmitrovsky, S. Hanash, I. Wistuba, 2017, Molecular Cancer Research.

Individual Palmitoyl Residues Serve Distinct Roles in H-Ras Trafficking, Microlocalization, and Signaling

J. Hancock, Y. Henis, S. Plowman, 2005, Molecular and Cellular Biology.

Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction*

Dharini van der Hoeven, J. Hancock, K. Inder, 2009, The Journal of Biological Chemistry.

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

S. Gygi, Mark P. Jedrychowski, J. Hancock, 2009, The Journal of cell biology.

Caveolin Regulates Endocytosis of the Muscle Repair Protein, Dysferlin*

J. Hancock, K. Bushby, R. Parton, 2008, Journal of Biological Chemistry.

RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics.

J. Hancock, Walaa E. Kattan, 2020, The Biochemical journal.

Signaling alterations caused by drugs and autophagy.

J. Hancock, P. Dent, A. Poklepovic, 2019, Cellular signalling.

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

M. Kirkham, J. Hancock, R. Parton, 2008, Cell.

Three distinct regions of cRaf kinase domain interact with membrane

Priyanka Prakash, A. Gorfe, J. Hancock, 2019, Scientific Reports.

Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.

Andrew M. Piggott, Kwang-jin Cho, J. Hancock, 2014, Organic & biomolecular chemistry.

Lipid rafts and membrane traffic

J. Hancock, M. Hanzal-Bayer, Michael F. Hanzal-Bayer, 2007, FEBS letters.

Figures and figure supplements Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

T. Aittokallio, Hong Liang, Yong Zhou, 2015 .

Ras trafficking, localization and compartmentalized signalling.

J. Hancock, I. Prior, Ian A Prior, 2012, Seminars in cell & developmental biology.

Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.

Nicole Cloonan, Andreas Suhrbier, N. Cloonan, 2007, Cellular signalling.

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

C. Marshall, J. Hancock, A. Hall, 1988, Nature.

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

M. Kirkham, S. Mayor, K. Cortese, 2010, The Journal of cell biology.

H-Ras Signaling and K-Ras Signaling Are Differentially Dependent on Endocytosis

J. Hancock, Sandrine Roy, B. Wyse, 2002, Molecular and Cellular Biology.

14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

R. McPherson, J. Hancock, S. Roy, 1998, Molecular and Cellular Biology.

The Function of the Mammalian Ras Proteins

M. Houslay, J. Hancock, A. Hall, 1989 .

Ras nanoclusters: Combining digital and analog signaling

Angus Harding, J. Hancock, A. Harding, 2008, Cell cycle.

Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy

Travis L. Rodkey, R. Broaddus, Dharini van der Hoeven, 2013, Molecular Cancer Therapeutics.

Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity

J. Hancock, C. Counter, Shivesh Kumar, 2021, Nature Communications.

Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes.

M. Neal Waxham, Priyanka Prakash, Alemayehu A. Gorfe, 2017, Journal of the American Chemical Society.

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

Robert G Parton, J. Hancock, S. Plowman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of RAS function through targeting an allosteric regulatory site.

Marc Therrien, Shohei Koide, Priyanka Gajwani, 2017, Nature chemical biology.

The development of multi-kinase inhibitors as pancreatic cancer therapeutics

J. Hancock, P. Dent, A. Poklepovic, 2021, Anti-cancer drugs.

Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane

Dharini van der Hoeven, Yong Zhou, Kwang-jin Cho, 2015, Molecular and Cellular Biology.

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

M. Waters, J. Hancock, J. Barclay, 2008, Nature Cell Biology.

ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis

Jeffrey T. Chang, M. A. Surma, Yong Zhou, 2017, Science Advances.

Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

S. Grinstein, Yong Zhou, J. Hancock, 2013, Molecular and Cellular Biology.

Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer.

J. Mccammon, A. Gorfe, J. Hancock, 2007, Journal of medicinal chemistry.

Ras plasma membrane signalling platforms.

J. Hancock, R. Parton, 2005, The Biochemical journal.

Monoubiquitination of KRAS at Lysine104 and Lysine147 Modulates Its Dynamics and Interaction with Partner Proteins.

A. Gorfe, J. Hancock, S. Campbell, 2021, The journal of physical chemistry. B.

Mechanisms of Ras membrane organization and signaling: Ras on a rocker

A. Gorfe, J. Hancock, D. Abankwa, 2008, Cell cycle.

RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains

A. Gorfe, Yong Zhou, J. Hancock, 2021, Frontiers in Molecular Biosciences.

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.

D. Esposito, D. Morrison, Yong Zhou, 2019, Molecular cell.

An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth

Kwang-jin Cho, J. Hancock, R. Capon, 2018, The Journal of Biological Chemistry.

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.

Yong Zhou, J. Hancock, D. Abankwa, 2015, Biochemistry.

A novel role for RhoGDI as an inhibitor of GAP proteins.

J. Hancock, A. Hall, A Hall, 1993, The EMBO journal.

HRAS‐driven cancer cells are vulnerable to TRPML1 inhibition

A. Naji, Dharini van der Hoeven, Hong Liang, 2019, EMBO reports.

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

Robert G. Parton, Angus Harding, J. Hancock, 2001, Nature Cell Biology.

Post-translational processing of Schizosaccharomyces pombe YPT proteins.

J. Armstrong, J. Hancock, A. Magee, 1992, The Journal of biological chemistry.

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K‐ras(B).

J. Hancock, K. Cadwallader, C. Marshall, 1991, The EMBO journal.

Identification of Residues and Domains of Raf Important for Function in Vivo and in Vitro*

J. Hancock, A. Harding, K. Kornfeld, 2003, Journal of Biological Chemistry.

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

J. Hancock, M. Jaumot, 2001, Oncogene.

Interactions of c-Raf-1 with phosphatidylserine and 14-3-3

J. Hancock, A. Harding, Sandrine Roy, 1999, Oncogene.

Expression of multiple endocrine neoplasia 2B RET in neuroblastoma cells alters cell adhesion in vitro, enhances metastatic behavior in vivo, and activates Jun kinase.

B. Ponder, J. Hancock, A. Peaston, 1997, Cancer research.

Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function

C. Marshall, J. Hancock, David C. S. Huang, 1993, Molecular and Cellular Biology.

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Jeffrey T. Chang, C. Lebrilla, Yong Zhou, 2023, Nature Communications.

Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function

Yong Zhou, Kwang-jin Cho, J. Hancock, 2019, Journal of Cell Science.

Ras and the Plasma Membrane: A Complicated Relationship.

Priyanka Prakash, A. Gorfe, Yong Zhou, 2018, Cold Spring Harbor perspectives in medicine.

Deciphering lipid codes: K‐Ras as a paradigm

Yong Zhou, J. Hancock, 2018, Traffic.

A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor

Yong Zhou, J. Hancock, 2018, Small GTPases.

Sphingomyelin Metabolism Is a Regulator of K-Ras Function

J. Frost, A. Naji, Dharini van der Hoeven, 2017, Molecular and Cellular Biology.

Ras Proteolipid Nanoassemblies on the Plasma Membrane Sort Lipids With High Selectivity

Yong Zhou, J. Hancock, 2017 .

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2

Priyanka Prakash, A. Gorfe, Dharini van der Hoeven, 2016, Molecular and Cellular Biology.

AMPK and eNOS signaling regulates K-Ras plasma membrane interactions via cGMP-dependent Protein Kinase 2

Priyanka Prakash, A. Gorfe, Kwang-jin Cho, 2016 .

Ras nanoclusters: Versatile lipid-based signaling platforms.

Yong Zhou, J. Hancock, 2015, Biochimica et biophysica acta.

Inhibitors of K-Ras plasma membrane localization.

Dharini van der Hoeven, Kwang-jin Cho, J. Hancock, 2013, The Enzymes.

Ras signaling from plasma membrane and endomembrane microdomains.

J. Hancock, S. Plowman, 2005, Biochimica et biophysica acta.

COS Cell Expression.

J. Hancock, 1992, Methods in molecular biology.

Kinase inhibitors: look beyond the label on the bottle

J. Hancock, P. Dent, A. Poklepovic, 2019, Cancer drug resistance.

Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate].

J. Hancock, P. Dent, A. Poklepovic, 2020, Cellular signalling.

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

D. Tuveson, J. Hancock, P. Dent, 2019, Oncogene.

p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1

Hong Liang, J. Hancock, K. Venkatachalam, 2021, iScience.

Elevated MCOLN1 Expression in p53-Deficient Bladder Cancer is Necessary for Oncogene-Induced Cell proliferation, Inflammation, and Invasion

Hong Liang, J. Hancock, K. Venkatachalam, 2020, bioRxiv.

Using plasma membrane nanoclusters to build better signaling circuits.

J. Hancock, A. Harding, John F Hancock, 2008, Trends in cell biology.

Nucleophosmin and nucleolin regulate K-Ras signaling

J. Hancock, K. Inder, M. Hill, 2010, Communicative & integrative biology.

Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins*

Andrew M. Piggott, Robert J Capon, Robert G Parton, 2012, The Journal of Biological Chemistry.

Jcb: Article

S. Gygi, Mark P. Jedrychowski, J. Hancock, 2022 .

Fingolimod Augments Monomethylfumarate Killing of GBM Cells

J. Hancock, P. Dent, Jane L. Roberts, 2020, Frontiers in Oncology.

Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.

J. Frost, Na Ye, Dharini van der Hoeven, 2021, European journal of medicinal chemistry.

Ras acylation, compartmentalization and signaling nanoclusters (Review)

Yoav I. Henis, J. Hancock, Y. Henis, 2009, Molecular membrane biology.

Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles

M. Kirkham, S. Mayor, J. Hancock, 2005, The Journal of cell biology.

Cholesterol‐Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway

S. Mayor, J. Hancock, S. Plowman, 2007, Traffic.

Lipid rafts: contentious only from simplistic standpoints

J. Hancock, John F. Hancock, 2006, Nature Reviews Molecular Cell Biology.

GPI-anchor synthesis: Ras takes charge.

J. Hancock, 2004, Developmental cell.

Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

T. Lan, Dharini van der Hoeven, J. Hancock, 2019, Life Science Alliance.

RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling

Yong Zhou, J. Hancock, 2023, FEBS letters.

Lipid Profiles of RAS Nanoclusters Regulate RAS Function

Yong Zhou, J. Hancock, 2021, Biomolecules.

Raf Inhibitors Target Ras Spatiotemporal Dynamics

A. Kusumi, S. Heidorn, Kwang-jin Cho, 2012, Current Biology.

Electron microscopic imaging of Ras signaling domains.

J. Hancock, I. Prior, 2005, Methods.

Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

A. Gorfe, J. Hancock, John F Hancock, 2012, Proceedings of the National Academy of Sciences.

The G protein–coupled receptor GPR31 promotes membrane association of KRAS

M. Pagano, D. Bar-Sagi, Yong Zhou, 2017, The Journal of cell biology.

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function

J. Hancock, S. Plowman, R. Parton, 2008, Molecular and Cellular Biology.

Ras membrane orientation and nanodomain localization generate isoform diversity

A. Gorfe, J. Hancock, K. Inder, 2010, Proceedings of the National Academy of Sciences.

Optimal microdomain characteristics for nano-scale protein-protein interactions

K. Burrage, D. Nicolau, J. Hancock, 2005 .

Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer.

Hong Liang, Yong Zhou, J. Hancock, 2021, Proceedings of the National Academy of Sciences of the United States of America.

Electron microscopy combined with spatial analysis: quantitative mapping of the nano-assemblies of plasma membrane-associating proteins and lipids

Yong Zhou, J. Hancock, 2018, Biophysics reports.

Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor

Yong Zhou, J. Hancock, Kelsey N Maxwell, 2018, Molecular and Cellular Biology.

Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role.

A. Gorfe, Kwang-jin Cho, J. Hancock, 2016, The journal of physical chemistry. B.

Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.

Priyanka Prakash, Priyanka Prakash, A. Gorfe, 2016, Biophysical journal.

Nonsteroidal Anti-inflammatory Drugs Alter the Spatiotemporal Organization of Ras Proteins on the Plasma Membrane*

Yong Zhou, Kwang-jin Cho, J. Hancock, 2012, The Journal of Biological Chemistry.

Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment To Induce Nanocluster Formation

Hong Liang, J. Hancock, S. Plowman, 2010, Molecular and Cellular Biology.

Subcellular Localization Determines MAP Kinase Signal Output

Tianhai Tian, Angus Harding, T. Tian, 2005, Current Biology.

Super-Resolution Imaging and Spatial Analysis of RAS on Intact Plasma Membrane Sheets.

Yong Zhou, J. Hancock, 2021, Methods in molecular biology.

Observing Cell Surface Signaling Domains Using Electron Microscopy

Robert G Parton, J. Hancock, I. Prior, 2003, Science's STKE.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer

G. Mills, Yiling Lu, M. Hung, 2016, Oncogene.

Regulation of longevity by depolarization-induced activation of PLC-β–IP3R signaling in neurons

Catherine A. Collins, Ryan Insolera, Yong Zhou, 2021, Proceedings of the National Academy of Sciences.

Hydrophobic and Basic Domains Target Proteins to Lipid Droplets

J. Hancock, S. Gross, R. Parton, 2009, Traffic.

Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation.

A. Perkins, J. Hancock, S. Plowman, 2008, Developmental biology.

Sources of anomalous diffusion on cell membranes: a Monte Carlo study.

Kevin Burrage, K. Burrage, D. Nicolau, 2007, Biophysical journal.

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions.

J. Hancock, D. Simanshu, M. Philips, 2023, Molecular cell.

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins: EMBO J. 10, 4033–4039

C. Marshall, J. Hancock, H. Paterson, 1992 .

(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo

J. Hancock, P. Dent, Jane L. Roberts, 2020, Journal of cellular physiology.

Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling

J. Hancock, P. Dent, Jennifer Martinez, 2020, Journal of cellular physiology.

Mechanism of Mitosis-specific Activation of MEK1*

Angus Harding, Andrew Burgess, Nichole Giles, 2003, The Journal of Biological Chemistry.

Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane

J. Hancock, Y. Henis, B. Rotblat, 2004, Molecular and Cellular Biology.

Conformational effects of nucleotide exchange in ras p21 proteins as studied by fluorescence spectroscopy

J. Hancock, A. Drake, S. Neidle, 1990, FEBS letters.

Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase.

J. de Gunzburg, J. Hancock, E. Porfiri, 1994, Journal of Biological Chemistry.

Corrigendum to "Ras nanoclusters: Versatile lipid-based signaling platforms" [Biochim. Biophys. Acta 1853/4 (2015) 841-849].

Yong Zhou, J. Hancock, 2017, Biochimica et biophysica acta. Molecular cell research.

Cell regulation: Cellular aspects of signal transduction: Editorial overview

R. Moon, J. Hancock, 2000 .

Modelling and simulation techniques for membrane biology

Dan V. Nicolau, André Leier, Kevin Burrage, 2007, Briefings Bioinform..

Membrane association and transformation by p21 ras

C. Marshall, J. Hancock, A. Hall, 1990 .

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

M. Kirkham, S. Mayor, K. Cortese, 2010, The Journal of cell biology.

Three distinct regions of cRaf kinase domain interact with membrane

Priyanka Prakash, A. Gorfe, J. Hancock, 2019, Scientific Reports.

Direct Modulators of K-Ras-Membrane Interactions.

K. Shokat, Hong Liang, Yong Zhou, 2023, ACS Chemical Biology.

Ras nanoclusters

Kwang-jin Cho, J. Hancock, 2013, Small GTPases.