J. Hoeng

发表

Identification of new human cadherin genes using a combination of protein motif search and gene finding methods.

M. Borodovsky, D. Gerhold, M. Xia, 2004, Journal of molecular biology.

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

M. Peitsch, A. Sewer, J. Hoeng, 2020, Computational and structural biotechnology journal.

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice—An Integrative Systems Toxicology Analysis

M. Peitsch, R. Laaksonen, J. Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.

Ashraf Elamin, Julia Hoeng, Manuel C Peitsch, 2016, Regulatory toxicology and pharmacology : RTP.

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

Manuel C. Peitsch, Kim Ekroos, Julia Hoeng, 2016, International journal of molecular sciences.

Verification of systems biology research in the age of collaborative competition

M. Peitsch, R. Norel, D. Vitkup, 2011, Nature Biotechnology.

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility.

M. Peitsch, V. Belcastro, J. Hoeng, 2018, Drug discovery today.

Novel approaches to develop community-built biological network models for potential drug discovery

Martin Hofmann-Apitius, Manuel C. Peitsch, Julia Hoeng, 2017, Expert opinion on drug discovery.

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure

Samik Ghosh, Barry Hardy, Joh Dokler, 2017, F1000Research.

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure

Samik Ghosh, Barry Hardy, Joh Dokler, 2017, F1000Research.

Mechanistic Network Models in Safety and Toxicity Evaluation of Nutraceuticals

M. Peitsch, J. Hoeng, I. Gonzalez-Suarez, 2016 .

Identification of gene expression signature for cigarette smoke exposure response—from man to mouse

J. Hoeng, F. Martin, M. Talikka, 2015, Human & experimental toxicology.

Enhancement of COPD biological networks using a web-based collaboration interface

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2015, F1000Research.

Proteomics for systems toxicology

Manuel C. Peitsch, Ashraf Elamin, Sophie Dijon, 2014, Computational and structural biotechnology journal.

Case study: the role of mechanistic network models in systems toxicology.

Julia Hoeng, Marja Talikka, Manuel C Peitsch, 2014, Drug discovery today.

The species translation challenge—A systems biology perspective on human and rat bronchial epithelial cells

Theodore Sakellaropoulos, Leonidas G Alexopoulos, Erhan Bilal, 2014, Scientific Data.

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

M. Peitsch, J. Hoeng, B. Titz, 2018, International journal of molecular sciences.

Next-generation tobacco and nicotine products

M. Peitsch, J. Hoeng, A. Hayes, 2018 .

Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, and Lipidomics in Predictive Mechanistic Toxicology

David A. Drubin, M. Peitsch, A. Sewer, 2014 .

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

Michael B. Stadler, M. Peitsch, V. Belcastro, 2013, BMC Genomics.

Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects.

M. Peitsch, A. Sewer, K. Luettich, 2015, Journal of proteomics.

Biology-Inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development

D. Ingber, B. Li, L. Smirnova, 2020, ALTEX.

Optimization of a NovelIn SituHybridization Technology on 3D Organotypic Cell Cultures

J. Hoeng, P. Leroy, Keyur C Trivedi, 2019, Applied In Vitro Toxicology.

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Manuel C. Peitsch, Marcel Geertz, Julia Hoeng, 2014, Toxicology mechanisms and methods.

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx

M C Peitsch, N V Ivanov, M. Peitsch, 2017, Toxicology research.

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

M. Peitsch, J. Hoeng, N. Ivanov, 2022, The AAPS journal.

Epigenomics in tobacco risk assessment: Opportunities for integrated new approaches

M. Peitsch, A. Sewer, J. Hoeng, 2018, Current Opinion in Toxicology.

The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status.

Carine Poussin, Julia Hoeng, Stéphanie Boué, 2017, Computational toxicology.

A Systems Toxicology Approach to Investigating the Cardiovascular Effects of Cigarette Smoke and Environmental Pollutants in ApoE -Deficient Mice

M. Peitsch, J. Hoeng, S. Boué, 2015 .

Construction of a Computable Network Model of Tissue Repair and Angiogenesis in the Lung

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013 .

Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Frontiers in Pharmacology.

Exploring the microbiome in health and disease

V. Belcastro, J. Hoeng, S. Boué, 2017 .

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS‐CoV-2 infection in reconstituted human airway epithelia

M. Peitsch, J. Hoeng, W. Schlage, 2021, Biochemistry and Biophysics Reports.

Systems Biology Approaches for Compound Testing

David A. Drubin, M. Peitsch, A. Sewer, 2013 .

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product.

M. Peitsch, V. Belcastro, J. Hoeng, 2017, Chemical research in toxicology.

Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems

J. Hoeng, Mark Bentley, D. Bovard, 2019, Metabolomics.

Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract

M. Peitsch, A. Sewer, K. Luettich, 2019, Front. Genet..

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2019, ALTEX.

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

M. Peitsch, J. Hoeng, S. Boué, 2020, Toxicology reports.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

New approaches to risk assessment of chemical mixtures

J. Hoeng, A. Hayes, A. Iskandar, 2019, Toxicology Research and Application.

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.

M. Peitsch, J. Hoeng, S. Boué, 2013, Atherosclerosis.

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

Rémi H. J. Dulize, M. Peitsch, V. Belcastro, 2019, Toxicology reports.

Translational Modeling of Chloroquine and Hydroxychloroquine Dosimetry in Human Airways for Treating Viral Respiratory Infections

J. Hoeng, A. Kolli, Florian Calvino-Martin, 2022, Pharmaceutical Research.

Aerosol Dosimetry and Human-Relevant Exposure

J. Hoeng, P. Vanscheeuwijck, W. Schlage, 2021 .

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

Rémi H. J. Dulize, M. Peitsch, B. Titz, 2020, Journal of Inflammation.

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

M. Peitsch, K. Luettich, J. Hoeng, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

A new fluorescence-based method for characterizing in vitro aerosol exposure systems.

J. Hoeng, S. Frentzel, S. Majeed, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors.

M. Peitsch, A. Mazurov, J. Hoeng, 2019, Phytochemistry.

Other Compounds From Tobacco With Potential Impact on Neurodegenerative Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients

M. Peitsch, J. Hoeng, A. Kondylis, 2020, Inflammatory bowel diseases.

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures.

M. Peitsch, J. Hoeng, E. Guedj, 2020, Toxicology letters.

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

M. Peitsch, V. Belcastro, B. Titz, 2019, Archives of Toxicology.

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

M. Peitsch, J. Hoeng, E. Guedj, 2019, Internal and Emergency Medicine.

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2019, ALTEX.

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium

M. Peitsch, A. Sewer, K. Luettich, 2017, Clinical medicine insights. Circulatory, respiratory and pulmonary medicine.

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

M. Peitsch, J. Hoeng, Davide Sciuscio, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette.

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2016, Chemical research in toxicology.

Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2.2.

M. Peitsch, J. Hoeng, N. Ivanov, 2016, Regulatory toxicology and pharmacology : RTP.

Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.

M. Peitsch, J. Hoeng, F. Martin, 2015, Toxicology in vitro : an international journal published in association with BIBRA.

Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke.

M. Peitsch, A. Sewer, J. Hoeng, 2016, Regulatory toxicology and pharmacology : RTP.

Systems biology approach for evaluating the biological impact of environmental toxicants in vitro.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2014, Chemical research in toxicology.

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro

M. Peitsch, V. Belcastro, A. Sewer, 2015, Bioinformatics and biology insights.

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™)

M. Peitsch, S. Gebel, J. Hoeng, 2014, Gene regulation and systems biology.

Anthropometry‐based generation of personalized and population‐specific human airway models

Z. J. Chen, J. Hoeng, A. Przekwas, 2020, International journal for numerical methods in biomedical engineering.

Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium.

M. Peitsch, J. Hoeng, E. Guedj, 2021, Food and Chemical Toxicology.

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids

M. Peitsch, J. Hoeng, K. Koshibu, 2022, Frontiers in Pharmacology.

Quantitative proteomics analysis using 2 D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modi fi ed risk tobacco product on the lung proteome in C 57 BL / 6 mice

M. Peitsch, J. Hoeng, Marcel Geertz, 2016 .

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice.

M. Peitsch, J. Hoeng, Marcel Geertz, 2016, Journal of proteomics.

Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review

M. Peitsch, J. Hoeng, S. Boué, 2019, Regulatory toxicology and pharmacology : RTP.

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

M. Peitsch, A. Sewer, J. Hoeng, 2019, Chemico-biological interactions.

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis

Rémi H. J. Dulize, M. Peitsch, V. Belcastro, 2016, Inhalation toxicology.

A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.

M. Peitsch, Ashutosh Kumar, A. Sewer, 2020, American journal of physiology. Heart and circulatory physiology.

Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC-MS deconvolution procedures.

M. Peitsch, J. Hoeng, N. Ivanov, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

P 8 . 8 Flavonoid-induced changes in oxygen consumption and mitochondrial membrane potential in isolated endothelial mitochondria

K. Luettich, J. Hoeng, Aleksandra Wojtala, 2018 .

Impact of aerosols on liver xenobiotic metabolism: A comparison of two methods of exposure.

M. Peitsch, J. Hoeng, K. Renggli, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model

M. Peitsch, F. Springer, P. Augat, 2020, Archives of Toxicology.

In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures

M. Peitsch, K. Luettich, J. Hoeng, 2020, SLAS technology.

Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge

M. Peitsch, V. Belcastro, A. Mchardy, 2022, BMC Genomics.

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

John H. Miller, Rémi H. J. Dulize, M. Peitsch, 2021, Archives of Toxicology.

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

M. Peitsch, J. Hoeng, Sylvain Gubian, 2019, BMC Bioinformatics.

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

M. Peitsch, J. Hoeng, Sam Ansari, 2018, Inhalation toxicology.

The Science behind the Tobacco Heating System

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2017 .

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells.

M. Peitsch, J. Hoeng, C. Poussin, 2016, Toxicology.

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion.

M. Peitsch, J. Hoeng, C. Poussin, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

M. Peitsch, J. Hoeng, S. Boué, 2015, Inhalation toxicology.

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice.

M. Peitsch, R. Laaksonen, J. Hoeng, 2012, Atherosclerosis.

Construction of a computable cell proliferation network focused on non-diseased lung cells

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2011, BMC Systems Biology.

28-day rat inhalation study: how systems toxicology complements OECD inhalation studies

M. Peitsch, J. Hoeng, Sam Ansari, 2015 .

Alternatives to Animal Use in Risk Assessment of Mixtures

M. Peitsch, J. Hoeng, A. Iskandar, 2020, International journal of toxicology.

Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity

B. Titz, J. Hoeng, N. Ivanov, 2020, Toxicology reports.

Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors

M. Peitsch, K. Luettich, J. Hoeng, 2020, Current research in toxicology.

Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations.

M. Peitsch, J. Hoeng, Yanfang Ren, 2019, Journal of dentistry.

Application of systems pharmacology to identify exposure response markers in peripheral blood after switching to a candidate modified risk tobacco product: the Tobacco Heating System 2.1 (THS 2.1)

M. Peitsch, J. Hoeng, F. Martin, 2015 .

Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond

M. Peitsch, J. Hoeng, A. Hayes, 2019, Critical reviews in toxicology.

A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, Bioinformatics and biology insights.

Human organotypic nasal epithelial tissue culture as an in vitro model to evaluate effects of cigarette smoke of a candidate Modified Risk Tobacco Product: the Tobacco Heating System 2.2

M. Peitsch, J. Hoeng, A. Elamin, 2015 .

Reduced impact of a prototypic modified risk tobacco product compared with conventional cigarette smoke on exposed human and rat primary normal bronchial epithelial cells

M. Peitsch, D. Messinis, J. Hoeng, 2014 .

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers.

M. Peitsch, V. Belcastro, A. Sewer, 2013, American journal of physiology. Lung cellular and molecular physiology.

Systems for Generation of ENDP Aerosols and Their Administration to In Vitro and In Vivo Experimental Models

J. Hoeng, S. Boué, P. Vanscheeuwijck, 2021 .

State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products

M. Peitsch, J. Hoeng, S. Boué, 2020 .

Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

Nicolas D. Castro, J. Hoeng, A. Kuczaj, 2018, Journal of Aerosol Science.

Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program.

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2016, Regulatory toxicology and pharmacology : RTP.

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes.

M. Peitsch, A. Sewer, K. Luettich, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

M. Peitsch, R. Eils, H. Fröhlich, 2021, Scientific Reports.

Divergence Weighted Independence Graphs for the Exploratory Analysis of Biological Expression Data

Yang Xiang, Manuel C. Peitsch, Joe Whittaker, 2013 .

Mitochondria as a possible target for nicotine action

M. Peitsch, K. Luettich, J. Hoeng, 2019, Journal of Bioenergetics and Biomembranes.

In vitro testing of salt coating of fabrics as a potential antiviral agent in reusable face masks

M. Peitsch, J. Hoeng, S. Lebrun, 2022, Scientific Reports.

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice

M. Peitsch, K. Luettich, J. Hoeng, 2022, Journal of applied toxicology : JAT.

Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES).

J. Hoeng, A. Kuczaj, S. Majeed, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

U. Marx, K. Luettich, J. Hoeng, 2020, Scientific Reports.

Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures.

J. Hoeng, G. Vuillaume, A. Kondylis, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice

M. Peitsch, A. Sewer, K. Luettich, 1984, The Journal of experimental medicine.

Research Models of Neurodegenerative Diseases: Major Considerations for Translatability

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

A simple method for decellularizing a cell-derived matrix for bone cell cultivation and differentiation

J. Hoeng, S. Ehnert, F. Zanetti, 2021, Journal of Materials Science: Materials in Medicine.

Systems biology reveals anatabine to be an NRF2 activator

Dimitris E. Messinis, Rémi H. J. Dulize, M. Peitsch, 2022, Frontiers in Pharmacology.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

M. Peitsch, J. Hoeng, S. Boué, 2015, Inflammation Research.

Novel α7 Nicotinic Acetylcholine Receptor Modulators as Potential Antitussive Agents.

A. Mazurov, J. Hoeng, J. Ho, 2022, Bioorganic & medicinal chemistry letters.

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification

Ajay K. Royyuru, Thomas Bonk, Pablo Meyer, 2012, Bioinform..

Embracing Transparency Through Data Sharing

Julia Hoeng, Stéphanie Boué, Michael Byrne, 2018, International journal of toxicology.

Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties.

M. Peitsch, A. Mazurov, J. Hoeng, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.

Uwe Marx, Murat Cirit, Hajime Kojima, 2016, ALTEX.

A Literature Review and Framework Proposal for Halitosis Assessment in Cigarette Smokers and Alternative Nicotine-Delivery Products Users

J. Hoeng, N. Ivanov, J. Battey, 2021, Frontiers in Oral Health.

Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds

M. Peitsch, K. Luettich, J. Hoeng, 2021, Frontiers in Pharmacology.

Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species

J. Hoeng, Csaba Laszlo, N. Ivanov, 2022, Molecules.

Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

M. Peitsch, J. Hoeng, N. Ivanov, 2022, The AAPS Journal.

Toxicological Assessment of Flavor Ingredients in E-Vapor Products

M. Peitsch, J. Hoeng, Davide Sciuscio, 2022, Frontiers in Toxicology.

Differential effects of alkaloids on memory in rodents

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Scientific Reports.

Systems Toxicology: From Basic Research to Risk Assessment

Manuel C. Peitsch, Alan R. Boobis, Julia Hoeng, 2014, Chemical research in toxicology.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Computational Systems Toxicology

Manuel C. Peitsch, Julia Hoeng, M. Peitsch, 2015, Methods in Pharmacology and Toxicology.

An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes

M. Peitsch, P. Vulto, J. Hoeng, 2020, SLAS technology.

Computational Epigenomics: From Fundamental Research to Disease Prediction and Risk Assessment

Manuel C. Peitsch, Julia Hoeng, Florian Martin, 2019, Computational Biology.

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke.

M. Peitsch, J. Hoeng, N. Ivanov, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data

Rémi H. J. Dulize, M. Peitsch, K. Luettich, 2021, Frontiers in Toxicology.

Effects of cigarette smoke exposure on a mouse model of multiple sclerosis

M. Peitsch, K. Luettich, J. Hoeng, 2022, Toxicology reports.

Effects of plant alkaloids on mitochondrial bioenergetic parameters.

M. Peitsch, B. Titz, J. Hoeng, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model

M. Peitsch, J. Hoeng, B. Titz, 2021, Journal of applied toxicology : JAT.

A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

M. Peitsch, Ashutosh Kumar, J. Hoeng, 2021, Toxicology Research and Application.

Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke.

M. Peitsch, J. Hoeng, S. Boué, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Genomic impact of cigarette smoke, with application to three smoking-related diseases

M. J. Peck, M. Peitsch, J. Hoeng, 2012, Critical reviews in toxicology.

Systems pharmacology investigation of mechanism of action of nutraceuticals

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2021 .

Assessment of ENDPs in Animal Models of Disease

M. Peitsch, K. Luettich, J. Hoeng, 2021 .

Lipid-based biomarkers for CVD, COPD, and aging - A translational perspective.

J. Hoeng, B. Titz, O. Lavrynenko, 2020, Progress in lipid research.

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

M. Peitsch, J. Hoeng, S. Boué, 2016, Journal of Translational Medicine.

bronchial epithelium from human smokers cigarette smoke at the air-liquid interface resemble Human bronchial epithelial cells exposed in vitro to

M. Peitsch, V. Belcastro, A. Sewer, 2013 .

The COVID-19 PHARMACOME: Rational Selection of Drug Repurposing Candidates from Multimodal Knowledge Harmonization

Martin Hofmann-Apitius, Andrea Zaliani, Reagon Karki, 2020, bioRxiv.

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

Erhan Bilal, Pablo Meyer, Raquel Norel, 2014, Bioinform..

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

Elena Scotti, Ashraf Elamin, Julia Hoeng, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

High-resolution crystal structure and in vivo function of a kinesin-2 homologue in Giardia intestinalis.

J. Löwe, J. Hoeng, S. Dawson, 2008, Molecular biology of the cell.

Systems Biology: Methods and Applications

M. Peitsch, A. Sewer, J. Hoeng, 2017 .

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

M. Peitsch, J. Hoeng, S. Boué, 2016, Journal of Translational Medicine.

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

M. Peitsch, J. Hoeng, K. Koshibu, 2019, Toxicology reports.

Analysis of Proteomic Data for Toxicological Applications

Manuel C. Peitsch, Bjoern Titz, Thomas Schneider, 2015 .

Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis

J. Hoeng, B. Titz, T. Schneider, 2021, Toxicology Research and Application.

Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish

M. Peitsch, E. Levin, J. Hoeng, 2021, Pharmacology Biochemistry and Behavior.

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

M. Peitsch, A. Sewer, K. Luettich, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

M. Peitsch, J. Hoeng, Davide Sciuscio, 2020, Archives of Toxicology.

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

Julia Hoeng, Emilija Veljkovic, Manuel C Peitsch, 2016, Regulatory toxicology and pharmacology : RTP.

Systems biology approach highlights mechanistic differences between Crohn’s disease and ulcerative colitis

M. Peitsch, J. Hoeng, Sylvain Gubian, 2021, Scientific Reports.

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

A Systems-Based Approach to Toxicity Testing

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2021 .

Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids

J. Hoeng, B. Titz, Catherine Nury, 2022, Toxicology mechanisms and methods.

An ATP Gate Controls Tubulin Binding by the Tethered Head of Kinesin-1

Julia Hoeng, Robert A. Cross, L. Amos, 2007, Science.

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

Yang Xiang, Manuel C. Peitsch, Julia Hoeng, 2014, BMC Bioinformatics.

Tobacco heating system has less impact on bone metabolism than cigarette smoke.

J. Hoeng, S. Ehnert, F. Zanetti, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Chapter 10 Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

M. Peitsch, J. Hoeng, B. Phillips, 2017 .

Pre-malignant processes of smoking-induced lung adenocarcinoma development: A conceptual biological model

M. Peitsch, F. Tobin, J. Hoeng, 2013 .

Semi-Automated Curation Allows Causal Network Model Building for the Quantification of Age-Dependent Plaque Progression in ApoE−/− Mouse

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2016, Gene regulation and systems biology.

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Manuel C. Peitsch, Ashraf Elamin, Julia Hoeng, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes.

M. Peitsch, J. Hoeng, S. Frentzel, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

M. Peitsch, J. Hoeng, S. Frentzel, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The extraction of complex relationships and their conversion to biological expression language (BEL) overview of the BioCreative VI (2017) BEL track

Juliane Fluck, K. E. Ravikumar, Richard Tzong-Han Tsai, 2019, Database J. Biol. Databases Curation.

3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product.

Julia Hoeng, Carole Mathis, Manuel C Peitsch, 2016, ALTEX.

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

Jennifer Park, Manuel C. Peitsch, Carine Poussin, 2011, BMC Systems Biology.

Developing Network-Based Systems Toxicology by Combining Transcriptomics Data with Literature Mining and Multiscale Quantitative Modeling

Julia Hoeng, Marja Talikka, Florian Martin, 2018, Bioinformatics in the Era of Post Genomics and Big Data.

Quantifying the Biological Impact of Active Substances Using Causal Network Models

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2015 .

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

M. Peitsch, J. Hoeng, Sylvain Gubian, 2021, Frontiers in Genetics.

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

M. Peitsch, A. Sewer, A. Hengstermann, 2014, BMC Research Notes.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

M. Peitsch, S. Gebel, J. Hoeng, 2014, Journal of Translational Medicine.

Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish.

M. Peitsch, V. Belcastro, J. Hoeng, 2020, Chemical research in toxicology.

Generalized Simulated Annealing for Global Optimization: The GenSA Package

Yang Xiang, Julia Hoeng, Sylvain Gubian, 2013, R J..

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Barry Hardy, Francois Busquet, Alice Krebs, 2019, ALTEX.

Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.

M. Peitsch, J. Hoeng, S. Boué, 2013, Toxicology.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Scientific Reports.

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy.

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Journal of Natural Products.

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

Jennifer Park, Manuel C. Peitsch, William Hayes, 2015, Database J. Biol. Databases Curation.

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2012, BMC Systems Biology.

A framework for in vitro systems toxicology assessment of e-liquids

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2016, Toxicology mechanisms and methods.

Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)

Juliane Fluck, Manuel C. Peitsch, Reagon Karki, 2016, Database J. Biol. Databases Curation.

Toxicological Assessment In Vitro

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2021 .

Translational Models for ENDP Assessment

M. Peitsch, J. Hoeng, B. Titz, 2021 .

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.

Julia Hoeng, Manuel C Peitsch, Jenny Ho, 2016, Regulatory toxicology and pharmacology : RTP.

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, BioMed research international.

Physiological and biological characterization of smokers with and without COPD

M. Peitsch, K. Luettich, J. Hoeng, 2018, F1000Research.

Data of physiological measurements and quality of life in subjects with mild to moderate COPD compared to asymptomatic current smokers, former smokers and never-smokers.

M. Peitsch, K. Luettich, J. Hoeng, 2017, F1000Research.

Systems toxicology meta-analysis—From aerosol exposure to nanotoxicology

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2019, Current Opinion in Toxicology.

Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols

M. Peitsch, A. Mazurov, J. Hoeng, 2022, Journal of the American Society for Mass Spectrometry.

Experimental and computational investigation of a nose-only exposure chamber

J. Hoeng, P. Vanscheeuwijck, A. Kuczaj, 2020 .

A crowd-sourcing approach for the construction of species-specific cell signaling networks

Theodore Sakellaropoulos, Erhan Bilal, Pablo Meyer, 2014, Bioinform..

Quantification and Mapping of Alkylation in the Human Genome Reveal Single Nucleotide Resolution Precursors of Mutational Signatures

J. Hoeng, V. Takhaveev, N. Ivanov, 2023, ACS central science.

Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations.

M. Peitsch, J. Hoeng, Yanfang Ren, 2019, Quintessence international.

Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract

M. Peitsch, J. Hoeng, J. Szostak, 2021, Frontiers in Microbiology.

M. Peitsch, J. Hoeng, S. Boué, 2021 .

Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies.

M. Peitsch, J. Hoeng, B. Titz, 2020, Life sciences.

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

Manuel C. Peitsch, Kim Ekroos, Ashraf Elamin, 2016, Scientific Data.

Modulation of the Hepatic Lipidome and Transcriptome of Apoe-/- Mice in Response to Smoking Cessation

Manuel C. Peitsch, Julia Hoeng, Stéphanie Boué, 2013 .

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

M. Peitsch, B. Titz, A. Sewer, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx00152e

Julia Hoeng, Carole Mathis, Manuel C Peitsch, 2017, Toxicology research.

A lung/liver-on-a-chip platform for acute and chronic toxicity studies.

Julia Hoeng, Manuel C Peitsch, Diego Marescotti, 2018, Lab on a chip.

Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract

Miroslav Jicha, Frantisek Lizal, Miloslav Belka, 2017, Inhalation toxicology.

A network-based approach to quantifying the impact of biologically active substances.

Julia Hoeng, Manuel C Peitsch, Dexter Pratt, 2012, Drug discovery today.

Long term exposure to cigarette smoke impacts genes involved in cardiac muscle structure and function in Apoe−/− mouse while exposure to the aerosol does not

M. Peitsch, J. Hoeng, S. Boué, 2016 .

Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery.

M. Peitsch, J. Hoeng, S. Boué, 2015, Current drug discovery technologies.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

M. Peitsch, J. Hoeng, S. Boué, 2015, Inflammation Research.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

Carine Poussin, Julia Hoeng, Stephan Gebel, 2014, Journal of Translational Medicine.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

Julia Hoeng, Stephan Gebel, Marja Talikka, 2013, Toxicology and applied pharmacology.

Systems Toxicology

Thomas B Knudsen, Thomas Hartung, Julia Hoeng, 2015, International journal of toxicology.

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

Julia Hoeng, Stephan Gebel, Manuel C Peitsch, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The Apoe -/- Mouse PhysioLab ® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe -/- Mouse

Manuel C. Peitsch, Julia Hoeng, Caitlin A. Bever, 2012 .

Applying Systems Toxicology Methods to Drug Safety

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2019 .

A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2)

M. Peitsch, J. Hoeng, N. Ivanov, 2019, Front. Pharmacol..

Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

U. Marx, K. Luettich, J. Hoeng, 2020, Scientific Reports.

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2015, Journal of visualized experiments : JoVE.

An in vitro evaluation of e-vapor products: The contributions of chemical adulteration, concentration, and device power.

M. Peitsch, J. Hoeng, A. Iskandar, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Toxicology reports.

Organs-on-a-chip

Manuel C. Peitsch, Julia Hoeng, Karsta Luettich, 2017 .

Characterization of the Vitrocell® 24/48 aerosol exposure system for its use in exposures to liquid aerosols.

J. Hoeng, G. Vuillaume, S. Frentzel, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures.

Ashraf Elamin, Julia Hoeng, Carole Mathis, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Ashraf Elamin, Julia Hoeng, Marja Talikka, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

M. Peitsch, J. Hoeng, P. Leroy, 2014, Chemistry Central Journal.

The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure

Marcel Geertz, Julia Hoeng, Carole Mathis, 2014, International journal of toxicology.

Mitochondrial Network and Biogenesis in Response to Short and Long-Term Exposure of Human BEAS-2B Cells to Aerosol Extracts from the Tobacco Heating System 2.2.

M. Peitsch, K. Luettich, J. Hoeng, 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products

M. Peitsch, J. Hoeng, S. Boué, 2020 .

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

M. Peitsch, J. Hoeng, Davide Sciuscio, 2020, Archives of Toxicology.

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.

Ashraf Elamin, Julia Hoeng, Carole Mathis, 2016, Chemical research in toxicology.

Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge

Mario Lauria, Preetam Nandy, Erhan Bilal, 2013, Bioinform..

Systems Toxicology Approach to Unravel Early Indicators of Squamous Cell Carcinoma Rate in Rat Nasal Epithelium Induced by Formaldehyde Exposure

Manuel C. Peitsch, Julia Hoeng, Marja Talikka, 2019, PACBB.

Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence

Manuel C. Peitsch, Julia Hoeng, Walter K. Schlage, 2013, Bioinformatics and biology insights.

Scientific Basis for Assessment of Electronic Nicotine Delivery Products

Manuel C. Peitsch, Julia Hoeng, Stéphanie Boué, 2021, Toxicological Evaluation of Electronic Nicotine Delivery Products.

CSEO – the Cigarette Smoke Exposure Ontology

Martin Hofmann-Apitius, Manuel C. Peitsch, Julia Hoeng, 2014, J. Biomed. Semant..

Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro

Rémi H. J. Dulize, M. Peitsch, J. Hoeng, 2021, Archives of Toxicology.

Use of micro‐CT to determine tracheobronchial airway geometries in three strains of mice used in inhalation toxicology as disease models

J. Hoeng, M. Peitsch, A. Kuczaj, 2021, Anatomical record.

Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2023, International journal of molecular sciences.

Deconvolution of Systemic Pharmacokinetics Predicts Inhaled Aerosol Dosimetry of Nicotine.

J. Hoeng, B. Titz, S. Lebrun, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Aerosol Filtration Testing of Fabrics for Development of Reusable Face Masks

M. Peitsch, Y. Tardy, J. Hoeng, 2021, Aerosol and Air Quality Research.

An interlaboratory in vitro aerosol exposure system reference study

J. Hoeng, M. Gaca, S. Frentzel, 2021, Toxicology Research and Application.

Toxicological Assessment of Flavors Used in E-vapor Products

Manuel C. Peitsch, Julia Hoeng, Carole Mathis, 2021 .

Assessment of Single-Photon Ionization Mass Spectrometry for Online Monitoring of in Vitro Aerosol Exposure Experiments.

J. Hoeng, A. Kuczaj, F. Lucci, 2020, Chemical research in toxicology.

Improved Knowledge Acquisition and Creation of Structured Knowledge for Systems Toxicology

Juliane Fluck, Julia Hoeng, Marja Talikka, 2016 .

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

M. Peitsch, J. Hoeng, S. Frentzel, 2016, Journal of visualized experiments : JoVE.

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

M. Peitsch, J. Hoeng, F. Martin, 2020, BMC Genomics.

Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications

Yang Xiang, Jennifer Park, Manuel C. Peitsch, 2016, Gene regulation and systems biology.

Enhancement of COPD biological networks using a web-based collaboration interface.

Jennifer Park, Julia Hoeng, Marja Talikka, 2015, F1000Research.

The BEL information extraction workflow (BELIEF): evaluation in the BioCreative V BEL and IAT track

Juliane Fluck, Manuel C. Peitsch, Julia Hoeng, 2016, Database J. Biol. Databases Curation.

Construction of biological networks from unstructured information based on a semi-automated curation workflow

Juliane Fluck, Manuel C. Peitsch, Martin Hofmann-Apitius, 2015, Database J. Biol. Databases Curation.

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

M. Peitsch, J. Hoeng, P. Vanscheeuwijck, 2019, Internal and Emergency Medicine.

On Crowd-verification of Biological Networks

Raquel Norel, Kahn Rhrissorrakrai, Manuel C. Peitsch, 2013, Bioinformatics and biology insights.

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

M. Peitsch, A. Sewer, K. Luettich, 2014, Interdisciplinary toxicology.

CSEO – the Cigarette Smoke Exposure Ontology

M. Peitsch, M. Hofmann-Apitius, J. Hoeng, 2014, J. Biomed. Semant..

Attention Deficit Hyperactivity Disorder in Children and Adults

M. Peitsch, J. Hoeng, B. Phillips, 2018 .

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis.

J. Hoeng, S. Lebrun, W. Schlage, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

sbv IMPROVER Diagnostic Signature Challenge

Yang Xiang, Erhan Bilal, Pablo Meyer, 2013 .

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

M. Peitsch, J. Hoeng, F. Martin, 2020, BMC Genomics.

Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset

Manuel C. Peitsch, Carine Poussin, Julia Hoeng, 2013, Bioinformatics and biology insights.

Development of a realistic human respiratory tract cast representing physiological thermal conditions

J. Hoeng, A. Kuczaj, F. Lucci, 2019, Aerosol Science and Technology.

Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration.

M. Peitsch, J. Hoeng, K. Koshibu, 2019, European journal of pharmacology.

The therapeutic potential of purified cannabidiol

J. Hoeng, G. Nikolajsen, S. Jensen, 2023, Journal of Cannabis Research.

GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology

Manuel C. Peitsch, Julia Hoeng, Florian Martin, 2019, Bioinform..

Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare.

D. Ingber, L. Smirnova, I. Rusyn, 2020, ALTEX.

Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System

J. Hoeng, B. Titz, K. Renggli, 2022, Bioengineering.

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Barry Hardy, Francois Busquet, Alice Krebs, 2020, ALTEX.

Conclusions and Outlook

M. Peitsch, J. Hoeng, 2021, Toxicological Evaluation of Electronic Nicotine Delivery Products.

A mechanistic study of cigarette smoke-induced COPD in C57BL/6 mice: the impact of switching to pMRTP

M. Peitsch, J. Hoeng, B. Phillips, 2015 .

Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish

M. Peitsch, J. Hoeng, K. Koshibu, 2021, Journal of Natural Medicines.

Comparison of experimentally measured and computational fluid dynamic predicted deposition and deposition uniformity of monodisperse solid particles in the Vitrocell® AMES 48 air-liquid-interface in-vitro exposure system.

Nicolas D. Castro, J. Hoeng, A. Kuczaj, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Deposition efficiency and uniformity of monodisperse solid particle deposition in the Vitrocell® 24/48 Air–Liquid-Interface in vitro exposure system

Nicolas D. Castro, J. Hoeng, A. Kuczaj, 2020, Aerosol Science and Technology.

BEL Networks Derived from Qualitative Translations of BioNLP Shared Task Annotations

Juliane Fluck, Manuel C. Peitsch, Martin Hofmann-Apitius, 2013, BioNLP@ACL.

AI-driven laboratory workflows enable operation in the age of social distancing

Samik Ghosh, J. Hoeng, Filipe Bonjour, 2021, SLAS Technology.

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™)

M. Peitsch, S. Gebel, J. Hoeng, 2014, Gene regulation and systems biology.

Faculty Opinions recommendation of A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play.

Julia Hoeng, Vincenzo Belcastro, V. Belcastro, 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

M. Peitsch, J. Hoeng, Davide Sciuscio, 2019, Inhalation toxicology.

Influence of tobacco smoking on the development of halitosis

J. Hoeng, F. Zanetti, A. Heremans, 2022, Toxicology reports.

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

M. Peitsch, A. Sewer, J. Hoeng, 2014, BMC Research Notes.

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

M. Peitsch, A. Sewer, J. Hoeng, 2014, BMC Bioinformatics.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2020, Scientific Reports.

Systems toxicology assessment of repeated exposure to cigarette smoke and a potential modified-risk tobacco product aerosol on gingival organotypic cultures

M. Peitsch, A. Sewer, J. Hoeng, 2017 .

The Adverse Outcome Pathway for Oxidative Stress-Mediated EGFR Activation Leading to Decreased Lung Function

K. Luettich, J. Hoeng, M. Talikka, 2017 .

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

Michael B. Stadler, M. Peitsch, V. Belcastro, 2013, BMC Genomics.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

M. Peitsch, V. Belcastro, A. Sewer, 2013, Toxicology and Applied Pharmacology.

A new fluorescence-based method for characterizing in vitro aerosol exposure systems.

J. Hoeng, S. Frentzel, S. Steiner, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

A lung/liver-on-a-chip platform for acute and chronic toxicity studies.

M. Peitsch, K. Luettich, J. Hoeng, 2018, Lab on a chip.

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product.

M. Peitsch, V. Belcastro, J. Hoeng, 2017, Chemical research in toxicology.

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Rémi H. J. Dulize, M. Peitsch, E. Masliah, 2023, Frontiers in neuroscience.

In Vitro Systems Toxicology Assessment of Nonflavored e-Cigarette Liquids in Primary Lung Epithelial Cells

MartinFlorian, Rémi H. J. Dulize, M. Peitsch, 2017 .

Novel approaches to develop community-built biological network models for potential drug discovery

M. Peitsch, M. Hofmann-Apitius, L. Alexopoulos, 2017, Expert opinion on drug discovery.

Simulated pharmacokinetics of inhaled caffeine and melatonin from existing products indicate the lack of dosimetric considerations

J. Hoeng, A. Kuczaj, A. Kolli, 2024, Food and Chemical Toxicology.