J. Garcia

发表

Orthologous gene-expression profiling in multi-species models: search for candidate genes

John Quackenbush, R. Irizarry, D. Grigoryev, 2004, Genome Biology.

Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing.

Y. Lussier, J. Garcia, N. Pouladi, 2016, Translational research : the journal of laboratory and clinical medicine.

Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium

J. Garcia, R. Wadgaonkar, S. Dudek, 2005, Journal of cellular biochemistry.

The role of the microtubules in tumor necrosis factor-α-induced endothelial cell permeability

J. Garcia, A. Verin, I. Petrache, 2003 .

The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability.

J. Garcia, A. Verin, I. Petrache, 2003, American journal of respiratory cell and molecular biology.

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.

J. Garcia, R. Machado, M. Bonini, 2015, American journal of physiology. Lung cellular and molecular physiology.

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent.

E. Burchard, M. Pino-Yanes, Á. Carracedo, 2015, The Journal of allergy and clinical immunology.

The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility

J. Garcia, C. Bime, S. Camp, 2020, Translational Research.

Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors

R. Salgia, Frances E. Lennon, J. Garcia, 2010, Journal of angiogenesis research.

Identification of a Gene Expression Profile That Differentiates Between Ischemic and Nonischemic Cardiomyopathy

G. Parmigiani, R. Irizarry, Jennifer L Hall, 2004, Circulation.

Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure.

R. Irizarry, G. Tomaselli, S. Ye, 2005, Physiological genomics.

Genome‐Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor

M. Gonzalez-Garay, R. Kittles, D. Christiani, 2018, American journal of respiratory and critical care medicine.

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury.

J. Garcia, S. Sammani, S. Palumbo, 2017, American journal of physiology. Lung cellular and molecular physiology.

Functional Genomics of Lung Disease

S. Redline, N. Friedman, A. Regev, 2004 .

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

G. Semenza, B. Kelly, S. Ye, 2005, Blood.

hypoxia by HIF-1 Transcriptional regulation of vascular endothelial cell responses to

G. Semenza, B. Kelly, S. Ye, 2013 .

Focal Adhesions Paradigm for a Signaling Nexus

Lewis H Romer, J. Garcia, L. Romer, 2006 .

Association of circulating transcriptomic profiles with mortality in sickle cell disease.

Amit R. Patel, Y. Lussier, J. Garcia, 2017, Blood.

Endothelial cell barrier regulation by sphingosine 1‐phosphate

J. Garcia, Joe G. N. Garcia, B. McVerry, 2004, Journal of cellular biochemistry.

Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement

J. Garcia, S. Dudek, S. Camp, 2005, Journal of Biological Chemistry.

Receptor tyrosine kinase inhibitors in rodent pulmonary hypertension.

J. Garcia, L. Moreno-Vinasco, Joe G. N. Garcia, 2010, Advances in experimental medicine and biology.

Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis.

Danny Bluestein, Marvin J Slepian, Jawaad Sheriff, 2017, Journal of biomechanics.

Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.

J. Chun, J. Garcia, Yutong Zhao, 2013, American journal of respiratory cell and molecular biology.

Racial Differences in Mortality from Severe Acute Respiratory Failure in the United States, 2008-2012.

Sairam Parthasarathy, S. Parthasarathy, M. Borgstrom, 2016, Annals of the American Thoracic Society.

Bioinformatic identification of novel early stress response genes in rodent models of lung injury.

Stephanie Nonas, Shui Qing Ye, D. Grigoryev, 2005, American journal of physiology. Lung cellular and molecular physiology.

Peripheral Blood Mononuclear Cell Gene Expression Profiles Predict Poor Outcome in Idiopathic Pulmonary Fibrosis

George C Tseng, Naftali Kaminski, Yong Huang, 2013, Science Translational Medicine.

EB2000 symposium report Mechanisms regulating endothelial cell barrier function

J. Garcia, A. Malik, J. Bhattacharya, 2000 .

Differential regulation of sphingosine kinases 1 and 2 in lung injury.

J. Garcia, R. Wadgaonkar, Yutong Zhao, 2009, American journal of physiology. Lung cellular and molecular physiology.

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

O. Volpert, J. Garcia, D. Brindley, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Interactions between PBEF and oxidative stress proteins – A potential new mechanism underlying PBEF in the pathogenesis of acute lung injury

Xiaoqin Zou, Li Qin Zhang, Shui Qing Ye, 2008, FEBS letters.

Novel Mechanism for Nicotinamide Phosphoribosyltransferase Inhibition of TNF‐&agr;‐mediated Apoptosis in Human Lung Endothelial Cells

J. Garcia, Xiaoguang Sun, M. Harbeck, 2018, American journal of respiratory cell and molecular biology.

Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation.

S. Ye, J. Garcia, A. Verin, 2005, Microvascular research.

Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation.

R. Weichselbaum, G. Fingerle-Rowson, R. Bucala, 2013, American journal of respiratory cell and molecular biology.

A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans

C. Ober, Shwu-Fan Ma, J. Garcia, 2007, Genetic epidemiology.

Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction

J. Garcia, Joe G. N. Garcia, H. Cai, 2020, Redox biology.

A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.

Amit R. Patel, Wei Zhang, M. Peters-Lawrence, 2012, American journal of respiratory and critical care medicine.

Rapid Porcine Lung Decellularization Using a Novel Organ Regenerative Control Acquisition Bioreactor

J. Garcia, P. Tran, Joe G. N. Garcia, 2015, ASAIO journal.

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

D. Valdez-Jasso, P. Thistlethwaite, J. Garcia, 2020, Pulmonary circulation.

Health Disparities in ARDS

J. Garcia, N. Casanova, H. Quijada, 2016 .

Hyper‐activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

J. Catravas, J. Garcia, M. Cherian‐Shaw, 2017, Free radical biology & medicine.

S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin.

J. Garcia, K. Birukov, Joe G. N. Garcia, 2003, Journal of applied physiology.

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60 src.

J. Garcia, A. Verin, V. Natarajan, 1999, American journal of physiology. Lung cellular and molecular physiology.

IL6 gene-wide haplotype is associated with susceptibility to acute lung injury.

Shwu-Fan Ma, J. Garcia, J. Villar, 2008, Translational research : the journal of laboratory and clinical medicine.

ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells.

S. Reddy, J. Garcia, A. Cress, 2016, American journal of physiology. Cell physiology.

MicroRNAs in Inflammatory Lung Disease

J. Garcia, C. Bime, Christopher I. Gurguis, 2017 .

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta.

F. Liu, J. Garcia, A. Verin, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β

J. Garcia, F. Liu, A. Verin, 2002 .

The role of caldesmon in the regulation of endothelial cytoskeleton and migration

J. Garcia, A. Verin, Joe G. N. Garcia, 2005, Journal of cellular physiology.

Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity

Frances E. Lennon, J. Garcia, P. Singleton, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.

J. Garcia, Yutong Zhao, V. Natarajan, 2004, The Journal of biological chemistry.

Protein Kinase Cδ Mediates Lysophosphatidic Acid-induced NF-κB Activation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells*

J. Garcia, Yutong Zhao, V. Natarajan, 2004, Journal of Biological Chemistry.

Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers

J. Garcia, S. Dudek, S. Camp, 2020, Pulmonary circulation.

Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells

J. Garcia, Xiaoguang Sun, B. Mathew, 2017, Pulmonary circulation.

"Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720".

J. Garcia, S. Dudek, V. Natarajan, 2015, Chemistry and physics of lipids.

6 – Pulmonary Circulation and Regulation of Fluid Balance

J. Garcia, Joe G. N. Garcia, 2016 .

Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate.

J. Garcia, S. Dudek, R. Bittman, 2015, Microvascular research.

Sphingolipids in lung endothelial biology and regulation of vascular integrity.

J. Garcia, Joe G. N. Garcia, T. Abbasi, 2013, Handbook of experimental pharmacology.

Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.

R. Weichselbaum, J. Garcia, S. Dudek, 2013, American journal of respiratory cell and molecular biology.

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

J. Garcia, Yutong Zhao, V. Natarajan, 2011, PloS one.

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.

J. Garcia, S. Dudek, Joe G. N. Garcia, 2011, Cellular signalling.

Concepts in microvascular endothelial barrier regulation in health and disease.

J. Garcia, Joe G. N. Garcia, 2009, Microvascular research.

Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products.

J. Garcia, A. Zaiman, V. Natarajan, 2003, American journal of physiology. Lung cellular and molecular physiology.

Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury.

B. Simon, J. Garcia, P. Hassoun, 2004, American journal of respiratory and critical care medicine.

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.

H. Rabb, J. Garcia, R. Tuder, 2004, American journal of respiratory and critical care medicine.

Transactivation of Sphingosine 1-Phosphate Receptors Is Essential for Vascular Barrier Regulation

Shwu-Fan Ma, J. Garcia, S. Dudek, 2006, Journal of Biological Chemistry.

Quantitative Proteomics Analysis of Human Endothelial Cell Membrane Rafts

R. Cole, J. Garcia, M. Gucek, 2007, Molecular & Cellular Proteomics.

Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.

J. Garcia, J. Moss, P. Singleton, 2007, American journal of respiratory cell and molecular biology.

Lipid mediators of angiogenesis and the signalling pathways they initiate.

S. Spiegel, J. Garcia, D. Brindley, 2002, Biochimica et biophysica acta.

Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury.

J. Garcia, V. Natarajan, V. Bochkov, 2006, American journal of respiratory and critical care medicine.

by the small GTPase Rac and cortactin Endothelial cell barrier enhancement by ATP is mediated

J. Garcia, S. Dudek, A. Verin, 2016 .

Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin.

J. Garcia, S. Dudek, A. Verin, 2006, American journal of physiology. Lung cellular and molecular physiology.

A Differentiation-dependent Splice Variant of Myosin Light Chain Kinase, MLCK1, Regulates Epithelial Tight Junction Permeability*

J. Alverdy, J. Garcia, S. Dudek, 2004, Journal of Biological Chemistry.

Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3–12q24.21 for asthma and total serum IgE in an African Caribbean population

Alan F Scott, Terri H Beaty, Rasika A Mathias, 2006, Genetic epidemiology.

Respiratory health of Hispanic migrant farm workers in Indiana

J. Garcia, Joe G.N. Garcia, K. S. Matheny Dresser, 1996 .

Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells.

J. Garcia, N. Parinandi, V. Natarajan, 1999, American journal of physiology. Lung cellular and molecular physiology.

Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia‐induced pulmonary hypertension

J. Garcia, J. Yuan, Zhihao Liang, 2017, British journal of pharmacology.

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

J. Garcia, Donna D. Zhang, G. Wondrak, 2016, Scientific Reports.

Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell–cell and cell–extracellular matrix interactions

J. Garcia, R. Nagle, A. Cress, 2019, Molecular biology of the cell.

Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke

E. Letsiou, J. Garcia, S. Dudek, 2021, Cells.

MicroRNA and Protein-Coding Gene Expression Analysis in Idiopathic Pulmonary Fibrosis Yields Novel Biomarker Signatures Associated to Survival.

I. Noth, M. Gonzalez-Garay, Y. Lussier, 2020, Translational research : the journal of laboratory and clinical medicine.

A Phase II Clinical Trial of Low‐Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis

H. Collard, F. Martinez, I. Noth, 2018, Chest.

Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human Cancers

Wei Zhang, Nikolai N. Khodarev, Ralph R. Weichselbaum, 2012, PloS one.

Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches.

J. Garcia, T. Zhou, N. Casanova, 2015, Clinics in chest medicine.

Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure

Shwu-Fan Ma, J. Garcia, R. Wadgaonkar, 2006, Journal of cellular biochemistry.

Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta

J. Garcia, Prasad Kanteti, S. Dudek, 2016, PloS one.

Nontuberculous Mycobacterial Disease Mortality in the United States, 1999–2010: A Population-Based Comparative Study

J. Garcia, R. Machado, M. Mirsaeidi, 2014, PloS one.

A Humanized Monoclonal Antibody Targeting Extracellular Nicotinamide Phosphoribosyltransferase Prevents Aggressive Prostate Cancer Progression

J. Garcia, Xiaoguang Sun, A. Cress, 2021, Pharmaceuticals.

Genetic determinants of risk and survival in pulmonary arterial hypertension

Lisa J. Martin, Ferhaan Ahmad, W. Ouwehand, 2018, bioRxiv.

AHA Policy Statement Genetics and Cardiovascular Disease A Policy Statement From the American Heart Association

E. Ashley, P. Ellinor, C. Caleshu, 2012 .

Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

J. Garcia, Xiaoguang Sun, S. Dudek, 2018, Pulmonary circulation.

Identification of novel in vitro protein kinase A phosphorylation sites on recombinant non-muscle myosin light chain kinase: Nano-liquid chromatography tandem mass spectrometry methodology

J. Garcia, S. Dudek, S. Camp, 2008 .

Mechanism of fluoride-induced MAP kinase activation in pulmonary artery endothelial cells.

J. Garcia, A. Verin, A. Birukova, 2006, American journal of physiology. Lung cellular and molecular physiology.

Lung endothelial heparan sulfates mediate cationic peptide-induced barrier dysfunction: a new role for the glycocalyx.

J. Garcia, R. Sasisekharan, Joe G. N. Garcia, 2003, American journal of physiology. Lung cellular and molecular physiology.

Microarray analysis of regional cellular responses to local mechanical stress in acute lung injury.

B. Simon, D. Grigoryev, Shwu-Fan Ma, 2006, American journal of physiology. Lung cellular and molecular physiology.

Integrating microRNAs into a system biology approach to acute lung injury.

Wei Zhang, J. Garcia, T. Zhou, 2011, Translational research : the journal of laboratory and clinical medicine.

Differential transcriptomics in sarcoidosis lung and lymph node granulomas with comparisons to pathogen-specific granulomas

M. Gonzalez-Garay, Y. Lussier, J. Garcia, 2020, Respiratory Research.

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

S. Novak, C. Gregorio, J. Garcia, 2021, Pulmonary circulation.

Effects of BAL Fluid on Neutrophil Function in Rheumatoid Arthritis

J. Garcia, Joe G. N. Garcia, B. Keogh, 1986 .

Transcriptional Events during the Recovery from MRSA Lung Infection: A Mouse Pneumonia Model

R. Wunderink, G. Feng, J. Garcia, 2013, PloS one.

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension

Nuofu Zhang, N. Zhong, J. Garcia, 2020, British journal of pharmacology.

Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice.

D. Kwiatkowski, J. Garcia, R. Wadgaonkar, 2003, American journal of respiratory cell and molecular biology.

Tissue ACE phenotyping in lung cancer

J. Garcia, K. Sotlar, S. Danilov, 2019, PloS one.

Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor–induced angiogenesis

J. Garcia, J. Moss, P. Singleton, 2008, Molecular Cancer Therapeutics.

expression analysis of cyclosporin A therapy Protection of lungs from hyperoxic injury: gene

D. Grigoryev, Shwu-Fan Ma, J. Garcia, 2015 .

Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

E. Letsiou, J. Garcia, S. Dudek, 2015, American journal of physiology. Lung cellular and molecular physiology.

Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

E. Letsiou, J. Garcia, S. Dudek, 2015, American journal of physiology. Lung cellular and molecular physiology.

MAP kinases in lung endothelial permeability induced by microtubule disassembly.

Feng Liu, J. Garcia, A. Verin, 2005, American journal of physiology. Lung cellular and molecular physiology.

Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis.

M. Crow, J. Garcia, I. Petrache, 2003, Biochemical and biophysical research communications.

Exon-based mapping of microarray probes: recovering differential gene expression signal in underpowered hypoxia experiment.

R. Johns, D. Grigoryev, Shwu-Fan Ma, 2007, Molecular and cellular probes.

Cohesive cancer invasion of the biophysical barrier of smooth muscle

J. Garcia, R. Nagle, A. Cress, 2021, Cancer and Metastasis Reviews.

An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform

Shwu-Fan Ma, J. Garcia, C. Flores, 2011, Journal of Molecular Medicine.

Genetic determinants of risk and survival in pulmonary arterial hypertension

Lisa J. Martin, Ferhaan Ahmad, W. Ouwehand, 2018, bioRxiv.

Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.

M. Pino-Yanes, R. Kittles, C. Ober, 2010, The Journal of allergy and clinical immunology.

Murine Lung Responses to Ambient Particulate Matter: Genomic Analysis and Influence on Airway Hyperresponsiveness

J. Samet, Y. Lussier, A. Geyh, 2008, Environmental health perspectives.

Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene.

M. Pino-Yanes, Á. Carracedo, Shwu-Fan Ma, 2016, The Journal of allergy and clinical immunology.

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension

J. Garcia, A. Abidov, J. Yuan, 2017, European Respiratory Journal.

IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias.

Tae Yun Kim, R. Kittles, P. Bronk, 2020, Blood.

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells

D. Valdez-Jasso, P. Thistlethwaite, J. Garcia, 2021, Frontiers in Physiology.

HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption.

J. Garcia, Joe G. N. Garcia, E. Chiang, 2011, Microvascular research.

Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells.

J. Zweier, J. Garcia, P. Kuppusamy, 2005, Antioxidants & redox signaling.

Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung

D. Kass, J. Garcia, R. Tuder, 2010, Acta Pharmacologica Sinica.

Temporal gene expression analysis of human coronary artery endothelial cells treated with Simvastatin.

R. Setterquist, D. Grigoryev, Shwu-Fan Ma, 2008, Gene expression.

cytoskeletonof CPI-17 in the regulation of endothelial

Shwu-Fan Ma, J. Garcia, A. Verin, 2016 .

Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular Biomarkers

J. Garcia, Ting Wang, Joe G. N. Garcia, 2010, Textbook of Pulmonary Vascular Disease.

Pulmonary Vascular Barrier Regulation by Thrombin and Edg Receptors

J. Garcia, Joe G. N. Garcia, J. Jacobson, 2005 .

Differential regulation of endothelial cell barrier function

J. Garcia, S. Dudek, Joe G. N. Garcia, 2005 .

The Role of Protein Kinase C in α-Thrombin-Mediated Endothelial Cell Activation

J. Garcia, Joe G. N. Garcia, J. Stasek, 1992 .

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension

R. Dweik, D. Valdez-Jasso, S. Ye, 2017, Circulation.

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling.

Gene Kim, J. Garcia, N. Sundaresan, 2013, American journal of physiology. Heart and circulatory physiology.

Nampt secreted from cardiomyocytes promotes development of

Gene Kim, J. Garcia, N. Sundaresan, 2012 .

Hyper-Activation of pp 60 ( Src ) Limits Nitric Oxide Signaling by Increasing Asymmetric Dimethylarginine Levels During Acute Lung Injury

Wang, Ting, J. Catravas, 2018 .

Novel Role for Non-muscle Myosin Light Chain Kinase (MLCK) in Hyperoxia-induced Recruitment of Cytoskeletal Proteins, NADPH Oxidase Activation, and Reactive Oxygen Species Generation in Lung Endothelium*

J. Garcia, S. Dudek, V. Natarajan, 2012, The Journal of Biological Chemistry.

Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells

J. Garcia, Yutong Zhao, V. Natarajan, 2007, Journal of Biological Chemistry.

Coronin 1B Regulates S1P-Induced Human Lung Endothelial Cell Chemotaxis: Role of PLD2, Protein Kinase C and Rac1 Signal Transduction

J. Garcia, V. Natarajan, J. Bear, 2013, PloS one.

Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins.

J. Garcia, V. Bochkov, N. Leitinger, 2004, Microvascular research.

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells*

J. Garcia, S. Dudek, V. Natarajan, 2009, Journal of Biological Chemistry.

Epoxycyclopentenone-Containing Oxidized Phospholipids Restore Endothelial Barrier Function via Cdc42 and Rac

A. Leitner, J. Garcia, G. Bokoch, 2004, Circulation research.

Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease.

J. Orens, F. Finkelman, S. Ye, 2006, American journal of respiratory cell and molecular biology.

Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding

E. Letsiou, J. Garcia, R. Minshall, 2016, Scientific Reports.

Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

Jieling Zhao, Jie Liang, Gamze Gursoy, 2015, Scientific Reports.

Regulation of endothelial cell myosin light chain phosphorylation and permeability by vanadate

J. Garcia, A. Verin, Joe G. N. Garcia, 1998, Journal of cellular biochemistry.

Attenuation of chronic hypoxic pulmonary hypertension by simvastatin.

R. Johns, J. Garcia, R. Tuder, 2003, American journal of physiology. Heart and circulatory physiology.

Critical involvement of p38 MAP kinase in pertussis toxin‐induced cytoskeletal reorganization and lung permeability

F. Liu, J. Garcia, A. Verin, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

p38 MAP kinase-dependent regulation of endothelial cell permeability.

F. Liu, J. Garcia, A. Verin, 2004, American journal of physiology. Lung cellular and molecular physiology.

Involvement of microtubules and Rho pathway in TGF‐β1‐induced lung vascular barrier dysfunction

J. Garcia, A. Verin, A. Birukova, 2005, Journal of cellular physiology.

Ezrin / radixin / moesin proteins differentially regulate endothelial 1 hyperpermeability after thrombin 2

Shwu-Fan Ma, J. Garcia, S. Dudek, 2013 .

Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis.

M. Crow, J. Garcia, R. Damico, 2008, American journal of respiratory cell and molecular biology.

Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop.

J. Knowles, D. Gail, S. Archer, 2004, Circulation.

Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension.

D. Valdez-Jasso, P. Thistlethwaite, J. Garcia, 2021, American journal of physiology. Cell physiology.

Conformational Changes of Blood ACE in Chronic Uremia

M. N. Petrov, J. Garcia, S. Danilov, 2012, PloS one.

Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

M. Gonzalez-Garay, J. Garcia, Xinshuai Qi, 2020, Pulmonary circulation.

Integrin β4 attenuates SHP‐2 and MAPK signaling and reduces human lung endothelial inflammatory responses

J. Garcia, Joe G. N. Garcia, J. Jacobson, 2010, Journal of cellular biochemistry.

Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension.

E. Bedrick, J. Garcia, A. Makino, 2018, The American journal of medicine.

Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses.

J. Garcia, A. Verin, Joe G. N. Garcia, 1998, American journal of physiology. Lung cellular and molecular physiology.

Role of type 2 deiodinase in response to acute lung injury (ALI) in mice

J. Garcia, R. Weiss, S. Refetoff, 2011, Proceedings of the National Academy of Sciences.

Akt-Mediated Transactivation of the S1P1 Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids

A. Klibanov, J. Garcia, A. Birukova, 2009, Circulation research.

The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.

J. Garcia, R. Machado, J. Yuan, 2014, American journal of respiratory and critical care medicine.

eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury

C. Karmonik, J. Garcia, C. Bime, 2022, Frontiers in Physiology.

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

J. Garcia, J. Yuan, Haiyang Tang, 2018, JACC. Basic to translational science.

Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury.

E. Letsiou, J. Garcia, R. Machado, 2014, American journal of respiratory cell and molecular biology.

Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium.

J. Garcia, Xiaoguang Sun, Brandon Mapes, 2013, American journal of respiratory cell and molecular biology.

Phospholipase D Activation by Sphingosine 1-Phosphate Regulates Interleukin-8 Secretion in Human Bronchial Epithelial Cells*

J. Garcia, A. Zaiman, N. Parinandi, 2002, The Journal of Biological Chemistry.

Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation.

Shwu-Fan Ma, J. Garcia, S. Dudek, 2014, American journal of respiratory cell and molecular biology.

New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension

M. Gonzalez-Garay, J. Garcia, R. Rafikov, 2018, PloS one.

Vascular endothelium summary statement V: Pulmonary hypertension and acute lung injury: public health implications.

G. Mensah, J. Garcia, S. Black, 2007, Vascular pharmacology.

Improved metabolism and redox state with a novel preservation solution: implications for donor lungs after cardiac death (DCD)

J. Garcia, S. Black, R. Smolenski, 2017, Pulmonary circulation.

Identification of candidate genes in scleroderma-related pulmonary arterial hypertension.

C. Cheadle, K. Barnes, D. Grigoryev, 2008, Translational research : the journal of laboratory and clinical medicine.

The Novel Role of the Mu Opioid Receptor in Lung Cancer Progression: A Laboratory Investigation

Chin-Tu Chen, R. Salgia, Frances E. Lennon, 2011, Anesthesia and analgesia.

Role Played by Paxillin and Paxillin Tyrosine Phosphorylation in Hepatocyte Growth Factor/Sphingosine-1-Phosphate-Mediated Reactive Oxygen Species Generation, Lamellipodia Formation, and Endothelial Barrier Function

R. Salgia, J. Garcia, A. Cress, 2015, Pulmonary Circulation.

Annexin A11 is associated with pulmonary fibrosis in African American patients with sarcoidosis.

J. Garcia, R. Machado, Z. Arbieva, 2016, Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.

Rheumatologic Manifestations of Sarcoidosis

J. Garcia, P. Korsten, R. Baughman, 2010, Seminars in respiratory and critical care medicine.

Impact of MHC Class II Incompatibility on Localization of Mononuclear Cell Infiltrates to the Bronchiolar Compartment of Orthotopic Lung Allografts

W. Baldwin, J. Garcia, B. Wąsowska, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Linkage of Type I Interferon Activity and TNF-Alpha Levels in Serum with Sarcoidosis Manifestations and Ancestry

Wei Zhang, J. Garcia, R. Baughman, 2011, PloS one.

Genomic investigations into acute inflammatory lung injury.

J. Garcia, Joe G. N. Garcia, 2011, Proceedings of the American Thoracic Society.

Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo.

B. Simon, M. Crow, A. Choi, 2008, Translational research : the journal of laboratory and clinical medicine.

Genomics made functional in ventilator-associated lung injury.

J. Garcia, Joe G. N. Garcia, J. Jacobson, 2003, American journal of respiratory and critical care medicine.

Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke

E. Letsiou, J. Garcia, S. Dudek, 2020, Cells.

State of the Art

J. Garcia, Xiaoguang Sun, Joe G. N. Garcia, 2008 .

eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

L. Cancio, J. Garcia, C. Bime, 2022, Scientific Reports.

Surfing the right ventricular pressure waveform: methods to assess global, systolic and diastolic RV function from a clinical right heart catheterization

J. Garcia, J. Yuan, S. Black, 2020, Pulmonary circulation.

Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.

J. Garcia, Xiaoguang Sun, S. Dudek, 2010, American journal of respiratory cell and molecular biology.

Alternative promoter and GATA5 transcripts in mouse.

E. Morrisey, J. Garcia, P. Gruber, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Use of consomic rats for genomic insights into ventilator-associated lung injury.

Lee T. Sam, Y. Lussier, D. Grigoryev, 2007, American journal of physiology. Lung cellular and molecular physiology.

Differential gene expression in chronic hypoxic pulmonary hypertension: effect of simvastatin treatment.

R. Johns, D. Grigoryev, S. Ye, 2005, Chest.

Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma*

Mingyao Li, Shwu-Fan Ma, J. Garcia, 2008, Critical care medicine.

Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress

J. Garcia, Xiaoguang Sun, S. Dudek, 2021, Clinical science.

Nonmuscle Myosin Light Chain Kinase Activity Modulates Radiation-Induced Lung Injury

R. Weichselbaum, J. Garcia, S. Dudek, 2016, Pulmonary circulation.

Healthcare disparities in patients with acute respiratory distress syndrome. Toward equity.

J. Sznajder, J. Garcia, Joe G. N. Garcia, 2013, American journal of respiratory and critical care medicine.

Focusing on the flood: targeting functional polymorphisms in ALI permeability pathways.

J. Garcia, Joe G. N. Garcia, 2011, American journal of respiratory and critical care medicine.

Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium.

J. Garcia, S. Dudek, Joe G. N. Garcia, 2010, Microvascular research.

In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip® technology

R. Irizarry, B. Simon, D. Grigoryev, 2005, BMC Genomics.

The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene

J. Garcia, T. Zhou, S. Danilov, 2017, American journal of respiratory cell and molecular biology.

Attenuation of Rodent Lung Ischemia Reperfusion Injury by Sphingosine 1 Phosphate

J. Garcia, P. Bonde, W. Vigneswaran, 2008 .

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter.

S. Reddy, J. Garcia, S. Kleeberger, 2011, Free radical biology & medicine.

EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.

S. Reddy, J. Garcia, P. Hassoun, 2007, American journal of respiratory cell and molecular biology.

TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation.

J. Garcia, V. Natarajan, S. Camp, 2022, Biochimica et biophysica acta. Molecular basis of disease.

Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.

Y. Lussier, J. Garcia, S. Dudek, 2011, American journal of respiratory cell and molecular biology.

TGFβ signaling induces expression of Gadd45b in retinal ganglion cells.

J. Garcia, Xiaoguang Sun, Bin Liu, 2013, Investigative ophthalmology & visual science.

Efficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis.

I. Noth, M. Strek, P. Caligiuri, 2014, Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody

Zhonglin Liu, J. Garcia, C. Bime, 2020, European Respiratory Journal.

J. Garcia, S. Sammani, S. Palumbo, 2017 .

Significant CD4, CD8, and CD19 Lymphopenia in Peripheral Blood of Sarcoidosis Patients Correlates with Severe Disease Manifestations

J. Garcia, R. Baughman, T. Niewold, 2010, PloS one.

Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement.

O. Zaborina, J. Alverdy, J. Garcia, 2009, Microvascular research.

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

D. Rossi, G. Gaidano, G. Inghirami, 2015, Blood.

Critical Role of S1PR1 and Integrin β4 in HGF/c-Met-mediated Increases in Vascular Integrity

R. Salgia, J. Garcia, Prasad Kanteti, 2012, The Journal of Biological Chemistry.

Endothelial cell barrier enhancement by HGF 1 Critical Role of S 1 PR 1 and Integrin β 4 in HGF / c-Met-Mediated Increases in Vascular Integrity

R. Salgia, J. Garcia, Prasad Kanteti, 2012 .

High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness.

Frances E. Lennon, J. Garcia, Yurong Guo, 2010, American journal of physiology. Lung cellular and molecular physiology.

Dynamin 2 and c-Abl Are Novel Regulators of Hyperoxia-mediated NADPH Oxidase Activation and Reactive Oxygen Species Production in Caveolin-enriched Microdomains of the Endothelium*

J. Garcia, V. Natarajan, P. Singleton, 2009, The Journal of Biological Chemistry.

Protective effect of purinergic agonist ATPgammaS against acute lung injury.

J. Garcia, A. Verin, S. Sammani, 2008, American journal of physiology. Lung cellular and molecular physiology.

Role of Ca2+ in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function.

J. Garcia, V. Natarajan, Joe G. N. Garcia, 2003, American journal of physiology. Lung cellular and molecular physiology.

Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition.

J. Garcia, V. Natarajan, Joe G. N. Garcia, 2008, American journal of physiology. Lung cellular and molecular physiology.

permeabilityMAP kinase-dependent regulation of endothelial cell

J. Garcia, F. Liu, A. Verin, 2016 .

Alterations in Alveolar Macrophage and Neutrophil Function 1 - 3

J. Garcia, A. Malik, W. Jubiz, 1988 .

Regulation of Thrombin-Induced Endothelial Barrier Dysfunction and Prostaglandin Synthesis

J. Aschner, J. Garcia, A. Malik, 1992 .

In silico Docking Studies of Fingolimod and S1P1 Agonists

J. Garcia, S. Camp, Joe G. N. Garcia, 2020, Frontiers in Pharmacology.

Protective Effect of Purinergic Agonist AtpΓS against Acute Lung Injury

J. Garcia, A. Verin, S. Sammani, 2006, Journal of Investigative Medicine.

Protein Kinase C-ϵ Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-ζ, and Rac1*

J. Garcia, Yutong Zhao, V. Natarajan, 2008, Journal of Biological Chemistry.

Interaction of Integrin β4 With S1P Receptors in S1P‐ and HGF‐Induced Endothelial Barrier Enhancement

J. Garcia, Joe G. N. Garcia, Y. Epshtein, 2014, Journal of cellular biochemistry.

Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.

J. Garcia, V. Natarajan, Joe G. N. Garcia, 2011, American journal of physiology. Lung cellular and molecular physiology.

Sphingolipids and lung vascular barrier regulation

J. Garcia, S. Dudek, Joe G. N. Garcia, 2006 .

Caldesmon is a cytoskeletal target for PKC in endothelium

F. Liu, J. Garcia, A. Verin, 2006, Journal of cellular biochemistry.

Searching for candidate genes in acute lung injury: SNPs, Chips and PBEF.

J. Garcia, Joe G. N. Garcia, 2005, Transactions of the American Clinical and Climatological Association.

Arg mediates LPS-induced disruption of the pulmonary endothelial barrier.

E. Letsiou, J. Garcia, S. Dudek, 2020, Vascular pharmacology.

Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.

J. Garcia, Yutong Zhao, V. Natarajan, 2011, American journal of respiratory cell and molecular biology.

An update on sphingosine-1-phosphate receptor 1 modulators.

J. Garcia, S. Camp, Joe G. N. Garcia, 2018, Bioorganic & medicinal chemistry letters.

The impact of intravenous dodecafluoropentane on a murine model of acute lung injury

J. Garcia, J. Mosier, E. Unger, 2020, bioRxiv.

Bluetongue Virus and Double-Stranded RNA Increase Human Vascular Permeability: Role of p38 MAPK

J. Garcia, Joe G. N. Garcia, E. Chiang, 2006, Journal of Clinical Immunology.

Substance P‐Induced Pulmonary Vasoreactivity in Isolated Perfused Guinea Pig Lung

J. Garcia, A. Malik, K. Burhop, 1988, Circulation research.

Rituximab in the treatment of refractory pulmonary sarcoidosis

J. Garcia, S. Dudek, R. Baughman, 2014, European Respiratory Journal.

Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation.

J. Garcia, V. Natarajan, B. Mathew, 2012, American journal of respiratory cell and molecular biology.

Epitope mapping of novel monoclonal antibodies to human angiotensin I‐converting enzyme

J. Garcia, S. Dudek, E. Sturrock, 2021, Protein Science.

Conflicting Physiological andGenomic Cardiopulmonary Effects of Recruitment Maneuvers in Murine Acute Lung Injury

L. Brochard, J. Garcia, S. Dudek, 2012 .

Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress

J. Garcia, A. Cress, Joe G. N. Garcia, 2015, Scientific Reports.

Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss

J. Garcia, A. Cress, V. Natarajan, 2021, Scientific Reports.

Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly.

F. Liu, J. Garcia, A. Verin, 2004, American journal of physiology. Lung cellular and molecular physiology.

Sphingosine Kinase 1 Deficiency Protects Rodents from Chronic Hypoxia-mediated Pulmonary Hypertension.

J. Garcia, R. Machado, J. Yuan, 2012, ATS 2012.