W. Holmes

发表

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.

L. Kuyper, L. Shewchuk, A. Hassell, 2000, Journal of medicinal chemistry.

Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1

John A Tainer, Yves Bourne, J. Tainer, 1996, Cell.

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

P. A. Harris, L. Kuyper, S. Frye, 2001, Journal of medicinal chemistry.

Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A

E. Fauman, H. Piwnica-Worms, W. Rocque, 1998, Cell.

A strategy for predicting the ligand binding competence of recombinant orphan nuclear receptors using biophysical characterization

M. Milburn, B. Wisely, W. Holmes, 1997 .

Structure-Function Studies on the Protein Kinase C Family Members

D. Burns, W. Holmes, R. Bell, 1992 .

Purification and Characterization of Recombinant Urokinase from Escherichia coli

W. Holmes, M. Blaber, G. Vehar, 1985, Bio/Technology.

Development of an acidic / neutral antibody flow-through polishing step using salt-tolerant anion exchange chromatography

Stanley, W. Holmes, M. Healy-Fried, 2016 .

Modulation of cyclin-dependent kinase 4 by binding of magnesium (II) and manganese (II).

W. Holmes, S. T. Davis, G. Tian, 2002, Biophysical chemistry.

Molecular and biochemical characterization of a recombinant human PKC-δ family member

G. Blobel, D. Burns, W. Holmes, 1993 .

Detailed characterization of a purified type 4 phosphodiesterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding.

W. Rocque, W. Holmes, G. B. Wisely, 1997, Protein expression and purification.

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.

A M Hassell, L. Shewchuk, W. Holmes, 2000, Structure.

Blood-Brain Barrier-Penetrating 6-Halogenopurines Suitable as Pro-Probes for Positron Emission Tomography are Substrates for Human Glutathione Transferases

W. Holmes, M. Healy-Fried, D. Ludwig, 2015 .

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity.

Y. Zhao, H. Ke, M. Lambert, 2000, Science.

Sequence and expression of human protein kinase C-ϵ

D. Burns, W. Holmes, C. Loomis, 1992 .

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.

B G Benson, A M Hassell, P. A. Harris, 2001, Science.

Solution studies of recombinant human stromal-cell-derived factor-1.

W. Rocque, W. Holmes, T. Consler, 2001, Protein expression and purification.

Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase.

D. Kassel, W. Rocque, W. Holmes, 1996, The Biochemical journal.

Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities.

W. Rocque, W. Holmes, W. C. Clay, 1997, Biochemistry.

Molecular and biochemical characterization of a recombinant human PKC-delta family member.

G. Blobel, D. Burns, W. Holmes, 1993, Biochimica et biophysica acta.