J. Veal

发表

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.

L. Kuyper, L. Shewchuk, A. Hassell, 2000, Journal of medicinal chemistry.

Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.

P. A. Harris, J. Veal, Liping Wang, 2005, Journal of medicinal chemistry.

Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.

P. A. Harris, J. Veal, Rakesh Kumar, 2008, Journal of medicinal chemistry.

Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.

D. J. Price, L. Shewchuk, J. Veal, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.

P. A. Harris, J. Veal, Megumi Shibahara, 2007, Journal of medicinal chemistry.

Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

J. Veal, F. Schoenen, J. Stafford, 1995, Journal of medicinal chemistry.

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

P. A. Harris, L. Kuyper, S. Frye, 2001, Journal of medicinal chemistry.

A quantum mechanical investigation of the annealing energy for phosphodiester, formacetal, and thioformacetal backbones

F. Brown, J. Veal, 1993 .

DAPI (4',6-diamidino-2-phenylindole) binds differently to DNA and RNA: minor-groove binding at AT sites and intercalation at AU sites.

J. Veal, W. Wilson, F. Tanious, 1992, Biochemistry.

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Laura G. Dubois, Philip F. Hughes, J. Strachan, 2009, Journal of medicinal chemistry.

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.

Philip F. Hughes, J. Veal, S. Hall, 2012, Bioorganic & medicinal chemistry letters.

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.

J. Veal, S. Hall, J. Rice, 2008, Bioorganic & medicinal chemistry letters.

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.

Laura G. Dubois, J. Veal, P. Fadden, 2008, Arthritis and rheumatism.

Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.

J. Veal, D. Hosfield, Jiangchun Xu, 2018, Bioorganic & medicinal chemistry letters.

Noncovalent DNA binding of bis(1,10-phenanthroline)copper(I) and related compounds.

J. Veal, R. Rill, 1991, Biochemistry.

Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).

J. Veal, D. Hosfield, L. Lawton, 2020, Journal of medicinal chemistry.

Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.

J. Veal, Jiangchun Xu, J. D. Del Rosario, 2019, Bioorganic & medicinal chemistry letters.

Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.

Matthew S. Johnson, M. Ultsch, J. Veal, 2022, Journal of medicinal chemistry.

Sequence specificity of DNA cleavage by bis(1,10-phenanthroline)copper(I): effects of single base pair transitions on the cleavage of preferred pyrimidine-purine-pyrimidine triplets.

J. Veal, R. Rill, 1989, Biochemistry.

The discovery of potent cRaf1 kinase inhibitors.

P. A. Harris, S. Frye, K. Lackey, 2000, Bioorganic & medicinal chemistry letters.

The influence of reducing agent and 1,10-phenanthroline concentration on DNA cleavage by phenanthroline + copper.

J. Veal, J M Veal, R L Rill, 1991, Nucleic acids research.

Novel carbazole and acyl-indole antimitotics.

J. Veal, S. Hall, J. Rice, 2009, Bioorganic & medicinal chemistry letters.

Sequence specificity of DNA cleavage by bis(1,10-phenanthroline)copper(I).

J. Veal, R. Rill, 1988, Biochemistry.

Interaction of a macrocyclic bisacridine with DNA.

W D Wilson, G. Zon, J. Veal, 1990, Biochemistry.

Solution conformation of a G-TA triple in an intramolecular pyrimidine purine pyrimidine DNA triplex

D. Patel, Xiaolian Gao, J. Veal, 1992 .

Modeling of nucleic acid complexes with cationic ligands: a specialized molecular mechanics force field and its application.

J. Veal, W. Wilson, 1991, Journal of biomolecular structure & dynamics.

NMR solution structure of a peptide nucleic acid complexed with RNA.

D. G. Davis, S. Brown, J. Veal, 1994, Science.

Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.

Philip F. Hughes, T. Haystead, J. Veal, 2013, ACS chemical biology.

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase.

J. Veal, Liping Wang, R. Nolte, 2005, Bioorganic & medicinal chemistry letters.

Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent α-Synuclein Oligomer Formation and Rescue α-Synuclein-Induced Toxicity

Carol D. Hicks, B. Hyman, J. Veal, 2010, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Benzamide Tetrahydro‐4H‐carbazol‐4‐ones as Novel Small Molecule Inhibitors of Hsp90.

J. Veal, 2008 .

Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.

Briana Foley, Laura G. Dubois, Philip F. Hughes, 2010, Chemistry & biology.

Structure-based design and discovery of potent and selective KDM5 inhibitors.

J. Veal, D. Hosfield, Jiangchun Xu, 2018, Bioorganic & medicinal chemistry letters.

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.

J. Veal, T. Bonaldi, D. Hosfield, 2017, ACS medicinal chemistry letters.

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.

B G Benson, A M Hassell, P. A. Harris, 2001, Science.

Melanocortin receptor binding determinants in the agouti protein.

W. Wilkison, J. Veal, K. Mountjoy, 1998, Biochemistry.

Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.

R. L. Jones, G. Zon, E. Garman, 1990, Nucleic acids research.

A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex

L. Betts, J. Veal, S. Jordan, 1995, Science.

Derives de carbazole

J. Veal, G. Hanson, K. Huang, 2006 .

Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA.

W D Wilson, J. Veal, W. Wilson, 1996, Biochemistry.

Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis

J. Veal, A. Feldstein, J. Stafford, 2023, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacology of a Potent and Novel Inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) Inflammasome that Attenuates Development of NASH and Liver Fibrosis

J. Veal, A. Feldstein, Christopher Mcbride, 2023 .

Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib.

J. Veal, P. Fadden, S. Hall, 2009, Oncology research.