T. Gallagher

发表

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase.

J. Boehm, S. Kassis, John C. Lee, 1997, Bioorganic & medicinal chemistry.

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site*

Steven A. Carr, Michael L. Doyle, Jerry L. Adams, 1997, The Journal of Biological Chemistry.

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Jerry L. Adams, John C. Lee, J. Adams, 1994, Nature.

Indole-2,3-quinodimethan route to Aspidosperma alkaloids: synthesis of dl-aspidospermidine

T. Gallagher, J. Huffman, P. Magnus, 1982 .

Rapid synthesis of diversely functionalized 3,4,7-trisubstituted indoles

T. Gallagher, J. Axten, Seth W. Grant, 2011 .

O-glycan inhibitors generate aryl-glycans, induce apoptosis and lead to growth inhibition in colorectal cancer cell lines.

T. Gallagher, C. Paraskeva, J. Michalski, 2009, Glycobiology.

Synthetic studies directed towards the vancomycin carboxylate binding pocket

T. Gallagher, I. Clemens, R. Lamont, 1992 .

Stereoselective synthesis of pyrrolizidine alkaloids via substituted nitrones

T. Gallagher, D. Lathbury, 1986 .

O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines.

T. Gallagher, C. Paraskeva, A. Corfield, 2007, Biochemical Society transactions.

Oxidative Fragmentation of Cytisine as an Entry to the Bis(piperidine) Scaffold of Virgidivarine

T. Gallagher, Worawat Niwetmarin, 2022, HETEROCYCLES.

Enantio‐ and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

F. Glorius, T. Gallagher, Daniel Moock, 2021, Angewandte Chemie.

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

J. Boehm, J. Adams, T. Gallagher, 1996, Journal of medicinal chemistry.

Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375

David G. Behm, H. Sarau, J. Foley, 2005, British journal of pharmacology.

Phenoxypyrimidine inhibitors of p38α kinase

Stephen R. Johnson, J. Boehm, M. Bower, 2001 .

Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

J. Boehm, S. Kassis, J. Adams, 1998, Bioorganic & medicinal chemistry letters.

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, T. Gallagher, 2011, Bioorganic & medicinal chemistry letters.

A Novel Approach to the Synthesis of Medium Ring Nitrogen Heterocycles

T. Gallagher, R. Shaw, MARTIN M. Anderson, 1990 .

Application of electrophile-mediated cyclisations to the synthesis of the hexahydroazepine ring system

T. Gallagher, R. Shaw, D. Lathbury, 1991 .

A new approach to cyclic nitrones: Application to the synthesis of α,α′-disubstituted piperidines and pyrrolidines

T. Gallagher, D. Lathbury, 1985 .

Lithiated dihydropyrans as ketone enolate equivalents: A model study for the herbicidins

T. Gallagher, K. Molloy,, M. Mahon, 1988 .

ENANTIOSELECTIVE SYNTHESIS OF PUMILIOTOXIN 251D. A STRATEGY EMPLOYING AN ALLENE-BASED ELECTROPHILE-MEDIATED CYCLIZATION

T. Gallagher, K. Molloy,, M. Mahon, 1991 .

C-H activation and palladium migration within Biaryls under Heck reaction conditions.

T. Gallagher, Nopporn Thasana, G. Karig, 2002, Organic letters.

Steroidal acetylenes: Mechanism-based inactivators of lanosterol 14α-demethylase

J. Adams, T. Gallagher, T. Tomaszek, 1991 .

Integrating Allyl Electrophiles into Nickel-Catalyzed Conjunctive Cross-Coupling.

T. Gallagher, Peng Liu, V. Tran, 2019, Angewandte Chemie.

Iron-Catalyzed Borylation of Alkyl, Allyl, and Aryl Halides: Isolation of an Iron(I) Boryl Complex

T. Gallagher, D. Murphy, P. Brenner, 2014 .

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.

J. Boehm, S. Kassis, J. Adams, 2001, Bioorganic & medicinal chemistry letters.

Palladium(0)-catalysed arylations using pyrrole and indole-2-boronic acids

T. Gallagher, Christopher N. Johnson, G. Stemp, 1998 .

Synthetic entries to substituted bicyclic pyridones.

T. Gallagher, A. Lightfoot, Muna Abdi, 2007, Organic letters.

Diastereoselective resolution of 6-substituted glycosides via enzymatic hydrolysis.

T. Gallagher, S. Davies, E. N. Vulfson, 1997, Carbohydrate research.

Samarium di-iodide: a useful electron donor in organic synthesis

T. Gallagher, P. Magnus, T. P. Ananthanarayan, 1982 .

Direct and regioselective C-H alkenylation of tetrahydropyrido[1,2-a]pyrimidines.

T. Gallagher, Dachen Cheng, 2009, Organic letters.

Regioselective synthesis of .DELTA.6-, .DELTA.7-, and .DELTA.8-14.alpha.-cyanosterol derivatives: versatile precursors to 14.alpha.-demethylase inhibitors

J. Adams, T. Gallagher, 1992 .

Studies on the synthesis of the antitumor agent CC-1065. Synthesis of the unprotected cyclopropapyrroloindole A portion using the 3,3'-bipyrrole strategy

T. Gallagher, P. Magnus, Y. Or, 1987 .

Radical-mediated synthesis of α- C -glycosides based on N -acyl galactosamine

T. Gallagher, D. Walter, R. SanMartin, 2000 .

Nucleophilic C-glycosyl donors for C-glycoside synthesis

T. Gallagher, J. Beau, 1997 .

Directed deprotonation-transmetalation as a route to substituted pyridines.

T. Gallagher, J. Spencer, G. Karig, 2001, Organic letters.

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

J. Boehm, J. Adams, T. Gallagher, 1996, Journal of medicinal chemistry.

2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis

Jerry L. Adams, John C. Lee, J. Adams, 1995 .

The indole 2-3-quinodimethane strategy for the synthesis of indole alkaloids

T. Gallagher, J. BrownPeter, P. Pappalardo, 1984 .

Stereoselectivity in the synthesis of 2,5-disubstituted pyrrolidines

T. Gallagher, R. G. Kinsman, D. Lathbury, 1987 .

Heterocyclic ketones as pre-formed building blocks. Synthesis of (−)-slaframine

T. Gallagher, P. Szeto, D. Lathbury, 1995 .

Carbohydrate building blocks in heterocyclic chemistry. Synthetic studies directed towards the herbicidins

T. Gallagher, A. Griffin, H. Binch, 1996 .

Reductive cleavage as a route to carbohydrate enolates. Applications to the synthesis of C-linked disaccharides

T. Gallagher, F. Lichtenthaler, M. Ramsay, 1995 .

Carbohydrate-Based Enolates as Heterocyclic Building Blocks. Synthesis of the Herbicidin Glycoside

T. Gallagher, N. Newcombe, M. Mahon, 1993 .

Kowalski ester homologation. application to the synthesis of beta-amino esters.

T. Gallagher, Carmen Concellón, D. Gray, 2004, The Journal of organic chemistry.

Synthesis of elusive 1,4-dihydrocarbazoles via intramolecular trapping of an indole-2,3-quinodimethane

T. Gallagher, P. Magnus, C. Exon, 1982 .

Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

D E Griswold, J. Boehm, S. Kassis, 1998, Bioorganic & medicinal chemistry letters.

C-Glycosides of 2-Amino-2-deoxy Sugars. β-C-Glycosides and 1,1-Disubstituted Variants.

T. Gallagher, Yan Liu, 2004 .

Galacto, gluco, manno, and disaccharide-based C-glycosides of 2-amino-2-deoxy sugars.

T. Gallagher, Yan Liu, D. Walter, 2002, Organic letters.

Asymmetric synthesis via electrophile-mediated cyclisations

T. Gallagher, D. N. A. Fox, 1990 .

Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens.

T. Gallagher, P. Brenner, R. Bedford, 2016, The Journal of organic chemistry.

Optically Active Compounds

T. Gallagher, D. N. A. Fox, 2000 .

Indole-2,3-quinodimethanes: a new strategy for the synthesis of tetracyclic systems of indole alkaloids

T. Gallagher, P. Magnus, C. Exon, 1983 .

Allene-based electrophile-mediated cyclisations: efficient synthesis of medium ring azacycles

T. Gallagher, R. Shaw, 1994 .

Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems

T. Gallagher, J. Bateson, P. O'hanlon, 2005 .

S-alkyl dithioformates as 1,3-dipolarophiles. Generation of C(2)-unsubstituted penems.

T. Gallagher, J. Bateson, P. O'hanlon, 2004, Organic letters.

The Azomethine Ylide Strategy for β-Lactam Synthesis

T. Gallagher, 2000 .

Electrophile-mediated cyclisations involving the allene π-system. Stereoselectivity and synthetic utility of PdII-catalysed heteroatom cyclisation reactions. X-Ray molecular structure of methyl 2-[trans-3-phenyl-N-(p-tolylsulfonyl)pyrrolidin-2-yl]acrylate

T. Gallagher, I. Davies, M. Mahon, 1992 .

Copper‐Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β‐and γ‐Aminoalkyl)boronic Esters

T. Gallagher, R. Bedford, Nina Ursinyova, 2015, European Journal of Organic Chemistry.

Hydroxyl-directed reduction of β-hydroxycycloalkanones as a stereoselective route to 1,3-diols: X-ray crystal structure and structural features of (1R*,2R*,6S*)-2-[hydroxy(phenyl)methyl]cyclopentanol

T. Gallagher, M. Mahon, S. Thompson, 1995 .

2-Amino ketene S,S-acetals as α-amino acid homoenolate equivalents. Synthesis of 3-substituted prolines and molecular structure of 2-(N-pivaloylpyrrolidin-2-ylidene)-1,3-dithiane

W. O. Moss, T. Gallagher, R. Bradbury, 1992 .

Synthesis of (.+-.)-10,22-dioxokopsane and (.+-.)-kopsanone, heptacyclic indole alkaloids. Synthetic and mechanistic studies

T. Gallagher, J. Huffman, P. Magnus, 1984 .

Metal ion-mediated heteroatom cyclisations. Application of aryl/alkenyl palladium(II)-based electrophilic triggers

T. Gallagher, I. Davies, D. Scopes, 1993 .

Synthesis of functionalised azabicycles via a regiospecific intramolecular aldol reaction

T. Gallagher, S. Thompson, R. Stockman, 1996 .

Heterocyclisation via 1,3-cyclic sulphates. Asymmetric synthesis of (+)-sedridine

T. Gallagher, B. Littler, I. Boddy, 2004 .

Synthesis of vinyl epoxides via a three-component coupling

T. Gallagher, N. Mathews, M. Rowbottom, 1998 .

Pentacyclic systems of indole alkaloids. Formation of the C11-C12 bond. Two syntheses of (.+-.)-aspidospermidine

T. Gallagher, J. Huffman, P. Magnus, 1983 .

Synthetic and stereochemical studies directed towards anatoxin-a

T. Gallagher, R. G. Kinsman, N. Huby, 1991 .

Stereoselectivity in electrophile-mediated cyclisations. AgI-Catalysed synthesis of disubstituted pyrrolidines; crystal structure of cis-5-phenyl-N-tosylpyrrolidin-2-ylmethyl 4-bromobenzoate

T. Gallagher, M. Mahon, K. Molloy, 1991 .

Asymmetric synthesis via allenes: synthesis of (R)-(−)-coniine

T. Gallagher, D. Lathbury, 1986 .

The cyclisation of secondary allenic alcohols

T. Gallagher, 1984 .

Chemistry of the herbicidins. Reactivity of silyl enol ethers derived from simple and carbohydrate-based tetrahydropyrans

T. Gallagher, N. Newcombe, D. Alker, 1994 .

Studies on the Synthesis of the Antitumor Agent CC-1065: Synthesis of the Unprotected Cyclopropapyrroloindole A Portion (XIV) Using the 3,3′-Bipyrrole Strategy.

T. Gallagher, P. Magnus, Y. Or, 1987 .

Neurotoxic alkaloids: synthesis of (±)-anatoxin-a

T. Gallagher, Peter G. Vernon, P. Vernon, 1987 .

Ketene S,S-acetals as 1,3-dipolarophiles: application to the synthesis of polyhydroxylated pyrrolidines

W. O. Moss, T. Gallagher, R. Bradbury, 1992 .

Asymmetric synthesis of functionalised pyrrolidines. Highly diastereoselective cyclisations mediated by sulfide and sulfoxide ligands

T. Gallagher, I. Davies, D. Scopes, 1992 .

N-substituted pyrrolidin-3-ones as heterocyclic building blocks. Enantioselective synthesis of 8-epi- and 1,8,8a-triepi-castanospermine

T. Gallagher, M. Hadley, R. Subramanian, 1992 .

C-Glycosides of 2-amino-2-deoxy sugars. beta-C-Glycosides and 1,1-disubstituted variants.

T. Gallagher, Yan Liu, 2004, Organic letters.

Action of a library of O-glycosylation inhibitors on the growth of human colorectal cancer cells in culture.

T. Gallagher, C. Paraskeva, A. Corfield, 2005, Biochemical Society transactions.

Radical-Mediated Synthesis of α-C-Glycosides Based on N-Acyl Galactosamine.

T. Gallagher, D. Walter, R. SanMartin, 2001 .

Asymmetric synthesis of functionalised pyrrolidines. The role of a stereogenic centre on nitrogen

T. Gallagher, M. Mahon, D. Lathbury, 1989 .

Palladium(II)-mediated routes to functionalised heterocycles

T. Gallagher, D. Lathbury, Peter G. Vernon, 1986 .

Studies directed towards the synthesis of herbicidins. Model study based on late stage N-glycosylation

T. Gallagher, H. Binch, 1996 .

Synthesis of a model herbicidin nucleoside via late stage N-glycosylation

T. Gallagher, H. Binch, 1996 .

2-Keto sugars as preformed heterocyclic building blocks. Synthetic studies

T. Gallagher, N. Newcombe, D. Alker, 1993 .

Regiospecific enolates from tetrahydropyran-3-one. Synthetic equivalents of a thermodynamically and kinetically disfavoured enolate isomer

T. Gallagher, P. Cox, S. Lister, 1990 .

Regioselective directed lithiation of N -Boc-3-hydroxypyrrolidine. Synthesis of 2-substituted 4-hydroxypyrrolidines

T. Gallagher, S. Macdonald, T. Peakman, 1998 .

Synthesis and reactivity of a novel group of hydroxylamine-containing 2π- and 4π-components

T. Gallagher, D. Walter, C. Frampton, 1998 .

ORGANOZINC REAGENTS FOR THE NUCLEOPHILIC C-GLYCOSYLATION OF GLYCALS

T. Gallagher, S. Thorn, 1996 .

New methods for alkaloid synthesis : Generation of indole-2, 3-diquinomethanes as a route to indole alkaloids

T. Gallagher, P. Magnus, 1981 .

Synthesis of the antileukemic agent (.+-.)-steganone using a stereoconvergent biaryl coupling reaction

T. Gallagher, P. Magnus, James Schultz, 1985 .

A short synthesis of (±)-steganone and (±)-steganacin

T. Gallagher, P. Magnus, James Schultz, 1984 .

Studies on the synthesis of the antitumour agent CC-1065. Synthesis of the cyclopropapyrroloindole portion

T. Gallagher, P. Magnus, 1984 .

Directed Deprotonation—Transmetalation as a Route to Substituted Pyridines.

T. Gallagher, J. Spencer, G. Karig, 2001 .

Synthesis of (.+-.)-kopsanone and (.+-.)-10,22-dioxokopsane, hetacyclic indole alkaloids

T. Gallagher, P. Magnus, 1983 .

Asymmetric Reduction of Lactam-Based β-Aminoacrylates. Synthesis of Heterocyclic β(2)-Amino Acids.

T. Gallagher, M. Perry, H. Campello, 2016, Organic letters.

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Philip R. Cohen, P. Cohen, John C. Lee, 1995, FEBS letters.

Enzymic glycosylation using 6-substituted glycosides as donor substrates: a novel route to functionalised disaccharides

T. Gallagher, E. Vulfson, S. Davies, 1999 .

Enzymic Glycosylation Using 6-Substituted Glycosides as Donor Substrates: A Novel Route to Functionalized Disaccharides.

T. Gallagher, E. Vulfson, S. Davies, 1999 .

Regiospecific tetrahydropyran-3-one enolates. Synthesis and reactivity of silyl enol ether derivatives

T. Gallagher, M. Mahon, P. Cox, 1989 .

Synthesis of 3-hydroxy and 3-amino 2-substituted N-heterocycles via enamine oxidation and aziridination

A. Orpen, T. Gallagher, K. M. Anderson, 1998 .

Indole-2,3-quinodimethan route to Aspidosperma alkaloids: synthesis of dl-aspidospermidine

T. Gallagher, J. Huffman, P. Magnus, 1982 .

Synthesis of 3-Hydroxy and 3-Amino 2-Substituted N-Heterocycles via Enamine Oxidation and Aziridination.

A. Orpen, T. Gallagher, K. M. Anderson, 1999 .

Donor-acceptor effects on the stability of radicals derived from .alpha.-dialkylamino ketones

T. Gallagher, Xian‐Man Zhang, F. Bordwell, 1991 .

Synthesis of medium ring azacycles via allene-based cyclisations: evaluation of possible mechanistic pathways

T. Gallagher, I. Davies, R. Wisedale, 1994 .

Synthesis and reactivity of lithiated γ-functionalised ketene dithioacetals. Generation of a flexible β-lithioacrylate equivalent

T. Gallagher, E. Dziadulewicz, D. M. Hodgson, 1988 .

Synthesis of methyl 2-acetamido-2,3,6-trideoxy-β-l-lyxo-hexopyranoside☆

T. Gallagher, D. Horton, 1983 .

Ketene-S,S-acetals as 1,3-dipolarophiles towards azides. A new synthetic entry into cyclic amino acids

W. O. Moss, T. Gallagher, R. Bradbury, 1992 .

Generation of α-amino acid homoenolate equivalents. Synthesis of 3-substituted prolines.

W. O. Moss, T. Gallagher, R. Bradbury, 1991 .

Ketene dithioacetals as 1,3-dipolarophiles. Applications to the synthesis of cyclic amino acids

W. O. Moss, T. Gallagher, R. Bradbury, 1990 .

Regioselective α-alkylation of extended enolates derived from enamines of β-keto esters. Studies relating to the synthesis of 2-substituted 2-alkoxycarbonylcycloalkanones

T. Gallagher, P. Hallett, J. Marshall, 1992 .

β-Lithiated enol ethers as enolate equivalents. Application to N-substituted pyrrolidin-3-ones

T. Gallagher, M. Hadley, M. Giles, 1990 .

Synthesis of 4‐[2‐(4‐Azidophenyl)‐5‐(3‐iodo‐125I‐phenyl)‐1H‐imidazol‐4‐yl]pyridine (SB 206718‐[125I]), a pyridinyl imidazole cytokine inhibitor

T. Gallagher, S. Landvatter, K. T. Garnes, 1996 .

β-Substituted ketene thioacetals as β-lithioacrylate equivalents. The synthesis of (±)-eldanolide

T. Gallagher, E. Dziadulewicz, 1985 .

Phenoxypyrimidine inhibitors of p38alpha kinase: synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles.

J. Boehm, M. Bower, S. Kassis, 2001, Bioorganic & medicinal chemistry letters.

Towards Iron-Catalysed Suzuki Biaryl Cross-Coupling: Unusual Reactivity of 2-Halobenzyl Halides

T. Gallagher, R. Bedford, Dominic R. Pye, 2015, Synthesis.

A novel method for the 1,2-carbonyl transposition of pleuromutilins

T. Gallagher, J. Axten, C. Duquenne, 2010 .

Homoanatoxin: a potent analogue of anatoxin-A.

E. Albuquerque, T. Gallagher, S. Wonnacott, 1992, Biochemical pharmacology.

Copper‐Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β‐and γ‐Aminoalkyl)boronic Esters

T. Gallagher, R. Bedford, Nina Ursinyova, 2015, European Journal of Organic Chemistry.

Palladium(0)-Catalyzed Arylations Using Pyrrole and Indole 2-Boronic Acids.

T. Gallagher, Christopher N. Johnson, G. Stemp, 1998 .