P. Lograsso

发表

Molecular basis for p38 protein kinase inhibitor specificity.

E. A. O'neill, J. Lisnock, A. Tebben, 1998, Biochemistry.

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow‐Derived Mouse Mesenchymal Stem Cells via a p53‐Dependent Mechanism: Implications for Long‐Term Culture Expansion

P. Lograsso, L. Ortiz, Siddaraju Boregowda, 2012, Stem cells.

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.

J. Lisnock, P. Lograsso, G. Scapin, 2003, Chemistry & biology.

Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.

P. Lograsso, M. Cameron, Hajeung Park, 2013, Angewandte Chemie.

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38*

P. Lograsso, J. Habel, Y. Ling, 2009, Journal of Biological Chemistry.

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.

P. Lograsso, Hajeung Park, Yangbo Feng, 2015, ACS medicinal chemistry letters.

JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of Parkinson's Disease.

G. Robertson, P. Lograsso, M. Cameron, 2011, ACS chemical neuroscience.

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2011, Bioorganic & medicinal chemistry letters.

Kinetic mechanism for p38 MAP kinase.

E. A. O'neill, B. Frantz, S. O'keefe, 1997, Biochemistry.

Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III.

D. Jewell, P. Lograsso, D. Silverman, 1990, Biochemistry.

Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis.

D. Jewell, P. Lograsso, D. Silverman, 1991, Biochemistry.

Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).

J. Trauger, P. Lograsso, A. Jiang, 2002, Biochemistry.

Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1).

P. Lograsso, J. Chambers, J. Laughlin, 2011, ACS chemical biology.

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation*

P. Lograsso, J. Chambers, 2011, The Journal of Biological Chemistry.

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.

P. Lograsso, J. Habel, Y. Ling, 2009, Bioorganic & medicinal chemistry letters.

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

P. Lograsso, J. Habel, Y. Ling, 2007, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

P. Lograsso, J. Habel, M. Cameron, 2010, Journal of medicinal chemistry.

Serum-glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway

P. Lograsso, S. Iqbal, S. Howard, 2015 .

Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway

P. Lograsso, S. Iqbal, S. Howard, 2015, Molecular and Cellular Biology.

Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo*

P. Lograsso, J. Chambers, S. Howard, 2012, The Journal of Biological Chemistry.

Enzyme Kinetics and Interaction Studies for Human JNK1β1 and Substrates Activating Transcription Factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun)*

P. Lograsso, Mariana Figuera-Losada, 2012, The Journal of Biological Chemistry.

Enzyme Kinetics and Interaction Studies for Human JNK11 and Substrates Activating Transcription Factor 2 (ATF2) and

P. Lograsso, Mariana Figuera-Losada, 2012 .

Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.

P. Lograsso, S. Schürer, J. Pocas, 2010, Journal of medicinal chemistry.

Rho kinase inhibitors: a patent review (2012 – 2013)

P. Lograsso, Yangbo Feng, 2014, Expert opinion on therapeutic patents.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

P. Lograsso, S. Schürer, J. Pocas, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.

P. Lograsso, J. Pocas, Yan Yin, 2011, Bioorganic & medicinal chemistry letters.

Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors

P. Lograsso, J. Pocas, T. Bannister, 2011 .

The development of benzimidazoles as selective rho kinase inhibitors.

P. Lograsso, J. Pocas, Yan Yin, 2010, Bioorganic & Medicinal Chemistry Letters.

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.

P. Lograsso, S. Schürer, J. Pocas, 2008, Bioorganic & medicinal chemistry letters.

Chroman-3-amides as potent Rho kinase inhibitors.

P. Lograsso, S. Schürer, M. Cameron, 2008, Bioorganic & medicinal chemistry letters.

Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells.

J. Trauger, P. Lograsso, J. Stephens, 2002, Archives of biochemistry and biophysics.

Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.

P. Lograsso, S. Pan, Valer Jeso, 2011, Organic letters.

Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats*

P. Lograsso, J. Chambers, S. Iqbal, 2012, The Journal of Biological Chemistry.

Assay for IκB Kinases Using an in Vivo Biotinylated IκB Protein Substrate

P. Lograsso, D. Wisniewski, J. Calaycay, 1999 .

Solvent history dependence of gramicidin A conformations in hydrated lipid bilayers.

P. Lograsso, T. Cross, F. Moll, 1988, Biophysical journal.

Mechanistic characterization for c-jun-N-Terminal Kinase 1alpha1.

P. Lograsso, Brian Ember, 2008, Archives of biochemistry and biophysics.

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.

P. Lograsso, J. Pocas, Yan Yin, 2013, Journal of medicinal chemistry.

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

P. Lograsso, S. Schürer, J. Pocas, 2009, Bioorganic & medicinal chemistry letters.

Solid-state 15N NMR of oriented lipid bilayer bound gramicidin A'.

L. Nicholson, P. Lograsso, T. Cross, 1987, Biochemistry.

Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III.

P. Lograsso, D. Silverman, P. Laipis, 1993, Biochemistry.

Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3alpha1.

P. Lograsso, T. Kamenecka, Brian Ember, 2008, Biochemistry.

Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

P. Lograsso, Hajeung Park, Yangbo Feng, 2015, Scientific Reports.

Synthesis of potent bicyclic bisarylimidazole c-Jun N-terminal kinase inhibitors by catalytic C-H bond activation.

P. Lograsso, J. Ellman, R. Bergman, 2007, Journal of the American Chemical Society.

Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

Weilin Wu, P. Lograsso, Ji-Hak Jeong, 2015, Journal of medicinal chemistry.

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

P. Lograsso, Hajeung Park, Yangbo Feng, 2014, Journal of medicinal chemistry.

Inhibitors of c-jun-N-terminal kinase (JNK).

P. Lograsso, T. Kamenecka, 2008, Mini reviews in medicinal chemistry.

Nitrogen-hydrogen bond length determinations and implications for the gramicidin channel conformation and dynamics from nitrogen-15-proton dipolar interactions

L. Nicholson, P. Lograsso, T. Cross, 1989 .

Experimental observation of orientational dispersion in the peptide backbone of the gramicidin cation channel

L. Nicholson, P. Lograsso, T. Cross, 1989 .

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.

Rongshi Li, P. Lograsso, Rongshi Li, 2016, Journal of medicinal chemistry.

Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine.

D. Jewell, P. Lograsso, D. Silverman, 1991, Biochemistry.

Comparison of Miniaturized Time-Resolved Fluorescence Resonance Energy Transfer and Enzyme-Coupled Luciferase High-Throughput Screening Assays to Discover Inhibitors of Rho-Kinase II (ROCK-II)

T. Spicer, P. Lograsso, J. Habel, 2008, Journal of biomolecular screening.

Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

P. Lograsso, Hajeung Park, Yangbo Feng, 2016, Journal of medicinal chemistry.

Discovery of potent and selective covalent inhibitors of JNK.

Taebo Sim, Mario Niepel, Scott B Ficarro, 2012, Chemistry & biology.

Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.

P. Lograsso, S. Pollack, P. Hunt, 2005, Archives of biochemistry and biophysics.

Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.

P. Lograsso, S. Harper, S J Harper, 2001, Cellular signalling.

Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III.

P. Lograsso, D. Silverman, P. Laipis, 1993, Biochemistry.

Mechanism of activation for Zap-70 catalytic activity.

P. Lograsso, L. Frank, J. Hawkins, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.

P. Lograsso, Yangbo Feng, 2009, Current topics in medicinal chemistry.

Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II.

P. Lograsso, M. Cameron, Claudia H. Ruiz, 2007, Bioorganic & medicinal chemistry letters.

A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

P. Lograsso, J. Chambers, Hajeung Park, 2013, ACS chemical biology.

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

N. Kamasawa, P. Lograsso, L. Volpicelli-Daley, 2018, Proceedings of the National Academy of Sciences.

Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38alpha protein kinase.

J. Lisnock, P. Lograsso, R. Cummings, 2005, Analytical biochemistry.

Structural mechanisms of allostery and autoinhibition in JNK family kinases.

Jerome C Nwachukwu, Kendall W Nettles, J. Nwachukwu, 2012, Structure.

Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Li Lin, P. Lograsso, M. Cameron, 2011, ACS chemical neuroscience.

Comparison of the Effects of Apo(a) Kringle IV-10 and Plasminogen Kringles on the Interactions of Lipoprotein(a) with Regulatory Molecules

P. Lograsso, L. Curtiss, E. Madison, 1999, Thrombosis and Haemostasis.

Cloning, expression, and characterization of human apolipoprotein(a) kringle IV37.

P. Lograsso, S. Cornell-Kennon, B. Boettcher, 1994, The Journal of biological chemistry.

p38 map kinase substrate specificity differs greatly for protein and peptide substrates.

B. Frantz, P. Lograsso, J. Hawkins, 2000, Archives of biochemistry and biophysics.

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

P. Lograsso, S. Schürer, Yan Yin, 2008, Journal of medicinal chemistry.

Inhibitors of the JNK signaling pathway

P. Lograsso, S. Harper, 2001 .

Detection of myosin light chain phosphorylation--a cell-based assay for screening Rho-kinase inhibitors.

P. Lograsso, Yangbo Feng, T. Schröter, 2008, Biochemical and biophysical research communications.

Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions

P. Lograsso, Su Gao, S. Howard, 2017, Scientific Reports.

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats.

P. Lograsso, S. Schürer, J. Pocas, 2010, ACS medicinal chemistry letters.

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

P. Lograsso, M. Cameron, Y. Ling, 2014, Bioorganic & medicinal chemistry letters.

Amino acid derived quinazolines as Rock/PKA inhibitors.

P. Lograsso, J. Pocas, M. Cameron, 2013, Bioorganic & medicinal chemistry letters.

Assay for IkappaB kinases using an in vivo biotinylated IkappaB protein substrate.

P. Lograsso, D. Wisniewski, J. Calaycay, 1999, Analytical biochemistry.

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

P. Lograsso, Hajeung Park, Yangbo Feng, 2014, Journal of medicinal chemistry.

Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase.

P. Lograsso, D. Soltis, B. Boettcher, 1993, Archives of biochemistry and biophysics.

Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.

P. Griffin, J. Lisnock, B. Frantz, 2000, Biochemistry.

Kinetic mechanism for human Rho-Kinase II (ROCK-II).

J. Trauger, P. Lograsso, F. Lin, 2002, Biochemistry.