R. Gussio

发表

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.

L. Meijer, E. Sausville, D. Zaharevitz, 1999, Journal of medicinal chemistry.

The Detection and Characterization of Ions, DNA, and Proteins Using Nanometer‐Scale Pores

R. Gussio, S. Henrickson, M. Misakian, 2008 .

All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach.

N. Pattabiraman, D. Zaharevitz, G. Kellogg, 1996, Journal of medicinal chemistry.

Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones.

L. Meijer, D. Zaharevitz, Alexander Weber, 2004, Journal of medicinal chemistry.

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

D. Zaharevitz, P. Wipf, R. Gussio, 2005, Journal of medicinal chemistry.

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.

E. Nogales, K. Downing, T. Fojo, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Rick Gussio, Sina Bavari, E. Sausville, 2003, Biochemical and biophysical research communications.

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

P. Wipf, A. Brunger, R. Gussio, 2010, PloS one.

Synthesis and biological evaluation of inhibitors of botulinum neurotoxin metalloprotease

P. Wipf, R. Gussio, S. Bavari, 2009 .

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.

P. Wipf, R. Gussio, S. Bavari, 2009, Bioorganic & medicinal chemistry letters.

Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore

P. Wipf, R. Gussio, S. Bavari, 2008, ChemMedChem.

Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.

W. Milhous, R. Gussio, S. Bavari, 2008, Journal of medicinal chemistry.

Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

R. Gussio, S. J. Hickford, J. Blunt, 2006, Molecular Pharmacology.

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

D. Zaharevitz, R. Gussio, K. Kodukula, 2005, Bioorganic & medicinal chemistry.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

N. Bottini, L. Cazares, R. Gussio, 2015, PloS one.

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate.

A. Brunger, R. Gussio, T. Fenn, 2008, Structure.

CDK1‐Inhibitory Activity of Paullones Depends on Electronic Properties of 9‐Substituents

L. Meijer, D. Zaharevitz, M. Leost, 2004, Archiv der Pharmazie.

A theoretical study of anthrax lethal factor inhibition by a set of novel carbamimidolyl-aryl-vinyl-carboxamidines: A possible mechanism involving zinc-ligation by amidine

R. Gussio, S. Bavari, I. Topol, 2007 .

A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds

A. Musacchio, R. Gussio, R. Silvestri, 2010, PloS one.

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

R. Gussio, L. Tessarollo, S. Bavari, 2011, Stem cell research.

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

G. Ruthel, P. Wipf, R. Gussio, 2010 .

Novel Broad-Spectrum Bis-(Imidazolinylindole) Derivatives with Potent Antibacterial Activities against Antibiotic-Resistant Strains

R. Ulrich, R. Gussio, D. Moir, 2009, Antimicrobial Agents and Chemotherapy.

Biochemical genetic analysis of indanocine resistance in human leukemia.

T. Kipps, R. Gussio, D. Carson, 2001, Cancer research.

Chemical synthesis and biological properties of pyridine epothilones.

D. Zaharevitz, K. Nicolaou, K. Altmann, 2000, Chemistry & biology.

Synthesis and Biological Evaluation of Inhibitors of Botulinum Neurotoxin Metalloprotease.

P. Wipf, R. Gussio, S. Bavari, 2009 .

A quantum-mechanical study of metal binding sites in zinc finger structures

J. Erickson, R. Gussio, J. Casas-Finet, 1998 .

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.

Brian D. Peyser, P. Wipf, M. Arkin, 2017, Organic & biomolecular chemistry.

Epoxide-containing side chains enhance antiproliferative activity of paullones.

L. Meijer, D. Zaharevitz, M. Leost, 2005, European journal of medicinal chemistry.

Homology Model of the CDK1/cyclin B Complex

E. Sausville, N. Pattabiraman, D. Zaharevitz, 2004, Journal of biomolecular structure & dynamics.

Synthesis and Biological Evaluation of 12,13‐Cyclopropyl and 12,13‐Cyclobutyl Epothilones

T. Fojo, D. Zaharevitz, A. Ritzén, 2001, Chembiochem : a European journal of chemical biology.

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

A. Marcus, R. Gussio, P. Giannakakou, 2005, Biochemistry.

A pseudoreceptor docking study of 4,5-α-epoxymorphinans with a range of dielectric constants

Jih-Hsiang Chen, Rick Gussio, Sovitj Pou, 1992, Journal of computer-aided molecular design.

2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.

L Meijer, R Gussio, D W Zaharevitz, 2000, Bioorganic & medicinal chemistry letters.

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.

Peter Wipf, Rick Gussio, William Furey, 2002, Molecular pharmacology.

Interactions of Halichondrin B and Eribulin with Tubulin

Amos B. Smith, Murray H. G. Munro, Rick Gussio, 2011, J. Chem. Inf. Model..

Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Eric A. Horne, R. Gussio, M. Wagenbach, 2018, European journal of medicinal chemistry.

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols).

R. Gussio, S. Bavari, J. Robertson, 2008, Biophysical journal.

Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition.

L Meijer, N Pattabiraman, R Gussio, 2000, Anti-cancer drug design.

A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.

Todd D. Westergard, Adam C. Searleman, Han Liu, 2012, Cancer research.

Therapeutics , Targets , and Chemical Biology A Pharmacologic Inhibitor of the Protease Taspase 1 Effectively Inhibits Breast and Brain Tumor Growth

Todd D. Westergard, Adam C. Searleman, Han Liu, 2012 .

Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Rick Gussio, Laurent Meijer, Conrad Kunick, 2005, Chembiochem : a European journal of chemical biology.

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy

Brian D. Peyser, P. Wipf, R. Gussio, 2019, Molecular Cancer Therapeutics.

Synthesis of Heterocyclic Triads by Pd-Catalyzed Cross-Couplings and Evaluation of Their Cell-Specific Toxicity Profile

P. Wipf, R. Gussio, J. Burnett, 2014, Organic letters.

Reduced Expression of CD45 Protein-tyrosine Phosphatase Provides Protection against Anthrax Pathogenesis*

Steven B. Bradfute, G. Ruthel, P. Iversen, 2009, Journal of Biological Chemistry.

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Rick Gussio, Sina Bavari, G. Ruthel, 2007, Journal of medicinal chemistry.

Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons*

Andrea M. Stahl, G. Ruthel, P. Wipf, 2007, Journal of Biological Chemistry.

Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons

Brian D. Peyser, R. Gussio, L. Tessarollo, 2015, Neurotoxicity Research.

Use of 3D QSAR methodology for data mining the National Cancer Institute Repository of Small Molecules: application to HIV-1 reverse transcriptase inhibition.

N Pattabiraman, R Gussio, G E Kellogg, 1998, Methods.

Solution Structure of Taxol Determined Using a Novel Feedback-Scaling Procedure for Noe-Restrained Molecular Dynamics

Raul E. Cachau, John W. Erickson, Rick Gussio, 1994, Int. J. High Perform. Comput. Appl..

The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.

R. Gussio, S. Bavari, J. Burnett, 2012, European journal of medicinal chemistry.

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.

Rick Gussio, Tam Luong Nguyen, D. Scudiero, 2006, Bioorganic & medicinal chemistry.

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

D. Zaharevitz, W. Weissenhorn, R. Gussio, 2005, Journal of structural biology.

Identification of small molecule inhibitors of anthrax lethal factor

Lewis C Cantley, Rick Gussio, Sina Bavari, 2004, Nature Structural &Molecular Biology.

Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade*

Rick Gussio, Martin Misakian, Sina Bavari, 2005, Journal of Biological Chemistry.

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

D. Taramelli, R. Gussio, S. Bavari, 2011, Journal of medicinal chemistry.

Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds

L. Lo Presti, R. Gussio, P. De Wulf, 2012, Molecular Cancer Therapeutics.

Interaction of pseudolaric acid B with the colchicine site of tubulin.

S. Qiu, R. Gussio, T. Nguyen, 2012, Biochemical pharmacology.

Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons

Brian D. Peyser, R. Gussio, L. Tessarollo, 2015, Neurotoxicity Research.

Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis.

G. Ruthel, J. Lazo, R. Gussio, 2007, Chemistry & biology.

The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A

Xiaoming Xu, Rick Gussio, Ernest Hamel, 2010, J. Chem. Inf. Model..

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

G L Snyder, L Meijer, D W Zaharevitz, 2000, European journal of biochemistry.

Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP.

R. Gussio, E. Hamel, C. McGrath, 2009, Archives of biochemistry and biophysics.

Anthrax toxin-induced rupture of artificial lipid bilayer membranes.

R. Gussio, S. Bavari, J. Reiner, 2013, The Journal of chemical physics.

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate.

A. Brunger, R. Gussio, T. Fenn, 2008, Structure.

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.

R. Gussio, A. Hermone, J. Burnett, 2009, Bioorganic & medicinal chemistry letters.

Anthrax toxin-induced rupture of artificial lipid bilayer membranes.

R. Gussio, S. Bavari, J. Reiner, 2013, The Journal of chemical physics.