J. Winum

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Sulfamates and their therapeutic potential

C. Supuran, A. Scozzafava, J. Winum, 2005, Medicinal research reviews.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

C. Supuran, A. Scozzafava, J. Winum, 2004, Bioorganic & medicinal chemistry letters.

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

P. Joseph, C. Supuran, A. Scozzafava, 2010, Journal of medicinal chemistry.

New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.

C. Supuran, A. Scozzafava, J. Winum, 2006, Mini reviews in medicinal chemistry.

Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

J. Winum, S. Ouahrani-Bettache, S. Köhler, 2017, Journal of enzyme inhibition and medicinal chemistry.

Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues.

J. Winum, Marie Lopez, François Turtaut, 2014, Bioorganic & medicinal chemistry letters.

Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors.

P. Joseph, J. Winum, J. Montero, 2011, Organic & biomolecular chemistry.

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.

P. Joseph, C. Supuran, A. Scozzafava, 2011, Bioorganic & medicinal chemistry.

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

C. Supuran, A. Scozzafava, J. Winum, 2010, Bioorganic & medicinal chemistry letters.

Drug Design of Zinc-Enzyme Inhibitors

C. Supuran, J. Winum, 2009 .

Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine.

P. Joseph, J. Winum, J. Montero, 2007, Bioorganic & medicinal chemistry.

Nanostructures and innovative delivery systems for overcoming cancer resistance

J. Winum, 2021 .

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

P. Lambin, L. Dubois, C. Supuran, 2020, Molecules.

Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.

C. Supuran, A. Scozzafava, J. Winum, 2008, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.

C. Supuran, J. Winum, A. Innocenti, 2010, Bioorganic & medicinal chemistry letters.

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.

C. Supuran, A. Scozzafava, J. Winum, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.

C. Supuran, A. Scozzafava, J. Winum, 2011, Bioorganic & medicinal chemistry letters.

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells

J. Winum, N. Zambrano, D. Sarnataro, 2015, BioMed research international.

Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases.

C. Supuran, J. Winum, S. Ulrich, 2015, Chemistry.

Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity

E. Langella, C. Supuran, J. Winum, 2019, Journal of enzyme inhibition and medicinal chemistry.

Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations

E. Langella, C. Supuran, J. Winum, 2017, Journal of enzyme inhibition and medicinal chemistry.

Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

C. Supuran, A. Scozzafava, B. Telfer, 2012, Journal of medicinal chemistry.

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.

C. Supuran, A. Scozzafava, J. Winum, 2012, Bioorganic & medicinal chemistry letters.

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

C. Supuran, A. Scozzafava, S. Dedhar, 2011, Journal of medicinal chemistry.

Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†

C. Supuran, J. Winum, A. Nocentini, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1

J. Winum, 2016, Expert opinion on therapeutic patents.

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

S. Carradori, C. Supuran, J. Winum, 2021, Journal of enzyme inhibition and medicinal chemistry.

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation.

C. Supuran, J. Winum, S. Ulrich, 2017, Chemistry.

Grafting of 4-aminomethylbenzensulfonamide-lipoic acid conjugate on gold nanoparticles

J. Winum, M. Abdaoui, M. Stiti, 2012 .

Carbonic Anhydrase Inhibitors: Design of Membrane‐Impermeant Copper(II) Complexes of DTPA‐, DOTA‐, and TETA‐Tailed Sulfonamides Targeting the Tumor‐Associated Transmembrane Isoform IX

C. Supuran, A. Scozzafava, J. Winum, 2008, ChemMedChem.

Designing carbonic anhydrase inhibitors for the treatment of breast cancer

C. Supuran, J. Winum, 2015, Expert opinion on drug discovery.

Carbonic Anhydrase Inhibitors Featuring a Porphyrin Scaffold: Synthesis, Optical and Biological Properties

C. Supuran, S. Clément, J. Winum, 2022, European Journal of Organic Chemistry.

Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.

C. Supuran, A. Scozzafava, J. Winum, 2008, Bioorganic & medicinal chemistry letters.

Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O6-Methylguanine DNA-Methyltransferase Expression

J. Winum, J. Montero, P. Cuq, 2003, Journal of Pharmacology and Experimental Therapeutics.

1,5‐Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors

C. Supuran, J. Winum, A. Nocentini, 2021, Archiv der Pharmazie.

Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)

C. Supuran, J. Winum, A. Nocentini, 2018, Expert opinion on therapeutic patents.

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition.

C. Supuran, J. Winum, D. Vullo, 2016, Chemical communications.

Emerging trends in enzyme inhibition by multivalent nanoconstructs.

J. Winum, S. Ulrich, A. Marra, 2015, Organic & biomolecular chemistry.

Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action.

C. Supuran, E. Masini, J. Winum, 2015, Journal of medicinal chemistry.

Synthesis of multiply substituted, ion channel forming octi(p-phenylene)s: theme and variations.

J. Winum, S. Matile, N. Sakai, 2000, Organic letters.

Meet the Editorial Board Member

J. Winum, 2022, Anti-Cancer Agents in Medicinal Chemistry.

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

P. Lambin, L. Dubois, C. Supuran, 2019, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.

C. Supuran, A. Scozzafava, J. Winum, 2006, Journal of medicinal chemistry.

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella.

J. Winum, Marie Lopez, S. Köhler, 2012, Journal of inorganic biochemistry.

Synthesis and biological evaluation of a new class of anti-brucella compounds targeting histidinol dehydrogenase: α-O-arylketones and α-S-arylketones derived from histidine

J. Winum, J. Montero, François Turtaut, 2011 .

Multivalent Carbonic Anhydrases Inhibitors †

C. Supuran, J. Winum, P. Dumy, 2019, International journal of molecular sciences.

Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms.

C. Supuran, A. Scozzafava, J. Winum, 2011, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

C. Supuran, A. Scozzafava, J. Winum, 2009, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.

C. Supuran, A. Scozzafava, J. Winum, 2005, Journal of medicinal chemistry.

Dominant behaviours in the expression of human carbonic anhydrase hCA I activity.

C. Supuran, J. Winum, M. Barboiu, 2014, Chemical communications.

Therapeutic applications of glycosidic carbonic anhydrase inhibitors

C. Supuran, J. Winum, S. Poulsen, 2009, Medicinal research reviews.

Synthesis of new Targretin analogues that induce apoptosis in leukemia HL-60 cells.

J. Winum, J. Montero, T. Commes, 2002, Bioorganic & medicinal chemistry letters.

Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors

C. Supuran, J. Winum, A. Maresca, 2013, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.

J. Winum, J. Montero, P. Cuq, 2003, European journal of medicinal chemistry.

N‐Chlorosulfonyloxazolidin‐2‐ones: Synthesis, Structure, and Reactivity Toward Aminoesters

J. Winum, J. Montero, L. Toupet, 2004 .

Homologation of carboxylic acids by arndt-eistert reaction under ultrasonic waves

J. Winum, J. Montero, J. Roque, 1996 .

tert-Butyl N-[N,N-bis(2-chloroethyl)sulfamoyl]-N-(2-chloroethyl)carbamate

J. Winum, M. Abdaoui, Achour Seridi, 2009, Acta crystallographica. Section E, Structure reports online.

Study on the Decomposition of 2‐Chloroethylnitro‐ sosulfamides (CENS) in Serum Using HPLC On‐line Solid Phase Extraction

J. Winum, J. Montero, M. Abdaoui, 2006, Archiv der Pharmazie.

Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide.

J. Winum, J. Montero, M. Abdaoui, 2006, Bioorganic & medicinal chemistry letters.

Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with β-cyclodextrin

J. Winum, J. Montero, M. Abdaoui, 2004 .

A convenient method for the alkylation of sulfamides using alkyl bromides and Mitsunobu betaine

J. Winum, J. Montero, V. Barragan, 2001 .

N-Chlorosulfonyloxazolidin-2-ones: Synthesis, Structure, and Reactivity Toward Aminoesters.

J. Winum, J. Montero, L. Toupet, 2004 .

General synthesis of n-membered cyclic sulfamides

J. Winum, J. Montero, L. Toupet, 2003 .

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

S. Carradori, C. Supuran, S. Dedhar, 2020, Metabolites.

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

S. Leung, A. Oloumi, B. Clarke, 2011, Cancer Research.

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.

C. Supuran, A. Scozzafava, J. Winum, 2012, Chemical communications.

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.

C. Supuran, A. Scozzafava, J. Winum, 2012, Chemical communications.

Homologation of Carboxylic Acids by Arndt-Eistert Reaction Under Ultrasonic Waves.

J. Winum, J. Montero, J. Roque, 1996 .

A convenient synthesis of peracetylated glycosyl halides using bismuth(III) halides as catalysts

J. Winum, J. Montero, J. Roque, 1997 .

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

Giuseppe Fasolis, Alessio Innocenti, Vladimir Garaj, 2005, Bioorganic & medicinal chemistry letters.

Targeting of the Brucella suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen

P. Joseph, J. Winum, J. Montero, 2007, Antimicrobial Agents and Chemotherapy.

New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.

P. Lambin, M. V. van Gisbergen, L. Dubois, 2017, European journal of medicinal chemistry.

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.

C. Supuran, J. Winum, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Design, synthesis and photoluminescent studies of new 1,5-benzodiazepines derivatives: Towards new ESIPT compounds

J. Winum, M. Msaddek, Hasan Mtiraoui, 2021 .

Therapeutic potential of sulfamides as enzyme inhibitors

C. Supuran, A. Scozzafava, J. Winum, 2006, Medicinal research reviews.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF A RETINYL PHOSPHONIC ACID DERIVATIVE AN ANALOG OF RETINYL PHOSPHATE: HOMORETINYLPHOSPHONIC ACID

J. Winum, J. Montero, A. Leydet, 1999 .

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

Claudiu T. Supuran, Paul C. McDonald, Jean-Yves Winum, 2012, Oncotarget.

Drug design of Zinc-enzyme inhibitors: functional, structural and disease applications

C. Supuran, J. Winum, 2009 .

Carbonic anhydrase IX: A new druggable target for the design of antitumor agents

Andrea Scozzafava, Jean-Yves Winum, C. Supuran, 2008, Medicinal research reviews.

Therapeutic applications of sulfamates

C. Supuran, A. Scozzafava, J. Winum, 2004 .

Inclusion complexes of N-sulfamoyloxazolidinones with β-cyclodextrin

J. Winum, J. Montero, F. Coutrot, 2005 .

N-(tert-butoxycarbonyl)-N-[4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl]azanide: a new sulfamyolating agent. Structure and reactivity toward amines.

J. Winum, J. Montero, L. Toupet, 2001, Organic letters.

A Convenient Method for the Alkylation of Sulfamides Using Alkyl Bromides and Mitsunobu Betaine.

J. Winum, J. Montero, V. Barragan, 2001 .

New pyrophosphate analogues: a facile access to N-(O-alkyl-sulfamoyl)phosphoramidic acids via a simple and quantitative reaction of N-(O-alkylsulfamoyl)trimethylphospha-λ5-azene with bromotrimethylsilane and water

J. Winum, J. Montero, L. Bonnac, 2004 .

Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases.

Eddy Petit, Mihail Barboiu, Claudiu T Supuran, 2009, Bioorganic & medicinal chemistry letters.

Inhibitors of Histidinol Dehydrogenase

J. Winum, S. Köhler, J. Dessolin, 2016 .

Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suis.

J. Winum, S. M. Monti, N. Dathan, 2014, Biochimie.

Carbonic anhydrase IX inhibitors in cancer therapy: an update.

C. Supuran, J. Winum, 2015, Future medicinal chemistry.

Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.

C. Supuran, A. Casini, A. Scozzafava, 2004, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.

C. Supuran, A. Scozzafava, J. Winum, 2008, Journal of the American Chemical Society.

Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates.

J. Winum, S. Ulrich, P. Dumy, 2017, Chemistry.

Design, implementation, and evaluation of a game-based application for aiding chemical engineering and chemistry students to review the organic reactions

Francisco Serra Oliveira Alexandre, Antonio José Melo Leite Junior, José Nunes da Silva Júnior, 2020 .

Inhibitors of Selected Bacterial Metalloenzymes.

J. Winum, R. Žalubovskis, 2019, Current medicinal chemistry.

Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.

J. Winum, J. Montero, J. Dogné, 2004, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.

C. Supuran, J. Winum, M. Barboiu, 2014, Bioorganic & medicinal chemistry.

Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.

Eddy Petit, Mihail Barboiu, Daniela Vullo, 2009, Journal of medicinal chemistry.

Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.

C. Supuran, J. Winum, P. Colinas, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide.

J. Winum, J. Montero, M. Seman, 2001, Farmaco.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

P. Lambin, L. Dubois, C. Supuran, 2018, Journal of enzyme inhibition and medicinal chemistry.

Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.

P. Lambin, L. Dubois, C. Supuran, 2013, Journal of medicinal chemistry.

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.

P. Lambin, L. Dubois, C. Supuran, 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

One-Pot Synthesis of Nucleosides Using Bismuth(III) Bromide as Catalyst.

J. Winum, J. Montero, A. Leydet, 1998 .

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding.

C. Supuran, J. Winum, A. Angeli, 2018, Chemical communications.

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

C. Supuran, J. Winum, S. Yous, 2019, Journal of enzyme inhibition and medicinal chemistry.

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.

C. Supuran, A. Scozzafava, J. Winum, 2014, Bioorganic & medicinal chemistry.

Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.

C. Supuran, A. Scozzafava, J. Winum, 2011, Bioorganic & medicinal chemistry letters.

The sulfamide motif in the design of enzyme inhibitors

C. Supuran, A. Scozzafava, J. Winum, 2006, Expert opinion on therapeutic patents.

ETUDE DE LA RÉACTION DE MICHAELISARBUZOV SOUS ACTIVATION ULTRASONORE

J. Winum, J. Montero, A. Leydet, 1997 .

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.

C. Supuran, A. Scozzafava, J. Winum, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.

C. Supuran, A. Scozzafava, J. Winum, 2004, Bioorganic & medicinal chemistry letters.

Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies

J. Winum, J. Peyron, B. Klaholz, 2020, Cells.

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.

C. Supuran, A. Casini, A. Scozzafava, 2004, Bioorganic & medicinal chemistry letters.

A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity

C. Supuran, J. Winum, A. Zannetti, 2020, International journal of molecular sciences.

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

S. C. Chafe, S. Aparicio, C. Supuran, 2013, Oncogene.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.

C. Supuran, J. Winum, C. Ghelardini, 2019, Bioorganic chemistry.

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study.

C. Supuran, J. Winum, C. Capasso, 2017, ACS Medicinal Chemistry Letters.

Introduction to Zinc Enzymes as Drug Targets

C. Supuran, J. Winum, 2009 .

Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors.

C. Supuran, J. Winum, J. Montero, 2013, Chemical communications.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.

C. Supuran, A. Scozzafava, J. Winum, 2011, Bioorganic & medicinal chemistry letters.

The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies.

C. Supuran, J. Winum, F. Carta, 2016, Organic & biomolecular chemistry.

Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.

C. Supuran, J. Winum, K. D'Ambrosio, 2012, Journal of medicinal chemistry.

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

C. Supuran, J. Winum, P. Dumy, 2017, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

C. Supuran, A. Scozzafava, J. Winum, 2006, Journal of medicinal chemistry.

Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors

C. Supuran, J. Winum, 2015, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions.

C. Supuran, A. Scozzafava, J. Winum, 2012, Journal of inorganic biochemistry.

Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.

S. Carradori, C. Supuran, S. Dedhar, 2020, Biophysical journal.

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.

C. Supuran, A. Scozzafava, J. Winum, 2009, Bioorganic & medicinal chemistry.

Design of zinc binding functions for carbonic anhydrase inhibitors.

C. Supuran, A. Scozzafava, J. Winum, 2008, Current pharmaceutical design.

Metal binding functions in the design of carbonic anhydrase inhibitors.

C. Supuran, A. Scozzafava, J. Winum, 2007, Current topics in medicinal chemistry.

Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae.

C. Supuran, J. Winum, C. Capasso, 2020, ACS medicinal chemistry letters.

Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1

J. Winum, C. Capasso, 2013, Expert opinion on therapeutic patents.

Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.

C. Supuran, J. Winum, M. Smietana, 2019, ACS medicinal chemistry letters.

Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis.

C. Supuran, J. Winum, D. Vullo, 2017, Bioorganic & medicinal chemistry.

N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases

C. Supuran, J. Winum, D. Vullo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.

C. Supuran, J. Winum, J. Montero, 2009, Bioorganic & medicinal chemistry letters.

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors.

A. Vergara, C. Supuran, J. Winum, 2015, Chemical communications.

Carbonic anhydrase inhibitors for the treatment of tumors

J. Winum, M. Ilies, 2019, Carbonic Anhydrases.

Synthesis, Crystal Structure, Inhibitory Activity and Molecular Docking of Coumarins/Sulfonamides Containing Triazolyl Pyridine Moiety as Potent Selective Carbonic Anhydrase IX and XII Inhibitors

C. Supuran, J. Winum, A. Nocentini, 2021, Crystals.

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.

C. Supuran, J. Winum, P. Dumy, 2015, ACS medicinal chemistry letters.

Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.

Andrea Scozzafava, Daniela Vullo, Claudiu T Supuran, 2007, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.

C. Supuran, A. Casini, A. Scozzafava, 2003, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.

C. Supuran, A. Casini, A. Scozzafava, 2003, Journal of medicinal chemistry.

Brucella carbonic anhydrases: new targets for designing anti-infective agents.

C. Supuran, J. Winum, S. Köhler, 2010, Current pharmaceutical design.

New ways to image and target tumour hypoxia and its molecular responses.

P. Lambin, M. V. van Gisbergen, L. Dubois, 2015, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type-2 inflammation: a patent evaluation (WO2017/058370)

J. Winum, 2018, Expert opinion on therapeutic patents.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.

C. Supuran, A. Casini, A. Scozzafava, 2005, Journal of medicinal chemistry.

Carbonic Anhydrase XIV: Structure, Functions, and Potential Medical Applications

J. Winum, 2015 .

The importance of sulfur-containing motifs in drug design and discovery

J. Winum, Muhamad Mustafa, 2022, Expert opinion on drug discovery.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

P. Lambin, L. Dubois, C. Supuran, 2015, Oncotarget.

Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.

C. Supuran, A. Scozzafava, J. Winum, 2007, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.

Andrea Scozzafava, Claudiu T Supuran, Jean-Yves Winum, 2003, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.

C. Supuran, A. Scozzafava, J. Winum, 2007, Bioorganic & Medicinal Chemistry Letters.

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity

J. Winum, M. Hanif, Z. Chohan, 2014, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and properties of isocannabinoid and cholesterol derivatized rhamnosurfactants: application to liposomal targeting of keratinocytes and skin.

J. Winum, J. Montero, J. Molès, 2005, European journal of medicinal chemistry.

Chem’Sc@pe: an Organic Chemistry Learning Digital Escape Game

J. Winum, B. Roy, Stéphan Gasca, 2023, Journal of Chemical Education.

Addition to “Stereochemistry Game: Creating and Playing a Fun Board Game To Engage Students in Reviewing Stereochemistry Concepts—The Online Version”

André Jalles Monteiro, J. Winum, Mary Anne Sousa Lima, 2021, Journal of Chemical Education.

Addition to “Reactions: An Innovative and Fun Hybrid Game to Engage the Students Reviewing Organic Reactions in the Classroom”: Using the Game Remotely during the COVID-19 Pandemic

J. Winum, Mary Anne Sousa Lima, Antonio José Melo Leite Júnior, 2021, Journal of Chemical Education.

HSG400 – Design, implementation, and evaluation of a hybrid board game for aiding chemistry and chemical engineering students in the review of stereochemistry during and after the COVID-19 pandemic

Antonio José Melo Leite Junior, J. Winum, A. Basso, 2021, Education for Chemical Engineers.

Interactions 500: Design, Implementation, and Evaluation of a Hybrid Board Game for Aiding Students in the Review of Intermolecular Forces During the COVID-19 Pandemic

Francisco Serra Oliveira Alexandre, Antonio José Melo Leite Junior, Antonia T. A. Pimenta, 2020 .

Reactions: An Innovative and Fun Hybrid Game to Engage the Students Reviewing Organic Reactions in the Classroom

J. Winum, Mary Anne Sousa Lima, José Nunes da Silva Júnior, 2020 .

Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.

C. Supuran, A. Scozzafava, J. Winum, 2005, Bioorganic & medicinal chemistry letters.

Inhibition of carbonic anhydrase IX: a new strategy against cancer.

Andrea Scozzafava, Claudiu T Supuran, Jean-Yves Winum, 2009, Anti-cancer agents in medicinal chemistry.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.

C. Supuran, A. Scozzafava, J. Winum, 2005, Bioorganic & medicinal chemistry letters.

Hypoxia-activated prodrug derivatives of anti-cancer drugs: a patent review 2006 – 2021

P. Lambin, L. Dubois, J. Winum, 2021, Expert opinion on therapeutic patents.

Carbonic anhydrase inhibitors: Gd(III) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII

P. Lambin, L. Dubois, C. Supuran, 2010 .

CHAPTER 1 Introduction to Zinc Enzymes as Drug Targets

C. Supuran, J. Winum, 2009 .

Comprar Plant Phenolics and Human Health : Biochemistry, Nutrition and Pharmacology | Claudiu T. Supuran | 9780470287217 | Wiley

C. Supuran, J. Winum, C. Fraga, 2009 .

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.

C. Supuran, A. Scozzafava, J. Winum, 2005, Bioorganic & medicinal chemistry letters.

A Combined DFT and Molecular docking study on novel tricarbonylrhenium(I) complexes bearing mono- and bivalent benzenesulfonamide scaffolds as human Carbonic Anhydrase IX and XII inhibitors

J. Winum, E. Benoist, Achour Seridi, 2023, Journal of Molecular Structure.

Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells

C. Supuran, J. Winum, V. Imbert, 2018, Leukemia & lymphoma.

Classical sulfonamides and their bioisosters as carbonic anhydrase inhibitors

J. Winum, 2014 .

Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.

C. Supuran, A. Scozzafava, J. Winum, 2009, Bioorganic & medicinal chemistry letters.

Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

P. Joseph, J. Winum, J. Montero, 2008 .

Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide.

P. Joseph, J. Winum, J. Montero, 2008, Journal of enzyme inhibition and medicinal chemistry.

Rigid Push−Pull Oligo(p-Phenylene) Rods: Depolarization of Bilayer Membranes with Negative Membrane Potential

J. Winum, S. Matile, 1999 .

Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.

C. Supuran, A. Scozzafava, J. Winum, 2007, Bioorganic & medicinal chemistry letters.

6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography.

C. Supuran, J. Winum, A. Nocentini, 2023, Journal of medicinal chemistry.

Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?

C. Supuran, S. Clément, J. Winum, 2023, Expert opinion on therapeutic targets.

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

C. Supuran, A. Scozzafava, S. Dedhar, 2011, Journal of medicinal chemistry.

Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates.

J. Winum, S. Ulrich, P. Dumy, 2017, Chemistry.

STR120: A Web-Based Board Game for Aiding Students in Review of the Structural Theory of Organic Compounds

Francisco Serra Oliveira Alexandre, André Jalles Monteiro, J. Winum, 2022, Journal of Chemical Education.

Carbonic anhydrase inhibitors. N-Cyanomethylsulfonamides—a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms

C. Supuran, A. Scozzafava, J. Winum, 2006, Journal of enzyme inhibition and medicinal chemistry.

Designing carbonic anhydrase inhibitors for the treatment of breast cancer

C. Supuran, J. Winum, 2015, Expert opinion on drug discovery.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.

Alessio Innocenti, Andrea Scozzafava, Daniela Vullo, 2005, Bioorganic & medicinal chemistry letters.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies

C. Supuran, J. Winum, M. Parikka, 2018, Molecules.

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation.

C. Supuran, J. Winum, S. Ulrich, 2017, Chemistry.

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.

C. Supuran, J. Winum, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.

C. Supuran, A. Scozzafava, J. Winum, 2011, Bioorganic & medicinal chemistry letters.