D. Vullo

发表

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

C. Supuran, A. Scozzafava, J. Winum, 2004, Bioorganic & medicinal chemistry letters.

Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Cancer-associated Isozyme IX with Lipophilic Sulfonamides

C. Supuran, A. Scozzafava, D. Vullo, 2003, Journal of enzyme inhibition and medicinal chemistry.

Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Bioorganic & medicinal chemistry letters.

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

P. Joseph, C. Supuran, A. Scozzafava, 2010, Journal of medicinal chemistry.

Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry.

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.

C. Supuran, P. Mader, D. Vullo, 2010, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.

Claudiu T. Supuran, Jochen Antel, Daniela Vullo, 2004, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.

Andrea Scozzafava, Daniela Vullo, Claudiu T Supuran, 2007, Journal of medicinal chemistry.

Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis.

C. Supuran, D. Vullo, C. Capasso, 2013, Journal of medicinal chemistry.

Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease.

Giseli Capaci Rodrigues, C. Supuran, D. Vullo, 2014, Journal of medicinal chemistry.

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis

C. Supuran, D. Vullo, Harlan R. Barker, 2015, Parasites & Vectors.

Comparison of the anion inhibition profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei.

C. Supuran, D. Vullo, V. Carginale, 2017, Bioorganic & medicinal chemistry.

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.

P. Joseph, C. Supuran, A. Scozzafava, 2011, Bioorganic & medicinal chemistry.

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

C. Supuran, A. Scozzafava, J. Winum, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors.

C. Supuran, A. Innocenti, D. Vullo, 2011, Journal of medicinal chemistry.

Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.

C. Supuran, A. Innocenti, D. Vullo, 2010, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.

C. Supuran, A. Scozzafava, A. Innocenti, 2008, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.

C. Supuran, D. Vullo, V. De Luca, 2021, European journal of medicinal chemistry.

Anion Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora

C. Supuran, D. Vullo, S. Pöggeler, 2020, Metabolites.

Production and covalent immobilisation of the recombinant bacterial carbonic anhydrase (SspCA) onto magnetic nanoparticles

C. Supuran, D. Vullo, M. Rossi, 2017, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.

C. Supuran, A. Scozzafava, J. Winum, 2008, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors.

C. Supuran, A. Innocenti, D. Vullo, 2012, Bioorganic & medicinal chemistry letters.

Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

C. Supuran, D. Vullo, A. Kazaks, 2017, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.

C. Supuran, D. Vullo, H. Abdel‐Aziz, 2013, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors. Benzenesulfonamides incorporating cyanoacrylamide moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase.

C. Supuran, D. Vullo, C. Capasso, 2013, Bioorganic & medicinal chemistry letters.

Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.

C. Supuran, D. Vullo, J. Pastorek, 2012, Bioorganic & medicinal chemistry.

The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.

C. Supuran, A. Scozzafava, D. Vullo, 2009, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides.

C. Supuran, A. Scozzafava, D. Vullo, 2005, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.

J. Voipio, K. Kaila, C. Supuran, 2005, Bioorganic & medicinal chemistry letters.

Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.

C. Supuran, D. Vullo, C. Steegborn, 2008, Journal of molecular biology.

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.

C. Supuran, A. Scozzafava, D. Vullo, 2007, Bioorganic & medicinal chemistry letters.

Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds

C. Supuran, D. Vullo, R. E. Salmas, 2016, Journal of enzyme inhibition and medicinal chemistry.

Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products

S. Carradori, C. Supuran, D. Vullo, 2015, Planta Medica.

Targeting Carbonic Anhydrases with Fluorescent BODIPY-Labelled Sulfonamides

A. Harris, C. Supuran, A. Innocenti, 2012 .

1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.

F. Da Settimo, S. Taliani, C. La Motta, 2016, Journal of medicinal chemistry.

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

C. Supuran, D. Vullo, D. Vega, 2016, Journal of enzyme inhibition and medicinal chemistry.

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.

C. Supuran, D. Vullo, R. McKenna, 2015, Journal of medicinal chemistry.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

C. Supuran, A. Coluccia, D. Vullo, 2015, Journal of medicinal chemistry.

Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates

C. Supuran, D. Vullo, B. Mahon, 2014, Journal of medicinal chemistry.

Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX

E. Langella, C. Supuran, D. Vullo, 2018, Cellular and Molecular Life Sciences.

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

C. Supuran, A. Scozzafava, D. Vullo, 2008, Bioorganic & medicinal chemistry.

A prodrug approach toward cancer-related carbonic anhydrase inhibition.

C. Supuran, D. Vullo, S. Charman, 2013, Journal of medicinal chemistry.

Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors

C. Supuran, D. Vullo, M. Fouad, 2022, Drug development research.

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.

C. Supuran, D. Vullo, A. Alafeefy, 2017, Bioorganic & medicinal chemistry.

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.

C. Supuran, A. Scozzafava, E. Masini, 2015, Bioorganic & medicinal chemistry.

Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity.

Abdul-Malek S. Al-Tamimi, C. Supuran, A. Scozzafava, 2015, Bioorganic & medicinal chemistry.

Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.

C. Supuran, D. Vullo, I. Gülçin, 2013, Bioorganic & medicinal chemistry.

Natural product coumarins that inhibit human carbonic anhydrases.

C. Supuran, D. Vullo, Rohan A. Davis, 2013, Bioorganic & medicinal chemistry.

Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII.

C. Supuran, A. Scozzafava, D. Vullo, 2011, Organic & biomolecular chemistry.

Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase

C. Supuran, A. Innocenti, D. Vullo, 2009, JBIC Journal of Biological Inorganic Chemistry.

Carbonic Anhydrase Inhibitors: Design of Membrane‐Impermeant Copper(II) Complexes of DTPA‐, DOTA‐, and TETA‐Tailed Sulfonamides Targeting the Tumor‐Associated Transmembrane Isoform IX

C. Supuran, A. Scozzafava, J. Winum, 2008, ChemMedChem.

Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.

C. Supuran, D. Vullo, D. A. Ibrahim, 2015, Bioorganic & medicinal chemistry.

Identification and characterization of a novel zebrafish (Danio rerio) pentraxin–carbonic anhydrase

C. Ortutay, C. Supuran, M. Hilvo, 2017, PeerJ.

Design, synthesis, and biological evaluation of selective hCA IX inhibitors

D. Vullo, A. Angeli, F. Carta, 2021 .

Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia.

P. Lambin, L. Dubois, G. Bormans, 2010, Nuclear medicine and biology.

Synthesis of sulfonamide conjugates of Cu(II), Ga(III), In(III), Re(V) and Zn(II) complexes: carbonic anhydrase inhibition studies and cellular imaging investigations.

C. Supuran, D. Vullo, J. Dilworth, 2015, Dalton transactions.

Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.

C. Supuran, A. Innocenti, D. Vullo, 2009, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

C. Supuran, A. Scozzafava, A. Innocenti, 2008, Bioorganic & medicinal chemistry letters.

The extremo-α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry.

Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry

C. Supuran, D. Vullo, C. Ghelardini, 2018, Journal of enzyme inhibition and medicinal chemistry.

Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.

C. Supuran, D. Vullo, B. Mahon, 2016, Bioorganic & medicinal chemistry letters.

Mechanisms of action of carbonic anhydrase inhibitors

D. Vullo, F. Carta, 2019, Carbonic Anhydrases.

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition.

C. Supuran, J. Winum, D. Vullo, 2016, Chemical communications.

Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action.

C. Supuran, E. Masini, J. Winum, 2015, Journal of medicinal chemistry.

Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I-XIV.

C. Supuran, D. Vullo, Z. Alothman, 2015, Organic & biomolecular chemistry.

Poly(amidoamine) dendrimers show carbonic anhydrase inhibitory activity against α-, β-, γ- and η-class enzymes.

C. Supuran, D. Vullo, C. Capasso, 2015, Bioorganic & medicinal chemistry.

Trimeric Radiofluorinated Sulfonamide Derivatives to Achieve In Vivo Selectivity for Carbonic Anhydrase IX–Targeted PET Imaging

F. Bénard, C. Supuran, D. Vullo, 2015, The Journal of Nuclear Medicine.

Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity

W. Sly, C. Supuran, D. Vullo, 2008, BMC Biochemistry.

o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.

C. Supuran, D. Vullo, Özlen Güzel-Akdemir, 2013, Bioorganic & medicinal chemistry.

Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2016, Bioorganic & medicinal chemistry letters.

DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Journal of medicinal chemistry.

Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.

C. Supuran, D. Vullo, V. De Luca, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.

C. Supuran, D. Vullo, C. Ghelardini, 2019, Journal of medicinal chemistry.

Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids.

C. Supuran, D. Vullo, C. Capasso, 2016, Bioorganic & medicinal chemistry letters.

Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies

C. Supuran, D. Vullo, S. Durdağı, 2014, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Journal of medicinal chemistry.

Cloning, expression and purification of the α-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis

C. Supuran, D. Vullo, M. Rossi, 2017, Journal of enzyme inhibition and medicinal chemistry.

Biochemical characterization of the δ-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA

C. Supuran, D. Vullo, V. De Luca, 2014, Journal of enzyme inhibition and medicinal chemistry.

Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases

S. Carradori, C. Supuran, D. Vullo, 2016, ChemMedChem.

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

C. Supuran, D. Vullo, M. Parikka, 2019, Journal of enzyme inhibition and medicinal chemistry.

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.

C. Supuran, A. Scozzafava, D. Vullo, 2017, Journal of medicinal chemistry.

Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) “Kuntze”

C. Supuran, D. Vullo, S. M. Monti, 2014, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry letters.

C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases

C. Supuran, D. Vullo, Leonardo E. Riafrecha, 2015, Journal of enzyme inhibition and medicinal chemistry.

Natural Product Polyamines That Inhibit Human Carbonic Anhydrases

C. Supuran, D. Vullo, Rohan A. Davis, 2014, BioMed research international.

Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry.

An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.

C. Supuran, T. Peat, D. Vullo, 2016, Journal of medicinal chemistry.

Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?

C. Supuran, A. Scozzafava, D. Vullo, 2011, Bioorganic & medicinal chemistry.

Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry letters.

Cloning, characterization and anion inhibition study of the δ-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry.

[18F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models

P. Lambin, L. Dubois, R. Schuit, 2015, Molecular Imaging and Biology.

Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms.

C. Supuran, A. Scozzafava, J. Winum, 2011, Journal of medicinal chemistry.

Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.

C. Supuran, D. Vullo, C. Capasso, 2013, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.

C. Supuran, D. Vullo, B. Żołnowska, 2014, European journal of medicinal chemistry.

Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Journal of inorganic biochemistry.

Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

C. Supuran, D. Vullo, F. Carta, 2021, Pharmaceuticals.

Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.

C. Supuran, A. Innocenti, D. Vullo, 2009, Bioorganic & medicinal chemistry.

Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.

C. Supuran, A. Innocenti, D. Vullo, 2007, Bioorganic & medicinal chemistry letters.

Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.

C. Supuran, D. Vullo, T. Martellini, 2015, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions.

C. Supuran, A. Scozzafava, D. Vullo, 2003, Bioorganic & medicinal chemistry letters.

Protein-protein interactions: inhibition of mammalian carbonic anhydrases I-XV by the murine inhibitor of carbonic anhydrase and other members of the transferrin family.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Journal of medicinal chemistry.

Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases.

S. Carradori, C. Supuran, D. Vullo, 2022, European journal of medicinal chemistry.

Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance

C. Supuran, D. Vullo, V. De Luca, 2022, Pharmaceuticals.

Identification of New Carbonic Anhydrase VII Inhibitors by Structure-Based Virtual Screening

A. Talevi, C. Supuran, D. Vullo, 2022, J. Chem. Inf. Model..

Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.

Brendan L Wilkinson, C. Supuran, A. Innocenti, 2007, Journal of medicinal chemistry.

Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.

C. De Monte, S. Carradori, C. Supuran, 2013, Bioorganic & medicinal chemistry letters.

N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.

C. Supuran, D. Vullo, A. Kazaks, 2017, Bioorganic & medicinal chemistry.

Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.

Brendan L Wilkinson, C. Supuran, A. Innocenti, 2008, Journal of medicinal chemistry.

Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & medicinal chemistry.

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

C. Supuran, A. Scozzafava, S. Dedhar, 2011, Journal of medicinal chemistry.

Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & medicinal chemistry.

Expression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc

C. Supuran, D. Vullo, V. De Luca, 2016, Journal of enzyme inhibition and medicinal chemistry.

Dithiocarbamates strongly inhibit the β-class carbonic anhydrases from Mycobacterium tuberculosis

C. Supuran, D. Vullo, F. Carta, 2013, Journal of enzyme inhibition and medicinal chemistry.

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of medicinal chemistry.

Designing of Novel Carbonic Anhydrase Inhibitors and Activators.

C. Supuran, A. Casini, A. Scozzafava, 2004, Current medicinal chemistry. Cardiovascular and hematological agents.

Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.

C. Supuran, A. Scozzafava, D. Vullo, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.

C. Supuran, A. Scozzafava, D. Vullo, 2006, Journal of medicinal chemistry.

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

C. Supuran, A. Scozzafava, E. Masini, 2014, Journal of medicinal chemistry.

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

C. Supuran, A. Scozzafava, M. Ferraroni, 2014, Bioorganic & medicinal chemistry.

Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates

C. Supuran, D. Vullo, C. Capasso, 2017, Journal of enzyme inhibition and medicinal chemistry.

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.

E. Novellino, C. Supuran, A. Scozzafava, 2016, Journal of medicinal chemistry.

Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moiet

Abdul-Malek S. Al-Tamimi, C. Supuran, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

Giuseppe Fasolis, Alessio Innocenti, Vladimir Garaj, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrases activation with 3-amino-1H-1,2,4-triazole-1-carboxamides: Discovery of subnanomolar isoform II activators.

C. Supuran, D. Vullo, M. Barboiu, 2017, Bioorganic & medicinal chemistry.

Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.

C. Supuran, D. Vullo, C. Capasso, 2015, Bioorganic & medicinal chemistry.

New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.

P. Lambin, M. V. van Gisbergen, L. Dubois, 2017, European journal of medicinal chemistry.

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.

C. Supuran, J. Winum, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.

C. Supuran, A. Scozzafava, D. Vullo, 2015, Bioorganic & medicinal chemistry.

Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.

C. Supuran, A. Scozzafava, P. Depreux, 2010, Bioorganic & medicinal chemistry.

Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII.

C. Supuran, D. Vullo, P. Sharma, 2014, Bioorganic & medicinal chemistry.

Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.

C. Supuran, D. Vullo, A. Alafeefy, 2017, Bioorganic & medicinal chemistry.

5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.

C. Supuran, D. Vullo, A. Kazaks, 2017, Bioorganic & medicinal chemistry.

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring

C. Supuran, D. Vullo, F. Carta, 2015, Journal of enzyme inhibition and medicinal chemistry.

Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.

C. Supuran, D. Vullo, Leonardo E. Riafrecha, 2014, Bioorganic & medicinal chemistry.

Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.

C. Supuran, D. Vullo, Leonardo E. Riafrecha, 2013, Bioorganic & medicinal chemistry.

New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.

C. Supuran, D. Vullo, A. Çetin, 2015, Bioorganic & medicinal chemistry letters.

Effects of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA

A. Casini, D. Vullo, L. Messori, 2000 .

Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.

C. Supuran, A. Innocenti, D. Vullo, 2011, Journal of medicinal chemistry.

Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCA.

C. Supuran, D. Vullo, C. Capasso, 2015, Bioorganic & medicinal chemistry letters.

Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Journal of medicinal chemistry.

Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action.

C. Supuran, D. Vullo, J. Csöllei, 2018, Bioorganic chemistry.

A new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target

C. Supuran, D. Vullo, V. De Luca, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

C. Supuran, D. Vullo, Suleyman Akocak, 2017, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of enzyme inhibition and medicinal chemistry.

Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases from Mycobacterium tuberculosis

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.

Eddy Petit, Mihail Barboiu, Daniela Vullo, 2009, Journal of medicinal chemistry.

Carbonic Anhydrase in the Scleractinian Coral Stylophora pistillata

D. Allemand, C. Supuran, D. Vullo, 2008, Journal of Biological Chemistry.

Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.

C. Supuran, A. Casini, A. Scozzafava, 2004, Bioorganic & medicinal chemistry letters.

A spectroscopic study of the reaction of NAMI, a novel ruthenium(III)anti-neoplastic complex, with bovine serum albumin.

D. Vullo, E. Alessio, L. Messori, 2000, European journal of biochemistry.

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.

P. Lambin, L. Dubois, C. Supuran, 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.

C. Supuran, D. Vullo, S. Poulsen, 2015, Journal of medicinal chemistry.

Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII.

C. Supuran, D. Landau, R. Ofir, 2010, American journal of human genetics.

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.

C. Supuran, A. Scozzafava, D. Vullo, 2011, Bioorganic & medicinal chemistry letters.

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes.

C. Supuran, D. Vullo, F. Carta, 2019, Current medicinal chemistry.

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.

C. Supuran, A. Scozzafava, J. Winum, 2014, Bioorganic & medicinal chemistry.

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.

C. Supuran, D. Vullo, C. Capasso, 2014, Bioorganic & medicinal chemistry letters.

Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.

C. Supuran, T. Peat, D. Vullo, 2014, Journal of medicinal chemistry.

S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.

C. Supuran, A. Innocenti, D. Vullo, 2009, Journal of medicinal chemistry.

N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.

C. Supuran, D. Vullo, G. Bartolucci, 2016, Bioorganic & medicinal chemistry.

Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases

C. Supuran, A. Scozzafava, D. Vullo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.

C. Supuran, D. Vullo, Krzysztof Szafrański, 2013, European journal of medicinal chemistry.

Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.

C. Supuran, P. Mader, D. Vullo, 2012, Journal of medicinal chemistry.

Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.

C. Supuran, D. Vullo, S. Ferro, 2011, Bioorganic & medicinal chemistry.

A Series of Thiadiazolyl‐Benzenesulfonamides Incorporating an Aromatic Tail as Isoform‐Selective, Potent Carbonic Anhydrase II/XII Inhibitors

C. Supuran, D. Vullo, E. Banoglu, 2022, ChemMedChem.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.

C. Supuran, A. Scozzafava, J. Winum, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.

C. Supuran, A. Scozzafava, J. Winum, 2004, Bioorganic & medicinal chemistry letters.

Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme.

W. Sly, C. Supuran, D. Vullo, 2010, Biochimie.

Effects of dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], on cell viability and gene expression of common human cancer drug targets in a melanoma cell line

C. Supuran, D. Vullo, A. Haverić, 2016, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.

C. Supuran, A. Scozzafava, D. Vullo, 2003, Bioorganic & medicinal chemistry letters.

Anion inhibition profiles of the γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & medicinal chemistry.

First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors

C. Supuran, D. Vullo, A. Papini, 2022, Journal of enzyme inhibition and medicinal chemistry.

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII

C. Supuran, E. Dreassi, M. Botta, 2017, Molecules.

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

C. Supuran, G. Vignaroli, I. Laurenzana, 2015, ACS chemical biology.

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.

C. Supuran, D. Vullo, S. Ferro, 2014, European journal of medicinal chemistry.

Identification of Potent and Selective Human Carbonic Anhydrase VII (hCA VII) Inhibitors

C. Supuran, D. Vullo, S. Ferro, 2010, ChemMedChem.

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

C. Supuran, D. Vullo, F. Awadallah, 2022, Journal of enzyme inhibition and medicinal chemistry.

One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.

C. Supuran, E. Masini, M. Ferraroni, 2021, Journal of medicinal chemistry.

An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus

C. Supuran, D. Vullo, S. Parkkila, 2021, Journal of enzyme inhibition and medicinal chemistry.

Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach

E. Langella, C. Supuran, D. Vullo, 2019, Journal of Enzyme Inhibition and Medicinal Chemistry.

Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases

C. Supuran, D. Vullo, V. Hytönen, 2011, Journal of enzyme inhibition and medicinal chemistry.

Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.

C. Supuran, A. Scozzafava, D. Vullo, 2011, Bioorganic & medicinal chemistry.

Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus

C. Supuran, A. Scozzafava, D. Vullo, 2017, Neuropharmacology.

Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase

C. Supuran, A. Scozzafava, D. Vullo, 2016, Journal of Enzyme Inhibition and Medicinal Chemistry.

Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.

S. Carradori, C. Supuran, D. Vullo, 2014, Bioorganic & medicinal chemistry.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

New Pyridinium Salt Derivatives of 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide as Selective Inhibitors of Tumour-Related Human Carbonic Anhydrase Isoforms IX and XII.

C. Supuran, D. Vullo, A. Akdemir, 2022, Anti-Cancer Agents in Medicinal Chemistry.

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

C. Supuran, D. Vullo, Ghada S. Hassan, 2019, Bioorganic chemistry.

Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.

C. Supuran, T. Peat, D. Vullo, 2015, Journal of medicinal chemistry.

Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties

Abdul-Malek S. Al-Tamimi, C. Supuran, D. Vullo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Out of the active site binding pocket for carbonic anhydrase inhibitors.

S. Carradori, C. Supuran, D. Vullo, 2015, Chemical communications.

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.

C. Supuran, A. Scozzafava, J. Winum, 2011, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

C. Supuran, A. Scozzafava, D. Vullo, 2006, Chemistry.

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

C. Supuran, A. Scozzafava, D. Vullo, 2006, Bioorganic & medicinal chemistry letters.

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.

C. Supuran, A. Scozzafava, D. Vullo, 2018, Journal of medicinal chemistry.

Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.

C. Supuran, A. Scozzafava, D. Vullo, 2008, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.

K. Kaila, C. Supuran, A. Scozzafava, 2007, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

C. Supuran, A. Scozzafava, J. Winum, 2006, Journal of medicinal chemistry.

Activation Profile Analysis of CruCA4, an α-Carbonic Anhydrase Involved in Skeleton Formation of the Mediterranean Red Coral, Corallium rubrum

C. Supuran, D. Vullo, C. Capasso, 2017, Molecules.

Cloning, expression and biochemical characterization of a β-carbonic anhydrase from the soil bacterium Enterobacter sp. B13

C. Supuran, D. Vullo, Aycan Aşık, 2016, Journal of enzyme inhibition and medicinal chemistry.

In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

C. Supuran, D. Vullo, E. Russo, 2016, ChemMedChem.

A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

C. Supuran, D. Vullo, H. Baldoni, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.

C. Supuran, D. Vullo, Krzysztof Szafrański, 2014, European journal of medicinal chemistry.

Biochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA

C. Supuran, A. Scozzafava, D. Vullo, 2014, Journal of enzyme inhibition and medicinal chemistry.

Crystal structures of two tetrameric β‐carbonic anhydrases from the filamentous ascomycete Sordaria macrospora

C. Supuran, D. Vullo, S. Pöggeler, 2014, The FEBS journal.

A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry.

The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Bioorganic & medicinal chemistry letters.

Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives

C. Supuran, D. Vullo, C. Capasso, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

C. Supuran, D. Vullo, E. Russo, 2009, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

Sulfonamide inhibition studies of two β-carbonic anhydrases from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2

C. Supuran, D. Vullo, S. Pöggeler, 2018, Journal of enzyme inhibition and medicinal chemistry.

Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae

C. Supuran, D. Vullo, S. Parkkila, 2018, Journal of enzyme inhibition and medicinal chemistry.

Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches

C. Supuran, D. Vullo, C. Capasso, 2016, ChemMedChem.

Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2015, Acta crystallographica. Section D, Biological crystallography.

Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.

C. Supuran, D. Vullo, V. De Luca, 2015, Bioorganic & medicinal chemistry letters.

Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.

C. D. Boone, C. Supuran, D. Vullo, 2015, Bioorganic & medicinal chemistry.

Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis

C. Supuran, D. Vullo, V. De Luca, 2015, Journal of enzyme inhibition and medicinal chemistry.

Anion inhibition study of the β-carbonic anhydrase (CahB1) from the cyanobacterium Coleofasciculus chthonoplastes (ex-Microcoleus chthonoplastes).

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.

C. Supuran, A. Scozzafava, A. Innocenti, 2009, Journal of medicinal chemistry.

Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.

C. Supuran, D. Vullo, V. De Luca, 2016, Bioorganic & medicinal chemistry.

Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2016, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.

C. Supuran, A. Scozzafava, D. Vullo, 2004, Journal of medicinal chemistry.

Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora

C. Supuran, D. Vullo, S. Pöggeler, 2020, Molecules.

Cloning, Purification, and Characterization of a β-Carbonic Anhydrase from Malassezia restricta, an Opportunistic Pathogen Involved in Dandruff and Seborrheic Dermatitis

C. Supuran, D. Vullo, C. Capasso, 2019, International journal of molecular sciences.

Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens

C. Supuran, A. Scozzafava, D. Vullo, 2017, Journal of enzyme inhibition and medicinal chemistry.

Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei

C. Supuran, D. Vullo, V. Carginale, 2017, Molecules.

Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.

C. Supuran, D. Vullo, V. De Luca, 2016, Bioorganic & medicinal chemistry.

Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.

C. Supuran, D. Vullo, V. De Luca, 2016, Bioorganic & medicinal chemistry letters.

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.

C. Supuran, A. Scozzafava, D. Vullo, 2015, Bioorganic & medicinal chemistry letters.

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.

C. Supuran, A. Scozzafava, D. Vullo, 2015, Bioorganic & medicinal chemistry.

Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis

C. Supuran, A. Scozzafava, D. Vullo, 2014, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.

C. Supuran, D. Vullo, B. Żołnowska, 2014, European journal of medicinal chemistry.

Cloning, polymorphism, and inhibition of β-carbonic anhydrase of Helicobacter pylori

C. Supuran, A. Scozzafava, D. Vullo, 2008, Journal of Gastroenterology.

Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.

C. Supuran, A. Scozzafava, D. Vullo, 2006, Bioorganic & medicinal chemistry letters.

Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII.

C. Supuran, D. Vullo, S. Charman, 2012, Journal of medicinal chemistry.

Pseudomonas aeruginosa β-carbonic anhydrase, psCA1, is required for calcium deposition and contributes to virulence.

C. Supuran, D. Vullo, R. McKenna, 2019, Cell calcium.

Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis.

C. Supuran, J. Winum, D. Vullo, 2017, Bioorganic & medicinal chemistry.

Kinetic properties and affinities for sulfonamide inhibitors of an α-carbonic anhydrase (CruCA4) involved in coral biomineralization in the Mediterranean red coral Corallium rubrum.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & medicinal chemistry.

Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & medicinal chemistry letters.

Biochemical characterization of the native α-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis

C. Supuran, D. Vullo, M. Rossi, 2017, Journal of enzyme inhibition and medicinal chemistry.

N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases

C. Supuran, J. Winum, D. Vullo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry letters.

Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of enzyme inhibition and medicinal chemistry.

Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii.

F. Morel, E. Langella, C. Supuran, 2012, Biochimie.

Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

C. Supuran, A. Scozzafava, D. Vullo, 2009, Bioorganic & medicinal chemistry letters.

Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.

C. Supuran, A. Scozzafava, D. Vullo, 2009, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.

C. Supuran, A. Scozzafava, D. Vullo, 2007, Bioorganic & medicinal chemistry letters.

Structural Mapping of Anion Inhibitors to β‐Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa

C. Supuran, D. Vullo, R. McKenna, 2018, ChemMedChem.

Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas)

C. Supuran, D. Vullo, M. Rossi, 2017, Marine drugs.

Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase

C. Supuran, D. Vullo, C. Capasso, 2014, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.

C. Supuran, J. Winum, J. Montero, 2009, Bioorganic & medicinal chemistry letters.

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.

F. Da Settimo, S. Taliani, C. La Motta, 2016, Bioorganic & medicinal chemistry.

Unconventional amino acids in medicinal chemistry: First report on taurine merged within carbonic anhydrase inhibitors.

C. Supuran, D. Vullo, A. Angeli, 2020, Bioorganic chemistry.

Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.

C. Supuran, M. Hilvo, D. Vullo, 2013, Bioorganic & medicinal chemistry.

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors.

A. Vergara, C. Supuran, J. Winum, 2015, Chemical communications.

Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.

C. Supuran, A. Scozzafava, D. Vullo, 2012, Chemical communications.

Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions

C. Supuran, A. Scozzafava, Alessandro Cecchi, 2009 .

Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.

C. Supuran, A. Scozzafava, Alessandro Cecchi, 2007, Bioorganic & medicinal chemistry.

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect.

C. Supuran, D. Vullo, M. Ilies, 2014, Chemical communications.

Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Cancer-associated Isozyme IX with Anions

C. Supuran, A. Scozzafava, D. Vullo, 2003, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.

Andrea Scozzafava, Daniela Vullo, Claudiu T Supuran, 2003, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.

Andrea Scozzafava, Daniela Vullo, Claudiu T Supuran, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.

Brendan L Wilkinson, C. Supuran, A. Innocenti, 2007, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.

C. Supuran, A. Casini, A. Scozzafava, 2003, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.

C. Supuran, A. Casini, A. Scozzafava, 2003, Journal of medicinal chemistry.

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors

C. Supuran, D. Vullo, F. Awadallah, 2022, Journal of enzyme inhibition and medicinal chemistry.

Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

C. Supuran, D. Vullo, A. Dessì, 2017, ACS medicinal chemistry letters.

A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes

C. Supuran, D. Vullo, V. De Luca, 2015, Journal of enzyme inhibition and medicinal chemistry.

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.

C. Supuran, A. Scozzafava, D. Vullo, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.

C. Supuran, D. Vullo, Z. Alothman, 2017, Bioorganic & medicinal chemistry.

Protonography and anion inhibition profile of the α-carbonic anhydrase (CruCA4) identified in the Mediterranean red coral Corallium rubrum.

C. Supuran, D. Vullo, C. Capasso, 2018, Bioorganic chemistry.

Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei

C. Supuran, D. Vullo, C. Capasso, 2017, Journal of enzyme inhibition and medicinal chemistry.

Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.

C. Supuran, D. Vullo, V. De Luca, 2016, Bioorganic & medicinal chemistry.

PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.

C. Supuran, D. Vullo, E. Swenson, 2016, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

Plasmonic Particles that Hit Hypoxic Cells

Francesca Tatini, Roberto Pini, Franco Fusi, 2015 .

The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.

C. Supuran, D. Vullo, S. Parkkila, 2015, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.

C. Supuran, A. Scozzafava, D. Vullo, 2011, Bioorganic & medicinal chemistry letters.

Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII

E. Kremmer, C. Supuran, D. Vullo, 2011, Cancer Immunology, Immunotherapy.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.

C. Supuran, A. Casini, A. Scozzafava, 2005, Journal of medicinal chemistry.

Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.

C. Supuran, D. Vullo, M. Tiwari, 2014, Bioorganic & medicinal chemistry letters.

Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.

C. Supuran, A. Scozzafava, D. Vullo, 2008, European journal of medicinal chemistry.

Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.

C. Supuran, D. Vullo, J. Sławiński, 2010, European journal of medicinal chemistry.

Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.

K. Kaila, C. Supuran, A. Scozzafava, 2006, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.

C. Supuran, A. Casini, A. Scozzafava, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.

C. Supuran, A. Scozzafava, J. Winum, 2007, Bioorganic & Medicinal Chemistry Letters.

Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry.

Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.

Sergio Marques, Alessio Innocenti, Andrea Scozzafava, 2007, Bioorganic & medicinal chemistry letters.

A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.

C. Supuran, D. Vullo, Federica Moraca, 2019, European journal of medicinal chemistry.

PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with (68)Ga-Labeled Benzenesulfonamides.

F. Bénard, C. Supuran, D. Vullo, 2016, Molecular pharmaceutics.

Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques.

C. Supuran, D. Vullo, S. Alcaro, 2016, Journal of agricultural and food chemistry.

4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII.

C. Supuran, D. Vullo, P. Sharma, 2014, European journal of medicinal chemistry.

Structural and biochemical characterization of novel carbonic anhydrases from Phaeodactylum tricornutum.

C. Supuran, D. Vullo, Yonggui Gao, 2020, Acta crystallographica. Section D, Structural biology.

Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.

C. Supuran, D. Vullo, Aycan Aşık, 2016, Bioorganic & medicinal chemistry letters.

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.

C. Supuran, A. Scozzafava, D. Vullo, 2016, Bioorganic & medicinal chemistry letters.

An α-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry.

3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors.

C. Supuran, A. Scozzafava, A. Innocenti, 2010, Current pharmaceutical design.

Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX

E. Langella, C. Supuran, D. Vullo, 2018, Cellular and Molecular Life Sciences.

Carbonic Anhydrase in the Scleractinian Coral

D. Allemand, C. Supuran, D. Vullo, 2008 .

External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans.

C. Supuran, A. Scozzafava, A. Innocenti, 2008, Molecular and biochemical parasitology.

Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.

C. Supuran, A. Scozzafava, D. Vullo, 2004, Bioorganic & medicinal chemistry letters.

Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry

C. Supuran, D. Vullo, S. Zozulya, 2016, Journal of enzyme inhibition and medicinal chemistry.

Carbonic Anhydrase Inhibitors With Strong Topical Antiglaucoma Properties Incorporating a 4-(2-amino-pyrimidin-4-yl-amino)-benzenesulfonamide Scaffold

C. Supuran, A. Casini, A. Scozzafava, 2002, Journal of enzyme inhibition and medicinal chemistry.

Bidentate Zinc Chelators for α‐Carbonic Anhydrases that Produce a Trigonal Bipyramidal Coordination Geometry

Seth M. Cohen, G. Klebe, A. Heine, 2010, ChemMedChem.

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.

C. Supuran, A. Scozzafava, J. Winum, 2005, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.

C. Supuran, A. Scozzafava, A. Innocenti, 2004, Bioorganic & medicinal chemistry letters.

Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors

C. Supuran, D. Vullo, P. Gratteri, 2023, ACS medicinal chemistry letters.

Erratum for: Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products

S. Carradori, C. Supuran, D. Vullo, 2015, Planta Medica.

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.

C. Supuran, A. Scozzafava, A. Innocenti, 2005, Bioorganic & medicinal chemistry letters.

Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.

C. De Monte, S. Carradori, C. Supuran, 2014, European journal of medicinal chemistry.

Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.

C. Supuran, A. Scozzafava, J. Winum, 2009, Bioorganic & medicinal chemistry letters.

Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine.

C. Supuran, A. Scozzafava, D. Vullo, 2006 .

Glycosyl Isoxazoles for Targeting of Tumor Microenvironment and Cancer Cells: Highly Selective Inhibitors of Carbonic Anhydrases IX and XII Showing Cytotoxic Activity

C. Supuran, D. Vullo, I. León, 2023, ChemistrySelect.

Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.

C. Supuran, D. Vullo, S. Tambutté, 2010, Bioorganic & medicinal chemistry.

Design and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis.

Qi Shi, Thomas M Kaiser, Zackery W Dentmon, 2015, ACS medicinal chemistry letters.

Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity.

W. Sly, C. Supuran, D. Vullo, 2008, BMC Biochemistry.

Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.

C. Supuran, A. Scozzafava, D. Vullo, 2006, Bioorganic & medicinal chemistry.

Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia.

C. Supuran, D. Vullo, C. Capasso, 2017, Bioorganic & Medicinal Chemistry.

N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.

C. Supuran, D. Vullo, G. Bartolucci, 2016, Bioorganic & medicinal chemistry.

Out of the active site binding pocket for carbonic anhydrase inhibitors.

S. Carradori, C. Supuran, D. Vullo, 2015, Chemical communications.

Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCA.

C. Supuran, D. Vullo, C. Capasso, 2015, Bioorganic & medicinal chemistry letters.

Carbonic anhydrases activation with 3-amino-1H-1,2,4-triazole-1-carboxamides: Discovery of subnanomolar isoform II activators.

C. Supuran, D. Vullo, M. Barboiu, 2017, Bioorganic & medicinal chemistry.

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.

C. Supuran, D. Vullo, C. Capasso, 2014, Bioorganic & medicinal chemistry letters.

Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.

C. Supuran, M. Hilvo, D. Vullo, 2013, Bioorganic & medicinal chemistry.

Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.

C. Supuran, D. Vullo, J. Pastorek, 2007, The Biochemical journal.

Membrane Permeability Is Required for the Vasodilatory Effect of Carbonic Anhydrase Inhibitors in Porcine Retinal Arteries

C. Supuran, D. Vullo, F. Carta, 2023, International journal of molecular sciences.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.

Alessio Innocenti, Andrea Scozzafava, Daniela Vullo, 2005, Bioorganic & medicinal chemistry letters.

Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases

C. Supuran, A. Scozzafava, D. Vullo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.

C. Supuran, D. Vullo, A. Alafeefy, 2017, Bioorganic & medicinal chemistry.

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.

C. Supuran, A. Scozzafava, D. Vullo, 2016, Bioorganic & Medicinal Chemistry.

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.

C. Supuran, D. Vullo, R. McKenna, 2015, Journal of medicinal chemistry.

Monoclonal antibodies raised against 167–180 aa sequence of human carbonic anhydrase XII inhibit its enzymatic activity

C. Supuran, D. Vullo, A. Zvirbliene, 2014, Journal of enzyme inhibition and medicinal chemistry.

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.

C. Supuran, J. Winum, D. Vullo, 2014, Bioorganic & medicinal chemistry.

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of medicinal chemistry.

Inhibition of Mammalian Carbonic Anhydrases I–XIV by Grayanotoxin III

C. Supuran, D. Vullo, S. Durdağı, 2012 .

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.

C. Supuran, A. Scozzafava, J. Winum, 2011, Bioorganic & medicinal chemistry letters.

Inhibition of the β-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: identification of the first inhibitor with anti-mycobacterial activity.

C. Supuran, D. Vullo, H. R. Morbidoni, 2013, Bioorganic & medicinal chemistry letters.

Carbonic Anhydrase in the Scleractinian Coral Stylophora pistillata

D. Allemand, C. Supuran, D. Vullo, 2008, Journal of Biological Chemistry.

A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.

E. Novellino, C. Supuran, D. Vullo, 2016, Chemistry.

Natural product coumarins that inhibit human carbonic anhydrases.

C. Supuran, D. Vullo, Rohan A. Davis, 2013, Bioorganic & medicinal chemistry.

A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells.

C. Supuran, D. Vullo, R. McKenna, 2024, Bioorganic chemistry.

Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2015, Acta crystallographica. Section D, Biological crystallography.

Carbonic anhydrase inhibitors. Benzenesulfonamides incorporating cyanoacrylamide moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase.

C. Supuran, D. Vullo, C. Capasso, 2013, Bioorganic & medicinal chemistry letters.

Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis

C. Supuran, A. Scozzafava, D. Vullo, 2014, Journal of enzyme inhibition and medicinal chemistry.