H. Sawada

发表

How does voluntary movement stop resting tremor?

H. Shibasaki, T. Nagamine, A. Ikeda, 2010, Clinical Neurophysiology.

Low body mass index and life prognosis in Parkinson's disease.

H. Sawada, A. Umemura, Kwiyoung Park, 2018, Parkinsonism & related disorders.

Compassionate open-label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration.

T. Misu, H. Sawada, Y. Shimizu, 2022, Multiple sclerosis and related disorders.

Diagnostic Accuracy of Apparent Diffusion Coefficient and 123I-Metaiodobenzylguanidine for Differentiation of Multiple System Atrophy and Parkinson’s Disease

H. Sawada, A. Umemura, T. Oeda, 2013, PloS one.

Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.

S. Shimohama, H. Sawada, A. Akaike, 2007, European journal of pharmacology.

Correction: Protocol for a randomised controlled trial: efficacy of donepezil against psychosis in Parkinson's disease (EDAP)

H. Sawada, T. Oeda, 2016, BMJ Open.

Trigger medications and patient-related risk factors for Parkinson disease psychosis requiring anti-psychotic drugs: a retrospective cohort study

H. Sawada, A. Umemura, T. Oeda, 2013, BMC Neurology.

Protocol for a randomised controlled trial: efficacy of donepezil against psychosis in Parkinson's disease (EDAP)

H. Sawada, T. Oeda, 2013, BMJ Open.

For peer review only Protocol for a randomized controlled trial: efficacy of donepezil against psychosis in Parkinson's disease (EDAP)

H. Sawada, 2013 .

Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons

H. Shibasaki, S. Shimohama, H. Sawada, 2003, Journal of neuroscience research.

p‐quinone mediates 6‐hydroxydopamine‐induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p‐quinone into melanin extracellularly

S. Shimohama, H. Sawada, A. Akaike, 2005, Journal of neuroscience research.

Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: Implication of inhibition of vesicular transport.

H. Sawada, A. Akaike, T. Kume, 2010, European journal of pharmacology.

Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures

H. Sawada, A. Akaike, T. Kume, 2010, Journal of Neuroscience Methods.

Proteasome Inhibition Induces Glutathione Synthesis and Protects Cells from Oxidative Stress

S. Shimohama, H. Sawada, A. Akaike, 2007, Journal of Biological Chemistry.

BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line.

H. Shibasaki, S. Shimohama, H. Sawada, 2004, Biochemical and biophysical research communications.

Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons

S. Shimohama, H. Sawada, 2000, Neuroscience & Biobehavioral Reviews.

MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons.

S. Shimohama, H. Sawada, 1999, Parkinsonism & related disorders.

Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress

S. Shimohama, H. Sawada, J. Kimura, 1998, Annals of neurology.

Considerations for pharmacotherapy use in patients with amyotrophic lateral sclerosis: the earlier it starts, the better the results

H. Sawada, 2019, Expert opinion on pharmacotherapy.

Neuroprotective Mechanism of Glial Cell Line‐Derived Neurotrophic Factor in Mesencephalic Neurons

S. Shimohama, H. Sawada, T. Kihara, 2000, Journal of neurochemistry.

Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons

S. Shimohama, H. Sawada, A. Akaike, 2005, Neuroscience Letters.

Iron accelerates the conversion of dopamine‐oxidized intermediates into melanin and provides protection in SH‐SY5Y cells

S. Shimohama, H. Sawada, A. Akaike, 2005, Journal of neuroscience research.

Protection of cultured spinal motor neurons by estradiol

S. Shimohama, H. Sawada, T. Kihara, 2000, Neuroreport.

Transient myoclonic state with asterixis presenting as persistent hyperperfusion on single‐photon emission computed tomography: A case report

H. Sawada, A. Umemura, T. Oeda, 2015 .

[A case of subarachnoid hemorrhage due to infective endocarditis by methicillin-resistant coagulase-negative staphylococcus].

H. Sawada, Kwiyoung Park, T. Oeda, 2017, Rinsho shinkeigaku = Clinical neurology.

N‐methyl‐D‐aspartate receptor‐mediated mitochondrial Ca2+ overload in acute excitotoxic motor neuron death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx

Tomoki, S. Shimohama, H. Sawada, 2001 .

Altered plasticity of the human motor cortex in Parkinson's disease

T. Mima, H. Fukuyama, T. Begum, 2006, Annals of neurology.

Search for a novel SIRT1 activator: structural modification of SRT1720 and biological evaluation.

Yukihiro Itoh, Takayoshi Suzuki, H. Sawada, 2013, Bioorganic & medicinal chemistry letters.

Nucleolar characteristics of reducing bodies in reducing body myopathy

H. Shibasaki, H. Sawada, S. Nakano, 2004, Acta Neuropathologica.

Endogenously Occurring β‐Carboline Induces Parkinsonism in Nonprimate Animals: A Possible Causative Protoxin in Idiopathic Parkinson's Disease

H. Sawada, A. Akaike, K. Matsubara, 1998 .

Seeking transpaRINcy for rituximab dosing in NMOSD – Authors' reply

H. Sawada, T. Oeda, M. Tahara, 2020, The Lancet Neurology.

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis

H. Sawada, 2017, Expert opinion on pharmacotherapy.

Identification of novel SIRT2-selective inhibitors using a click chemistry approach.

Peng Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2014, Bioorganic & medicinal chemistry letters.

Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation

H. Sawada, A. Akaike, H. Katsuki, 2009, Journal of neurochemistry.

Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons

S. Shimohama, H. Sawada, T. Kihara, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein

H. Sawada, T. Oeda, K. Yamamoto, 2013, Diagnostics.

Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons

S. Shimohama, H. Sawada, T. Kihara, 2000, Journal of neuroscience research.

Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia and transient hypoxemia.

H. Fukuyama, H. Shibasaki, T. Begum, 2006, Internal medicine.

Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter.

H. Sawada, A. Akaike, H. Katsuki, 2008, European journal of pharmacology.

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

Y. Itoyama, S. Tsuji, G. Sobue, 2017, The Lancet Neurology.

Delirium and High Fever Are Associated with Subacute Motor Deterioration in Parkinson Disease: A Nested Case-Control Study

H. Sawada, A. Umemura, Kwiyoung Park, 2014, PloS one.

Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade

S. Shimohama, H. Sawada, T. Kihara, 2002, Journal of neuroscience research.

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

P. Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2013, Journal of medicinal chemistry.

A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus.

H. Sawada, Kwiyoung Park, T. Oeda, 2015, Neurology. Clinical practice.

Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.

K. Takata, Y. Kitamura, T. Taniguchi, 2005, Journal of pharmacological sciences.

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone‐induced Parkinson's disease models

K. Takata, Y. Kitamura, T. Taniguchi, 2009, Journal of neuroscience research.

Elevation of heme oxygenase‐1 by proteasome inhibition affords dopaminergic neuroprotection

H. Sawada, A. Akaike, T. Kume, 2010, Journal of neuroscience research.

[A case of refractory generalized myasthenia gravis with anti-acetylcholine receptor antibodies treated with rituximab].

H. Sawada, T. Oeda, M. Tahara, 2015, Rinsho shinkeigaku = Clinical neurology.

Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia.

Hidekazu Tomimoto, Shun Shimohama, Makoto Matsui, 2006, Internal medicine.

Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: Involvement of glutamate‐induced nitric oxide in motor neuron toxicity and nonmotor neuron protection

Y. Kitamura, T. Taniguchi, S. Shimohama, 1998, Annals of neurology.

Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons

H. Shibasaki, S. Shimohama, H. Sawada, 2001, Journal of neuroscience research.

Stimulation of nicotinic acetylcholine receptors protects motor neurons.

S. Shimohama, H. Sawada, T. Kihara, 2005, Biochemical and biophysical research communications.

Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures

H. Sawada, A. Akaike, T. Kume, 2010, Neuroscience Letters.

Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons

H. Shibasaki, S. Shimohama, H. Sawada, 2004, Brain Research.

Disease model: Parkinson's disease.

Y. Kitamura, T. Taniguchi, S. Shimohama, 2003, Trends in molecular medicine.

Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease

S. Shimohama, H. Sawada, M. Ohba, 2009, European journal of neurology.

Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity.

S. Shimohama, A. Maelicke, H. Sawada, 2004, Biochemical and biophysical research communications.

α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity*

H. Shibasaki, S. Shimohama, H. Sawada, 2001, The Journal of Biological Chemistry.

Title Baseline Plasma C-Reactive Protein Concentrations and MotorPrognosis in Parkinson Disease

H. Sawada, A. Umemura, Kwiyoung Park, 2019 .

Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease

H. Sawada, A. Umemura, Kwiyoung Park, 2015, PloS one.

Baseline C-Reactive Protein Levels and Life Prognosis in Parkinson Disease

H. Sawada, A. Umemura, Kwiyoung Park, 2015, PloS one.

Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial

T. Misu, H. Sawada, Y. Shimizu, 2020, The Lancet Neurology.

Amantadine for Dyskinesias in Parkinson's Disease: A Randomized Controlled Trial

K. Hisanaga, H. Sawada, Mitsutoshi Yamamoto, 2010, PloS one.

α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP3 receptor

H. Sawada, T. Kume, Yasuhiko Izumi, 2019, Scientific Reports.

Gas Transport Properties and Crystalline Structures of Poly(lactic acid) Membranes

Shuichi Sato, K. Nagai, H. Sawada, 2010 .

Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease

Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, 2015, Neurobiology of Aging.

Pharmacological interventions for anxiety in Parkinson’s disease sufferers

H. Sawada, A. Umemura, Kwiyoung Park, 2018, Expert opinion on pharmacotherapy.

Early use of donepezil against psychosis and cognitive decline in Parkinson’s disease: a randomised controlled trial for 2 years

H. Sawada, M. Goto, T. Kawamura, 2018, Journal of Neurology, Neurosurgery, and Psychiatry.

Estradiol protects dopaminergic neurons in a MPP+Parkinson’s disease model

Akinori Akaike, Shun Shimohama, S. Shimohama, 2002, Neuropharmacology.

Clinical Factors Associated with Abnormal Postures in Parkinson's Disease

Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, 2013, PloS one.

Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.

Yukihiro Itoh, Miki Suzuki, Takayoshi Suzuki, 2015, ACS medicinal chemistry letters.

Neuroprotective effect of cyclic GMP against radical‐induced toxicity in cultured spinal motor neurons

H. Shibasaki, S. Shimohama, H. Sawada, 2000, Journal of neuroscience research.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, H. Sawada, 2012, Journal of medicinal chemistry.

Proteasome Mediates Dopaminergic Neuronal Degeneration, and Its Inhibition Causes α-Synuclein Inclusions*

Hiroshi Shibasaki, Yasuhiko Izumi, Akinori Akaike, 2004, Journal of Biological Chemistry.

Oxybuprocaine for apraxia of lid opening in Parkinson's disease: A placebo‐controlled pilot trial

H. Sawada, A. Umemura, Kwiyoung Park, 2018, Movement disorders : official journal of the Movement Disorder Society.

Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone

Yasuhiko Izumi, Shuji Kaneko, Akinori Akaike, 2003, Neuroreport.

Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells.

Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume, 2010, Biochemical and biophysical research communications.

Impact of Aspiration Pneumonia on the Clinical Course of Progressive Supranuclear Palsy: A Retrospective Cohort Study

H. Sawada, H. Fujimura, A. Umemura, 2015, PloS one.

Associative plasticity of the motor cortex in Parkinson's disease

T. Mima, H. Fukuyama, T. Nagamine, 2005 .

Estradiol protects mesencephalic dopaminergic neurons from oxidative stress‐induced neuronal death

Akinori Akaike, Shun Shimohama, S. Shimohama, 1998, Journal of neuroscience research.

Depletion of Intracellular Glutathione Increases Susceptibility to Nitric Oxide in Mesencephalic Dopaminergic Neurons

S. Shimohama, H. Sawada, A. Akaike, 1999 .

Cocaine and phenylephrine eye drop test for Parkinson disease.

S. Shimohama, H. Sawada, M. Ohba, 2005, Journal of the American Medical Association (JAMA).

Early-start vs delayed-start donepezil against cognitive decline in Parkinson disease: a randomized clinical trial

H. Sawada, K. Kiyohara, A. Umemura, 2020, Expert opinion on pharmacotherapy.

Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson’s disease

H. Sawada, A. Umemura, Kwiyoung Park, 2018, PloS one.

Subclinical Elevation of Plasma C-Reactive Protein and Illusions/Hallucinations in Subjects with Parkinson’s Disease: Case–control Study

H. Sawada, A. Umemura, T. Oeda, 2014, PloS one.

Estrogens and parkinson disease

S. Shimohama, H. Sawada, 2003, Endocrine.

Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture

S. Shimohama, H. Sawada, A. Akaike, 2001, Neuropharmacology.

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

S. Shimohama, H. Sawada, J. Kimura, 1997 .

alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.

H Shibasaki, T Kihara, S Shimohama, 2001, The Journal of biological chemistry.

Methylphenylpyridium ion enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon

S. Shimohama, H. Sawada, J. Kimura, 1994 .

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

S. Shimohama, H. Sawada, J. Kimura, 1998, Brain Research.

Dopamine D2-Type Agonists Protect MesenceDhalic Neurons from Glutamate Nebotoxicitv: Mechanisms

S. Shimohama, H. Sawada, T. Kihara, 2004 .

Different mechanisms of glutamate‐induced neuronal death between dopaminergic and non‐dopaminergic neurons in rat mesencephalic culture

S Shimohama, H Sawada, A Akaike, 1996, Journal of neuroscience research.