A. Mathur

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Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Ping Chen, S. Spergel, S. Chong, 2003, Journal of medicinal chemistry.

Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent.

J. Fargnoli, S. Sheriff, A. Mathur, 2020, ACS medicinal chemistry letters.

Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).

S. Spergel, N. Murugesan, Z. Gu, 1998, Journal of medicinal chemistry.

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

S. Spergel, J. Barrish, N. Murugesan, 2000, Journal of Medicinal Chemistry.

Microwave accelerated Castagnoli-Cushman reaction: Synthesis of novel 6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines

A. Mathur, A. Roy, Devaiah Vytla, 2021 .

Synthesis and Ion-Binding Properties of Polymeric Pseudocrown Ethers - a Molecular-Dynamics Study

A. Mathur, A. Scranton, 1995 .

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.

Punit Marathe, Ravindra Tejwani, Arvind Mathur, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

G. Trainor, A. Mathur, D. Langley, 2009, Journal of medicinal chemistry.

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

A. Mathur, J. Cutrone, N. Meanwell, 2017, Bioorganic & medicinal chemistry letters.

Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.

Michael A. Galella, D. Shen, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.

J. Tokarski, A. Mathur, L. Leith, 2004, Bioorganic & medicinal chemistry letters.

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.

A. Mathur, N. Meanwell, Chaoqun Chen, 2020, Journal of medicinal chemistry.

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

J. Macor, A. Mathur, M. Ahlijanian, 2019, ACS medicinal chemistry letters.

Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles

A. Mathur, N. Meanwell, A. Gupta, 2020, Synthesis.

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

Malcolm E. Davis, A. Mathur, G. Bisacchi, 2004, Bioorganic & medicinal chemistry letters.

Separation and preparative purification of l ‐ and d ‐valine ester: Diastereomeric conjugates of atazanavir using a combination of 2‐propanol and acetonitrile in reversed‐phase high‐performance liquid chromatography

Murugaiah A. M. Subbaiah, A. Mathur, M. Shyamsundar, 2020 .

Integrating a post-column makeup pump into preparative supercritical fluid chromatography systems to address stability and recovery issues during purifications.

A. Mathur, Dauh-Rurng Wu, R. Sarabu, 2017, Journal of chromatography. A.

Beta 3 agonists. Part 1: evolution from inception to BMS-194449.

R. Gregg, A. Mathur, T. Waldron, 2001, Bioorganic & medicinal chemistry letters.

BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor.

A. Mathur, T. Waldron, K. Dickinson, 2001, Bioorganic & medicinal chemistry letters.

Advances in the synthesis of three-dimensional molecular architectures by dearomatizing photocycloadditions

A. Mathur, N. Meanwell, T. G. Dhar, 2021 .

Intramolecular [2+2] Cycloaddition of N-Allylcinnamamines and N -Allylcinnamamides by Visible-Light Photocatalysis

A. Mathur, N. Meanwell, Jianqing Li, 2020 .

Utilization of C( sp 3 )‐Carboxylic Acids and Their Redox‐Active Esters in Decarboxylative Carbon−Carbon Bond Formation

A. Mathur, N. Meanwell, A. Gupta, 2021 .

Methyl-2,2-difluoro-2-(fluorosulfonyl) acetate (MDFA)/copper (I) iodide mediated and tetrabutylammonium iodide promoted trifluoromethylation of 1-aryl-4-iodo-1,2,3-triazoles

A. Mathur, Anuradha Gupta, R. Nimje, 2020 .

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

A. Mathur, B. Warrack, A. Rajpal, 2020, Journal of medicinal chemistry.

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.

A. Mathur, P. Stein, M. Conder, 2001, Journal of Medicinal Chemistry.

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable IKs blockers

A. Mathur, P. Stein, Mark A. Smith, 2001 .

Regioselective Synthesis of Substituted 4-Alkylamino and 4-Arylaminophthalazin-1(2H)-ones.

A. Mathur, Jianqing Li, Dauh-Rurng Wu, 2016, The Journal of organic chemistry.

Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Michael G. Yang, K. McIntyre, D. Shen, 2019, Journal of medicinal chemistry.

Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.

P. Lam, Hong Shen, A. Mathur, 2014, Bioorganic & medicinal chemistry letters.

Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-β3 binding selectivity

A. Mathur, K. Dickinson, Gang Wu, 1997 .

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.

Michael G. Yang, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

David S. Nirschl, Kimberly A. Foster, David S Nirschl, 2017, Journal of medicinal chemistry.

The effect of water on the large-scale supercritical fluid chromatography purification of two factor XIa active pharmaceutical ingredients.

A. Mathur, Dawn Sun, Dauh-Rurng Wu, 2021, Journal of chromatography. A.

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.

Vijay T. Ahuja, Derek J. Norris, J. Tokarski, 2021, Journal of medicinal chemistry.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

J. Macor, A. Mathur, B. Srikumar, 2018, ACS medicinal chemistry letters.

Sub/supercritical Fluid Chromatography Purification and Desalting of a Cyclic Dinucleotide STING Agonist.

A. Mathur, Dawn Sun, Dauh-Rurng Wu, 2021, Journal of chromatography. A.

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.

Michael A. Galella, S. Sheriff, A. Mathur, 2021, Journal of medicinal chemistry.

Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.

P. Lam, S. Sheriff, A. Mathur, 2020, Journal of medicinal chemistry.

BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.

J. Barrish, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Journal of medicinal chemistry.

An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

A. Mathur, W. Pitts, P. Carter, 2016 .

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Michael G. Yang, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272

Lidet K. Negash, A. Mathur, R. Lawrence, 2022, Organic Process Research & Development.

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

K. McIntyre, J. Barrish, A. Mathur, 2016, Journal of medicinal chemistry.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Ping Chen, Henry H. Gu, E. Iwanowicz, 2007, Journal of medicinal chemistry.

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

L. Mueller, K. Kish, H. Klei, 2016, Journal of medicinal chemistry.

Equilibrium swelling of poly(methacrylic acid-g-ethylene glycol) hydrogels. Effect of swelling medium and synthesis conditions.

A. Mathur, A. Scranton, J. Klier, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Separation of Bruton's tyrosine kinase inhibitor atropisomers by supercritical fluid chromatography.

A. Mathur, Peng Li, J. Tino, 2019, Journal of chromatography. A.

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

Michael A. Galella, D. Shuster, D. Shen, 2019, ACS medicinal chemistry letters.

Evolution of a Scale-Up Synthesis to a Potent GluN2B Inhibitor and Its Prodrug

Michael A. Galella, A. Mathur, M. Dabros, 2018, Organic Process Research & Development.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.

Michael A. Galella, K. McIntyre, J. Barrish, 2020, ACS medicinal chemistry letters.

Synthesis and ion-binding properties of polymeric pseudocrown ethers II: template ion induced cyclization of oligomeric ethylene glycol diacrylates

A. Mathur, A. Scranton, A. Mathur, 1997 .

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).

P. Lam, S. Sheriff, A. Mathur, 2017, Journal of medicinal chemistry.

Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.

A. Mathur, P. Morin, D. Seiffert, 2014, Journal of medicinal chemistry.

A mild and readily scalable procedure for the N-1-difluoromethylation of ethyl 6-((tert-butyldiphenylsilyl)oxy)-1H-indazole-3-carboxylate and its applications to the N-difluoromethylation of indazole, benzotriazole, imidazole, indole and pyrazole derivatives

A. Mathur, Leon M. Smith, Jianqing Li, 2020, Journal of Fluorine Chemistry.

An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist

Vijay T. Ahuja, J. Barrish, A. Mathur, 2012 .

Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

A. Mathur, A. Gupta, P. Carter, 2019, Organic Process Research & Development.

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.

A. Mathur, G. Bisacchi, W. Meng, 2004, Bioorganic & medicinal chemistry letters.

Solvent-specific, DAST-mediated intramolecular Friedel-Crafts reaction: access to dibenzoxepine-fused spirooxindoles.

A. Mathur, Jianqing Li, Anuradha Gupta, 2021, Organic & biomolecular chemistry.

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

B. Beno, A. Mathur, Chunjian Liu, 2022, Journal of medicinal chemistry.

Route evaluation and development of a practical synthesis of methyl (S)-2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-7-carboxylate

A. Mathur, Martins S Oderinde, J. Kempson, 2020 .

α -Unsubstituted β -Lactams as Synthons for Antibiotics

A. Mathur, A. Bose, M. S. Manhas, 1993 .

Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

David K. Leahy, Martin D. Eastgate, A. Mathur, 2020 .

Vinyl-β-lactams as Efficient Synthons. Eco-friendly Approaches via Microwave Assisted Reactions

A. Mathur, B. Banik, A. Bose, 2000 .

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

J. Fargnoli, Derek J. Norris, J. Tokarski, 2009, Journal of medicinal chemistry.

Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.

Kimberly A. Foster, C. Chu, A. Mathur, 2021, Journal of medicinal chemistry.

Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process

A. Mathur, N. Meanwell, Jianqing Li, 2020 .

One-pot synthesis of 2-aryl-1,2-fused pyrimidones

A. Mathur, P. Arunachalam, Ramasamy Duraisamy, 2017, Journal of Chemical Sciences.

Photo-Initiated Nickel Catalysis (PiNiC): Unmasking Dimethylnickel with Light

A. Mathur, N. Meanwell, T. G. Dhar, 2022, ACS Catalysis.

Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

A. Mathur, Zhiwei Guo, A. Goswami, 2017 .

Process Optimization for the Large-Scale Preparation of (2S,3aR,7aS)-tert-Butyl Hexahydro-2,5-methanopyrrolo[3,2-c]pyridine-1(4H)-carboxylate, an Intermediate for Nicotinic Acetylcholine Receptor Agonists

A. Mathur, I. Mcdonald, R. Olson, 2018, Organic Process Research & Development.

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.

A. Mathur, N. Meanwell, P. Li, 2017, The Journal of organic chemistry.

Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.

P. Lam, S. Sheriff, A. Mathur, 2019, Journal of medicinal chemistry.

A Short and Scalable Synthesis of Orthogonally Protected Bis(aminomethyl)malonic Acid: Access to Bioactive Macrocyclic Peptides

A. Mathur, Anuradha Gupta, M. Vetrichelvan, 2017 .

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.

Antonio Ramirez, A. Mathur, N. Meanwell, 2020, The Journal of organic chemistry.

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity.

Antonio Ramirez, A. Mathur, N. Meanwell, 2020, Journal of the American Chemical Society.

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.

Shana L. Posy, A. Mathur, J. Guay, 2022, Journal of medicinal chemistry.

Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

J. Fargnoli, G. Derbin, J. Barrish, 2006, Journal of medicinal chemistry.

Characterization of hydrogels using nuclear magnetic resonance spectroscopy.

A. Mathur, A. Scranton, 1996, Biomaterials.

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

Interactions of surfactants with polymers and proteins

A. Mathur, A. Scranton, 1996 .

Reverse-phase HPLC purification for an extremely unstable glucuronide metabolite.

A. Mathur, Peng Li, Dawn Sun, 2020, Journal of pharmaceutical and biomedical analysis.

Polymeric emulsifiers based on reversible formation of hydrophobic units

A. Mathur, A. Scranton, J. Klier, 1998, Nature.

UV Curable Epoxidized Oils with Vinylethers as Reactive Diluents

A. Mathur, 1998 .

From analytical methods to large scale chiral supercritical fluid chromatography using chlorinated chiral stationary phases.

A. Mathur, P. Li, Dawn Sun, 2016, Journal of chromatography. A.

Large-scale supercritical fluid chromatography purification of unstable STING agonist intermediates.

A. Mathur, Dawn Sun, Dauh-Rurng Wu, 2021, Journal of chromatography. A.

Large‐scale chiral supercritical fluid chromatography of a key intermediate in the synthesis of two S1P 1 final active pharmaceutical ingredients

A. Mathur, P. Li, Dawn Sun, 2019, SEPARATION SCIENCE PLUS.

Additive free preparative chiral SFC separations of 2,2-dimethyl-3-aryl-propanoic acids.

A. Mathur, P. Li, Dawn Sun, 2016, Journal of pharmaceutical and biomedical analysis.

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Methods for Synthesis of Hydrogel Networks: A Review

A. Mathur, A. Scranton, S. K. Moorjani, 1996 .

Crystallization-Induced Dynamic Resolution toward the Synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]-azepin-6-one: An Important Scaffold for γ-Secretase Inhibitors

A. Mathur, Anuradha Gupta, Richard Rampulla, 2016 .

Tertiary-butoxycarbonyl (Boc) – A strategic group for N-protection/deprotection in the synthesis of various natural/unnatural N-unprotected aminoacid cyanomethyl esters

A. Mathur, A. Gupta, R. Rampulla, 2018, Tetrahedron Letters.

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.

P. Lam, W. Humphreys, A. Mathur, 2015, The Journal of organic chemistry.

Chlorotrimethylsilane and Sodium Iodide: An Expedient Combination for the Chemo/Regioselective Dehalogenation of Benzothiazole and Thiazole Derivatives

A. Mathur, Anuradha Gupta, M. Vetrichelvan, 2023, ChemistrySelect.

Synthesis of Differentially Protected Azatryptophan Analogs via Pd2(dba)3/XPhos Catalyzed Negishi Coupling of N-Ts Azaindole Halides with Zinc Derivative from Fmoc-protected tert-Butyl (R)-2-amino-3-iodopropanoate.

A. Mathur, C. Cavallaro, A. Roy, 2020, The Journal of organic chemistry.

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Michael A. Galella, K. McIntyre, J. Macor, 2019, Journal of medicinal chemistry.

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

David S. Nirschl, David S Nirschl, G. Trainor, 2012, Bioorganic & medicinal chemistry letters.

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Isolation and characterization of pseudo degradation products of acalabrutinib using ESI-HRMS/MS and NMR: Formation of possible geometrical isomers.

A. Mathur, A. Roy, Muralidhararao Bagadi, 2022, Journal of pharmaceutical and biomedical analysis.

Applications of 2, 2, 2 trifluoroethanol as a versatile co-solvent in supercritical fluid chromatography for purification of unstable boronate esters, enhancing throughput, reducing epimerization, and for additive free purifications.

A. Mathur, A. Gupta, Siddheshwar K Chauthe, 2018, Journal of chromatography. A.

Chemical Modification of Linkers Provides Stable Linker-Payloads for the Generation of Antibody-Drug Conjugates.

A. Mathur, H. D. King, G. Vite, 2020, ACS medicinal chemistry letters.

Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.

A. Mathur, G. Vite, Y. Poudel, 2019, Bioorganic & medicinal chemistry letters.

Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

Amol G. Dikundwar, A. Mathur, A. Gupta, 2021, Organic Process Research & Development.

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

P. M. Davis, V. Goldfarb, D. Cheney, 2006, Journal of medicinal chemistry.

Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.

David S. Nirschl, David S Nirschl, Arthur M Doweyko, 2007, Bioorganic & medicinal chemistry letters.

Enantioselective synthesis of BMS-911278: a triple reuptake inhibitor

A. Mathur, Paul C. Lobben, Shuang Liu, 2017 .

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

J. Tokarski, G. Trainor, A. Mathur, 2015, ACS medicinal chemistry letters.

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.

K. McIntyre, D. Shuster, D. Shen, 2016, Journal of medicinal chemistry.

Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.

S. Mandlekar, A. Mathur, Abhisek Banerjee, 2017, Journal of medicinal chemistry.

Identification of potent tricyclic prodrug S1P1 receptor modulators.

K. McIntyre, D. Shen, A. Mathur, 2017, MedChemComm.

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.

K. McIntyre, D. Shen, J. Barrish, 2016, ACS medicinal chemistry letters.

Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.

Alan G. E. Wilson, G. Shankar, J. Macor, 2022, Journal of medicinal chemistry.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

High-Throughput GC-FID Method for the Determination of Residual Solvents in Early-Phase Drug Discovery Samples

A. Mathur, S. Chauthe, Muralidhararao Bagadi, 2022, Chromatographia.

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.

A. Good, K. Kish, H. Klei, 2018, ACS medicinal chemistry letters.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

Development of a Rapid Scale-Up Synthesis of (S)-N-(8-((2-Amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide, a Potent Adaptor-Associated Kinase 1 Inhibitor

J. Macor, A. Mathur, Jianqing Li, 2022, Organic Process Research & Development.

Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".

P. Lam, W. Humphreys, A. Mathur, 2015, Journal of Organic Chemistry.

Metallaphotoredox Decarboxylative Arylation of Natural Amino Acids via an Elusive Mechanistic Pathway

A. Mathur, N. Meanwell, Darpandeep Aulakh, 2022, ACS Catalysis.

Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.

A. Mathur, N. Meanwell, Zeyu Lin, 2020, Bioorganic & medicinal chemistry.

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.

Michael G. Yang, K. McIntyre, D. Shen, 2020, ACS medicinal chemistry letters.

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.

Kimberly A. Foster, Michael A. Galella, J. Barrish, 2023, Bioorganic & medicinal chemistry.

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019 .

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019, Bioorganic & medicinal chemistry letters.

Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, Journal of medicinal chemistry.

Solid-phase synthesis of JBIR-126 (Tambromycin), JBIR-35 and their analogs

A. Mathur, A. Roy, Anuradha Gupta, 2021 .

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Discovery of Novel Pyridinones as MGAT2 Inhibitors for the Treatment of Metabolic Disorders.

Kimberly A. Foster, C. Chu, A. Mathur, 2023, Bioorganic & Medicinal Chemistry Letters.

A chiral route to the synthesis of (2S,3aR,7aS)-tertbutyl hexahydro-2,5-methanopyrrolo[3,2-c]pyridine1(4H)-carboxylate, an intermediate for nicotinic acetylcholine receptors agonists

A. Mathur, Jianqing Li, Anuradha Gupta, 2022, Social Science Research Network.

J. Fargnoli, G. Derbin, J. Barrish, 2008, Bioorganic & medicinal chemistry letters.

A. Mathur, A. Gupta, Siddheshwar K Chauthe, 2018, Journal of chromatography. A.

Concise synthesis of chiral pyrazolo[4,3‐ f ] [1,4]oxazepines and pyrazolo[4,3‐ f ] [1,4]thiazepines bearing pyrazole unit

A. Mathur, Anuradha Gupta, R. Rampulla, 2020 .

Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders.

Lidet K. Negash, Kimberly A. Foster, A. Mathur, 2023, Journal of medicinal chemistry.

Integrating a post-column makeup pump into preparative supercritical fluid chromatography systems to address stability and recovery issues during purifications.

A. Mathur, R. Sarabu, P. Arunachalam, 2017, Journal of chromatography. A.

Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

J. Macor, A. Mathur, B. Srikumar, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Tunable Synthesis of Pyrazolo Oxepines, Pyrazolo Thiophenes and 1H‐Indazoles Using Alkylation, Aldol Condensation and Thermal Rearrangement

A. Mathur, Anuradha Gupta, M. Pavan, 2024, ChemistrySelect.

Synthesis of 1-(tert-Butyl) 4-Methyl (1R,2S,4R)-2-Methylcyclohexane-1,4-Dicarboxylate from Hagemann's tert-Butyl Ester for an Improved Synthesis of BMS-986251.

A. Mathur, Darpandeep Aulakh, Jianqing Li, 2020, The Journal of organic chemistry.

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

Murugaiah A. M. Subbaiah, G. Schieven, A. Mathur, 2024, ACS medicinal chemistry letters.

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

G. Schieven, A. Mathur, D. Critton, 2024, ACS medicinal chemistry letters.

Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.

A. Mathur, E. Priestley, J. M. Richter, 2024, Journal of medicinal chemistry.