A. Marino

发表

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Ping Chen, S. Spergel, S. Chong, 2003, Journal of medicinal chemistry.

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

S. Spergel, J. Barrish, N. Murugesan, 2000, Journal of Medicinal Chemistry.

Use of Cryopreserved Transiently Transfected Cells in High-Throughput Pregnane X Receptor Transactivation Assay

Zhengrong Zhu, M. Banks, A. Cacace, 2007, Journal of biomolecular screening.

P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?

S. Chong, A. Marino, P. Balimane, 2008, The AAPS Journal.

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys

A. Marino, P. Marathe, Y. Lai, 2017, The AAPS Journal.

Application of structure–metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties

S. Chong, J. Barrish, W. Humphreys, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Michael G. Yang, K. McIntyre, D. Shen, 2019, Journal of medicinal chemistry.

Tobacco-specific nitrosamines (TSNA) in heated tobacco product IQOS

M. Goniewicz, A. Marino, R. O’Connor, 2018, Tobacco Control.

Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

W. Humphreys, A. Marino, Y. Lai, 2019, Front. Pharmacol..

Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).

Michael A. Galella, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Development of a quantitative LC-MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay.

A. Marino, T. Olah, P. Balimane, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Michael G. Yang, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.

A. Marino, N. Meanwell, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.

A. Marino, N. Meanwell, I. Medina, 2009, Bioorganic & medicinal chemistry letters.

Modulation of tight junctions does not predict oral absorption of hydrophilic compounds: Use of caco-2 and calu-3 cells

S. Chong, A. Marino, R. Morrison, 2007, Archives of pharmacal research.

Suitability of Enalapril as a Probe of the Dipeptide Transporter System: InVitro and In Vivo Studies

W. J. Irwin, S. Chong, A. Marino, 1996, Pharmaceutical Research.

Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds.

S. Chong, A. Marino, P. Balimane, 2005, International journal of pharmaceutics.

Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprotein efflux.

S. Chong, A. Marino, R. Morrison, 2005, Journal of pharmaceutical sciences.

Prodrugs of BMS-183920: metabolism and permeability considerations.

S. Chong, A. Marino, R. Morrison, 1996, Journal of pharmaceutical sciences.

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.

K. McIntyre, D. Shuster, D. Shen, 2016, Journal of medicinal chemistry.

Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.

S. Spergel, R. Moquin, K. McIntyre, 2016, Journal of medicinal chemistry.

Identification of potent tricyclic prodrug S1P1 receptor modulators.

K. McIntyre, D. Shen, A. Mathur, 2017, MedChemComm.

Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).

S. Spergel, K. McIntyre, D. Shuster, 2016, Bioorganic & medicinal chemistry letters.

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.

K. McIntyre, D. Shen, J. Barrish, 2016, ACS medicinal chemistry letters.

Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery.

S. Chong, A. Marino, P. Balimane, 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.

A. Marino, N. Meanwell, R. Colonno, 2010, Journal of pharmaceutical sciences.

Preclinical pharmacokinetics of a novel HIV‐1 attachment inhibitor BMS‐378806 and prediction of its human pharmacokinetics

A. Marino, N. Meanwell, R. Colonno, 2005, Biopharmaceutics & drug disposition.

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.

Michael G. Yang, K. McIntyre, D. Shen, 2020, ACS medicinal chemistry letters.

Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852.

S. Chong, A. Marino, R. Morrison, 1996, Journal of pharmaceutical sciences.

Intestinal absorption of captopril and two thioester analogs in rats and dogs.

A. Marino, S. Singhvi, R. A. Morrison, 1997, Biopharmaceutics & drug disposition.