R. Morrison

发表

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Ping Chen, S. Spergel, S. Chong, 2003, Journal of medicinal chemistry.

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

S. Spergel, J. Barrish, N. Murugesan, 2000, Journal of Medicinal Chemistry.

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Natesan Murugesan, S. Chong, J. Barrish, 2002, Journal of medicinal chemistry.

Evaluation of Biocoat® Intestinal Epithelium Differentiation Environment (3-Day Cultured Caco-2 Cells) as an Absorption Screening Model with Improved Productivity

Richard A. Morrison, S. Chong, R. Morrison, 1997, Pharmaceutical Research.

Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.

Walter A. Korfmacher, R. Morrison, F. G. Njoroge, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

High-performance liquid chromatography–atmospheric pressure chemical ionization/tandem mass spectrometry for the determination of a thiol compound in plasma

Walter A. Korfmacher, R. Morrison, Y. Hsieh, 2003 .

Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans.

R. Morrison, F. G. Njoroge, K. Cheng, 2008, Biochemical pharmacology.

Supercritical fluid chromatography-tandem mass spectrometry for the enantioselective determination of propranolol and pindolol in mouse blood by serial sampling.

Walter A. Korfmacher, J. Cook, R. Morrison, 2006, Analytical chemistry.

Application of structure–metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties

S. Chong, J. Barrish, W. Humphreys, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in Dogs

R. Morrison, C. D’arienzo, M. Arnold, 1991, Pharmaceutical Research.

Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery.

Walter A. Korfmacher, R. Morrison, A. Nomeir, 2009, Journal of pharmaceutical sciences.

The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.

Ping Chen, W. Greenlee, A. Stamford, 2014, Journal of medicinal chemistry.

Thromboxane receptor antagonist BMS-180291: A new pre-clinical lead

J. Barrish, P. Sprague, R. Morrison, 1992 .

Oxidative activation of acylguanidine prodrugs: intestinal presystemic activation in rats limits absorption and can be inhibited by co-administration of ketoconazole

J. Das, R. Moquin, S. Chong, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Modulation of tight junctions does not predict oral absorption of hydrophilic compounds: Use of caco-2 and calu-3 cells

S. Chong, A. Marino, R. Morrison, 2007, Archives of pharmacal research.

Rapid in vivo oral screening in rats: Reliability, acceptance criteria, and filtering efficiency

Walter A. Korfmacher, Walter Korfmacher, R. Morrison, 2006, The AAPS Journal.

Current methodologies used for evaluation of intestinal permeability and absorption.

R A Morrison, S. Chong, R. Morrison, 2000, Journal of pharmacological and toxicological methods.

Suitability of Enalapril as a Probe of the Dipeptide Transporter System: InVitro and In Vivo Studies

W. J. Irwin, S. Chong, A. Marino, 1996, Pharmaceutical Research.

A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.

W. J. Irwin, S. Chong, R. Morrison, 2000, International journal of pharmaceutics.

Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats

Ming Yao, Richard A. Morrison, S. Chong, 2003, Archives of pharmacal research.

Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.

R. Morrison, K. Cheng, Ronald E. White, 2005, Journal of pharmacological and toxicological methods.

Prediction of the Oral Absorption of Low-Permeability Drugs Using Small Intestine-Like 2/4/A1 Cell Monolayers

Per Artursson, Staffan Tavelin, S. Chong, 2003, Pharmaceutical Research.

Continuous Blood Withdrawal as a Rapid Screening Method for Determining Clearance and Oral Bioavailability in Rats

W. Humphreys, R. Morrison, M. Obermeier, 1998, Pharmaceutical Research.

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.

Weiying Yang, Frank Bennett, Jesse Wong, 2010, ACS medicinal chemistry letters.

Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprotein efflux.

S. Chong, A. Marino, R. Morrison, 2005, Journal of pharmaceutical sciences.

Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers.

R. Morrison, K. Cheng, Richard A Morrison, 2008, Biochemical pharmacology.

A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma.

S. Chong, R. Morrison, Hongjiang Zhang, 2003, Journal of pharmaceutical and biomedical analysis.

Prodrugs of BMS-183920: metabolism and permeability considerations.

S. Chong, A. Marino, R. Morrison, 1996, Journal of pharmaceutical sciences.

Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system.

R. Morrison, A. Nomeir, Tongtong Liu, 2003, Rapid communications in mass spectrometry : RCM.

Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue.

Walter A. Korfmacher, R. Morrison, Y. Hsieh, 2006, Rapid communications in mass spectrometry : RCM.

Vicriviroc, A Novel CCR5 Inhibitor, is NOT A p-glycoprotein Substrate In Vitro

R. Morrison, Ronald E. White, Cheng Li, 2005, Retrovirology.

PK Principles and PK/PD Applications

R. Morrison, H. Mei, 2009 .

Exploratory drug safety: a discovery strategy to reduce attrition in development.

Richard Morrison, John Hunter, Alan S Bass, 2009, Journal of pharmacological and toxicological methods.

Uptake and transport of the ACE-inhibitor ceronapril (SQ 29852) by monolayers of human intestinal absorptive (Caco-2) cells in vitro

W. J. Irwin, R. Morrison, P. Nicklin, 1996 .

Pharmacokinetics of pseudoephedrine in rats, dogs, monkeys and its pharmacokinetic-pharmacodynamic relationship in a feline model of nasal congestion.

Walter A. Korfmacher, M. Corboz, R. Morrison, 2010, Drug Metabolism Letters.

Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors.

Robert Chase, Sony Agrawal, X. Tong, 2008, Biochemical pharmacology.

In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System

S. Chong, R. Morrison, S. Dando, 2004, Pharmaceutical Research.

Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852.

S. Chong, A. Marino, R. Morrison, 1996, Journal of pharmaceutical sciences.

Prediction of the Oral Absorption of Low-Permeability Drugs Using Small Intestine-Like 2/4/A1 Cell Monolayers

S. Chong, P. Artursson, R. Morrison, 2003, Pharmaceutical Research.

Pharmacokinetics and oral bioavailability of pravastatin in dogs

R. Morrison, S. Singhvi, 1996 .

The impact of protein on Caco-2 permeability of low mass balance compounds for absorption projection and efflux substrate identification.

R. Morrison, K. Cheng, Tongtong Liu, 2010, Journal of pharmaceutical and biomedical analysis.