M. Webb

发表

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Ping Chen, S. Spergel, S. Chong, 2003, Journal of medicinal chemistry.

The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

N. Murugesan, E. Liu, M. Webb, 1994, Journal of medicinal chemistry.

Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis.

M. Webb, R. Dolle, T. Guo, 2004, Bioorganic & medicinal chemistry letters.

Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).

S. Spergel, N. Murugesan, Z. Gu, 1998, Journal of medicinal chemistry.

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

S. Spergel, J. Barrish, N. Murugesan, 2000, Journal of Medicinal Chemistry.

Functional Assay Screens

M. Webb, B. Damaj, K. McMillan, 2001 .

The Use and Promise of Stem Cells in Drug Discovery

M. Glicksman, M. Webb, Kelvin T Lam, 2010 .

Successful screening of large encoded combinatorial libraries leading to the discovery of novel p38 MAP kinase inhibitors.

M. Webb, D. Diller, A. Metzger, 2006, Combinatorial chemistry & high throughput screening.

Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB.

M. Webb, Y. Wang, M. Dunn, 1994, The American journal of physiology.

Angiotensin-converting enzyme inhibition and angiotensin II subtype-1 receptor blockade during the progression of left ventricular dysfunction: differential effects on myocyte contractile processes.

M. Webb, F. Spinale, J. Powell, 1997, The Journal of pharmacology and experimental therapeutics.

Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).

M. Webb, P. Stein, D. Diller, 2018, Bioorganic & medicinal chemistry letters.

Discovery of novel quinolinone adenosine A2B antagonists.

A. Klon, M. Webb, V. Srivastava, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of (3,4-dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonists.

M. Webb, I. Henderson, J. Saunders, 2008, Bioorganic & medicinal chemistry letters.

Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists.

D. Auld, M. Webb, I. Henderson, 2007, Bioorganic & medicinal chemistry letters.

Small molecule antagonists of the bradykinin B1 receptor.

N. Sigal, M. Webb, J. Baldwin, 1999, Immunopharmacology.

Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice.

S. Oparil, M. Webb, S. Lira, 1997, American journal of physiology. Lung cellular and molecular physiology.

A Time-Resolved Fluorometric Assay for Galanin Receptors

M. Webb, R. Horlick, A. Robbins, 1998 .

Endothelin-1 and angiotensin-II stimulate delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for common signaling mechanisms.

M. Webb, S. Moreland, C. Molloy, 1994, Molecular endocrinology.

The effects of endothelin-A receptor blockade during the progression of pacing-induced congestive heart failure.

M. Webb, S. Moreland, F. Spinale, 1998, Journal of the American College of Cardiology.

Exogenous effects and endogenous production of endothelin in cardiac myocytes: potential significance in heart failure.

E. Liu, M. Webb, F. Spinale, 1996, The American journal of physiology.

Expression of endothelin receptor subtypes in rabbit saphenous vein.

E. Liu, M. Webb, C. Chao, 1993, Molecular pharmacology.

Binding and signal transduction of the cloned vascular angiotensin II (AT1a) receptor cDNA stably expressed in Chinese hamster ovary cells

M. Webb, S. Moreland, K. Dickinson, 1993, Regulatory Peptides.

Characterization of binding of a specific antagonist, [3H]-SQ 29,548, to soluble thromboxane A2/prostaglandin H2 (TP) receptors in human platelet membranes.

M. Webb, H. Monshizadegan, A. Hedberg, 1992, Life sciences.

DuP 753, the selective angiotensin II receptor blocker, is a competitive antagonist to human platelet thromboxane A2/prostaglandin H2 (TP) receptors.

E. Liu, M. Webb, D. Harris, 1992, Prostaglandins.

Molecular characterization of angiotensin II type II receptors in rat pheochromocytoma cells

E. Liu, M. Webb, S. Moreland, 1992, Peptides.

Identification and characterization of small‐molecule inhibitors of Tie2 kinase

M. Webb, R. Wen, I. Henderson, 2008, FEBS letters.

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists.

D. Auld, J. van der Louw, M. Webb, 2006, Bioorganic & medicinal chemistry letters.

Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.

S. Spergel, J. Barrish, N. Murugesan, 2002, Bioorganic & medicinal chemistry letters.

Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice.

S. Oparil, M. Webb, S. Lira, 1997, The American journal of physiology.

Pharmacological profile of BMS 180,291: a potent, long-acting, orally active thromboxane A2/prostaglandin endoperoxide receptor antagonist.

M. Webb, R. Misra, M. Ogletree, 1993, The Journal of pharmacology and experimental therapeutics.

Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).

M. Webb, P. Stein, D. Hilbert, 2018, Bioorganic & medicinal chemistry letters.

Treatment of Clostridium difficile Infection with a Small-Molecule Inhibitor of Toxin UDP-Glucose Hydrolysis Activity

M. Webb, P. Stein, D. Hilbert, 2018, Antimicrobial Agents and Chemotherapy.

Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone omega-chains.

M. Webb, R. Misra, W. Han, 1991, Journal of medicinal chemistry.

Peptidases and smooth muscle cell angiotensin II receptor pharmacology

M. Webb, K. Dickinson, R. Cohen, 1993, Peptides.

Control of peptide disulfide regioisomer formation by mixed cysteine-penicillamine bridges. Application to endothelin-1.

E. Liu, M. Webb, S. Moreland, 2009, International journal of peptide and protein research.

Cloning and expression of a human endothelin receptor: subtype A.

M. Runge, E. Liu, M. Webb, 1992, The American journal of the medical sciences.

Vascular A10 cell membranes contain an endothelin metabolizing neutral endopeptidase.

E. Liu, M. Webb, K. Dickinson, 1991, Biochemical and biophysical research communications.

Novel pyrrolidine heterocycles as CCR1 antagonists.

M. Webb, M. Ohlmeyer, Camelia Chiriac, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

D. Auld, M. Webb, M. Ohlmeyer, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

D. Auld, M. Webb, M. Ohlmeyer, 2011, Bioorganic & medicinal chemistry letters.

Early signal transduction by the receptor to the chemokine monocyte chemotactic protein-1 in a murine T cell hybrid.

M. Webb, J. Ledbetter, R. Shapiro, 1996, Journal of immunology.

Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists.

Maria L Webb, Michael Snider, Zahid Hussain, 2006, Bioorganic & medicinal chemistry letters.

Thromboxane receptor antagonist BMS-180291: A new pre-clinical lead

J. Barrish, P. Sprague, R. Morrison, 1992 .

A novel class of non-peptidic endothelin antagonists isolated from the medicinal herb Phyllanthus niruri

M. Webb, J. Dickey, M. Rosser, 1995 .

Inhibitors of endothelin

M. Webb, T. Meek, 1997, Medicinal research reviews.

Effect of in-house transport on murine plasma corticosterone concentration and blood lymphocyte populations.

M. Webb, C. Lang, T. A. Bowman, 1990, American journal of veterinary research.

Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.

Xin Xu, Mary Collins, Maria L Webb, 2010, Arthritis and rheumatism.

Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges

Maria L Webb, M. Webb, C. Carroll, 2008 .

Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.

Yajing Rong, A. Klon, M. Webb, 2009, Bioorganic & medicinal chemistry letters.

The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.

Wei Li, Gulzar Ahmed, John Dodd, 2004, Journal of medicinal chemistry.

Discovery and Characterization of Triaminotriazine Aniline Amides as Highly Selective p38 Kinase Inhibitors

M. Webb, D. Diller, A. Metzger, 2006, Journal of Pharmacology and Experimental Therapeutics.

Discovery and Characterization of Triaminotriazine Aniline Amides as Highly Selective p 38 Kinase Inhibitors

M. Webb, D. Diller, A. Metzger, 2006 .

Binding and function of a potent new thromboxane receptor antagonist, BMS 180,291, in human platelets.

E. Liu, M. Webb, R. Misra, 1993, The Journal of pharmacology and experimental therapeutics.

Novel Antifungal Drug Discovery Based on Targeting Pathways Regulating the Fungus-Conserved Upc2 Transcription Factor

M. Webb, J. Nickels, R. Swanson, 2013, Antimicrobial Agents and Chemotherapy.

Molecular and Structural Biology of Endothelin Receptors

Stanley R. Krystek, M. Webb, S. Krystek, 1998 .

Comparison of a novel ETA receptor antagonist and phosphoramidon in renal ischemia.

E. Liu, M. Webb, S. Durham, 1995, Pharmacology.

Aspartate mutation distinguishes ETA but not ETB receptor subtype‐selective ligand binding while abolishing phospholipase C activation in both receptors

E. Liu, M. Webb, S. Krystek, 1995, FEBS letters.

Identification of a Novel Allosteric Binding Site in the CXCR2 Chemokine Receptor

R. Leurs, D. Auld, C. de Graaf, 2011, Molecular Pharmacology.

Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3

Anthony E. Klon, N. Vaidehi, A. Klon, 2012, British journal of pharmacology.

Cloning and expression of an endothelin receptor subtype B from human prostate that mediates contraction.

E. Liu, M. Webb, B. Treiger, 1995, Molecular pharmacology.

BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist.

E. Liu, M. Webb, S. Moreland, 1995, The Journal of pharmacology and experimental therapeutics.

A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats.

M. Webb, C. Chao, M. Giancarli, 1995, European journal of pharmacology.

Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.

Ruiyan Liu, Maria L Webb, M. Webb, 2009, Journal of medicinal chemistry.

2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.

David J Diller, Maria L Webb, M. Webb, 2009, Bioorganic & medicinal chemistry letters.

Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity.

J. Novotný, E. Liu, M. Webb, 1994, The Journal of biological chemistry.

Mutational analysis of the endothelin type A receptor (ETA): interactions and model of selective ETA antagonist BMS-182874 with putative ETA receptor binding cavity.

J. Barrish, E. Liu, M. Webb, 1996, Biochemistry.

The endothelin receptor antagonist, BQ-123, inhibits angiotensin II-induced contractions in rabbit aorta.

E. Liu, M. Webb, S. Moreland, 1992, Biochemical and biophysical research communications.

Role of endothelin receptor subtype B (ET-B) in myocardial ischemia.

E. Liu, M. Webb, G. Grover, 1994, Life sciences.

Evidence of an endothelin-1 autocrine loop in cardiac myocytes: Relation to contractile function with congestive heart failure

E. Liu, M. Webb, F. Spinale, 1996 .

Thoromboxane A2/endoperoxide receptor antagonists: 1,3-Dioxane and 1,3-dioxolane analogs

M. Webb, J. Das, H. Monshizadegan, 1993 .

Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).

M. Webb, M. Ohlmeyer, Hong Li, 2009, Bioorganic & medicinal chemistry letters.

-Small-molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3

Anthony E. Klon, N. Vaidehi, M. Webb, 2015 .

Design and synthesis of nonpeptidal endothelin receptor antagonists based on the structure of a cyclic pentapeptide

M. Hermsmeier, N. Murugesan, Z. Gu, 1995 .

Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges.

M. Webb, C. Carroll, K. Appell, 2008, Expert opinion on therapeutic targets.

Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries.

Maria L Webb, M. Webb, I. Henderson, 2006, Biochemical and biophysical research communications.