R. Silvestri

发表

Imidazole analogues of fluoxetine, a novel class of anti-Candida agents.

R. Silvestri, M. Artico, G. La Regina, 2004, Journal of medicinal chemistry.

Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor

A. Coluccia, R. Silvestri, G. La Regina, 2022, Cancers.

New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains.

C. Limatola, O. Turriziani, A. Coluccia, 2020, European journal of medicinal chemistry.

Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.

A. Bergamini, E. Novellino, A. Coluccia, 2007, Journal of medicinal chemistry.

Looking for an Active Conformation of the Future HIV Type-1 Non-Nucleoside Reverse Transcriptase Inhibitors

A. Coluccia, R. Silvestri, G. L. Regina, 2010, Antiviral chemistry & chemotherapy.

Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.

Ettore Novellino, Luciana Marinelli, Sandro Cosconati, 2017, Journal of medicinal chemistry.

Chiral resolution and binding study of 1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino[2,1-d]pyrrolo[1,2-b] [1,2,5]benzotriazepine (10-methyl-10-azaaptazepine) and 2-methyl-1,3,4,14b-tetrahydro-2H-pyrazino[2,1-d]pyrrolo[1,2-b] [1,2,5]benzothiadiazepine 10,10-dioxide (tiaaptazepine).

R. Silvestri, M. Artico, G. La Regina, 2005, Farmaco.

Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo

R. Silvestri, G. La Regina, R. Bei, 2016, Tumor Biology.

De novo computer-aided design of novel antiviral agents.

A. Coluccia, A. Brancale, R. Silvestri, 2012, Drug discovery today. Technologies.

Pyrrolo[1,2‐b][1,2,5]benzothiadiazepines (PBTDs) exert their anti‐proliferative activity by interfering with Akt–mTOR signaling and bax:bcl‐2 ratio modulation in cells from chronic myeloid leukemic patients

R. Silvestri, S. Amadori, G. Marfé, 2010, Cancer science.

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

A. Coluccia, R. Silvestri, G. La Regina, 2017, Journal of enzyme inhibition and medicinal chemistry.

Apple Can Act as Anti-Aging on Yeast Cells

R. Silvestri, G. La Regina, C. Mazzoni, 2012, Oxidative medicine and cellular longevity.

Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors

R. Silvestri, G. La Regina, V. Jovanović, 2017, Arabian Journal of Chemistry.

New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation.

A. Coluccia, R. Silvestri, G. La Regina, 2016, Journal of medicinal chemistry.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

C. Martini, A. Coluccia, R. Silvestri, 2018, European journal of medicinal chemistry.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

C. Supuran, A. Coluccia, D. Vullo, 2015, Journal of medicinal chemistry.

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents

A. Coluccia, R. Silvestri, G. La Regina, 2019, ACS medicinal chemistry letters.

Arylthioindoles: Promising compounds against cancer cell proliferation.

R. Silvestri, G. La Regina, A. Scovassi, 2010, Oncology Letters.

Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.

E. Novellino, A. Lavecchia, A. Coluccia, 2009, Journal of medicinal chemistry.

Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

R. Silvestri, Valeria Famiglini, 2016, Molecules.

Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and immobilized polysaccharide-based chiral stationary phases.

R. Silvestri, G. De Martino, R. Cirilli, 2006, Chirality.

New prospects for vinblastine analogues as anticancer agents.

R. Silvestri, 2013, Journal of medicinal chemistry.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds

A. Musacchio, R. Gussio, R. Silvestri, 2010, PloS one.

Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells

I. Pogribny, R. Silvestri, V. Tryndyak, 2015, Cancer biology & therapy.

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells

R. Silvestri, G. La Regina, A. Santoni, 2017, Oncoimmunology.

Enantioselective HPLC combined with spectroscopic methods: a valid strategy to determine the absolute configuration of potential beta-secretase inhibitors.

R. Silvestri, G. La Regina, R. Cirilli, 2010, Talanta.

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses

C. Lacroix, A. Coluccia, R. Silvestri, 2015, Virology Journal.

Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress.

A. Coluccia, R. Silvestri, F. Lezoualc’h, 2019, Cardiovascular research.

Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects

R. Silvestri, F. Violi, L. Loffredo, 2018, British journal of clinical pharmacology.

Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.

S. Zanoli, G. Maga, R. Silvestri, 2009, Antiviral research.

Design, Synthesis and Discovery of N,N’‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

D. Barlow, R. Silvestri, E. Decroly, 2019, ChemMedChem.

Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors

R. Silvestri, Valeria Famiglini, 2018, Antiviral chemistry & chemotherapy.

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

E. Novellino, A. Mollica, R. Silvestri, 2017, Journal of enzyme inhibition and medicinal chemistry.

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.

E. Novellino, R. Silvestri, G. La Regina, 2011, European journal of medicinal chemistry.

RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway.

R. Silvestri, G. La Regina, Haoyan Wang, 2021, European journal of pharmacology.

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment.

A. Coluccia, R. Silvestri, G. La Regina, 2022, European journal of medicinal chemistry.

Towards modern anticancer agents that interact with tubulin

A. Coluccia, R. Silvestri, G. La Regina, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Structure-based Virtual Screening to Get New Scaffold Inhibitors of the Ser/Thr Protein Kinase PknB from Mycobacterium tuberculosis

A. Coluccia, A. Brancale, R. Silvestri, 2016 .

[5-Aroyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-carboxylic acids: synthesis and analgesic and neurobehavioral activity].

A. Mai, R. Silvestri, M. Artico, 1989, Farmaco.

Radiosynthesis and in vivo evaluation of [11C]-labelled pyrrole-2-carboxamide derivates as novel radioligands for PET imaging of monoamine oxidase A.

R. Silvestri, G. La Regina, S. Staelens, 2010, Nuclear medicine and biology.

Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors.

M. Glass, R. Silvestri, V. Di Marzo, 2015, Journal of medicinal chemistry.

Exploring CCRL2 chemerin binding using accelerated molecular dynamics

D. Raimondo, A. Coluccia, R. Silvestri, 2022, Proteins.

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

A. Coluccia, A. Ciogli, R. Silvestri, 2022, Journal of medicinal chemistry.

Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.

A. Coluccia, R. Silvestri, M. Artico, 2005, Journal of medicinal chemistry.

Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase

A. Brancale, R. Silvestri, J. Neyts, 2022, Viruses.

Mechanism of Interaction of Novel Indolylarylsulfone Derivatives with K103N and Y181I Mutant HIV-1 Reverse Transcriptase in Complex with its Substrates

G. Maga, R. Silvestri, G. L. Regina, 2011, Antiviral chemistry & chemotherapy.

Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies.

Mohammad K. Islam, A. Coluccia, R. Silvestri, 2019, European journal of medicinal chemistry.

Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.

A. Coluccia, A. Brancale, R. Silvestri, 2013, Future medicinal chemistry.

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.

Andrea Brancale, Gabriela Chiosis, Ernest Hamel, 2006, Journal of medicinal chemistry.

Arylthioindoles, potent inhibitors of tubulin polymerization.

Andrea Brancale, Ernest Hamel, Antonio Coluccia, 2004, Journal of medicinal chemistry.

Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Romano Silvestri, G. Maga, R. Silvestri, 2006 .

Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.

E. Novellino, G. Greco, R. Silvestri, 2000, Journal of medicinal chemistry.

New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

E. Novellino, A. Lavecchia, R. Silvestri, 2007, Journal of medicinal chemistry.

Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.

E. Novellino, A. Lavecchia, R. Silvestri, 2008, Bioorganic & medicinal chemistry.

Structure-Activity Relationship of Dibenzylideneacetone Analogs Against the Neglected Disease Pathogen, Trypanosoma brucei.

R. Silvestri, C. Caffrey, L. Regasini, 2023, Bioorganic & medicinal chemistry letters.

New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.

E. Novellino, B. Maresca, A. Coluccia, 2009, Journal of medicinal chemistry.

Indolyl Aryl Sulphones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Synthesis, Biological Evaluation and Binding Mode Studies of New Derivatives at Indole-2-carboxamide

A. Bergamini, C. Ciaprini, A. Coluccia, 2006, Antiviral chemistry & chemotherapy.

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.

E. Novellino, C. Pannecouque, A. Coluccia, 2011, Journal of medicinal chemistry.

Indole, a core nucleus for potent inhibitors of tubulin polymerization

Andrea Brancale, Romano Silvestri, A. Brancale, 2007, Medicinal research reviews.

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

Anna Ivana Scovassi, Ettore Novellino, Andrea Brancale, 2007, Journal of medicinal chemistry.

Anti-HIV-1 activity of pyrryl aryl sulfone (PAS) derivatives: synthesis and SAR studies of novel esters and amides at the position 2 of the pyrrole nucleus.

R. Silvestri, M. Artico, G. La Regina, 2004, Farmaco.

2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.

R. Silvestri, M. Artico, P. la Colla, 1996, Journal of medicinal chemistry.

Synthesis of Pyrryl Aryl Sulfones Targeted at the HIV‐1 Reverse Transcriptase

R. Silvestri, M. Artico, P. la Colla, 1995, Archiv der Pharmazie.

Non‐steroidal antiinflammatory agents. VI. Synthesis of 10‐oxo‐5H‐pyrrolo[1,2‐b]isoquinoline‐3‐acetic Acid, a conformationally restricted analogue of tolmetin

R. Silvestri, M. Artico, P. Prosini, 1990 .

Potential antitumor agents. III. Synthesis of pyrazolo[3,4‐e]pyrrolo[3,4‐g]indolizine and 1H‐pyrazolo[3,4‐e]indolizine derivatives

R. Silvestri, M. Artico, R. D. Santo, 1989 .

Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles.

R. Silvestri, G. La Regina, F. Piscitelli, 2012, ACS combinatorial science.

Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.

A. Bergamini, C. Ciaprini, E. Novellino, 2006, Journal of medicinal chemistry.

Open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones.

R. Silvestri, G. La Regina, F. Piscitelli, 2011, ACS combinatorial science.

Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors.

M. Conconi, A. Coluccia, P. Brun, 2014, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors.

E. Novellino, A. Coluccia, A. Brancale, 2013, Journal of medicinal chemistry.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Ettore Novellino, Andrea Brancale, Ilaria Granata, 2011, Journal of medicinal chemistry.

New Frontiers in Selective Human MAO-B Inhibitors.

S. Carradori, R. Silvestri, 2015, Journal of medicinal chemistry.

Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.

Enzo Agostinelli, Romano Silvestri, R. Silvestri, 2003, Journal of medicinal chemistry.

Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides.

E. Novellino, A. Lavecchia, M. Botta, 2008, Journal of medicinal chemistry.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

E. Novellino, L. Di Marcotullio, C. Martini, 2015, Journal of medicinal chemistry.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

Ettore Novellino, Andrea Brancale, Ruoli Bai, 2014, Journal of medicinal chemistry.

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.

E. Novellino, A. Lavecchia, R. Silvestri, 2010, European journal of medicinal chemistry.

Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation.

A. Bergamini, C. Ciaprini, E. Crespan, 2005, Journal of medicinal chemistry.

Comparative study between the polysaccharide-based chiralcel OJ and chiralcel OD CSPSs in chromatographic enantioseparation of imidazole analogues of fluoxetine and miconazole.

R. Silvestri, G. La Regina, R. Cirilli, 2005, Journal of separation science.

Indolyl aryl sulfones (IASs): development of highly potent NNRTIs active against wt-HIV-1 and clinically relevant drug resistant mutants.

R. Silvestri, M. Artico, 2005, Current pharmaceutical design.

Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.

R. Silvestri, M. Artico, G. La Regina, 2004, Journal of medicinal chemistry.

Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.

Silvio Massa, Romano Silvestri, R. Silvestri, 2003, Journal of medicinal chemistry.

Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study.

A. Coluccia, R. Silvestri, J. Neyts, 2017, European journal of medicinal chemistry.

VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection.

A. Coluccia, R. Silvestri, J. Neyts, 2016, European journal of medicinal chemistry.

5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors.

R. Silvestri, M. Artico, P. la Colla, 1996, Bioorganic & medicinal chemistry.

Reductive Smiles Rearrangement of 1-[(5-Chloro-2-nitrophenyl)- sulfonyl]-1H-pyrrole-2-carbo-hydrazide to 1-Amino-6-chloro-2- (1H-pyrrol-2-yl)benzimidazole

R. Silvestri, M. Artico, C. Saturnino, 2000 .

Synthesis and anti-HIV activity of 10,11-dihydropyrrolo [1,2-b][1,2,5]benzothiadiazepine-11-acetic acid 5,5-dioxide derivatives and related compounds.

R. Silvestri, M. Artico, P. la Colla, 1996, Farmaco.

Heterocycles with a Benzothiadiazepine Moiety. Part 2. Synthesis of 2- Methyl-1,3,4,14b-tetrahydro-2H-pyrazino(2,1-d)pyrrolo(1,2-b)(1,2,5) benzothiadiazepine 10,10-Dioxide (Tiaaptazepine).

R. Silvestri, M. Artico, G. Stefancich, 1995 .

Heterocycles with a benzothiadiazepine moiety.3.Synthesis of imidazo[5,1-d]pyrrolo[1,2-b][1,2,5]benzothiadiazepine 9,9-dioxide

R. Silvestri, M. Artico, G. Stefancich, 1994 .

Heterocycles with a Benzothiadiazeypine Moiety. I. Synthesis of Pyrrolo[1,2-b]-s-triazolo[3,4-d] [1,2,5]benzothiadiazepine 5,5-Dioxide

R. Silvestri, M. Artico, G. Stefancich, 1992 .

Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

R. Silvestri, M. Artico, G. Simonetti, 1992 .

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. Novellino, A. Coluccia, A. Brancale, 2014, Journal of Medicinal Chemistry.

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. Novellino, B. Clotet, A. Coluccia, 2014, European journal of medicinal chemistry.

1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole: a potent lead for the design of novel NNRTIs.

R. Silvestri, M. Artico, P. la Colla, 2000, Bioorganic & medicinal chemistry letters.

Single‐run chemo‐ and enantio‐selective high‐performance liquid chromatography separation of tramadol and its principal metabolite, O‐desmethyltramadol, using a chlorinated immobilized amylose‐based chiral stationary phase under multimodal elution conditions

R. Silvestri, G. La Regina, Chiara Cantatore, 2022, SEPARATION SCIENCE PLUS.

Antibacterial and Antifungal Agents, XV: Synthesis and Antifungal Activity of Structural Analogues of Bifonazole and Ketoconazole

R. Silvestri, M. Artico, G. Simonetti, 1992, Archiv der Pharmazie.

Antifungal agents. 10. Synthesis and antifungal activities of aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl) methane derivatives.

R. Silvestri, G. Simonetti, S. Massa, 1995, Farmaco.

Researches on Antibacterial and Antifungal Agents, X. Synthesis and Antifungal Activities of 1‐{p‐Methyl‐α‐[4‐(1H‐pyrrol‐1‐yl)phenyl]benzyl}azoles and Some Related Products

A. Mai, R. Silvestri, F. Corelli, 1989, Archiv der Pharmazie.

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.

E. Novellino, M. Russo, A. Lavecchia, 2006, Journal of medicinal chemistry.

Chemo- and enantio-selective reversed-phase HPLC analysis of rosuvastatin using a cellulose-based chiral stationary phase in gradient elution mode.

R. Silvestri, Michela Puxeddu, R. Cirilli, 2023, Journal of pharmaceutical and biomedical analysis.

Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.

Silvio Massa, Rino Ragno, Alessandra Pani, 2002, Journal of medicinal chemistry.

N-Pyrrylarylsulfones with High Therapeutic Potential

R. Silvestri, S. Castellano, Valeria Famiglini, 2017, Molecules.

Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.

E. Novellino, A. Lavecchia, R. Silvestri, 2009, Bioorganic & medicinal chemistry.

PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells

M. Russo, R. Silvestri, G. La Regina, 2007, BMC Cancer.

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.

A. Coluccia, A. Brancale, R. Silvestri, 2013, Antiviral research.

Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors.

S. Carradori, R. Silvestri, D. Secci, 2013, European journal of medicinal chemistry.

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

R. Silvestri, E. Agostinelli, A. Giulio, 1992 .

Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase

A. Coluccia, R. Silvestri, D. De Biase, 2016, Journal of enzyme inhibition and medicinal chemistry.

Bicyclic g-amino acids as inhibitors of g-aminobutyrate aminotransferase

A. Coluccia, R. Silvestri, A. Pinto, 2015 .

Research on nitrogen containing heterocyclic compounds. XIX: Synthesis of 8H-imidazo[2,1-c]-s-triazolo[4,3-a]-[1,4]benzodiazepine and its 1-derivatives

R. Silvestri, M. Artico, G. Stefancich, 1993 .

Boom in the development of non‐peptidic β‐secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

Romano Silvestri, R. Silvestri, 2009, Medicinal research reviews.

Research on Nitrogen‐Containing Heterocyclic Compounds. Part 19. Synthesis of 8H‐Imidazo(2,1‐c)‐s‐triazolo(4,3‐a)(1,4)benzodiazepine and Its 1‐Derivatives.

R. Silvestri, M. Artico, G. Stefancich, 1993 .

Research on nitrogen containing heterocyclic compounds. XVIII. Synthesis of 9H-pyrrolo[2,1-c]-s-triazolo[4,3-a][1,4]benzodiazepine, a novel tetracyclic ring of pharmaceutical interest

R. Silvestri, M. Artico, G. Stefancich, 1992 .

Research on nitrogen containing heterocyclic compounds. XVII. Synthesis of 8H-diimidazo[1,5-a:2′,1′-c][1,4]benzodiazepine, a novel tetracyclic ring of pharmaceutical interest

R. Silvestri, M. Artico, G. Stefancich, 1992 .

High Potency of Indolyl Aryl Sulfone Nonnucleoside Inhibitors towards Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutants Is Due to Selective Targeting of Different Mechanistic Forms of the Enzyme

E. Crespan, S. Zanoli, G. Maga, 2005, Antimicrobial Agents and Chemotherapy.

The Tubulin Colchicine Domain: a Molecular Modeling Perspective

Andrea Brancale, Alberto Massarotti, Antonio Coluccia, 2012, ChemMedChem.

CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme.

E. Novellino, S. Taliani, C. Martini, 2021, European journal of pharmacology.

Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells.

E. Novellino, F. Da Settimo, S. Taliani, 2017, ACS chemical neuroscience.

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules

E. Cundari, A. Coluccia, R. Silvestri, 2017, Oncotarget.

Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection

O. Turriziani, A. Coluccia, R. Silvestri, 2023, Circulation research.

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

A. Coluccia, R. Silvestri, G. La Regina, 2021, Biology direct.

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

A. Coluccia, R. Silvestri, S. Gianni, 2020, Cells.

Emerging Therapeutic Agents for Colorectal Cancer

R. Silvestri, G. La Regina, S. Gianni, 2021, Molecules.

Sulfonamide Inhibitors of β‐Catenin Signaling as Anticancer Agents with Different Output on c‐MYC

A. Coluccia, A. Ciogli, R. Silvestri, 2020 .

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

C. Limatola, E. Novellino, A. Coluccia, 2017, Journal of medicinal chemistry.

Kinetic characterization of 4,4′-biphenylsulfonamides as selective non-zinc binding MMP inhibitors

C. Supuran, R. Silvestri, G. La Regina, 2015, Journal of enzyme inhibition and medicinal chemistry.

An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors

E. Cundari, A. Coluccia, R. Silvestri, 2014, PloS one.

Nox2‐mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin

A. Coluccia, R. Silvestri, F. Violi, 2019, Biochemical pharmacology.

Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands

A. Mollica, R. Silvestri, G. La Regina, 2023, ACS medicinal chemistry letters.

Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.

E. Novellino, S. Taliani, C. Martini, 2015, Journal of medicinal chemistry.

Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites

L. Federici, P. Visca, A. Coluccia, 2020, Scientific Reports.

Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

A. Mollica, E. Cundari, A. Coluccia, 2018, Molecules.

Small molecule inhibitors of KDM 5 histone demethylases increase radio-sensitivity of breast cancer cells overexpressing JARID 1 B

Enrico, A. Mollica, A. Coluccia, 2018 .

Pharmacological folding chaperones act as allosteric ligands of Frizzled4.

E. Novellino, R. Silvestri, G. La Regina, 2015, Nature chemical biology.

Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2000, Bioorganic & medicinal chemistry.

3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.

A. Coluccia, A. Brancale, R. Silvestri, 2017, ACS medicinal chemistry letters.

Researches on psychotropic agents. IV. Synthesis and neuropsychopharmacological effects of 1,3,4,14 b-tetrahydro-10-methyl-2H,10H- pyrazino[2,1-d] pyrrolo[1,2-b][1,2,5]benzotriazepine and its derivatives.

R. Silvestri, M. Artico, G. Stefancich, 1992, Farmaco.

One-pot synthesis of novel spiro-annelated pyrrole-containing heterocyclic systems from suitable synthons

A. Mai, R. Silvestri, S. Massa, 1992 .

Research on psychotropic agents. III. Antidepressant activity and neuropsychobehavioural effects of new 5H-Pyrrolo[1,2-b][1,2,5]benzotriazepine derivatives.

R. Silvestri, M. Artico, G. Stefancich, 1990, Farmaco.

Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

J. Matthijnssens, R. Silvestri, G. La Regina, 2021, Pharmaceuticals.

RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota

R. Silvestri, Changpeng Han, Te Liu, 2021, International journal of biological sciences.

Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.

E. Novellino, A. Coluccia, R. Silvestri, 2012, Journal of medicinal chemistry.

Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics

Antonio Coluccia, Marianna Bufano, Marion Laudette, 2020, Journal of Computer-Aided Molecular Design.

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

C. Martini, A. Coluccia, R. Silvestri, 2019, European journal of medicinal chemistry.

Synthesis, neuropsychopharmacological effects and analgesic-antiinflammatory activities of pyrrole analogues of lefetamine.

R. Silvestri, M. Artico, F. Corelli, 1989, Il Farmaco.

Bovine serum amine oxidase: half-site reactivity with phenylhydrazine, semicarbazide, and aromatic hydrazides.

R. Silvestri, M. Artico, E. Agostinelli, 1992, Biochemistry.

Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3D QSAR studies

R. Silvestri, G. La Regina, R. Ragno, 2007, Expert opinion on drug discovery.

Emerging Direct Targeting β-Catenin Agents

R. Silvestri, G. La Regina, A. Urbani, 2022, Molecules.

A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist.

Ettore Novellino, Antonella Accardo, Romano Silvestri, 2018, Biochemistry.

Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication.

A. Coluccia, R. Silvestri, G. La Regina, 2018, Journal of medicinal chemistry.

New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.

A. Coluccia, C. Zamperini, M. Botta, 2015, European journal of medicinal chemistry.

Study of the effects of a new pyrazolecarboxamide: changes in mitochondria and induction of apoptosis.

R. Silvestri, G. La Regina, A. Scovassi, 2009, The international journal of biochemistry & cell biology.

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.

S. Kelly, D. Lamb, M. Botta, 2008, Journal of medicinal chemistry.

β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

I. Fournier, A. Coluccia, R. Silvestri, 2018, Oncogene.

HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53.

R. Silvestri, Jean-William Dupuy, M. Hagedorn, 2019, Neuro-oncology.

Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1‐mediated nuclear export

C. Supuran, R. Silvestri, W. Link, 2022, Traffic.

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses

C. Lacroix, A. Coluccia, R. Silvestri, 2015, Virology Journal.

A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations

R. Silvestri, G. La Regina, Michela Puxeddu, 2023, Molecules.

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines

R. Silvestri, C. Muller, D. Stanković, 2016 .

Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

S. Carradori, A. Mollica, R. Silvestri, 2017 .

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.

D. Trisciuoglio, R. Silvestri, G. La Regina, 2022, European journal of medicinal chemistry.

Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent.

A. Coluccia, R. Silvestri, G. La Regina, 2023, ACS pharmacology & translational science.

Sulfonamide Inhibitors of ß-Catenin Signaling with Different Output on c-MYC as Anticancer Agents.

A. Coluccia, A. Ciogli, R. Silvestri, 2020, ChemMedChem.

Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.

C. Martini, A. Coluccia, R. Silvestri, 2021, European journal of medicinal chemistry.

Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.

A. Coluccia, R. Silvestri, G. La Regina, 2023, Bioorganic chemistry (Print).

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. Novellino, B. Clotet, A. Coluccia, 2012, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of 5H-Indolo [3,2-b][1,5]Benzothiazepine Derivatives, Designed as Conformationally Constrained Analogues of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor L-737,126

E. Novellino, G. Greco, R. Silvestri, 1998, Antiviral chemistry & chemotherapy.

Anti-HIV-1 NNRT agents: Acylamino Pyrryl Aryl Sulfones (APASs) as truncated analogues of tricyclic PBTDs

R. Silvestri, M. Artico, R. Loddo, 2002 .

Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage.

A. Coluccia, R. Silvestri, G. La Regina, 2020, ACS medicinal chemistry letters.

Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments

E. Novellino, R. Silvestri, M. Stornaiuolo, 2015, Scientific Reports.

Modulating undruggable targets to overcome cancer therapy resistance.

R. Silvestri, G. La Regina, A. Vessières, 2021, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at the indole-2-carboxamide

E. Novellino, A. Coluccia, A. Brancale, 2011 .

Synthesis of 9H-pyrrolo[2,1-b][1,3,6]benzothiadiazocin-10(11H)-one 4,4-dioxide, a potential anti-HIV-1 agent

R. Silvestri, M. Artico, S. Massa, 1995 .

Boom in the Development of Non‐Peptidic β‐Secretase (BACE1) Inhibitors for the Treatment of Alzheimer′s Disease

R. Silvestri, 2009 .

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

C. Limatola, E. Novellino, A. Coluccia, 2017, Journal of medicinal chemistry.

Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase

A. Coluccia, R. Silvestri, D. De Biase, 2016, Journal of enzyme inhibition and medicinal chemistry.

The Tubulin Colchicine Domain: a Molecular Modeling Perspective

A. Brancale, R. Silvestri, A. Massarotti, 2012, ChemMedChem.

Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment

R. Silvestri, G. La Regina, C. Naro, 2023, Molecules.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

E. Novellino, L. Di Marcotullio, A. Brancale, 2014, Journal of medicinal chemistry.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.

D. Trisciuoglio, R. Silvestri, G. La Regina, 2022, European journal of medicinal chemistry.

3-Aroyl-1-arylpyrroles: a New Class of Potent Inhibitors of Tubulin Polymerization.

E. Novellino, R. Silvestri, E. Hamel, 2014 .

Open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones.

R. Silvestri, G. La Regina, F. Piscitelli, 2011, ACS combinatorial science.

Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy

R. Silvestri, G. La Regina, Michela Puxeddu, 2024, Molecules.

4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

C. Supuran, R. Silvestri, G. La Regina, 2023, Journal of medicinal chemistry.