R. Hanson

发表

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

W. Humphreys, A. Fura, Y. Shu, 2004, Journal of medicinal chemistry.

Rabbit muscle phosphofructokinase. The kinetic mechanism of action and the equilibrium constant.

R. Hanson, F. Rudolph, H. Lardy, 1973, The Journal of biological chemistry.

Genetic mapping of a mutation affecting pyridine nucleotide transhydrogenase in Escherichia coli

R. Hanson, C. Rose, 1979, Journal of bacteriology.

A Scalable Synthesis of (R,R)-2,6-Dimethyldihydro-2H-pyran-4(3H)-one

R. Hanson, A. Goswami, Steven A. Tymonko, 2015 .

Enantioselective microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic acid, ethyl ester

Ramesh N. Patel, R. Hanson, D. Brzozowski, 1993 .

Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase from Bacillus megaterium

Ramesh N. Patel, R. Hanson, S. Goldberg, 2008 .

Enantioselective Synthesis of a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 5 (mGluR5) Receptor via Dynamic Kinetic Resolution of α-Amino Ketones

R. Hanson, Zhiwei Guo, A. Goswami, 2016 .

Inhibition by hydrazine of gluconeogenesis in the rat.

R. Hanson, P. Ray, H. Lardy, 1970, The Journal of biological chemistry.

Mode of action of hypoglycemic agents. I. Inhibition of gluconeogenesis by quinaldic acid and 5-methoxyindole-2-carboxylic acid.

R. Hanson, P. Ray, H. Lardy, 1969, The Journal of biological chemistry.

Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol.

R. Hanson, James, E. S. Younathan, 1984, The Journal of biological chemistry.

Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid

Ramesh N. Patel, R. Hanson, S. Goldberg, 2011 .

Carbon‐14 labeling of Saxagliptin (BMS‐477118)

R. Hanson, R. Iyer, H. Su, 2007 .

Purification and Cloning of a Ketoreductase used for the Preparation of Chiral Alcohols

Ramesh N. Patel, R. Hanson, S. Goldberg, 2005 .

Biochemical approaches to the synthesis of ethyl 5-(s)-hydroxyhexanoate and 5-(s)-hydroxyhexanenitrile.

T. LaPorte, R. Hanson, H. Chung, 2001, Enzyme and microbial technology.

Biocatalytic preparation of a chiral synthon for a vasopeptidase inhibitor: enzymatic conversion of N2-[N-Phenylmethoxy)carbonyl] L-homocysteinyl]- L-lysine (1- > 1′)-disulfide to [4S-(4I,7I,10aJ)] 1-octahydro-5-oxo-4-[phenylmethoxy)carbonyl]amino]-7H-pyrido-[2,1-b] [1,3]thiazepine-7-carboxylic acid

Ramesh N. Patel, R. Hanson, Chien-Kuang Chen, 2000 .

Enzymatic preparation of 5-hydroxy-L-proline, N-Cbz-5-hydroxy-L-proline, and N-Boc-5-hydroxy-L-proline from (α-N-protected)-L-ornithine using a transaminase or an amine oxidase.

R. Hanson, S. Goldberg, R. Patel, 2011, Enzyme and microbial technology.

Enzymatic synthesis of L-6-hydroxynorleucine.

Ramesh N. Patel, R. Hanson, D. Brzozowski, 1999, Bioorganic & medicinal chemistry.

Crystallization and quaternary structure analysis of the NAD(+)-dependent leucine dehydrogenase from Bacillus sphaericus.

T. J. Stillman, D. Rice, P. Baker, 1994, Journal of molecular biology.

Synthesis of l-β-hydroxyvaline from α-keto-β-hydroxyisovalerate using leucine dehydrogenase from Bacillus species

Ramesh N. Patel, R. Hanson, L. Szarka, 1990 .

Biotechnology Based Process for Production of a Disulfide-Bridged Peptide.

Steven H. Chan, Olav K. Lyngberg, M. Witmer, 2016, Bioconjugate chemistry.

Enzymatic Preparation of a d-Amino Acid from a Racemic Amino Acid or Keto Acid

Ramesh N. Patel, R. Hanson, S. Goldberg, 2008 .

Preparation of (S)-1-Cyclopropyl-2-methoxyethanamine by a Chemoenzymatic Route Using Leucine Dehydrogenase

R. Hanson, S. Goldberg, A. Goswami, 2012 .

Energy-Transducing Adenosine Triphosphatase from Escherichia coli: Purification, Properties, and Inhibition by Antibody

E. P. Kennedy, R. Hanson, 1973, Journal of bacteriology.

Preparation of an Amino Acid Intermediate for the Dipeptidyl Peptidase IV Inhibitor, Saxagliptin, using a Modified Phenylalanine Dehydrogenase

Ramesh N. Patel, Olav K. Lyngberg, R. Hanson, 2007 .

Enzymatic Reduction of Adamantanones to Chiral Adamantanol Intermediates for the Synthesis of 11-β-Hydroxysteroid Dehydrogenase Inhibitors

Ramesh N. Patel, R. Hanson, Zhiwei Guo, 2014 .

Site-specific enzymatic hydrolysis of taxanes at C-10 and C-13.

R. Hanson, V. Nanduri, L. Szarka, 1994, The Journal of biological chemistry.

Inhibition of Phosphofructokinase by Quinone Methide and α-Methylene Lactone Tumor Inhibitors

R. Hanson, S. M. Kupchan, H. Lardy, 1970, Science.

Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug.

R. Hanson, D. Brzozowski, R. Patel, 2000, Bioorganic & medicinal chemistry.

Enzymatic Preparation of an R-Amino Acid Intermediate for a γ-Secretase Inhibitor

R. Hanson, S. Goldberg, A. Goswami, 2013 .

Biocatalytic synthesis of some chiral drug intermediates by oxidoreductases

Ramesh N. Patel, R. Hanson, A. Banerjee, 1997 .

Discovering Drugs Through Biological Transformation: Role of Pharmacologically Active Metabolites in Drug Discovery

W. Humphreys, A. Fura, Y. Shu, 2004 .

Enzymatic reduction of α-substituted ketones with concomitant dynamic kinetic resolution

R. Hanson, Zhiwei Guo, A. Goswami, 2016 .

Enzymatic synthesis of chiral intermediates for pharmaceuticals

Steven Goldberg, Ramesh N. Patel, Animesh Goswami, 2003, Journal of Industrial Microbiology and Biotechnology.

Synthesis of ethyl and t-butyl (3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction

Ramesh N. Patel, R. Hanson, Zhiwei Guo, 2006 .

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.

P. Lam, W. Humphreys, A. Mathur, 2015, The Journal of organic chemistry.

Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds

R. Hanson, 2007 .

Selection of an Enantioselective Process for the Preparation of a CGRP Receptor Inhibitor

W. A. Nugent, R. Nielsen, R. Hanson, 2012 .

Fermentation and isolation of C10-deacetylase for the production of 10-deacetylbaccatin III from baccatin III.

T. LaPorte, R. Hanson, V. Nanduri, 1995, Biotechnology and bioengineering.

The kinetic mechanism of pyridine nucleotide transhydrogenase from Escherichia coli.

R. Hanson, 1979, The Journal of biological chemistry.

Efficient and scalable enantioselective synthesis of a CGRP antagonist.

David K. Leahy, R. Hanson, M. Sugiyama, 2012, Organic letters.

Repression of Escherichia coli pyridine nucleotide transhydrogenase by leucine

R. Hanson, B. Gerolimatos, 1978, Journal of bacteriology.

Isolation and partial characterization of a mutant of Escherichia coli lacking pyridine nucleotide transhydrogenase.

R. Hanson, C. Rose, K. Zahl, 1978, Archives of biochemistry and biophysics.

Inhibition of phosphofructokinase by quinone methide and alpha-methylene lactone tumor inhibitors.

R. Hanson, S. M. Kupchan, H. Lardy, 1970, Science.

Microbial reduction of 1‐(4‐fluorophenyl)‐4‐[4‐(5‐fluoro‐2‐pyrimidinyl)‐1‐ piperazinyl]butan‐1‐one

R. Hanson, A. Banerjee, R. Ko, 1993, Biotechnology and applied biochemistry.

Effects of an insertion mutation in a locus affecting pyridine nucleotide transhydrogenase (pnt::Tn5) on the growth of Escherichia coli

R. Hanson, C. Rose, 1980, Journal of bacteriology.

Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".

P. Lam, W. Humphreys, A. Mathur, 2015, Journal of Organic Chemistry.

Transformation of Nε‐Z‐l‐Lysine to Z‐l‐Oxylysine Using L‐Amino Acid Oxidase from Providencia alcalifaciens and l‐2‐Hydroxyisocaproate Dehydrogenase from Lactobacillus confusus

Ramesh N. Patel, R. Hanson, L. Szarka, 1992 .

Transformation of Nε-CBZ-l-lysine to CBZ-l-oxylysine using l-amino acid oxidase from Providencia alcalifaciens and l-2-hydroxy-isocaproate dehydrogenase from Lactobacillus confusus

Ramesh N. Patel, R. Hanson, L. Szarka, 1992, Applied Microbiology and Biotechnology.

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.

David K. Leahy, J. Barrish, M. Kirby, 2017, Journal of medicinal chemistry.

Enzymic hydrolysis of 7‐xylosyltaxanes by xylosidase from Moraxella sp.

Ramesh N. Patel, R. Hanson, L. Szarka, 1997 .

Synthesis and activity of a C-8 keto pleuromutilin derivative.

Ramesh N. Patel, T. LaPorte, Stella Huang, 2003, Bioorganic & Medicinal Chemistry Letters.

Resolution of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (BMS 181100) and α-(3-chloropropyl)-4-fluorobenzenemethanol using lipase-catalyzed acetylation or hydrolysis

Ramesh N. Patel, R. Hanson, A. Banerjee, 1994 .

Resolution of α‐(4‐Fluorophenyl)‐4‐(5‐fluoro‐2‐pyrimidinyl)‐1‐ piperazinebutanol (BMS 181100) (II) and α‐(3‐Chloropropyl)‐4‐ fluorobenzenemethanol (III) Using Lipase‐Catalyzed Acetylation or Hydrolysis.

Ramesh N. Patel, R. Hanson, Abhisek Banerjee, 1995 .

Synthesis of allysine ethylene acetal using phenylalanine dehydrogenase from Thermoactinomyces intermedius.

Harris, Lust, Montana., 2000, Enzyme and microbial technology.

Biotechnology Based Process for Production of a Disulfide-Bridged Peptide.

M. Witmer, R. Hanson, J. Bryson, 2016, Bioconjugate chemistry.